DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)09851 and RGD1563620

DIOPT Version :9

Sequence 1:	NP_001260713.1	Gene:	l(2)09851 / 46662	FlyBaseID:	FBgn0022288	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	XP_038959637.1	Gene:	RGD1563620 / 310511	RGDID:	1563620	Length:	423	Species:	Rattus norvegicus

Alignment Length:	441	Identity:	121/441 - (27%)
Similarity:	194/441 - (43%)	Gaps:	67/441 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 AEDDTAEPKAPKEVYLPGTKLADDEELVCDESAYVMLHQASTGAPCLSFDVIPDELGSGRQSFPM 94
            |.:|..|.:...|.|    |:..:...:.|   .||.|....  |.|:...:||......:.|.:
  Rat     7 AFEDVVEERVINEEY----KIWKNTPFLYD---LVMTHALEW--PSLTAQWLPDVTRPEGKDFGI 62

  Fly    95 TAYIVAGTQASRAHVNNLIV-MKMSNLHKTQDNDGDEDEELEDDQ-------DDVTDREELKKPQ 151
            .. :|.||..|... |:|:. :::.|      :|...|....|.:       ..|:.:.|::
  Rat    63 HR-LVLGTHTSDEQ-NHLVASVQLPN------DDAQFDASYYDSEKGEFGGFGSVSGKIEIE--- 116

  Fly   152 MTCALVKHQGCVNRVRARRLGNSVYAASWSELGRVNIWDLTQPLQAVENAQLAKQYEQSEARPVF 216
               ..:.::|.|||.|... .|....|:.:....|.::|.|:        ..:|.....|.....
  Rat   117 ---IKINYEGEVNRARYMP-QNPCIIATKTPSSDVLVFDYTK--------HPSKPDPSGECNSDL 169

  Fly   217 TFGGHQQEGFAIDWSPSADGVLATGDCRRDIHVW----TPVEDGTWKVDQRPLAGHSQSVEDLQW 277
            ...|||:||:.:.|:|...|.|.:......|.:|    .| ::|.....:....||:..|||:.|
  Rat   170 HLRGHQKEGYGLSWNPYLSGYLLSASDDHTICLWDISAVP-KEGKVVGAKTIFTGHTAVVEDVSW 233

  Fly   278 SPNERSVLASCSVDKTIRIWDCRAS----PQKACMLTCEDAHQSDVNVISWNRNEPFI-ASGGDD 337
            .....|:..|.:.|:.:.|||.|::    |..:.     ||:.::||.:|:|.|..|| |||..|
  Rat   234 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSV-----DAYTAEVNCLSFNPNSEFILASGSPD 293

  Fly   338 GYLHIWDLRQFQSKKPIATFKHHTDHITTVEWSPAEATVLASGGDDDQIALWDLAVEKDIDQAVD 402
            ..:.:||||..:.|  :.:|:.|.|.|..|:|||...|:|||.|.|.::.:|||:   .|.:...
  Rat   294 KTVALWDLRNLKLK--LHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLS---KIGEEQS 353

  Fly   403 PAQNEDVLNKLPPQLLFIHQGQ-KEIKELHWHPQLPGVLLSTAHSGFNIFR 452
            |...||.    ||:|||||.|. .:|.:..|:|..|.|:.|.:..  ||.:
  Rat   354 PEDAEDG----PPELLFIHGGHTAKISDFSWNPNEPWVICSVSED--NIMQ 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)09851	NP_001260713.1	CAF1C_H4-bd	53..120	CDD:289068	15/67 (22%)
		WD40	152..>395	CDD:295369	74/251 (29%)
		WD40	<172..>447	CDD:225201	87/284 (31%)
		WD40 repeat	226..267	CDD:293791	8/44 (18%)
		WD40 repeat	272..312	CDD:293791	12/43 (28%)
		WD40 repeat	320..357	CDD:293791	15/37 (41%)
RGD1563620	XP_038959637.1	CAF1C_H4-bd	19..86	CDD:403473	18/77 (23%)
		WD40	122..401	CDD:421866	94/303 (31%)
		WD40 repeat	126..173	CDD:293791	10/55 (18%)
		WD40 repeat	178..222	CDD:293791	9/44 (20%)
		WD40 repeat	229..263	CDD:293791	10/33 (30%)
		WD40 repeat	274..312	CDD:293791	16/39 (41%)
		WD40 repeat	318..369	CDD:293791	24/57 (42%)
		WD40 repeat	375..400	CDD:293791	8/26 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D831322at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920