Protein Alignment NAGLU and Naglu

DIOPT Version :10

• Sequence 1: XP_024306539.1
• Gene: NAGLU / 4669
• HGNCID: 7632
• Length: 762
• Species: Homo sapiens
• Sequence 2: NP_652045.1
• Gene: Naglu / 46386
• FlyBaseID: FBgn0014417
• Length: 778
• Species: Drosophila melanogaster
• Alignment Length: 750
• Identity: 302/750 - (40%)
• Similarity: 422/750 - (56%)
• Gaps: 42/750 - (5%)

Human    10 VGVLLLAGAGGAAGDEAREAAAVRALVARLLGPGPAADFSVSVERALAAKPGLDTYSLGGGGAAR 74
            :|:.:.|....:...:.:|.||: |:::|::|...:..|.|.|.:.:    .|.::.:......|
  Fly    35 MGLQMAAHLAPSTPKDVQETAAM-AVISRVIGERSSQLFKVQVNKNM----DLRSFQISMLDDGR 94

Human    75 VRVRGSTGVAAAAGLHRYLRDFCGCHVAWSGSQLRLPRPLPAVPGELTEATPNRASAGPPEKRKE 139
            :.:.|..||:....||.||:......|.|...::.||..|     :|...|....||.|
  Fly    95 ILLMGWDGVSVCKALHHYLKYVLNKDVDWFKMRIELPTNL-----QLPNVTIESKSASP------ 148

Human   140 DAYRAVLLYRYYQNVCTQSYSFVWWDWARWEREIDWMALNGINLALAWSGQEAIWQRVYLALGLT 204
                    ..|:|||||.||||.||...:|.|.:|||||.||:|.:| ..|||||.:||..:||.
  Fly   149 --------IIYHQNVCTWSYSFAWWGIEQWRRHLDWMALMGISLTIA-PVQEAIWVKVYTDMGLR 204

Human   205 QAEINEFFTGPAFLAWGRMGNLHTWDGPLPPSWHIKQLYLQHRVLDQMRSFGMTPVLPAFAGHVP 269
            ..||:|...||||.||.||||:..|.|||.|:|...||.||..::...|:.||:..|||||||||
  Fly   205 MEEIDEHLAGPAFQAWQRMGNIRGWAGPLTPAWRRYQLLLQQEIITAQRNLGMSVALPAFAGHVP 269

Human   270 EAVTRVFPQVNVTKMGSWGHFNCSYSCSFLLAPEDPIFPIIGSLFLRELIKEFGTDHIYGADTFN 334
            .|:.|:.|:....::..|..|...|.|...:.|.:.:|..|.|.||..:|.::|::||:..|.||
  Fly   270 RALKRLNPESTFMEVQRWNQFPDRYCCGLFVEPTENLFKEIASRFLHNIITKYGSNHIFFCDPFN 334

Human   335 EMQPPSSEPSYLAAATTAVYEAMTAVDTEAVWLLQGWLFQHQPQFWGPAQIRAVLGAVPRGRLLV 399
            |::||.::|.|:.:...|:||:|..:|.:|:||||||:|...| ||......|.|.|.||||:||
  Fly   335 ELEPPVAKPEYMRSTAAAIYESMRGIDPQAIWLLQGWMFVKNP-FWTTDMAEAFLTAAPRGRILV 398

Human   400 LDLFAESQPVYTRTASFQGQPFIWCMLHNFGGNHGLFGALEAVNGGPEAARLFPNSTMVGTGMAP 464
            |||.:|..|.|..|.|:.||||||||||||||..|:||:.:.:|.|.|.||..|||::||||:.|
  Fly   399 LDLQSEQFPQYELTRSYFGQPFIWCMLHNFGGTLGMFGSAKLINSGIEEARRLPNSSLVGTGITP 463

Human   465 EGISQNEVVYSLMAELGWRKDPVPDLAAWVTSFAARRYGVSHPDAGAAWRLLLRSVYNCSG-EAC 528
            |||.||.|:||...|.||....: ||.:|.|:|:..||||.......||.||..|||:..| :..
  Fly   464 EGIGQNYVMYSFTLERGWSNTSL-DLDSWFTNFSHSRYGVKDERLEQAWLLLKNSVYSFRGLQKM 527

Human   529 RGHNRSPLVRRPSLQMNTSIWYNRSDVFEAWRLLLTSAPSLATS----PAFRYDLLDLTRQAVQE 589
            ||  :..:.||||.......|||.|.|.:||.||||....:...    ..:.:||:|:|||.:|.
  Fly   528 RG--QYVVTRRPSFNQEPFTWYNASAVLDAWHLLLTFRAIIPLEDNRYEIYEHDLVDITRQFLQI 590

Human   590 LVSLYYEEARSAYLSKELASLLRAGGVLAYELLPALDE---VLASDSRFLLGSWLEQARAAAVSE 651
            .....|...||||..::::..    ..|:.:||...|:   :|||...||||:||:||:.||.:.
  Fly   591 SADQLYINLRSAYRKRQVSRF----EFLSVKLLKLFDDMELILASSRNFLLGNWLQQAKQAAPNT 651

Human   652 AEADFYEQNSRYQLTLWGPEGNILDYANKQLAGLVANYYTPRWRLFLEALVDSVAQGIPFQQHQF 716
            .:...:|.|:|.|:|.|||:|.|||||.||.:|||::||.||||||||.:..::..|.||....|
  Fly   652 GQQRNFEFNARNQITAWGPDGQILDYACKQWSGLVSDYYRPRWRLFLEDVTVALHAGRPFNGTAF 716

Human   717 DKNV-FQLEQAFVLSKQRYPSQPRGDTVDLAKKIF 750
            ...| .::|..|......||..|.|:|..:::.||
  Fly   717 KLKVSHEIELPFSNKDDVYPVTPVGNTWLISQDIF 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NAGLU	XP_024306539.1	NAGLU_N	42..115	CDD:463762	16/72 (22%)
		NAGLU	149..484	CDD:461545	166/334 (50%)
		NAGLU_C	493..747	CDD:463763	102/262 (39%)
Naglu	NP_652045.1	NAGLU_N	54..134	CDD:463762	21/84 (25%)
		NAGLU	151..483	CDD:461545	166/333 (50%)
		NAGLU_C	491..748	CDD:463763	102/262 (39%)