DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NAP1L2 and CG3708

DIOPT Version :9

Sequence 1:	NP_068798.1	Gene:	NAP1L2 / 4674	HGNCID:	7638	Length:	460	Species:	Homo sapiens
Sequence 2:	NP_569871.2	Gene:	CG3708 / 31039	FlyBaseID:	FBgn0040345	Length:	362	Species:	Drosophila melanogaster

Alignment Length:	389	Identity:	109/389 - (28%)
Similarity:	180/389 - (46%)	Gaps:	76/389 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    50 EAAAGLGEEGENGEDTAAG-SGEDGKKGGDTDEDSE-----ADRP----KGLIGYVLDTDFVESL 104
            ::|.|:.:|..:.|..|.| ||.....|..|.|.:|     ||.|    |..:.::     :..|
  Fly     6 DSAEGVTQEDSHTESRADGISGSLRSLGTYTQESTEPALSPADLPARSRKAFLRHM-----IGQL 65

Human   105 PVKVKYRVLALKKLQTRAANLESKFLREFHDIERKFAEMYQPLLEKRRQIINAIYE-PTEEECEY 168
            ...|:.|:.||:..|.:...:..:|.||.:::||:|......|.:.||.|:....| |.:.|..:
  Fly    66 AEPVQNRIRALRHNQLQQVRISEQFFREVYELERRFYGQSCALFDARRDILEGSVEPPIQTEKTW 130

Human   169 KSDSEDCDDEEMCHEEMYGNEEGMVHEYVDEDDGYEDYYYDYAVEEE--EEEEEEDDIEATGEEN 231
            ..|.:|.                              .|.|:...||  :..::...:..|
  Fly   131 PEDPQDA------------------------------LYLDFGNNEELRQLRQKLAPVSPT---- 161

Human   232 KEEEDPKGIPDFWLTVLKNVDTLTPLIKKYDEPILKLLTDIKVKLSDPGEPLSFTLEFHFKPNEY 296
                 ..|:|.|||||.:||..|:.|::.:|||:|:.|.|:::.....    |:.:.|.|:||.:
  Fly   162 -----TLGVPRFWLTVFQNVPLLSELVQDHDEPLLESLMDVRLAYDQD----SYMVIFQFRPNSF 217

Human   297 FKNE--LLTKTYVLKSKLAYYDPHPYRGTAIEYSTGCEIDWNEGKNVTLKTIKKKQKHRIWGTIR 359
            ..:.  ||||.|.|:.......|..:.|..|....||.|.|.:|.|:||:|::.::::|    ..
  Fly   218 LHDSSLLLTKRYFLQHSADPEYPFLFEGPEIVRCEGCHIHWRDGSNLTLQTVESRRRNR----AH 278

Human   360 TVTEDFPKDSFFNFFS-PHGITSNGRD-------GNDDFLLGHNLRTYIIPRSVLFFSGDALES 415
            .||:..|::|||.||: |..:..:..|       || ||.:|..|||.|:|::|||::||.::|
  Fly   279 RVTKVMPRESFFRFFAPPQALDLSLADEKTKLILGN-DFEVGFLLRTQIVPKAVLFYTGDLVDS 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAP1L2	NP_068798.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..88		14/43 (33%)
		NAP	111..410	CDD:279323	88/311 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..238		3/25 (12%)
		Nuclear localization signal. /evidence=ECO:0000255	346..352		0/5 (0%)
CG3708	NP_569871.2	NAP	71..336	CDD:279323	88/312 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152008
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1507
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53841
OrthoDB	1	1.010	-	-		D1216172at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11875
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X426
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.820