Protein Alignment NAGLU and naglu

DIOPT Version :10

• Sequence 1: XP_024306539.1
• Gene: NAGLU / 4669
• HGNCID: 7632
• Length: 762
• Species: Homo sapiens
• Sequence 2: XP_688608.4
• Gene: naglu / 560126
• ZFINID: ZDB-GENE-100726-2
• Length: 757
• Species: Danio rerio
• Alignment Length: 741
• Identity: 422/741 - (56%)
• Similarity: 545/741 - (73%)
• Gaps: 23/741 - (3%)

Human    15 LAGAGGAAGDEAREAAAVRALVARLLGPGPAADFSVSVERALAAKPGLDTYSLGGGGAARVRVRG 79
            ||.....|.|:: ::.||..|:.|||| ..|.:|.|||.|.|:| .|||...|......:|...|
Zfish    28 LAHLRAKASDKS-QSRAVLDLLRRLLG-NRAREFIVSVNRTLSA-DGLDVCELRSAKNNKVVAVG 89

Human    80 STGVAAAAGLHRYLRDFCGCHVAWSGSQLRLPRPLPAVPGELTEATPNRASAGPPEKRKEDAYRA 144
            |||||.|.|::.||:.||.|||:|:|.||.|||||||:.|.|..:||:|
Zfish    90 STGVAVATGIYNYLKYFCNCHVSWAGDQLNLPRPLPALTGVLRISTPHR---------------- 138

Human   145 VLLYRYYQNVCTQSYSFVWWDWARWEREIDWMALNGINLALAWSGQEAIWQRVYLALGLTQAEIN 209
               :||||||||.|||.|||||.||:|||||||||||||.||::|||.:||.|||:|||.|.|::
Zfish   139 ---FRYYQNVCTASYSSVWWDWPRWQREIDWMALNGINLPLAFTGQEVLWQEVYLSLGLNQTELD 200

Human   210 EFFTGPAFLAWGRMGNLHTWDGPLPPSWHIKQLYLQHRVLDQMRSFGMTPVLPAFAGHVPEAVTR 274
            .||:|||||||.|||||..|.||||.|||:||||||.::||:||||||.||||||:|.|||.:||
Zfish   201 RFFSGPAFLAWNRMGNLFQWGGPLPQSWHVKQLYLQFKILDRMRSFGMIPVLPAFSGIVPEGITR 265

Human   275 VFPQVNVTKMGSWGHFNCSYSCSFLLAPEDPIFPIIGSLFLRELIKEFGTDHIYGADTFNEMQPP 339
            :||:.||||:..|.||||:|||:::|.|.||:|..||:|||.::|:||||||||..||||||.|.
Zfish   266 LFPKANVTKLSPWSHFNCTYSCAYVLDPRDPLFHRIGALFLTQVIEEFGTDHIYNTDTFNEMPPA 330

Human   340 SSEPSYLAAATTAVYEAMTAVDTEAVWLLQGWLFQHQPQFWGPAQIRAVLGAVPRGRLLVLDLFA 404
            ||:|:|||:.:.|::..||:||.:|:||:|||||...|.||...|::|:|..||.||::||||||
Zfish   331 SSDPTYLASISRAIFNTMTSVDPQAIWLMQGWLFISDPSFWKADQVKALLHGVPLGRMIVLDLFA 395

Human   405 ESQPVYTRTASFQGQPFIWCMLHNFGGNHGLFGALEAVNGGPEAARLFPNSTMVGTGMAPEGISQ 469
            ||.|||:.|.||.|||||||||||||||.||||.::::|.||..|..|||||:||.||.||||.|
Zfish   396 ESMPVYSSTNSFYGQPFIWCMLHNFGGNSGLFGTVDSINSGPFNAVRFPNSTLVGLGMTPEGIEQ 460

Human   470 NEVVYSLMAELGWRKDPVPDLAAWVTSFAARRYGVSHPDAGAAWRLLLRSVYNCSGEACRGHNRS 534
            |.|:|.||:||.|||||| :|..||:.:|.||||....:...||:||.||||||:....:.||||
Zfish   461 NPVIYELMSELAWRKDPV-NLYKWVSLYALRRYGSMDENLALAWQLLFRSVYNCTLPKYKNHNRS 524

Human   535 PLVRRPSLQMNTSIWYNRSDVFEAWRLLLTSAPSLATSPAFRYDLLDLTRQAVQELVSLYYEEAR 599
            |||.||||.|.|.|||:.:|.:.||:||..:||.|.|...|||||:|:||||:|.|.:.:|::.:
Zfish   525 PLVHRPSLHMQTDIWYDPADFYRAWKLLFEAAPGLVTLETFRYDLVDVTRQALQLLTTEFYKDIK 589

Human   600 SAYLSKELASLLRAGGVLAYELLPALDEVLASDSRFLLGSWLEQARAAAVSEAEADFYEQNSRYQ 664
            ||:.:::|:.||.|||||.|:|||.||.:|:|:..||||:||:||::..|.|.||..|:.|:|.|
Zfish   590 SAFQTQKLSDLLTAGGVLVYDLLPELDRILSSNEHFLLGAWLQQAQSQGVDEHEAHLYDINARNQ 654

Human   665 LTLWGPEGNILDYANKQLAGLVANYYTPRWRLFLEALVDSVAQGIPFQQHQFDKNVFQLEQAFVL 729
            :|||||.|.|||||:|:.||||.:||..||.||:..||:.:.:|.||:|..|::.|||:|:.||.
Zfish   655 ITLWGPNGEILDYASKEWAGLVEDYYLQRWGLFVNTLVECLDRGRPFKQDVFNQAVFQVEKGFVF 719

Human   730 SKQRYPSQPRGDTVDLAKKIFLKYYP 755
            ::::||::|.|||.|:|::|||||||
Zfish   720 NQRKYPTKPLGDTYDIARRIFLKYYP 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NAGLU	XP_024306539.1	NAGLU_N	42..115	CDD:463762	36/72 (50%)
		NAGLU	149..484	CDD:461545	222/334 (66%)
		NAGLU_C	493..747	CDD:463763	131/253 (52%)
naglu	XP_688608.4	None