DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NAP1L1 and CG3708

DIOPT Version :9

Sequence 1:	NP_001317160.1	Gene:	NAP1L1 / 4673	HGNCID:	7637	Length:	391	Species:	Homo sapiens
Sequence 2:	NP_569871.2	Gene:	CG3708 / 31039	FlyBaseID:	FBgn0040345	Length:	362	Species:	Drosophila melanogaster

Alignment Length:	377	Identity:	118/377 - (31%)
Similarity:	200/377 - (53%)	Gaps:	52/377 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    17 DDVEEVEEEETGEETK-------LKARQLTVQMMQNPQILAA----------LQERLDGLVETPT 64
            |..|.|.:|::..|::       |::.....|....|.:..|          |:..:..|.|.
  Fly     6 DSAEGVTQEDSHTESRADGISGSLRSLGTYTQESTEPALSPADLPARSRKAFLRHMIGQLAEP-- 68

Human    65 GYIESLPRVVKRRVNALKNLQVKCAQIEAKFYEEVHDLERKYAVLYQPLFDKRFEIINAIYE-PT 128
                     |:.|:.||::.|::..:|..:|:.||::|||::......|||.|.:|:....| |.
  Fly    69 ---------VQNRIRALRHNQLQQVRISEQFFREVYELERRFYGQSCALFDARRDILEGSVEPPI 124

Human   129 EEECEWKPDEEDEI------SEELKEKAKIEDEKKDEEKEDPKGIPEFWLTVFKNVDLLSDMVQE 187
            :.|..|..|.:|.:      :|||::..    :|.........|:|.||||||:||.|||::||:
  Fly   125 QTEKTWPEDPQDALYLDFGNNEELRQLR----QKLAPVSPTTLGVPRFWLTVFQNVPLLSELVQD 185

Human   188 HDEPILKHLKDIKVKFSDAGQPMSFVLEFHFEPNEYF--TNEVLTKTYRMRSEPDDSDPFSFDGP 250
            ||||:|:.|.|:::.:...    |:::.|.|.||.:.  ::.:|||.|.::...|...||.|:||
  Fly   186 HDEPLLESLMDVRLAYDQD----SYMVIFQFRPNSFLHDSSLLLTKRYFLQHSADPEYPFLFEGP 246

Human   251 EIMGCTGCQIDWKKGKNVTLKTIKKKQKHKGRGTVRTVTKTVSNDSFFNFFAPPEVPESGDLDDD 315
            ||:.|.||.|.|:.|.|:||:|::.:::::    ...|||.:..:|||.|||||:..:....|:.
  Fly   247 EIVRCEGCHIHWRDGSNLTLQTVESRRRNR----AHRVTKVMPRESFFRFFAPPQALDLSLADEK 307

Human   316 AEAILAADFEIGHFLRERIIPRSVLYFTGEAIED---DDDDYDEEGEEADEE 364
            .:.||..|||:|..||.:|:|::||::||:.::.   ...|......||::|
  Fly   308 TKLILGNDFEVGFLLRTQIVPKAVLFYTGDLVDSLSAASPDSRSLSSEAEQE 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAP1L1	NP_001317160.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		5/14 (36%)
		NAP	76..343	CDD:307208	99/275 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	132..163		7/36 (19%)
		Nuclear localization signal. /evidence=ECO:0000255	273..279		0/5 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..391		4/22 (18%)
CG3708	NP_569871.2	NAP	71..336	CDD:279323	99/276 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1507
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53841
OrthoDB	1	1.010	-	-		D1216172at2759
OrthoFinder	1	1.000	-	-		FOG0000988
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11875
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X426
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.930