Protein Alignment MYOC and myoc

DIOPT Version :10

• Sequence 1: NP_000252.1
• Gene: MYOC / 4653
• HGNCID: 7610
• Length: 504
• Species: Homo sapiens
• Sequence 2: NP_001015062.1
• Gene: myoc / 548602
• ZFINID: ZDB-GENE-050425-2
• Length: 474
• Species: Danio rerio
• Alignment Length: 501
• Identity: 223/501 - (44%)
• Similarity: 310/501 - (61%)
• Gaps: 80/501 - (15%)

Human    34 TAQLRKANDQSGRCQYTFSVASPNESSCPEQSQAMSVIHNLQRDSSTQRLDLEATKARLSSLESL 98
            :|.||:||..:|||||||.|.||.|:|||.             ..||.  ::||..:||..||:|
Zfish    21 SANLRRANAGNGRCQYTFMVDSPTEASCPS-------------PGSTP--EMEALMSRLGLLEAL 70

Human    99 LHQLTLDQAARPQETQ---EGLQRELGTLRRERDQLETQTRELETAYSNLLRDKSVLEEEKKRLR 160
            :.:| :...|.|:.:|   .|||                     .:|:.::.:.:.|:.||:||.
Zfish    71 VARL-VGGEAMPESSQSSGSGLQ---------------------DSYNQVMGENAQLKREKQRLD 113

Human   161 QENENLARRLESSSQEVARLRRGQCPQTRDTARAVP-------PGSREVST-------------- 204
            ::.::|.:|:|...||..|||...|.|  .|:..||       |||..|.:
Zfish   114 RQVQDLQQRMEELRQEAERLRSRPCMQ--QTSSRVPQKDNSFRPGSGHVPSNLASRPGNPQEDKS 176

Human   205 ------WNLDTLAFQELKSELTEVPASRILKESPSGYLRSGEGD-TGCGELVWVGEPLTLRTAET 262
                  |......:|||.:.:|||.|..          :.|..| :|||:||||..|...|.|::
Zfish   177 SLRDPAWQYSNPGYQELTAVVTEVTAPN----------QDGPADISGCGDLVWVENPEVHRKADS 231

Human   263 ITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLISQFMQGYPSKVHILPRPLESTGA 327
            |.|||||||:||:...||..:..||||:||::|||:|.|:.:.|..:|:|:||.:||..:|||||
Zfish   232 IAGKYGVWMQDPEAKEPYGPDMVWRIDSVGSEVRQLFGYENMDQLTRGFPTKVLLLPESVESTGA 296

Human   328 VVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIY 392
            .:|.||||:|...|||:|||:|:.|::.|.:::|.||:|||||||||||||||||:||.|||.||
Zfish   297 TMYKGSLYYQRRLSRTLIRYDLHAESIAARRDLPHAGFHGQFPYSWGGYTDIDLAIDENGLWAIY 361

Human   393 STDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYTSADATVNFAYDTGT 457
            ||::||||||:|:|:|.|||::.||||.|||.||||||:|||.||||:||||.:.|||:.:||.|
Zfish   362 STNKAKGAIVISQLDPHNLEVKGTWETKIRKTSVANAFMICGKLYTVASYTSPNTTVNYMFDTAT 426

Human   458 GISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLSK 503
            ...|.:::||||||:|:||:|||..::||:||||..||:|.::|.|
Zfish   427 SQGKAISVPFKNRYRYNSMVDYNSAKRKLYAWDNYYMVSYSVRLGK 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYOC	NP_000252.1	COG4913	<71..>196	CDD:443941	33/127 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	106..131		6/27 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..200		13/36 (36%)
		OLF	246..502	CDD:470611	151/255 (59%)
		Microbody targeting signal. /evidence=ECO:0000255	502..504		1/2 (50%)
myoc	NP_001015062.1	ZapB	<101..>134	CDD:442308	11/32 (34%)
		PRK13729	103..>187	CDD:184281	23/85 (27%)
		OLF	217..470	CDD:460482	150/252 (60%)