Protein Alignment NAIP and Bruce

DIOPT Version :9

• Sequence 1: NP_001333799.1
• Gene: NAIP / 4671
• HGNCID: 7634
• Length: 1403
• Species: Homo sapiens
• Sequence 2: NP_001262460.1
• Gene: Bruce / 41260
• FlyBaseID: FBgn0266717
• Length: 4976
• Species: Drosophila melanogaster
• Alignment Length: 1700
• Identity: 305/1700 - (17%)
• Similarity: 543/1700 - (31%)
• Gaps: 640/1700 - (37%)

Human    18 NLLPELSALLGLDA-VQLAKELEEEEQKERAKMQKGYNSQMRSEAKRLKTFVTYEPYSSWIPQEM 81
            |.:.||.: .||:. ..::.||.::..:.:.|.:||.      :|:|..|.....||||
  Fly   138 NCITELES-EGLECPCDISNELTQKINQAQLKAKKGI------KAQRWNTICLEVPYSS------ 189

Human    82 AAAGFYFTGVKSGIQCFCCSLILFGAGLTR-LPI-----EDHKRFH--------PDCGFLLNKDV 132
                         ::....::::....|.| :|:     ..::|..        ||.|:
  Fly   190 -------------LKLVSNNMVILLKRLERHIPVLAIASAINERLTDMMMGSRVPDFGW------ 235

Human   133 GNIAKYDIRVKNLKSRLRGGKMRYQEEEARLASFRNWPF--YVQGISPCVLSEAGFVF---TGKQ 192
             |.:.:.             ::....|..|..:|..||.  |...: |..:::|||..   :..:
  Fly   236 -NFSNFQ-------------RVLMHSEAVRRQTFEKWPHMDYKWAL-PDQMAQAGFYHQPSSSGE 285

Human   193 DTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLRSKKSSEEITQYIQ---SYK---------- 244
            |...||:|..||..||:.|:||.||.:..|.|.|::.     |.||.:.   :|.
  Fly   286 DRAMCFTCSVCLVCWEKTDEPWSEHERHSPLCPFVKG-----EYTQNVPLSITYATNPALPAPGL 345

Human   245 GFVDITGEHFVN-------------SW-VQRELPMASAYCNDSI--FAYEELRLDSFKDWPRESA 293
            ||..|:...:.|             .| ::|.|.:...:...::  :.:||    || :|.|.:|
  Fly   346 GFDIISNSDYANVLCTSCSQTGELSVWSIERHLKLMHTFHVPTLLNYIFEE----SF-EWARVTA 405

Human   294 VGVAALAKAGLFYTGIKDIVQCFSCG--------GCLEKWQEGDDPLDDHTRCFPNCPFLQNMKS 350
            :.|...|:|   .|.:..:....:.|        ||    ..|.:.:........|.   |::.|
  Fly   406 ICVLPNARA---RTKVNYVYSAANYGGSGSSNGAGC----NSGLNAVSGGKFGSVNA---QHITS 460

Human   351 SAEVTPDL------------QSRGELC------ELLE-------TTSESNLEDSIAVG------- 383
            ::.:...:            ||.|||.      .::|       :||.||...|::.|
  Fly   461 TSTLRAGVVGSKIVLGVSVRQSSGELALRMVVLNIVEVDRNSESSTSVSNDSGSVSSGGGQLMKS 525

Human   384 --PIVPEMAQGEAQWFQ---EAKNLNEQLRAAY------------TSASFRHMSLLDISSDLATD 431
              |:|...|:..|...|   |:|:.:.:....|            .||...:.....:|.:  ||
  Fly   526 SSPMVNVSAENNATVTQVNLESKDDDNKAMTPYEKFADGFDSNGFVSALMTYNKNNGVSQN--TD 588

Human   432 H---LLGCDLSIASKHISKPVQEPLVLPEVFGNLNSV---------------------------- 465
            .   |...||...|:.:...::|||.|  :.|:.|:|
  Fly   589 DASALYDFDLCTLSQILDHNLEEPLSL--MVGSSNTVNVSNIGMGNEINKLVVDVEISHQNNNNN 651

Human   466 --------------------MCVEGEAGSG--KTVLLKKIAFL---WAS--------GCCPLLNR 497
                                :.:.|...|.  |...:::|..:   |.|        |....:|.
  Fly   652 NNNNNEASSLGGNSSNNNNNIMINGGTNSSIDKMTAIEEIDCVVESWTSVKRMNALDGASSGVNG 716

Human   498 F-----QLVFYLSLSSTRPDEGLASIICDQLL---------EKEGSVTEMCV------------- 535
            .     :::....:..|.|.       |:|||         |.|||...|..
  Fly   717 VNHMDQEVIEIAEILPTTPK-------CNQLLVKLLRTKAPEAEGSKIIMATVAKEEEEEDEEQR 774

Human   536 ------------RNIIQQLKNQVLFLLDDY------------------KEICSIPQVIGKLIQKN 570
                        .|:..||   ::|..||.                  |::|.:|........|:
  Fly   775 TDESMETDNNAEGNVAAQL---LVFDYDDTEISNDYTLAMTFSRAKFPKQLCILPHFNSSPEHKD 836

Human   571 HLSRTCLLIAVRTNRARDIRRYLET-ILEIKAFPFYNTVCILRKLFSHNMTRL----RKFMVYF- 629
             ....|::.|..|.....:..:..| ::|.:...|.:.|      :..|:.||    |:..:.|
  Fly   837 -AGSICVVCADGTVEIYSLADFQGTMVIEEEGEHFESVV------YCRNLDRLCCCSRQGGLLFY 894

Human   630 ----GKNQS--------------------------------LQKIQKTPLFVAAIC--------- 649
                |:|.|                                ...:.||.|...:||
  Fly   895 SLSDGENDSGDELLEMDDDCSTTLTQAADVSVTDGGRQLARTDLLGKTLLANESICMDAGSEAAA 959

Human   650 ----------AHWFQYP-----------------FDPSFDDVAVFKSYMERLSLRNKATAEILKA 687
                      ||....|                 .|.:.:|:.||.:..:   ..:|.|  :..|
  Fly   960 IPNSSSAAQGAHVQTSPSASSAPSTNANLLAYKTADLTLEDLKVFYALTQ---FDDKLT--VYSA 1019

Human   688 TVSSCGELALKGFFSCCFEFND-----------DDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYR 741
            .|.||              :||           .::...|.:.|...|..|.:..|
  Fly  1020 EVPSC--------------WNDIGQVQNQRKQSQNMRHGGDERDFTRTWRLHNDAT--------- 1061

Human   742 FLSPAFQEFLAGMRLIELLDSDRQEHQDLGLYHLKQINSP----MMTVSAYNNFLNYVSSLPSTK 802
                .:.|.:..:.|.:.:...   |.||.....:|.::|    :..:...||...|....|.:.
  Fly  1062 ----TWDEHIIELNLAQPVSLG---HIDLKFTVYQQCSNPAAIQVTLLKQNNNGFGYRMKGPHSS 1119

Human   803 AGPKIVSHLLHLVDNKESLENISENDDYLKHQPEISLQMQLLRGLWQICPQAYFSMVSEHLLVLA 867
            ..|.:       :|:...|..|:..:..|..:..::...::|.|..::
  Fly  1120 YKPNV-------IDDNIDLSYIANENPVLSEEYLLAHNAEVLAGPIEL----------------- 1160

Human   868 LKTAYQSNTVAACSPFVLQFLQGRTLTLGALNL-----QYFFDHPESLSLLRSIHFPIRG--NKT 925
                  |:.:..|.       ||.|.||.:..|     :.|..|      ::::..|.:.  |||
  Fly  1161 ------SSCIDLCD-------QGGTATLTSPKLFKTRTRNFLLH------IKTVSDPSKDGQNKT 1206

Human   926 --SPRAH-------------------FSVLETCFDKSQVPTIDQDYASAFEPMNEWERNLAEKED 969
              ||..|                   |:|........:...::...|:....:...:.|..:.:|
  Fly  1207 RDSPTRHKRPHHVEGFVERNKVSRNPFNVAANIISVVKTAVLEVFPAAKNACVKIIQVNKPKTQD 1271

Human   970 NVKSYM-------DMQRRASPDLSTGYWKLSPKQYKIPCLEVDVNDIDVVGQDML-EILMTVFSA 1026
            |.|.::       ...:.|:...|.|     .:..::|..|         |.|.| ||.::|
  Fly  1272 NEKVFVAKIIKNKTQSQSAAVAPSVG-----RRLEQLPSRE---------GCDWLHEISISV--- 1319

Human  1027 SQRIELHLNHSRGFIESIRPALELSKASVTKCSISKLELSAAEQELLLTLPSLESLEVSGTIQSQ 1091
             :.::.|...|.|.::.|    .:.:::|....:.::....|...|...|    ||::...|
  Fly  1320 -RAVKSHSRISNGRMQRI----AMLESNVLLVQLLRIASDPASSSLAKNL----SLDILNWI--- 1372

Human  1092 DQIFPNLDKFLC-----LKELSVDLEGNINVFSVIPEEFPNF----HHMEKLL---IQISAEYDP 1144
              .|..|::|..     ||: .::.:...|:..::.::|...    .|:|:||   :..|.....
  Fly  1373 --CFIRLNRFRSPKSERLKD-QINKQTAANIQDLLAQQFECISLAEKHIEQLLRNCVIYSERSTA 1434

Human  1145 SKLVKLI----QNSPNL------HV---FHLKCNFFSDF--------GSLMT--MLVSCKKLTEI 1186
            .|.|||:    :.:.||      |.   :..|....:.|        ||::.  |:::|...|..
  Fly  1435 HKCVKLLIMLTEGATNLPAEVQDHTTLDYSFKAAIANTFPELPRAQCGSVVRWYMMLTCATSTAE 1499

Human  1187 KFSDSFFQAVPFVASLPNFISLKI--------------LNLEGQQFPDEETSEKFAYIL-----G 1232
            ..:....||:    ||...|:.:|              ..|.|..|..|.....|..:.     .
  Fly  1500 SHNSISEQAI----SLLKEIAAEIDKRWDPHCALLCTRFGLYGYPFEPEIFDFDFPNVSRQGPGS 1560

Human  1233 SLSNL---EELILP-TG---------DGI-YRVAKLIIQ------------QCQQLH--CLRVLS 1269
            |::|:   ...||| ||         ||: :|....:|:            :..|||  |::...
  Fly  1561 SVANVIRSSPTILPVTGLDIKRLSSIDGVDFRTFPYLIRGKSISNQLRGLLEVVQLHFNCVQTSE 1625

Human  1270 FFKTLNDDSV 1279
            ..:..|.|||
  Fly  1626 ATRIDNIDSV 1635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NAIP	NP_001333799.1	BIR 1	60..127		14/80 (18%)
		BIR 2	159..227		25/72 (35%)
		BIR 3	278..345		16/74 (22%)
Bruce	NP_001262460.1	BIR	251..321	CDD:279047	25/70 (36%)
		DUF3643	3539..3664	CDD:289152
		UQ_con	4636..4790	CDD:278603

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810