DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NCAM1 and ncam1

DIOPT Version :9

Sequence 1:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens
Sequence 2:	XP_017951446.2	Gene:	ncam1 / 100038291	XenbaseID:	XB-GENE-923171	Length:	1119	Species:	Xenopus tropicalis

Alignment Length:	883	Identity:	614/883 - (69%)
Similarity:	712/883 - (80%)	Gaps:	51/883 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPN 65
            |||.|||||||:|:||||:|:|.|||.|||||:||||||||||:|:|  .||||:||.||||. |
Frog    24 MLQIKDLIWTLYFIGTAVALEVTIVPDQGEISLGESKFFLCQVSGEA--SDISWYSPAGEKLL-N 85

Human    66 QQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR 130
            ||:||||.||..:|||||||.:..||||||||.:.|...|||.|||:||:|||.||||||||||.
Frog    86 QQQISVVKNDGYTSTLTIYNVSSQDAGIYKCVASSETEGESEGTVNLKIYQKLTFKNAPTPQEFI 150

Human   131 EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILA 195
            |||||||:|||.||:|..|.|:|:|:||||||||||:|||||||||||:||||||||||||||||
Frog   151 EGEDAVIICDVSSSIPSIITWRHRGKDVILKKDVRFVVLSNNYLQIRGVKKTDEGTYRCEGRILA 215

Human   196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260
            |||||:|||.||||||||:||||..||||||:.:||.|.|||:|||:|.:||.|.||.|  |:.:
Frog   216 RGEINYKDIHVIVNVPPTVQARQIRVNATANMDESVVLSCDADGFPDPEISWLKKGEPI--EDGE 278

Human   261 EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQV 325
            ||..|::|.|::||.:|.|:|||||.|||.|||||.:|.|.|||:||||||||||:||:||:| :
Frog   279 EKISFNEDKSEMTIYRVGKDDEAEYSCIANNKAGEAEAIILLKVYAKPKITYVENKTAVELDE-I 342

Human   326 TLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQEVHAPWNWQVGRQKGQAGSAGFPGSHET 390
            ||||||||||||||:|||:|||||||||                                    |
Frog   343 TLTCEASGDPIPSISWRTATRNISSEEK------------------------------------T 371

Human   391 LDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEG 455
            ||||:||:.|.|:|:||||.|||||||||||.|||.||:|.::||.|||||||::|||.||||||
Frog   372 LDGHIVVKEHIRMSALTLKDIQYTDAGEYICIASNAIGEDMRAMYFEVQYAPKIKGPVVVYTWEG 436

Human   456 NQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNR 520
            |.|||||||.|||||.:|||||||||||||:||||||:.||:|.|||.||||||||||||||||.
Frog   437 NPVNITCEVLAYPSAVVSWFRDGQLLPSSNFSNIKIYSGPSSSSLEVNPDSENDFGNYNCTAVNS 501

Human   521 IGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKW 585
            ||.||.|||||||||||||:|.:|||||||..|.||||:||||||||||||||:.:|:|.||:|:
Frog   502 IGHESSEFILVQADTPSSPAILRVEPYSSTVMVIFDEPDATGGVPILKYKAEWKVIGQEKWHAKY 566

Human   586 YDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPV-----QGEPSAPKLEG 645
            |||||.|.|.|:|:.||||||:|.|:|:|:||||||:.:.:.||.||||     |||||||||..
Frog   567 YDAKEVSAESIITVTGLKPETSYLVKLSAVNGKGLGDSTPSQEFTTQPVNIAKPQGEPSAPKLVW 631

Human   646 QMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRAL-SSEWKPEIRLPSGSDHVMLKSLDWNAEYEVY 709
            .:.||||::||.:|||||||||||||||.|||| :::||||:|:||.|.|||||:|:||.||||.
Frog   632 HLNEDGNNVKVEIIKQDDGGSPIRHYLVNYRALNAADWKPEMRVPSSSHHVMLKALEWNVEYEVI 696

Human   710 VVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIVGILIVIFVLLLVVVDITCYFLNK 774
            |||||||||||.|...|||:|:|||..|..|.::||.||||||||||||||||||||:||:||||
Frog   697 VVAENQQGKSKPARLSFRTTAKPTATTATTSASAGLGTGAIVGILIVIFVLLLVVVDVTCFFLNK 761

Human   775 CGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFSKDESKEPIVEVRTEEERTPNHDGGKHTEPNETT 839
            |||.||||||.||||||||||||:|||||||||||||||||||||||||||||||....||||||
Frog   762 CGLLMCIAVNFCGKAGPGAKGKDIEEGKAAFSKDESKEPIVEVRTEEERTPNHDGSNQIEPNETT 826

Human   840 PLTEPEKGPVEAKPECQETETKPAPAEVKTVPNDATQT 877
            ||||||. |.:.....:  :..|:...|.|..:..|:|
Frog   827 PLTEPEH-PADTTATVE--DMLPSVTTVTTNSDTITET 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273	64/94 (68%)
		IG	124..190	CDD:214652	53/65 (82%)
		Ig	211..307	CDD:325142	57/95 (60%)
		Ig	306..438	CDD:325142	74/131 (56%)
		Ig_3	447..519	CDD:316449	60/71 (85%)
		FN3	534..631	CDD:238020	65/96 (68%)
		fn3	639..720	CDD:306538	59/81 (73%)
		Trypan_PARP	<792..>864	CDD:330686	51/71 (72%)
ncam1	XP_017951446.2	Ig	43..136	CDD:416386	65/95 (68%)
		Ig strand A	43..48	CDD:409353	2/4 (50%)
		Ig strand A'	51..55	CDD:409353	3/3 (100%)
		Ig strand B	57..67	CDD:409353	9/9 (100%)
		Ig strand C	71..77	CDD:409353	4/5 (80%)
		Ig strand C'	80..82	CDD:409353	1/1 (100%)
		Ig strand D	89..95	CDD:409353	4/5 (80%)
		Ig strand E	97..105	CDD:409353	5/7 (71%)
		Ig strand F	112..120	CDD:409353	6/7 (86%)
		Ig strand G	124..135	CDD:409353	7/10 (70%)
		IG	144..210	CDD:214652	53/65 (82%)
		IgI_3_NCAM-1	231..325	CDD:143207	57/95 (60%)
		Ig strand B	251..255	CDD:143207	2/3 (67%)
		Ig strand C	264..268	CDD:143207	1/3 (33%)
		Ig strand E	288..292	CDD:143207	1/3 (33%)
		Ig strand F	302..307	CDD:143207	3/4 (75%)
		Ig strand G	315..318	CDD:143207	1/2 (50%)
		Ig	324..419	CDD:416386	74/131 (56%)
		Ig strand A	324..329	CDD:409353	4/4 (100%)
		Ig strand A'	333..337	CDD:409353	2/3 (67%)
		Ig strand B	341..349	CDD:409353	6/8 (75%)
		Ig strand C	355..361	CDD:409353	4/5 (80%)
		Ig strand C'	364..367	CDD:409353	2/2 (100%)
		Ig strand D	375..381	CDD:409353	3/5 (60%)
		Ig strand E	384..390	CDD:409353	3/5 (60%)
		Ig strand F	398..406	CDD:409353	6/7 (86%)
		Ig strand G	409..419	CDD:409353	4/9 (44%)
		Ig_3	423..500	CDD:404760	63/76 (83%)
		Ig strand B	439..443	CDD:409353	3/3 (100%)
		Ig strand C	452..456	CDD:409353	1/3 (33%)
		Ig strand E	479..483	CDD:409353	2/3 (67%)
		Ig strand F	493..498	CDD:409353	4/4 (100%)
		FN3	517..612	CDD:238020	63/94 (67%)
		FN3	624..709	CDD:238020	62/84 (74%)
		Herpes_BLLF1	<776..>1116	CDD:282904	58/89 (65%)
		PRK07994	<918..1075	CDD:236138
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	260	1.000	Domainoid score	I11257
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H40754
Inparanoid	1	1.050	1303	1.000	Inparanoid score	I1913
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48678
OrthoDB	1	1.010	-	-		D129648at2759
OrthoFinder	1	1.000	-	-		FOG0002001
OrthoInspector	1	1.000	-	-		oto153392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X10022
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.980