Protein Alignment NAGLU and Naglu

DIOPT Version :10

• Sequence 1: XP_024306539.1
• Gene: NAGLU / 4669
• HGNCID: 7632
• Length: 762
• Species: Homo sapiens
• Sequence 2: NP_038820.2
• Gene: Naglu / 27419
• MGIID: 1351641
• Length: 739
• Species: Mus musculus
• Alignment Length: 756
• Identity: 610/756 - (80%)
• Similarity: 665/756 - (87%)
• Gaps: 21/756 - (2%)

Human     1 MEAVAVAAAVGVLLLAGAGGAAGDEAREAAAVRALVARLLGPGPAADFSVSVERALAAKPGLDTY 65
            |||..:|..:|.|||  |||:.|||||||.|||.||.|||||||||:|.||||||||.:.|||||
Mouse     1 MEAAGLAVILGFLLL--AGGSVGDEAREAKAVRELVVRLLGPGPAANFLVSVERALADESGLDTY 63

Human    66 SLGGGGAARVRVRGSTGVAAAAGLHRYLRDFCGCHVAWSGSQLRLPRPLPAVPGELTEATPNRAS 130
            ||.|||...|.|||||||||||||||||||||||.||||.:||.||.||||||..|||.||||
Mouse    64 SLSGGGGVPVLVRGSTGVAAAAGLHRYLRDFCGCQVAWSSAQLHLPWPLPAVPDGLTETTPNR-- 126

Human   131 AGPPEKRKEDAYRAVLLYRYYQNVCTQSYSFVWWDWARWEREIDWMALNGINLALAWSGQEAIWQ 195
                             |||||||||.|||||||||||||:||||||||||||||||:|||||||
Mouse   127 -----------------YRYYQNVCTHSYSFVWWDWARWEQEIDWMALNGINLALAWNGQEAIWQ 174

Human   196 RVYLALGLTQAEINEFFTGPAFLAWGRMGNLHTWDGPLPPSWHIKQLYLQHRVLDQMRSFGMTPV 260
            ||||||||||:||:.:|||||||||||||||||||||||.|||:.|:|||||:||:||||||.||
Mouse   175 RVYLALGLTQSEIDTYFTGPAFLAWGRMGNLHTWDGPLPRSWHLSQVYLQHRILDRMRSFGMIPV 239

Human   261 LPAFAGHVPEAVTRVFPQVNVTKMGSWGHFNCSYSCSFLLAPEDPIFPIIGSLFLRELIKEFGTD 325
            |||||||||:|:|||||||||.|:||||||||||||||||||.||:||:||:||||||.||||||
Mouse   240 LPAFAGHVPKAITRVFPQVNVIKLGSWGHFNCSYSCSFLLAPGDPMFPLIGNLFLRELTKEFGTD 304

Human   326 HIYGADTFNEMQPPSSEPSYLAAATTAVYEAMTAVDTEAVWLLQGWLFQHQPQFWGPAQIRAVLG 390
            ||||||||||||||.|:||||||.|.||||||..||.:|||||||||||||||||||:||||||.
Mouse   305 HIYGADTFNEMQPPFSDPSYLAATTAAVYEAMVTVDPDAVWLLQGWLFQHQPQFWGPSQIRAVLE 369

Human   391 AVPRGRLLVLDLFAESQPVYTRTASFQGQPFIWCMLHNFGGNHGLFGALEAVNGGPEAARLFPNS 455
            ||||||||||||||||.|||..||||.|||||||||||||||||||||||.||.||:||||||||
Mouse   370 AVPRGRLLVLDLFAESHPVYMHTASFHGQPFIWCMLHNFGGNHGLFGALEDVNRGPQAARLFPNS 434

Human   456 TMVGTGMAPEGISQNEVVYSLMAELGWRKDPVPDLAAWVTSFAARRYGVSHPDAGAAWRLLLRSV 520
            ||||||:|||||.||||||:|||||||||||||||.|||:|||.||||||.|||.|||:||||||
Mouse   435 TMVGTGIAPEGIGQNEVVYALMAELGWRKDPVPDLMAWVSSFAIRRYGVSQPDAVAAWKLLLRSV 499

Human   521 YNCSGEACRGHNRSPLVRRPSLQMNTSIWYNRSDVFEAWRLLLTSAPSLATSPAFRYDLLDLTRQ 585
            ||||||||.||||||||:||||||:|::||||||||||||||||:||:|.|||||||||||:|||
Mouse   500 YNCSGEACSGHNRSPLVKRPSLQMSTAVWYNRSDVFEAWRLLLTAAPNLTTSPAFRYDLLDVTRQ 564

Human   586 AVQELVSLYYEEARSAYLSKELASLLRAGGVLAYELLPALDEVLASDSRFLLGSWLEQARAAAVS 650
            ||||||||.|||||:|||.:||..||||||:|.|:|||.|||:|||.|.||||:||:|||.||||
Mouse   565 AVQELVSLCYEEARTAYLKQELDLLLRAGGLLVYKLLPTLDELLASSSHFLLGTWLDQARKAAVS 629

Human   651 EAEADFYEQNSRYQLTLWGPEGNILDYANKQLAGLVANYYTPRWRLFLEALVDSVAQGIPFQQHQ 715
            ||||.|||||||||:||||||||||||||||||||||:||.|||.|||..|..|:|:|:|||||:
Mouse   630 EAEAQFYEQNSRYQITLWGPEGNILDYANKQLAGLVADYYQPRWCLFLGTLAHSLARGVPFQQHE 694

Human   716 FDKNVFQLEQAFVLSKQRYPSQPRGDTVDLAKKIFLKYYPR 756
            |:||||.||||||.:|:|||||||||||||:|||||||:|:
Mouse   695 FEKNVFPLEQAFVYNKKRYPSQPRGDTVDLSKKIFLKYHPQ 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NAGLU	XP_024306539.1	NAGLU_N	42..115	CDD:463762	57/72 (79%)
		NAGLU	149..484	CDD:461545	291/334 (87%)
		NAGLU_C	493..747	CDD:463763	205/253 (81%)
Naglu	NP_038820.2	NAGLU_N	28..113	CDD:463762	66/84 (79%)
		NAGLU	128..463	CDD:461545	291/334 (87%)
		NAGLU_C	472..726	CDD:463763	205/253 (81%)