DRSC/TRiP Functional Genomics Resources

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Protein Alignment MYOC and cof-2

DIOPT Version :10

Sequence 1:NP_000252.1 Gene:MYOC / 4653 HGNCID:7610 Length:504 Species:Homo sapiens
Sequence 2:NP_491804.2 Gene:cof-2 / 183582 WormBaseID:WBGene00000583 Length:486 Species:Caenorhabditis elegans


Alignment Length:389 Identity:100/389 - (25%)
Similarity:169/389 - (43%) Gaps:94/389 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   146 LRDKSVLEEEKKRLRQENENLARRLESSSQEVARLRRGQCPQTRDTARAVP---------PGSRE 201
            :||:.::|.|.|....||      ||             || .|:.....|         ||..:
 Worm   144 IRDELLMEREFKCPTIEN------LE-------------CP-NREAIPTTPWPSVTHQPMPGLVQ 188

Human   202 ----------------VSTWNLDTLAFQELKSELTEVPASRILKESPSGYLRSGEGDTGCGELVW 250
                            :..:.||    :|::..:|          :|..|:   :|.|....|..
 Worm   189 QILSNYSEVEGCVKICLKNYTLD----EEIEETIT----------TPVAYI---QGVTAHCRLQN 236

Human   251 VGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVR-----------QVFEYDLI 304
            ||:|:....:.|.   ||.||||   .||.|          |.|.|           ::.|:...
 Worm   237 VGKPVFHSHSTTY---YGSWMRD---AYPPT----------GDDARKRYVMNHFQGHELIEFRNE 285

Human   305 SQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHG-Q 368
            ::..:.:..|||.||...:.|..|:::.||::|.|....:.:||.|::.. ::.|||||.|.| |
 Worm   286 AEMRRDHVGKVHRLPYIFDGTNHVIFNASLFYQRAGYPIIAKYEFNSKQY-SQFEIPGAAYRGDQ 349

Human   369 FPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWE-TNIRKQSVANAFII 432
            :.|: ......|||:||..|||::...| :..:.::|::..||.:.:.:. |.:....|||..::
 Worm   350 YLYN-NSMNYFDLAIDENALWVMFHYQE-EAFLSVAKVDINNLTIYEAFNLTTVNHTDVANGIVV 412

Human   433 CGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVT 496
            |||:|.|.|.:.....::.|||..........|.:.|.||.::||.||..:|:::.:|:..|::
 Worm   413 CGTIYLVESASEQSTYISTAYDFYRNTYSQPLIKWINLYKNANMISYNAYDKRIYIYDHGYMLS 476

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYOCNP_000252.1 COG4913 <71..>196 CDD:443941 12/49 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 106..131
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 170..200 8/38 (21%)
OLF 246..502 CDD:470611 77/264 (29%)
Microbody targeting signal. /evidence=ECO:0000255 502..504
cof-2NP_491804.2 OLF 234..478 CDD:460482 77/262 (29%)
Blue background indicates that the domain is not in the aligned region.

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