Protein Alignment dlt and Cdan1

DIOPT Version :10

• Sequence 1: NP_728672.1
• Gene: dlt / 46719
• FlyBaseID: FBgn0024510
• Length: 1240
• Species: Drosophila melanogaster
• Sequence 2: NP_081167.2
• Gene: Cdan1 / 68968
• MGIID: 1916218
• Length: 1239
• Species: Mus musculus
• Alignment Length: 1347
• Identity: 321/1347 - (23%)
• Similarity: 501/1347 - (37%)
• Gaps: 350/1347 - (25%)

  Fly    58 EDFATYFLGALRQSTKRYYYSQNSETPVFPLTPIHQLKPPVADVVKEEEQQQLNESSILSRSSC- 121
            ::|..:.|..||:.:.|          |.|..|....|.|||.......|.........:||..
Mouse    46 KEFVPFLLNFLREQSSR----------VLPQGPSTPAKTPVASAALPARQGAPARGGRGARSQLF 100

  Fly   122 -SMSSTSNTTPAP-QQPQGRRSTPGSGAQFCSTPNRS-GGGGAGGGHSICLGNFLVNTPIQSHQR 183
             :....|....|| .:..|||..||.|      |:|. ||.|:|.......|    .:|..:..|
Mouse   101 PAAEPLSAAAEAPLARRAGRRRGPGPG------PSRERGGRGSGAAEEGASG----ESPPWAGGR 155

  Fly   184 SKK------------KITPQKQQQNQHASLGSGTGAGATPQSKPRRRVLPMTISKNVSASSSFGD 236
            ..|            ...|......:...:|: ...|:..::||.||:.|..:|:..|.|..  .
Mouse   156 KPKGSGSPGSPRLSLSDPPNLSNLEEFPPVGT-VPPGSAGRTKPSRRINPTPVSEERSLSKP--K 217

  Fly   237 TSSFSNENNFWRISQSSEIFDRSQEAALEMEARKFLLLKKQEIKSEAPVNVSQQERTPEDEVFPE 301
            |...|...:....||.|.:........|....|.  |.:::|:..:|.....||..||...: ||
Mouse   218 TCFTSPPISCVPSSQPSTLDTSPWGLGLPPGCRS--LQEEREMLRKARTKQLQQSPTPASPI-PE 279

  Fly   302 --------------EAISLEGVANANHLQLLSTIYSLLMDLNLVPNVLRELSFVVHLLNVRDF-- 350
                          |......|::...|:|::.|||..:..|||||:..||.||:.||..|..
Mouse   280 SGSPVPSRTGNLTAEPADPARVSSRQRLELVALIYSSCIAENLVPNLFLELFFVLQLLTARRMVA 344

  Fly   351 -GQSPVKSYVPSALEGL------TQHKSCVYFAAKLLENQKKLLLQLDKRTLSVLLQNERL---S 405
             ..|.::| ...||:.|      :.| .||:||.::||:|.::|..|||.||.:|.:||||   |
Mouse   345 TKDSDLES-SQGALDSLDTPLFRSIH-DCVFFAVQVLEHQFQVLSYLDKGTLKLLAENERLLCFS 407

  Fly   406 LLPQGVVQELETHCQRRQDSTTPFAMDTSSSSQQNVYYHVENDSRDNFPSQNEFGAFKSQRDLFY 470
            ...||.::........:.....|       .|.|.|.:..|.|:|.||.|...|..||.|||:||
Mouse   408 PALQGRLRAAYEGSVAKVSLVIP-------PSAQAVSFQPETDNRANFSSDRAFHTFKKQRDVFY 465

  Fly   471 KALKRWEVSHLNRGFNFPSELGPRIMDIYKKSEHPVNMTHLAKLFVNQLL--------ISATETT 527
            :.|:.||..|....::|...||.||..:..:.....:.:|..:||..|||        ...:...
Mouse   466 EVLREWEDHHEEPSWDFEKGLGSRIRAMMGQLSAACSHSHFVRLFQKQLLQMCQSPGGAGGSVLG 530

  Fly   528 ESPEELGL----KLDPLRHNKLAQRLVTSSSS----VEGQFPRSQAFFRDFIAVCSSVAFLVHLK 584
            |:|:.|.:    ||..||  :|.:||:...||    ....||..|.||||||...||..|..||.
Mouse   531 EAPDVLNMLGADKLGRLR--QLQERLIAPQSSGGPCPPPTFPGCQGFFRDFIMSASSFHFNQHLM 593

  Fly   585 LELFVQLMRNNDSTFDLLQLTD----DVAVEEQSAQQGPYIVRVQTMANMLILAKFLGYVTVMPF 645
            ..|.:::...|.     |:|..    |...|.....||........:.::.:||||||:|..:|:
Mouse   594 DSLSLKIRELNG-----LRLPQHEPGDEDGESDMDWQGERRQFAVVLLSLRLLAKFLGFVAFLPY 653

  Fly   646 SGTTQHGNPTPPYLCPQQLQLRNHFRPDFNLREILERSMRQGKLLITLPWLVQYLAMLDLVSLHL 710
            .|   |..|....|....|.||:...|..::|.:|::.:...:.::|:||||::|:..|.:...|
Mouse   654 RG---HEPPPTRELQDSILALRSQVPPVLDIRALLQQGLWARRAVLTVPWLVEFLSFADHIVPLL 715

  Fly   711 PDAVATLELLYGLYADIRMAKLQPAAV-----FIARSCIGWL--LDAQPQ----LVNGYYN---- 760
            ....:...||..|:..:.::|.....:     .:..:.:|||  :...|:    |.:|..:
Mouse   716 DYYRSVFTLLLRLHRSLVLSKENEGEMCFLNKLLLLAVLGWLFQIPTVPEDLFFLEDGQVDAFEV 780

  Fly   761 -YRAQEAGVGSISAIVDICLKDLSCHDKSHAPLLD-ELLPVACPFLQEFR---VSITPSRQAKSG 820
             ..|.|.|:.|:                   |::| :||...||::.|.|   .|.......:||
Mouse   781 TTTASEHGLDSV-------------------PVVDQQLLYTCCPYIGELRKLLASWVSGSSGRSG 826

  Fly   821 RF-RYITTRLEQLQQNSSSISKDAIVASELSPAEQQQRKLVDAYLQSQNASTRRLIEFVTERTFK 884
            .| |.||      ...:||:.     |..|..::..|.:|.:|:..:|..|.||.:|||.||...
Mouse   827 GFVRKIT------PTTTSSLG-----ALPLQTSQGLQAQLAEAFFHNQPPSLRRTVEFVAERIGS 880

  Fly   885 CVVKDAQQEILLPSKASADAKVNEIKSTMLEEVFQELHEIFQD---AR-----------ENACQR 935
            ..||                   .||:|::.::..:...:.|:   ||           |:.|.:
Mouse   881 NCVK-------------------HIKATLVADLVHQAESLLQEQLVARGQEGGDPAQLLESLCSQ 926

  Fly   936 WKEHVHQML-------DRRIEHSLDGLLPSSTNAVLRSTYAHLIRVQAQTQLQQWLQSSVL---- 989
            ...|..|.|       .|:...::..|||..|.|.:.|:..::....|..:...||.:::.
Mouse   927 LCPHGAQALTQGREFCQRKSPTAVRALLPEETPAAVLSSAENIAVGLATEKACSWLSANITALIR 991

  Fly   990 -------------------------------------------QSTFYHGDLQELATKVCNCNRN 1011
                                                       :..|:|..||::
Mouse   992 REVKAAVSRMLRAQGPEPTARVERRGCSRACEHHAPLPSHLISEIKFHHCSLQDV---------- 1046

  Fly  1012 KADAAAAGGGGSSELQLSPDIGFSLSEFLYQLQQWLHCL-----SLRPEYVGSQEDLAELLRKAQ 1071
               .:.|.|....|..:||:   .|.:.|.|:.|.|.|.     :..........:||.||...|
Mouse  1047 ---LSLAAGPRDPEEGVSPE---HLEQLLNQMGQSLRCRQFLCPTAEQHLAKCSVELASLLVADQ 1105

  Fly  1072 KAVLLPKMPTVFYHLIGSG----LVHLLQLLITRKPNFLDKDIISASCSVWRSQQLMDSKASPGI 1132
            ..:|.|  ||  .|.:..|    |:|:|                   .|:|:..
Mouse  1106 IPILGP--PT--QHRLERGHARRLLHML-------------------LSLWKDD----------- 1136

  Fly  1133 FDGLISISFVQEMANSADSFRMLETILRSMLQSGAIRADHLNELFMPLFAENWSPKVWCMLSELL 1197
            |.|.:.:..:....|                              :.|.|:. .|:.|.:|..||
Mouse  1137 FQGPVPLQLLLSPRN------------------------------VGLLADT-RPREWDLLLFLL 1170

  Fly  1198 QQL------------SLSGKDSEAHYASGDSPEDEAKSHLFMEMLAD 1232
            ::|            :..|:.:||.: .||..|:  .|.||...||:
Mouse  1171 RELVEKDLMGHLEIEACLGRLNEAQW-PGDFSEE--LSTLFRLFLAE 1214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dlt	NP_728672.1	Codanin-1_C	786..908	CDD:464622	33/126 (26%)
Cdan1	NP_081167.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	61..249		47/210 (22%)
		PHA03247	<63..305	CDD:223021	58/257 (23%)
		Interaction with ASF1A/B. /evidence=ECO:0000250	193..213		6/19 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..299		8/38 (21%)
		Codanin-1_C	789..904	CDD:464622	37/163 (23%)