Protein Alignment NAGLU and K09E4.4

DIOPT Version :10

• Sequence 1: XP_024306539.1
• Gene: NAGLU / 4669
• HGNCID: 7632
• Length: 762
• Species: Homo sapiens
• Sequence 2: NP_496948.2
• Gene: K09E4.4 / 175063
• WormBaseID: WBGene00010722
• Length: 715
• Species: Caenorhabditis elegans
• Alignment Length: 761
• Identity: 246/761 - (32%)
• Similarity: 370/761 - (48%)
• Gaps: 94/761 - (12%)

Human     9 AVGVLLLAGAGGAAGDEAREAAAVR---------ALVARLLGPGPAADFSVSVERALAAKPGLDT 64
            |:.:|:|.||     :.||.|..|:         ..|.|.:.|....:....|:...||:.|
 Worm     8 ALLILVLCGA-----ERARGALRVQLQDYDKNSWRSVLRRVAPEWVLEEFADVKVLSAAENG--- 64

Human    65 YSLGGGGAARVRVRGS--------TGVAAAAGLHRYLRDFCGCHVAWSGSQLRLPRPLPAVPGEL 121
            :.|...|.|::.:..|        |...|...::.|||..|...|:||.|..
 Worm    65 FQLPKSGLAQIEINKSGRKTVTANTPTDALNAINTYLRTECLSQVSWSNSSF------------- 116

Human   122 TEATPNRASAGPPEKRKEDAYRAVLLYRYYQNVCTQSYSFVWWDWARWEREIDWMALNGINLALA 186
                    |:|..::..:.........||:.|:||.||||.||:|.:|||.|||:||||.|..|.
 Worm   117 --------SSGCRKRTSDFINFESKQIRYFGNMCTFSYSFAWWEWPQWERFIDWIALNGFNTVLM 173

Human   187 WSGQEAIWQRVYLALGLTQAEINEFFTGPAFLAWGRMGNLHTWDGPLPPSWHIKQLYLQHRVLDQ 251
            ..|||.||:.:::.||:.:.|::.:||..|:|||.|||||..:.|.|..:..:....|..|::|:
 Worm   174 PLGQEIIWRDIFMGLGVQRDELDSYFTSQAYLAWHRMGNLKAYGGGLSDAQMLNDHNLAKRIIDR 238

Human   252 MRSFGMTPVLPAFAGHVPEAVTRVFPQVNVTKMGSWGHFNCSYSCSFLLAPEDPIFPIIGSLFLR 316
            :...|:||:||.|||.||:.:..:||.....::..|.:|....||...::|.||:|..|||.|||
 Worm   239 LLELGITPILPTFAGFVPDHLETLFPASKFNRLPRWNNFTSETSCMLSVSPFDPLFQKIGSTFLR 303

Human   317 ELIKEFGTD--HIYGADTFNEMQPPSS---EPSYLAAATTAVYEAMTAVDTEAVWLLQGWLFQHQ 376
            ...|.||.|  ::|.||.|||:.|..|   :..::.....|:..:...||...||:||.|.|.:.
 Worm   304 HQKKMFGGDVTNMYSADPFNEILPSESAKFDAKFVKQTAQAIMNSCKKVDKNCVWVLQSWSFTYD 368

Human   377 PQFWGPAQIRAVLGAVPRGRLLVLDLFAESQPVYTRTASFQGQPFIWCMLHNFGGNHGLFGALEA 441
            .  |....|::.|.|:|.|.||:|||:||..|.:..|:||||..|:||:||||||:..|.|.|:.
 Worm   369 Q--WPAWAIKSFLSAIPVGNLLILDLYAEVVPAWQMTSSFQGHHFVWCLLHNFGGSRELRGNLQK 431

Human   442 VNGGPEAARLFPNSTMVGTGMAPEGISQNEVVYSLMAELGWRKDPVPDLAAWVTSFAARRYGVSH 506
            ::.|.:.|.:...|.:||.|::.|.|.||.|||..|.:..|..:|:| |..|:.:::..||....
 Worm   432 IDKGYQLALMKAGSNLVGAGLSMEAIDQNYVVYQFMIDRMWSPEPLP-LNNWLKAYSESRYSADF 495

Human   507 PDAGAAWRLLLRSVYNCSGEACRGHNRSP-----------LVRRPSLQMNTSIWYNRSDVFEAWR 560
            ..|...|.||..:.||           .|           |..||........|:...:.|..:|
 Worm   496 KVAQKFWTLLAGTFYN-----------QPEKWGTPRFSVFLYHRPGFGRKIEYWFPVEETFSRFR 549

Human   561 LLLTS-APSLATSPAFRYDLLDLTRQAVQELVSLYYEEARSAYLSKELASLL----RAGGVLAYE 620
            .||.: ...|...|.||.||.|:.|:..|      :|....|.||...|.|:    :.|.  :.|
 Worm   550 ELLPALVHVLGEHPLFREDLNDVMREMTQ------FEMGNEAALSMSEAFLMEDKQQVGA--SCE 606

Human   621 LLPALDEVLASDSRFLLGSWLEQARAAAVSEAEADFYEQNSRYQLTLWGPEGNILDYANKQLAGL 685
            :|..:.:.|.|.|...:..|:|.|::.|.:..|...:...:...||:|||.|..||||:::.|||
 Worm   607 MLMEMFQKLESYSNRDVRQWIENAKSIAPTSEERQVFPVTAGDILTVWGPTGQNLDYAHREWAGL 671

Human   686 VANYYTPRWRLFLEALVDSVAQGIPFQQHQFDKNVFQ-LEQAFVLS 730
            ::.||..||:.|    .|.:.:...|...:|..:||: :|:.|.:|
 Worm   672 MSGYYGRRWQYF----CDWILEHDDFNHTEFSISVFRDVERPFSIS 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NAGLU	XP_024306539.1	NAGLU_N	42..115	CDD:463762	19/80 (24%)
		NAGLU	149..484	CDD:461545	141/339 (42%)
		NAGLU_C	493..747	CDD:463763	70/255 (27%)
K09E4.4	NP_496948.2	NAGLU	136..474	CDD:461545	141/339 (42%)
		NAGLU_C	482..710	CDD:463763	68/250 (27%)