DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)09851 and grwd1

DIOPT Version :9

Sequence 1:	NP_001260713.1	Gene:	l(2)09851 / 46662	FlyBaseID:	FBgn0022288	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_989268.3	Gene:	grwd1 / 394881	XenbaseID:	XB-GENE-986093	Length:	466	Species:	Xenopus tropicalis

Alignment Length:	462	Identity:	259/462 - (56%)
Similarity:	319/462 - (69%)	Gaps:	16/462 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DDGNENISMEV--VEPEDAESDMSSDSGSDAEDDTAEPKAPKEVYLPGTK-LADDEELVCDESAY 63
            :|..|:..||.  .|.||.|.|:..:     |:|..:.|.||.|||||.: |.:.||||.|:.||
Frog    14 EDEEEDEGMEESGSEDEDDEGDIMEE-----EEDDEKDKGPKRVYLPGMEPLKEGEELVMDQEAY 73

  Fly    64 VMLHQASTGAPCLSFDVIPDELGSGRQSFPMTAYIVAGTQASRAHVNNLIVMKMSNLHKTQDNDG 128
            |:.|||.|||||||||||.|.||..|..:|:|.|:.|||||..|..|.::||||.|||:|.....
Frog    74 VLYHQAQTGAPCLSFDVIRDTLGENRTDYPLTMYLCAGTQADSAQGNRMLVMKMYNLHRTSKEKK 138

  Fly   129 DEDEELEDDQDDVTDREELKKPQMTCALVKHQGCVNRVRARRLGNSVYAASWSELGRVNIWDLTQ 193
            |:.:....|..:..|.|| ||||:..|:|.|.|.:||:|...:|....||.|||.|:|:|:||.:
Frog   139 DDSDSESSDSGEEEDEEE-KKPQLELAMVPHYGGINRIRVSTMGEVPVAAVWSEKGQVDIYDLRK 202

  Fly   194 PLQAVENAQLAKQY---EQSEARPVFTFGGHQQEGFAIDWSPSADGVLATGDCRRDIHVWTPVED 255
            .|.||.::|:...:   ||::.:|||:|.||..||||:||||...|.|.||||.::||:|.|.|.
Frog   203 QLSAVSDSQVLAAFLKEEQAKIKPVFSFSGHMTEGFAMDWSPKTAGRLVTGDCNKNIHLWDPREG 267

  Fly   256 GTWKVDQRPLAGHSQSVEDLQWSPNERSVLASCSVDKTIRIWDCRASPQKACMLTCEDAHQSDVN 320
            |||.|||||..||::|||||||||.|.:|.||||||.:|||||.||:|.||||||...||:||||
Frog   268 GTWHVDQRPFTGHTKSVEDLQWSPTEATVFASCSVDASIRIWDVRAAPNKACMLTASQAHESDVN 332

  Fly   321 VISWNRNEPFIASGGDDGYLHIWDLRQFQSKKPIATFKHHTDHITTVEWSPAEATVLASGGDDDQ 385
            |||||..||||.||||||.|.||||||||....:|.||.||..||:|||.|.::.|.|:.|.|||
Frog   333 VISWNHQEPFIVSGGDDGVLKIWDLRQFQKGVSVAKFKQHTAPITSVEWHPTDSGVFAASGADDQ 397

  Fly   386 IALWDLAVEKDIDQAVDPAQNED-VLNKLPPQLLFIHQGQKEIKELHWHPQLPGVLLSTAHSGFN 449
            |..||||||:|.||   .|:.|| .|..:||||||:|||:|:|||||||||.|||::|||.||||
Frog   398 ITQWDLAVERDQDQ---EAETEDPALAGIPPQLLFVHQGEKDIKELHWHPQCPGVVVSTALSGFN 459

  Fly   450 IFRTISV 456
            :||||||
Frog   460 VFRTISV 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)09851	NP_001260713.1	CAF1C_H4-bd	53..120	CDD:289068	40/66 (61%)
		WD40	152..>395	CDD:295369	143/245 (58%)
		WD40	<172..>447	CDD:225201	169/278 (61%)
		WD40 repeat	226..267	CDD:293791	25/40 (63%)
		WD40 repeat	272..312	CDD:293791	30/39 (77%)
		WD40 repeat	320..357	CDD:293791	26/36 (72%)
grwd1	NP_989268.3	CAF1C_H4-bd	63..131	CDD:372002	41/67 (61%)
		WD40	226..>404	CDD:392136	116/177 (66%)
		WD40 repeat	238..279	CDD:293791	25/40 (63%)
		WD40 repeat	284..324	CDD:293791	30/39 (77%)
		WD40 repeat	332..370	CDD:293791	26/37 (70%)
		WD40 repeat	376..417	CDD:293791	23/43 (53%)
		WD40 repeat	437..463	CDD:293791	20/25 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	112	1.000	Domainoid score	I6143
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6644
Inparanoid	1	1.050	493	1.000	Inparanoid score	I1372
OMA	1	1.010	-	-		QHG53774
OrthoDB	1	1.010	-	-		D414254at33208
OrthoFinder	1	1.000	-	-		FOG0005244
OrthoInspector	1	1.000	-	-		oto104854
Panther	1	1.100	-	-	LDO	PTHR45903
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1211
SonicParanoid	1	1.000	-	-		X3761
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110