Protein Alignment NBN and Nbn

DIOPT Version :10

• Sequence 1: NP_002476.2
• Gene: NBN / 4683
• HGNCID: 7652
• Length: 754
• Species: Homo sapiens
• Sequence 2: XP_030109452.1
• Gene: Nbn / 27354
• MGIID: 1351625
• Length: 757
• Species: Mus musculus
• Alignment Length: 747
• Identity: 521/747 - (69%)
• Similarity: 604/747 - (80%)
• Gaps: 13/747 - (1%)

Human     1 MWKLLPAAGPAGGEPYRLLTGVEYVVGRKNCAILIENDQSISRNHAVLTANFSVTNLSQTDEIPV 65
            |||||||||.|.|||||||.|||||||||||.|||||||||||||||||.||.||:||||||||.
Mouse     1 MWKLLPAAGAAPGEPYRLLAGVEYVVGRKNCGILIENDQSISRNHAVLTVNFPVTSLSQTDEIPT 65

Human    66 LTLKDNSKYGTFVNEEKMQNGFSRTLKSGDGITFGVFGSKFRIEYEPLVACSSCLDVSGKTALNQ 130
            ||:||||||||||||||||.|.|.|||:||.:|||||.||||:||||||.|||||||||||.|||
Mouse    66 LTIKDNSKYGTFVNEEKMQTGLSCTLKTGDRVTFGVFESKFRVEYEPLVVCSSCLDVSGKTVLNQ 130

Human   131 AILQLGGFTVNNWTEECTHLVMVSVKVTIKTICALICGRPIVKPEYFTEFLKAVESKKQPPQIES 195
            |||||||.|.||||||||||||.:|||||||||||||||||:|||||:|||||||||||||.|||
Mouse   131 AILQLGGLTANNWTEECTHLVMSAVKVTIKTICALICGRPIIKPEYFSEFLKAVESKKQPPDIES 195

Human   196 FYPPLDEPSIGSKNVDLSGRQERKQIFKGKTFIFLNAKQHKKLSSAVVFGGGEARLITEENEEEH 260
            ||||:|||:||||:||||||.|||||||||||:||||||||||||||.||||||||:.|::|||.
Mouse   196 FYPPIDEPAIGSKSVDLSGRHERKQIFKGKTFVFLNAKQHKKLSSAVAFGGGEARLMAEDDEEEQ 260

Human   261 NFFLAPGTCVVDTGITNSQTLIPDCQKKWIQSIMDMLQRQGLRPIPEAEIGLAVIFMTTKNYCDP 325
            :||.||||||||.||||:|.:|...|||||..|||.|||.|||||||||||||||||||:|||:|
Mouse   261 SFFSAPGTCVVDVGITNTQLIISHSQKKWIHLIMDTLQRNGLRPIPEAEIGLAVIFMTTENYCNP 325

Human   326 QGHPSTGLKTTTPGPSLSQGVSVDEKLMPSAPVNTTTYVADTESEQADT-WDLSERPKEIKVSKM 389
            ||.|.|.||||||||||||.:|.:.|::||||||.||||||||||.||| ..|||||:|:|:..:
Mouse   326 QGQPCTELKTTTPGPSLSQVLSANGKIIPSAPVNMTTYVADTESEPADTCMPLSERPEEVKIPGL 390

Human   390 EQKFRMLSQDAPTVKESCKTSSNNNSMVSNTLAKMRIPNYQLSPTKLPSINKSKDRASQQQQTNS 454
            ||..|.|||:...:||:.|.||..|::.|:||.:.:.|:|||||.|.|..||:||..||||| ||
Mouse   391 EQSSRKLSQETFNIKEAPKPSSKANNVASDTLVRGKTPSYQLSPMKFPVANKNKDWTSQQQQ-NS 454

Human   455 IRNYFQPSTKKRERDEENQEMSSCKSARIETSCSLLEQTQPATPSLWKNKEQHLSENEPVDTNSD 519
            |:|||||.|:||||||:|.|:|||||:|:|.|||||||||||.|||||:|| |.|:|..:|..:|
Mouse   455 IKNYFQPCTRKRERDEDNPELSSCKSSRMELSCSLLEQTQPAGPSLWKSKE-HQSQNATLDREAD 518

Human   520 NNLFTDTDLKSIVKNSASKSHAAEKLRSNKKREMDDVAIEDEVLEQLFKDTKPELEIDVKVQKQE 584
            .:.....|::...|:...|....|.||..|:::: |:|.|:||||:|.:.|||||.:.|||:|||
Mouse   519 TSSVGGMDIELNRKSPDRKPLPTETLRPRKRKDV-DLATEEEVLEELLRSTKPELAVQVKVEKQE 582

Human   585 EDVNVRKRPRMDIETNDTFSDEAVPESSKISQENEIGKKRELKEDSLWSAK-EISNNDKLQDDSE 648
            .|..:||:||||.|.|...:..:.|||:...||:|..||.||:.:| ||.| ||:|:|.|||.||
Mouse   583 ADDTIRKKPRMDAERNRPLNGGSEPESNSALQEDEREKKDELQTES-WSTKHEIANSDGLQDSSE 646

Human   649 MLPKKLLLTEFRSLVIK--NSTSRNPSGINDDYGQLKNFKKFKKVTYPGAGKLPHIIGGSDLIAH 711
            .||:|||||||||||:.  ||||||.. :| :.|.|||||||||.|:|||||||||||||||:.|
Mouse   647 ELPRKLLLTEFRSLVVSNHNSTSRNLC-VN-ECGPLKNFKKFKKATFPGAGKLPHIIGGSDLVGH 709

Human   712 HARKNTELEEWLRQEMEVQNQ---HAKEESLA 740
            ||||||||||||:|||||..:   |.::.:||
Mouse   710 HARKNTELEEWLKQEMEVSRKGGPHTRDCTLA 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NBN	NP_002476.2	FHA_NBN	2..110	CDD:438719	90/107 (84%)
		Mediates interaction with SP100. /evidence=ECO:0000250|UniProtKB:Q9R207	111..328		181/216 (84%)
		BRCT_nibrin	111..184	CDD:349372	64/72 (89%)
		NIBRIN_BRCT_II	217..325	CDD:465151	86/107 (80%)
		Interaction with MTOR, MAPKAP1 and RICTOR. /evidence=ECO:0000269|PubMed:23762398	221..402		133/181 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	326..346		16/19 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	396..415		8/18 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	430..478		33/47 (70%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:16188882	461..467		3/5 (60%)
		Nbs1_C	683..744	CDD:462531	45/61 (74%)
		FxF/Y motif. /evidence=ECO:0000269|PubMed:15758953, ECO:0000269|PubMed:35076389	740..749		1/1 (100%)
Nbn	XP_030109452.1	FHA_NBN	2..110	CDD:438719	90/107 (84%)
		BRCT_nibrin	111..184	CDD:349372	64/72 (89%)
		NIBRIN_BRCT_II	217..325	CDD:465151	86/107 (80%)
		Nbs1_C	681..741	CDD:462531	43/59 (73%)