Protein Alignment NBN and Nbn

DIOPT Version :10

• Sequence 1: NP_002476.2
• Gene: NBN / 4683
• HGNCID: 7652
• Length: 754
• Species: Homo sapiens
• Sequence 2: NP_620228.1
• Gene: Nbn / 85482
• RGDID: 621420
• Length: 750
• Species: Rattus norvegicus
• Alignment Length: 755
• Identity: 526/755 - (69%)
• Similarity: 618/755 - (81%)
• Gaps: 7/755 - (0%)

Human     1 MWKLLPAAGPAGGEPYRLLTGVEYVVGRKNCAILIENDQSISRNHAVLTANFSVTNLSQTDEIPV 65
            ||||||||..|.|||.|||.||||:|||||||||||||||||||||||..||.||:||||||||.
  Rat     1 MWKLLPAASAAPGEPCRLLAGVEYIVGRKNCAILIENDQSISRNHAVLRVNFPVTSLSQTDEIPT 65

Human    66 LTLKDNSKYGTFVNEEKMQNGFSRTLKSGDGITFGVFGSKFRIEYEPLVACSSCLDVSGKTALNQ 130
            |.:|||||||||:||||||||.|.|||:||.:|||||.||||:||||||.|||||||||||.|||
  Rat    66 LIIKDNSKYGTFINEEKMQNGLSSTLKTGDRVTFGVFESKFRVEYEPLVVCSSCLDVSGKTVLNQ 130

Human   131 AILQLGGFTVNNWTEECTHLVMVSVKVTIKTICALICGRPIVKPEYFTEFLKAVESKKQPPQIES 195
            |||||||.|.|:||||||||.|.||||||||||||||||||||||||:|||||||||.|||:|||
  Rat   131 AILQLGGLTANSWTEECTHLAMSSVKVTIKTICALICGRPIVKPEYFSEFLKAVESKTQPPEIES 195

Human   196 FYPPLDEPSIGSKNVDLSGRQERKQIFKGKTFIFLNAKQHKKLSSAVVFGGGEARLITEENEEEH 260
            ||||:|||:||:|:||||||:|||||||||||:||||||||||.||||||||||||:.|..|||.
  Rat   196 FYPPIDEPAIGNKSVDLSGRRERKQIFKGKTFVFLNAKQHKKLGSAVVFGGGEARLMAEGGEEEQ 260

Human   261 NFFLAPGTCVVDTGITNSQTLIPDCQKKWIQSIMDMLQRQGLRPIPEAEIGLAVIFMTTKNYCDP 325
            :||.||||||||.||||:|.:|.|.|:|||..|||:|||..||||||||||||||||||::||:|
  Rat   261 SFFSAPGTCVVDVGITNTQLIITDSQRKWIHLIMDILQRHDLRPIPEAEIGLAVIFMTTESYCNP 325

Human   326 QGHPSTGLKTTTPGPSLSQGVSVDEKLMPSAPVNTTTYVADTESEQADT-WDLSERPKEIKVSKM 389
            ||.|.|.:||||||||||||:|.:.|::||||:|.||||||||||.||| ..|||||:|:|:..:
  Rat   326 QGQPCTEVKTTTPGPSLSQGLSANGKVIPSAPMNMTTYVADTESEPADTCMSLSERPEEVKIFGL 390

Human   390 EQKFRMLSQDAPTVKESCKTSSNNNSMVSNTLAKMRIPNYQLSPTKLPSINKSKDRASQQQQTNS 454
            :|..|.|.|....:||:...|||:|:..||||.:.:.|||||||.|.|:.:|:||.:| |||.||
  Rat   391 DQNSRKLLQGTCNIKETSNQSSNSNNAASNTLVRGKAPNYQLSPMKCPAASKNKDWSS-QQQLNS 454

Human   455 IRNYFQPSTKKRERDEENQEMSSCKSARIETSCSLLEQTQPATPSLWKNKEQHLSENEPVDTNSD 519
            |:|||||.::||||||||.|.|||||:|:|.|||||||||||.|||||:|: |.|::|.:...|:
  Rat   455 IKNYFQPCSRKRERDEENPEQSSCKSSRVELSCSLLEQTQPAEPSLWKSKD-HESQSETLGRASN 518

Human   520 NNLFTDTDLKSIVKNSASKSHAAEKLRSNKKREMDDVAIEDEVLEQLFKDTKPELEIDVKVQKQE 584
            .:.....|:|...|:..|||.:.|.||:.|::|: |::.|:||||:|.:.|||||.:.|||:|||
  Rat   519 ASSVGGIDIKPNGKSPDSKSFSTEDLRARKRKEV-DLSTEEEVLEELLRSTKPELAVQVKVEKQE 582

Human   585 EDVNVRKRPRMDIETNDTFSDEAVPESSKISQENEIGKKRELKEDSLWSAK-EISNNDKLQDDSE 648
            .||::||:||||.|.|...:...||||:...||:|..||.||:.:: ||.| |:||.|:|||.||
  Rat   583 ADVSIRKKPRMDAERNQHLNGGPVPESNSALQEDETEKKDELQIEA-WSTKREVSNTDELQDSSE 646

Human   649 MLPKKLLLTEFRSLVIKNSTSRNPSGINDDYGQLKNFKKFKKVTYPGAGKLPHIIGGSDLIAHHA 713
            .||:|||||||||||:.|::|||...:| ..|:|||||||||.|.||||||||||||||||.|||
  Rat   647 ELPRKLLLTEFRSLVVHNNSSRNLCPLN-GRGELKNFKKFKKATCPGAGKLPHIIGGSDLIGHHA 710

Human   714 RKNTELEEWLRQEMEVQNQHAKEESLADDLFRYNPYLKRR 753
            ||||||||||:.|||||.|.|||:|||||||||||.:|||
  Rat   711 RKNTELEEWLKHEMEVQKQQAKEDSLADDLFRYNPNVKRR 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NBN	NP_002476.2	FHA_NBN	2..110	CDD:438719	86/107 (80%)
		Mediates interaction with SP100. /evidence=ECO:0000250|UniProtKB:Q9R207	111..328		177/216 (82%)
		BRCT_nibrin	111..184	CDD:349372	64/72 (89%)
		NIBRIN_BRCT_II	217..325	CDD:465151	84/107 (79%)
		Interaction with MTOR, MAPKAP1 and RICTOR. /evidence=ECO:0000269|PubMed:23762398	221..402		128/181 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	326..346		15/19 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	396..415		7/18 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	430..478		31/47 (66%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:16188882	461..467		2/5 (40%)
		Nbs1_C	683..744	CDD:462531	52/60 (87%)
		FxF/Y motif. /evidence=ECO:0000269|PubMed:15758953, ECO:0000269|PubMed:35076389	740..749		8/8 (100%)
Nbn	NP_620228.1	FHA_NBN	2..110	CDD:438719	86/107 (80%)
		Mediates interaction with SP100. /evidence=ECO:0000250|UniProtKB:Q9R207	111..328		177/216 (82%)
		BRCT_nibrin	111..184	CDD:349372	64/72 (89%)
		NIBRIN_BRCT_II	217..325	CDD:465151	84/107 (79%)
		Interaction with MTOR, MAPKAP1 and RICTOR. /evidence=ECO:0000250|UniProtKB:O60934	221..403		128/181 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	429..479		34/50 (68%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O60934	461..467		2/5 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	494..550		23/56 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	581..622		20/40 (50%)
		Nbs1_C	680..741	CDD:462531	52/60 (87%)
		FxF/Y motif. /evidence=ECO:0000250|UniProtKB:O60934	737..746		8/8 (100%)