Protein Alignment NAGLU and naglu

DIOPT Version :10

• Sequence 1: XP_024306539.1
• Gene: NAGLU / 4669
• HGNCID: 7632
• Length: 762
• Species: Homo sapiens
• Sequence 2: XP_031758141.1
• Gene: naglu / 100489327
• XenbaseID: XB-GENE-6030768
• Length: 759
• Species: Xenopus tropicalis
• Alignment Length: 764
• Identity: 426/764 - (55%)
• Similarity: 549/764 - (71%)
• Gaps: 40/764 - (5%)

Human     8 AAVGVLLLAGAGGAA----------------GDEAREAAAVRALVARLLGPGPAADFSVSVERAL 56
            ||:.||||.......                ||:. :.||||.|:||||| |.|::|||:|..:|
 Frog     3 AALLVLLLLSCSETVVPTRVFPALSHLKPQKGDDV-QTAAVRELLARLLG-GRASEFSVTVNSSL 65

Human    57 AAKPGLDTYSLGGGGAARVRVRGSTGVAAAAGLHRYLRDFCGCHVAWSGSQLRLPRPLPAVPGEL 121
             |:.|.|||.|..|....|.|.||:|||||:|.:.||:.|||.|::|||:||:||..||.||..|
 Frog    66 -AEGGRDTYRLSSGAGGTVLVVGSSGVAAASGCYTYLKAFCGAHLSWSGAQLQLPPALPPVPAPL 129

Human   122 TEATPNRASAGPPEKRKEDAYRAVLLYRYYQNVCTQSYSFVWWDWARWEREIDWMALNGINLALA 186
            |.:.|:|                   :.|||||||.|||||||||||||:|||||||:|||:.||
 Frog   130 TRSAPHR-------------------FHYYQNVCTSSYSFVWWDWARWEKEIDWMALSGINMPLA 175

Human   187 WSGQEAIWQRVYLALGLTQAEINEFFTGPAFLAWGRMGNLHTWDGPLPPSWHIKQLYLQHRVLDQ 251
            ::||||||.:|||:|||.::||.:|||||||||||||||:|||.|||..||..|:|.||.::.::
 Frog   176 FTGQEAIWYKVYLSLGLNESEIFDFFTGPAFLAWGRMGNIHTWGGPLSISWMEKRLSLQLQITER 240

Human   252 MRSFGMTPVLPAFAGHVPEAVTRVFPQVNVTKMGSWGHFNCSYSCSFLLAPEDPIFPIIGSLFLR 316
            |||.||..||||||||:||.:.||||:|.|:::|.|.:|||:||||:||.||||:|..||.|||.
 Frog   241 MRSLGMITVLPAFAGHIPEGILRVFPKVTVSRLGGWSNFNCTYSCSYLLDPEDPLFQWIGELFLS 305

Human   317 ELIKEFGTDHIYGADTFNEMQPPSSEPSYLAAATTAVYEAMTAVDTEAVWLLQGWLFQHQPQFWG 381
            ::::.|||||||.|||||||.|.||:|.||:|.:.|::::|..||.:|:||:|||||.:.|.||.
 Frog   306 QMVQSFGTDHIYSADTFNEMSPTSSDPGYLSAVSGAIFKSMAKVDPDAIWLMQGWLFINNPSFWQ 370

Human   382 PAQIRAVLGAVPRGRLLVLDLFAESQPVYTRTASFQGQPFIWCMLHNFGGNHGLFGALEAVNGGP 446
            |||.:|:|...|.||::|||||||:.|||..|.||.|||||||||:||||||||||.:|.||.||
 Frog   371 PAQTKALLHGAPIGRIIVLDLFAETVPVYLTTESFYGQPFIWCMLNNFGGNHGLFGNIEGVNRGP 435

Human   447 EAARLFPNSTMVGTGMAPEGISQNEVVYSLMAELGWRKDPVPDLAAWVTSFAARRYGVSHPDAGA 511
            ..|..||||||||||:.||||.||:::|..|.|:||...|: :|..|:::::.||||.|:.||..
 Frog   436 FDAAKFPNSTMVGTGLTPEGIEQNDMIYEFMNEIGWSSQPI-NLTKWISNYSDRRYGQSNTDARM 499

Human   512 AWRLLLRSVYNCSGEACRGHNRSPLVRRPSLQMNTSIWYNRSDVFEAWRLLLTSAPSLATSPAFR 576
            ||::||||||||: :....||.|||||||||.|||.|.||::|::||||.:..::.:|..|..|.
 Frog   500 AWQILLRSVYNCT-QILHNHNHSPLVRRPSLNMNTDICYNKADIYEAWRFMHNASFALGKSATFL 563

Human   577 YDLLDLTRQAVQELVSLYYEEARSAYLSKELASLLRAGGVLAYELLPALDEVLASDSRFLLGSWL 641
            |||:|:||:|||:|||.||.|.:.||..|.|..|:.|||||.|:|||.||.:|:|...|||||||
 Frog   564 YDLVDITREAVQQLVSEYYLEIKEAYGKKSLQQLMTAGGVLVYDLLPELDSLLSSQPGFLLGSWL 628

Human   642 EQARAAAVSEAEADFYEQNSRYQLTLWGPEGNILDYANKQLAGLVANYYTPRWRLFLEALVDSVA 706
            :.|::.|.:.|||..|:.|:|.|:|||||.||||||||||..|||.:|||.||.||:..||.|:.
 Frog   629 KAAKSMASTPAEAALYDMNARNQITLWGPTGNILDYANKQYGGLVQDYYTERWGLFVWFLVQSLN 693

Human   707 QGIPFQQHQFDKNVFQLEQAFVLSKQRYPSQPRGDTVDLAKKIFLKYYP 755
            :|..|.|.:|:|.||.||:.||.:.:.|.:.|.|||:::|.||:|||.|
 Frog   694 KGEHFNQDKFNKAVFVLEEDFVYNGKEYMASPTGDTLEIANKIYLKYQP 742

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NAGLU	XP_024306539.1	NAGLU_N	42..115	CDD:463762	37/72 (51%)
		NAGLU	149..484	CDD:461545	218/334 (65%)
		NAGLU_C	493..747	CDD:463763	136/253 (54%)
naglu	XP_031758141.1	NAGLU_N	40..113	CDD:463762	41/74 (55%)
		NAGLU	139..473	CDD:461545	218/333 (65%)
		NAGLU_C	481..733	CDD:463763	136/252 (54%)