DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment arg and Arg2

DIOPT Version :9

Sequence 1:	NP_524875.1	Gene:	arg / 46717	FlyBaseID:	FBgn0023535	Length:	351	Species:	Drosophila melanogaster
Sequence 2:	NP_033835.1	Gene:	Arg2 / 11847	MGIID:	1330806	Length:	354	Species:	Mus musculus

Alignment Length:	316	Identity:	129/316 - (40%)
Similarity:	192/316 - (60%)	Gaps:	19/316 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SLGIIGVPFAKGQAKQGVELAPDLLRQSSLRQVLQSSHDGLVIRDYGNLQYA---VDEPLLQQQR 92
            |:.|:|.||::||.|.|||..|..:|::.|.:.|  |..|..::|:|:|.:.   .|:|
Mouse    25 SVAIVGAPFSRGQKKLGVEYGPAAIREAGLLKRL--SRLGCHLKDFGDLSFTNVPQDDP------ 81

  Fly    93 VHYHHIRNYADFMA-CNRALIEQVKLMLVENTQFLAIGGDHAIGFGSVAGHLQHTPNLSLVWIDA 156
              |:::..|...:. .|:.|.|.|...:......:.:||||::..|::.||.:|.|:|.::|:||
Mouse    82 --YNNLVVYPRSVGLANQELAEVVSRAVSGGYSCVTMGGDHSLAIGTIIGHARHRPDLCVIWVDA 144

  Fly   157 HADINLHSTSQSGNIHGMPVSFLLEQLRN-TWQHAGLQEIAPNCLPKDQLVYIGLRDIDPYEAFI 220
            |||||...|:.||||||.|:|||:::|:: ..|..|...|.| ||....:|||||||::|.|.||
Mouse   145 HADINTPLTTVSGNIHGQPLSFLIKELQDKVPQLPGFSWIKP-CLSPPNIVYIGLRDVEPPEHFI 208

  Fly   221 LNKVGIRYYAMDTIDRVGVPKIIEMTLDAL--NPQNKIHVSFDIDALDSNVAPSTGTAVRGGLTL 283
            |....|:|::|..|||:|:.|::|.|.|.|  ..|..||:||||||.|..:||:|||.|.||||.
Mouse   209 LKNYDIQYFSMREIDRLGIQKVMEQTFDRLIGKRQRPIHLSFDIDAFDPKLAPATGTPVVGGLTY 273

  Fly   284 REGISIVEALRDTKRVQGVDLVEINPKLG-SERDVRTTVESGLEILKSMFGYRRSG 338
            |||:.|.|.:.:|..:..:||||:||.|. ||.:.:.|....::::.|.||..|.|
Mouse   274 REGVYITEEIHNTGLLSALDLVEVNPHLATSEEEAKATARLAVDVIASSFGQTREG 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arg	NP_524875.1	Arginase	32..331	CDD:212515	123/306 (40%)
Arg2	NP_033835.1	Arginase	26..321	CDD:212515	123/305 (40%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P05089	145..149		3/3 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P05089	156..158		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836781
Domainoid	1	1.000	220	1.000	Domainoid score	I2611
eggNOG	1	0.900	-	-		E1_COG0010
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H906
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3418
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56454
OrthoDB	1	1.010	-	-		D1179130at2759
OrthoFinder	1	1.000	-	-		FOG0001970
OrthoInspector	1	1.000	-	-		otm44371
orthoMCL	1	0.900	-	-		OOG6_102008
Panther	1	1.100	-	-	O	PTHR43782
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R79
SonicParanoid	1	1.000	-	-		X1288
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800