DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)09851 and Grwd1

DIOPT Version :9

Sequence 1:	NP_001260713.1	Gene:	l(2)09851 / 46662	FlyBaseID:	FBgn0022288	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_700468.2	Gene:	Grwd1 / 101612	MGIID:	2141989	Length:	446	Species:	Mus musculus

Alignment Length:	444	Identity:	233/444 - (52%)
Similarity:	307/444 - (69%)	Gaps:	21/444 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 DSGSDAEDDTAEP--KAPKEVYLP--GTKLADDEELVCDESAYVMLHQASTGAPCLSFDVIPDEL 85
            ::|...|.:|.:|  :.|.:||||  |..|::.||||.||.|||:.|:|.|||||||||::.|.|
Mouse    12 ETGEPMEAETCDPGTEGPSQVYLPGRGPPLSEGEELVMDEEAYVLYHRAQTGAPCLSFDIVRDHL 76

  Fly    86 GSGRQSFPMTAYIVAGTQASRAHVNNLIVMKMSNLHKTQ--DNDGDEDEELEDDQDDVTDREELK 148
            |..|...|::.|:.|||||..|..|.|::::|.|||.|:  .::|.:|:|.::|::|    ||.:
Mouse    77 GDNRTELPLSLYLCAGTQAESAQSNRLMMLRMHNLHGTRPSPSEGSDDDEEDEDEED----EEEQ 137

  Fly   149 KPQMTCALVKHQGCVNRVRARRLGNSVYAASWSELGRVNIWDLTQPLQAVENAQLAKQY---EQS 210
            |||:..|:|.|.|.:||||...||....|..|||.|:|.::.|.:.||.|::.|....:   ||:
Mouse   138 KPQLELAMVPHYGGINRVRVSWLGEEPVAGVWSEKGQVEVFALRRLLQVVDDPQALAIFLRDEQA 202

  Fly   211 EARPVFTFGGHQQEGFAIDWSPSADGVLATGDCRRDIHVWTPVEDGTWKVDQRPLAGHSQSVEDL 275
            ..:|:|:|.||..||||:||||...|.|.||||::::|:|||.|.|:|.|||||..||::|||||
Mouse   203 RIKPIFSFAGHMGEGFALDWSPRVPGRLLTGDCQKNVHLWTPTEGGSWNVDQRPFVGHTRSVEDL 267

  Fly   276 QWSPNERSVLASCSVDKTIRIWDCRASPQKACMLTCEDAHQSDVNVISWNRNEPFIASGGDDGYL 340
            ||||.|.:|.||||.|.:|||||.||:|.||||||...||..|||||||:|.|||:.||||||.|
Mouse   268 QWSPTEDTVFASCSADASIRIWDIRAAPGKACMLTTATAHDGDVNVISWSRREPFLLSGGDDGAL 332

  Fly   341 HIWDLRQFQSKKPIATFKHHTDHITTVEWSPAEATVLASGGDDDQIALWDLAVEKDIDQA---VD 402
            .:||||||:|..|:||||.|...:|:|||.|.::.|.|:.|.|:||..||||||:|.:..   .|
Mouse   333 KVWDLRQFKSGSPVATFKQHMAPVTSVEWHPQDSGVFAASGADNQITQWDLAVERDPESGETETD 397

  Fly   403 PAQNEDVLNKLPPQLLFIHQGQKEIKELHWHPQLPGVLLSTAHSGFNIFRTISV 456
            |.     |..||.||||:|||:.::||||||||.||||:|||.|||.:||||||
Mouse   398 PG-----LAALPQQLLFVHQGETDLKELHWHPQCPGVLISTALSGFTVFRTISV 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)09851	NP_001260713.1	CAF1C_H4-bd	53..120	CDD:289068	35/66 (53%)
		WD40	152..>395	CDD:295369	135/245 (55%)
		WD40	<172..>447	CDD:225201	155/280 (55%)
		WD40 repeat	226..267	CDD:293791	24/40 (60%)
		WD40 repeat	272..312	CDD:293791	29/39 (74%)
		WD40 repeat	320..357	CDD:293791	25/36 (69%)
Grwd1	NP_700468.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		4/16 (25%)
		CAF1C_H4-bd	44..111	CDD:289068	35/66 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	111..141		12/33 (36%)
		WD40 repeat	175..212	CDD:293791	11/36 (31%)
		WD40	<194..>383	CDD:225201	110/188 (59%)
		WD40	206..>384	CDD:295369	109/177 (62%)
		WD 1	212..252		23/39 (59%)
		WD40 repeat	218..259	CDD:293791	24/40 (60%)
		WD 2	259..299		27/39 (69%)
		WD40 repeat	265..306	CDD:293791	28/40 (70%)
		WD 3	306..345		27/38 (71%)
		WD40 repeat	311..350	CDD:293791	27/38 (71%)
		WD 4	351..391		19/39 (49%)
		WD 5	412..445		23/32 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850186
Domainoid	1	1.000	133	1.000	Domainoid score	I5071
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6644
Inparanoid	1	1.050	479	1.000	Inparanoid score	I1455
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53774
OrthoDB	1	1.010	-	-		D831322at2759
OrthoFinder	1	1.000	-	-		FOG0005244
OrthoInspector	1	1.000	-	-		oto94661
orthoMCL	1	0.900	-	-		OOG6_102504
Panther	1	1.100	-	-	LDO	PTHR45903
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1211
SonicParanoid	1	1.000	-	-		X3761
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940