DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)09851 and Y54H5A.1

DIOPT Version :9

Sequence 1:	NP_001260713.1	Gene:	l(2)09851 / 46662	FlyBaseID:	FBgn0022288	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_498091.1	Gene:	Y54H5A.1 / 175701	WormBaseID:	WBGene00021899	Length:	453	Species:	Caenorhabditis elegans

Alignment Length:	462	Identity:	198/462 - (42%)
Similarity:	281/462 - (60%)	Gaps:	20/462 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GNENISMEVVEPEDAESDMSSDSGSDAEDDTAE-PKAPKEVYLPGTK--LADDEELVCDESAYVM 65
            |..::.|...:|.: :.|.|.:...:.:|:..| |:..::.|:||..  |...|||..|.|||.:
Worm     3 GENDVEMHDEDPVE-DIDESEEEVDETDDEDEEVPENQRQAYIPGLSRPLKKGEELDFDPSAYKL 66

  Fly    66 LHQASTGAPCLSFDVIPDELGSGRQSFPMTAYIVAGTQASRAHVNNLIVMKMSNL---HKTQDND 127
            .|..::..|||||||:.|.||..|..||...|||:||||.:...|.:|||.:.||   .|.::|.
Worm    67 FHSFNSDWPCLSFDVVKDGLGENRTQFPAECYIVSGTQADKPRDNEIIVMGLKNLTTMRKEKENK 131

  Fly   128 GDEDEELEDDQDDVTDREELKK--PQMTCALVKHQGCVNRVRARRLGNSVYAASWSELGRVNIWD 190
            ||:.:..||:.:| .|.||.||  |:|....:.|.|.:||:|:.|||:|...|.||:.|||.:|:
Worm   132 GDDSDTSEDESED-EDAEEEKKREPKMHAVSIPHYGGINRIRSDRLGDSTVCACWSDQGRVQVWN 195

  Fly   191 LTQPLQAVENAQLAKQYE-QSEARPVFTFGGHQQEGFAIDWSPSADGVLATGDCRRDIHVWTPVE 254
            :|..|..........:.| |...||:||..|..:||:.:.||....|.|||||..:.|::|...|
Worm   196 ITDALNYTHGMSGESKTEVQKIDRPLFTNNGSGKEGYGLAWSSLKTGDLATGDIIKKIYLWQMKE 260

  Fly   255 DGTWKVDQRPLAGHSQSVEDLQWSPNERSVLASCSVDKTIRIWDCRASPQKACMLTCEDAHQSDV 319
            .|.|.|...||.||.:|||||.|||.|..:|||||.|.:|::||.|::|:.||:.|.:.||:|||
Worm   261 GGQWAVGANPLTGHKKSVEDLAWSPTETGLLASCSADGSIKLWDTRSAPKDACVCTVQKAHESDV 325

  Fly   320 NVISWNRNEPFIASGGDDGYLHIWDLRQFQSKKPIATFKHHTDHITTVEWSPAEATVLASGGDDD 384
            |||||||:|..|.||||||.|.||.|:..|..:|:|.||:|...||:|:|.|.|.|...:.|:||
Worm   326 NVISWNRHENLIVSGGDDGELKIWSLKTIQFGQPVALFKYHNSPITSVDWHPHETTTFMASGEDD 390

  Fly   385 QIALWDLAVEKDIDQAVDPAQNEDVLNKLPPQLLFIHQGQKEIKELHWHPQLPGVLLSTAHSGFN 449
            |..:||:|.|.|         .:..:..:||||:|:|.||.|:||:|||.|:||:.::|:..|||
Worm   391 QTTIWDIATEAD---------GQTNIEGVPPQLMFVHMGQNEVKEVHWHQQIPGLAINTSIDGFN 446

  Fly   450 IFRTISV 456
            :|:||::
Worm   447 VFKTINI 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)09851	NP_001260713.1	CAF1C_H4-bd	53..120	CDD:289068	32/66 (48%)
		WD40	152..>395	CDD:295369	113/243 (47%)
		WD40	<172..>447	CDD:225201	125/275 (45%)
		WD40 repeat	226..267	CDD:293791	16/40 (40%)
		WD40 repeat	272..312	CDD:293791	22/39 (56%)
		WD40 repeat	320..357	CDD:293791	22/36 (61%)
Y54H5A.1	NP_498091.1	CAF1C_H4-bd	54..122	CDD:372002	33/67 (49%)
		WD40	182..>401	CDD:392136	103/218 (47%)
		WD40 repeat	232..273	CDD:293791	16/40 (40%)
		WD40 repeat	278..318	CDD:293791	22/39 (56%)
		WD40 repeat	326..364	CDD:293791	22/37 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167353
Domainoid	1	1.000	104	1.000	Domainoid score	I4223
eggNOG	1	0.900	-	-		E1_KOG0302
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6644
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1114
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53774
OrthoDB	1	1.010	-	-		D414254at33208
OrthoFinder	1	1.000	-	-		FOG0005244
OrthoInspector	1	1.000	-	-		oto20114
orthoMCL	1	0.900	-	-		OOG6_102504
Panther	1	1.100	-	-	LDO	PTHR45903
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1211
SonicParanoid	1	1.000	-	-		X3761
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.840