DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NARS1 and AsnRS

DIOPT Version :9

Sequence 1:	NP_004530.1	Gene:	NARS1 / 4677	HGNCID:	7643	Length:	548	Species:	Homo sapiens
Sequence 2:	NP_001260561.1	Gene:	AsnRS / 35194	FlyBaseID:	FBgn0086443	Length:	558	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	394/550 - (71%)
Similarity:	469/550 - (85%)	Gaps:	2/550 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MVLAELYVSDREGSDATGDGTKEKPFKTGLKALMTVGKEPFPTIYVDSQKEN--ERWNVISKSQL 63
            :.|..::.|:::|||.:|||::.|||||.|:|:...|||||||||||::..|  |.:...:||||
  Fly     9 LTLGAIFTSEKKGSDESGDGSESKPFKTILQAMRHAGKEPFPTIYVDTKDPNAAEPYEPAAKSQL 73

Human    64 KNIKKMWHREQMKSESREKKEAEDSLRREKNLEEAKKITIKNDPSLPEPKCVKIGALEGYRGQRV 128
            |.|:|::.||..|:..:.::||||:.:|::|||:|:|:.|..|||||..:.::|......|..||
  Fly    74 KKIQKLFVRESHKNADKLQREAEDAEKRQQNLEDARKVKISEDPSLPVARKIRIYEGTANRDSRV 138

Human   129 KVFGWVHRLRRQGKNLMFLVLRDGTGYLQCVLADELCQCYNGVLLSTESSVAVYGMLNLTPKGKQ 193
            ||:|||||||||||:|:|:.||||||:|||||.|:|||.|:.:.|||||||.::|.|.|.|:||.
  Fly   139 KVYGWVHRLRRQGKSLIFITLRDGTGFLQCVLNDQLCQTYDALTLSTESSVVLFGTLKLVPEGKT 203

Human   194 APGGHELSCDFWELIGLAPAGGADNLINEESDVDVQLNNRHMMIRGENMSKILKARSMVTRCFRD 258
            |||||||:.|:||||||||.||||.::|||:..||||:|||:||||||.||:||.||:||:.||.
  Fly   204 APGGHELNVDYWELIGLAPPGGADAILNEEAQPDVQLDNRHIMIRGENTSKVLKMRSVVTQAFRG 268

Human   259 HFFDRGYYEVTPPTLVQTQVEGGATLFKLDYFGEEAFLTQSSQLYLETCLPALGDVFCIAQSYRA 323
            |:..|||.|||||||||||||||:|||||.||||||:||||||||||||||||||||.|:|||||
  Fly   269 HYEARGYNEVTPPTLVQTQVEGGSTLFKLKYFGEEAYLTQSSQLYLETCLPALGDVFTISQSYRA 333

Human   324 EQSRTRRHLAEYTHVEAECPFLTFDDLLNRLEDLVCDVVDRILKSPAGSIVHELNPNFQPPKRPF 388
            ||||||||||||||||||||||||||||:||||||||||||:||||.|.:|.||||:|:||::||
  Fly   334 EQSRTRRHLAEYTHVEAECPFLTFDDLLDRLEDLVCDVVDRVLKSPWGYLVKELNPDFKPPQKPF 398

Human   389 KRMNYSDAIVWLKEHDVKKEDGTFYEFGEDIPEAPERLMTDTINEPILLCRFPVEIKSFYMQRCP 453
            :||||.|||.||||::|.|:|||||||||||||||||.|||||||||:|||||.||||||||||.
  Fly   399 RRMNYEDAIKWLKENNVTKDDGTFYEFGEDIPEAPERKMTDTINEPIMLCRFPAEIKSFYMQRCK 463

Human   454 EDSRLTESVDVLMPNVGEIVGGSMRIFDSEEILAGYKREGIDPTPYYWYTDQRKYGTCPHGGYGL 518
            ||.|||||||||:|||||||||||||:||||:|.|||||||||.|||||||||.|||.|||||||
  Fly   464 EDQRLTESVDVLLPNVGEIVGGSMRIYDSEELLKGYKREGIDPQPYYWYTDQRVYGTMPHGGYGL 528

Human   519 GLERFLTWILNRYHIRDVCLYPRFVQRCTP 548
            ||||||.|:|||||||:|||||||:.||.|
  Fly   529 GLERFLCWLLNRYHIREVCLYPRFLDRCRP 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NARS1	NP_004530.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		8/23 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..91		7/21 (33%)
		AsnS	125..548	CDD:223096	337/422 (80%)
AsnRS	NP_001260561.1	AsnS	122..558	CDD:223096	339/435 (78%)
		AsnRS_cyto_like_N	137..219	CDD:239818	57/81 (70%)
		AsxRS_core	233..552	CDD:238399	265/318 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160480
Domainoid	1	1.000	562	1.000	Domainoid score	I236
eggNOG	1	0.900	-	-		E1_COG0017
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68404
Inparanoid	1	1.050	831	1.000	Inparanoid score	I461
Isobase	1	0.950	-	0	Normalized mean entropy	S358
OMA	1	1.010	-	-		QHG62167
OrthoDB	1	1.010	-	-		D1056670at2759
OrthoFinder	1	1.000	-	-		FOG0005762
OrthoInspector	1	1.000	-	-		oto90206
orthoMCL	1	0.900	-	-		OOG6_103052
Panther	1	1.100	-	-	LDO	PTHR22594
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1451
SonicParanoid	1	1.000	-	-		X4153
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750