Protein Alignment MYT1 and CG43689

DIOPT Version :10

• Sequence 1: NP_004526.1
• Gene: MYT1 / 4661
• HGNCID: 7622
• Length: 1121
• Species: Homo sapiens
• Sequence 2: NP_001259230.1
• Gene: CG43689 / 31353
• FlyBaseID: FBgn0263772
• Length: 1706
• Species: Drosophila melanogaster
• Alignment Length: 1306
• Identity: 274/1306 - (20%)
• Similarity: 437/1306 - (33%)
• Gaps: 438/1306 - (33%)

Human    28 LSCPTPGCTGSGHVRGKYSRHRSLQSCPLAKKRK-----------LEGAEAEHLVSKRKSHPL-K 80
            |.||||||.|.|||:...|.||||..||.|.:|.           |..|.|:....:::.||| |
  Fly   414 LKCPTPGCNGRGHVQPHRSVHRSLSGCPRAVRRSGGTSRRPGAAPLAAAAADLDKHEKELHPLDK 478

Human    81 LALDEGYGVDSDGSEDTEVKDASVSDESEGTLEGAEAETSGQDEIHRPETAEGRSPV---KSHFG 142
            |.|...:.::::.|               ..:....::.||...:  |......|||   ||.:.
  Fly   479 LKLASNHYLNNNNS---------------NCINNNSSKLSGSTTM--PIIKSEYSPVASIKSEYN 526

Human   143 SNPI-----GSATASSKGSYSSYQGIIATSLLNLGQIAEETLVEEDLGQAAKPGPGIVHLLQEAA 202
            .:|:     |.|.|.:..:.||...:                      ||.:.|         :|
  Fly   527 KSPMHSYLSGEAAAPAPAAPSSASAV----------------------QAPRSG---------SA 560

Human   203 EGAASEEGEKGLFIQPEDAEEVVEVTTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEE 267
            .||.:..||..|.                             :...|:..|:.|...:.......
  Fly   561 SGATAANGENNLH-----------------------------APHLSRFVGLQSPPHQPHLNPHG 596

Human   268 EEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSHTSAQKAPELRGPE 332
            ..::::.::::::::::::::::::                     |:.|.|  .|:.|.:.|.:
  Fly   597 HHQQQQQQQQQQQQQQQQQQQQQQQ---------------------QQHTLH--QQRGPFIEGND 638

Human   333 SPSPKPEYSVIVEVRSDDDKDEDTHSRKSTVTDESEMQDMMTRGNLGLLEQAIALKAEQVRTVCE 397
            .|.|...|       ..:.:.:....::....||.:.|                  .||:|..
  Fly   639 VPDPSANY-------HSEHQQQQQQQQQQQQADERQQQ------------------YEQMRYA-- 676

Human   398 PGCPPAEQSQLGLGEPGKAAKP-----LDTVRKSYYSKDPSRAEKREIKCPTPGCDGTGHVTGLY 457
                   ||.:.:|..|:...|     .....:|.|...|....      |.||          :
  Fly   677 -------QSHVSVGPSGELMAPNGGELSPGTARSAYEAHPGHPH------PHPG----------H 718

Human   458 PHHRSLSGCPHKDRIPPEILAMHENVLKCP------TPGCTGQGHVN---------SNRNTHRSL 507
            ||       ||    ||..|:.    |..|      ....:|.|...         ||.....:.
  Fly   719 PH-------PH----PPVSLSS----LSSPAFTVDAVTAASGAGFERYDPSGVCCPSNGQRATAA 768

Human   508 SGCPIAAAEKLAKSHEKQQPQTGDPSKSS--------------------SNSDRILRPMCFVKQL 552
            :....|.|...|.::. ..|||.|..::.                    :|..:.|.|.
  Fly   769 TAATAAGASAAAAAYH-YLPQTTDEMQAQQQKYLQEQQLMLAKAEHEELANGGQPLYPR------ 826

Human   553 EVPPYGSYRPNVAPATP---RANLAKELEKFSKVTFDYASFDAQVFGKRMLAPKIQTSETSPKAF 614
               |...|.|.:.|..|   ..||:.::.. ::.....|::..|...::....:.|..:...:..
  Fly   827 ---PMYHYDPTMGPLPPGFSAINLSVKMAA-AQAAAAAAAYQNQQQQQQQQQQQQQHHQQQQQQQ 887

Human   615 QCFDYSQDAEAAHMAATAILNLSTRCWEMPENLSTKPQDLPSKSVDIEVDENGTLDLSMHKHRKR 679
            |.....|..:....:::...|:|          .....||...:.......:|....:.|.....
  Fly   888 QQQQQQQQQQHGKQSSSPAPNVS----------GVPAVDLSGSTSVTSSSPHGFNSPASHNQYTA 942

Human   680 ENAFPSSSSCSSSPGVKSPDASQRH------SSTSAPSSSMTSPQ-------------------- 718
            :.....|....:||.:.||......      |.|..|.|.:||||
  Fly   943 QRMGNGSPQPGASPNIASPQVPSPQGQTLDLSVTRLPHSIITSPQYGADGLVVGHAQGFVSGATG 1007

Human   719 -----SSQASRQDEWDRPLDYTKPSR----------------LREEEPEES---------EPAAH 753
                 :....|..:.: |:|::.|.|                .||..|:..         :|:.:
  Fly  1008 PLGPGNGGPPRSPQME-PVDFSGPPRPLGFGLVGHISGPRPYSRESTPDSGGSHYIETYRDPSGY 1071

Human   754 SFASS-----EADDQEVSEENFEERKY-----------PGEVTLTNFKLKFLSKDIKKELLTC-- 800
            |....     ::|........:....|           ||.....      :|........||
  Fly  1072 SPHPGYGMVVQSDYPPAGYHGYGPAAYQCSNPYATAVGPGGYPTP------VSGGYSPSPATCYS 1130

Human   801 -PTPGCDGSGHITGNYASHRSLSGCPLADKSLRNLMAAHSADLKCPTPGCDGSGHITGNYASHRS 864
             |.|     .||..:..|...|:||..:|   ||.:.:||.:|||||||||||||:||||:||||
  Fly  1131 MPPP-----QHIPQHDKSKDGLTGCSRSD---RNHLQSHSQELKCPTPGCDGSGHVTGNYSSHRS 1187

Human   865 LSGCPRAKKSGVKVAPTKDDKEDPELMKCPVPGCVGLGHISGKYASHRSASGCPLAARRQKEGSL 929
            |||||||.|.  |..|.  |.:|.|.::||:|||.|.||.:||:.|||||||||:|.|.:.....
  Fly  1188 LSGCPRANKP--KSKPR--DGQDSEPLRCPIPGCDGSGHSTGKFLSHRSASGCPIANRNKMRVLE 1248

Human   930 NGSSFSWKSLKNEGPT------CPTPGCDG--------------SGHANGSFL------------ 962
            .|.:...........|      |.|.|..|              .|:..||.|
  Fly  1249 AGGTVEQHKAAVAAATAMKFDACTTVGSQGIKKPKFDEVTMVYPKGYTGGSGLDIVMGGVGSSVG 1313

Human   963 -----------THRSLSGCPRATFAGKKGKLSG--DEVLSPKFKT----SDVLENDEEIKQLNQE 1010
                       |..|.|    ::.||.....||  :.|::.|..:    |......:::..|..|
  Fly  1314 VGLGLNVGIGVTSSSSS----SSSAGGNNNNSGSSNTVVTDKNPSGGGASSGANGSDDLNTLEAE 1374

Human  1011 IRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLELSGLSQALIQSLANIR 1075
            |.:|...|:.:|:.|::|:|.|::||..|...:.|..           .|||..|.  |..:::.
  Fly  1375 ISELQRENARVESQMMRLKSDINAMESQLSTSDREAS-----------PLSGHQQQ--QQRSSVA 1426

Human  1076 LPHMEPICEQNFDAYVST------LTDMYSNQDPEN----------KDLLESI-----------K 1113
            |  ..|..:..|.:..||      ::...:|.:..|          .||..||           .
  Fly  1427 L--ASPSGQSPFASVSSTSGASSSVSGATTNSNNNNSSSGGGTTNANDLNHSISNLAPSSGSNPN 1489

Human  1114 QAVRGI 1119
            ||:.|:
  Fly  1490 QAIEGV 1495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYT1	NP_004526.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..156		42/147 (29%)
		zf-C2HC	30..57	CDD:460240	17/26 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	200..376		21/175 (12%)
		zf-C2HC	441..467	CDD:460240	5/25 (20%)
		zf-C2HC	485..513	CDD:460240	5/42 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	517..540		6/42 (14%)
		MYT1	560..791	CDD:462489	44/305 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	668..774		25/166 (15%)
		zf-C2HC	799..827	CDD:460240	10/30 (33%)
		zf-C2HC	843..871	CDD:460240	25/27 (93%)
		zf-C2HC	892..920	CDD:460240	19/27 (70%)
		zf-C2HC	945..973	CDD:460240	12/70 (17%)
		Mplasa_alph_rch	<993..>1065	CDD:275316	18/75 (24%)
CG43689	NP_001259230.1	zf-C2HC	415..443	CDD:460240	17/27 (63%)
		zf-C2HC	1166..1194	CDD:460240	25/27 (93%)
		zf-C2HC	1211..1239	CDD:460240	19/27 (70%)