DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYO10 and ck

DIOPT Version :9

Sequence 1:NP_036466.2 Gene:MYO10 / 4651 HGNCID:7593 Length:2058 Species:Homo sapiens
Sequence 2:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster


Alignment Length:2384 Identity:637/2384 - (26%)
Similarity:1025/2384 - (42%) Gaps:581/2384 - (24%)


- Green bases have known domain annotations that are detailed below.


Human     6 TEGTRVWLR-ENGQHFPSTVNS---CAEG--IVVFRTDYGQVFTYKQSTITHQKVTAMHPTNEEG 64
            |.|..:|:. .:|:.|...:.:   .|||  |.|...|..:|:...:     :::.|||.::.:|
  Fly     5 TRGDYIWIEPASGREFDVAIGARVVSAEGRRIQVRDDDGDEVWLAPE-----RRIKAMHASSVQG 64

Human    65 VDDMASLTELHGGSIMYNLFQRYKRNQIYTYIGSILASVNPYQPIAGLYEPATMEQYSRRHLGEL 129
            |:||.||.:||...|:.||..|||.|.||||.||||.:||||| |..:|....::.|..|.:|||
  Fly    65 VEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQ-ILPIYTGDQIKLYKERKIGEL 128

Human   130 PPHIFAIANECYRCLWKRHDNQCILISGESGAGKTESTKLILKFLSVISQQSLELSLKEKTSCVE 194
            |||||||.:..|..:.:...:|||:|||||||||||||||||::|:.||         .|.|.:|
  Fly   129 PPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAIS---------GKHSWIE 184

Human   195 RAILESSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQKGNIQGGRIVDYLLEKNRVVRQNPGERN 259
            :.|||::||:||||||||:.|:|||||||::.::....|.|:|.:|..|||||:|:|.||..|||
  Fly   185 QQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERN 249

Human   260 YHIFYALLAGLEHEEREEFYLSTPENYHYLNQSGCVEDKTISDQESFREVITAMDVMQFSKEEVR 324
            ||:||.:||||..:|:....|....:|.||.....:..:...|...|.::.:||.|:.||.:|:.
  Fly   250 YHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIW 314

Human   325 EVSRLLAGILHLGNIEFITA-----GGAQVSFKTALGRSAELLGLDPTQLTDALTQRSMFLRGEE 384
            |:.:|||.:||.|||::...     ...::.....:.|.|.||||....|.||||:|::|..||.
  Fly   315 EIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGET 379

Human   385 ILTPLNVQQAVDSRDSLAMALYACCFEWVIKKINSRIKGNEDFK-------SIGILDIFGFENFE 442
            :::.|:..|:||.||:....:|...|..:::|||:.|     ||       :||:|||||||||:
  Fly   380 VVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAI-----FKPRGTSRNAIGVLDIFGFENFD 439

Human   443 VNHFEQFNINYANEKLQEYFNKHIFSLEQLEYSREGLVWEDIDWIDNGECLDLIE-KKLGLLALI 506
            .|.||||.||||||.||::|.:|||.|||.||:.|.:.|:.|:::||.:.||||. |:|.::|||
  Fly   440 QNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALI 504

Human   507 NEESHFPQATDSTLLEKLHSQHANNHFYVKPRVAVN-NFGVKHYAGEVQYDVRGILEKNRDTFRD 570
            :||:.||:.||.|:|.|||..|.::..|:||:..:| :||:.|:||.|.||.||.|:||||||..
  Fly   505 DEEARFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSP 569

Human   571 DLLNLLRESRFDFIYDLFEHVSSRNNQDTLKCGSKHRR--PTVSSQFKDSLHSLMATLSSSNPFF 633
            |||:|:.:|...|:..:|.       || ::.|::.|:  ||:|:||:.||.:||.||||..|||
  Fly   570 DLLHLVSQSTNKFLRQIFA-------QD-IEMGAETRKRTPTLSTQFRKSLDALMKTLSSCQPFF 626

Human   634 VRCIKPNMQKMPDQFDQAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLMRNLALPED 698
            :||||||..|.|..||:.:...|||||||:||:|||:|||.:|..|::|.:||:.|:.  .:|..
  Fly   627 IRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP--GVPPA 689

Human   699 VRGKC---TSLLQLYDASNSEWQLGKTKVFLRESLEQKLEKRREEEVSHAAMVIRAHVLGFLARK 760
            .|..|   ||.:.......|::|||.|||||:::.:..||:.|:.               .|.||
  Fly   690 HRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDR---------------VLTRK 739

Human   761 QYRKVLYCVVIIQKNYRAFLLRRRFLHLKKAAIVFQKQLRGQIARRVYRQLLAEKREQEEKKKQE 825
                    ::|:|::.|.::.|||||.|:.|||..|:..:|...|:.||.:              
  Fly   740 --------ILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNM-------------- 782

Human   826 EEEKKKREEEERERERERREAELRAQ-------------QEEETRKQQELEALQKSQKEAELTRE 877
            .....:.:...|.|....|...||..             :.|...|...:..:|...:.....|.
  Fly   783 RVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRR 847

Human   878 LEKQK-ENKQVEEILRLEKEIEDLQRMKEQQELSLTEASLQKLQERRDQELRRLEEEACRAAQEF 941
            ..|.: |:||..|:|:|.|       ::||:.|.......:::.|:..::  ||.|...|..||.
  Fly   848 YRKLRLEHKQFAEVLQLRK-------LEEQELLHRGNKHAREIAEQHYRD--RLHELERREIQEQ 903

Human   942 LESLNFDEIDECVRNIERSLSVGSEFSSELAESACEEKPNFNFSQPYPEEEVDEG------FEAD 1000
            ||:.         |.:|.::::                  .|.:....||.||:|      |:..
  Fly   904 LENR---------RRVEVNMNI------------------INDAARKQEEPVDDGKLVEAMFDFL 941

Human  1001 DDAFKDSPNPSEHGHSDQRTSGIRTSDDSSEEDPYMNDTVVPTSPSADSTVLLAPSVQDSGSLHN 1065
            .|:..|:|.|    |..:.||..  :|....::...:|.:.|...|.|...|.....|...:.:.
  Fly   942 PDSSSDAPTP----HGGRETSVF--NDLPHAQNVNQDDIIAPIHISEDEEDLSEFKFQKFAATYF 1000

Human  1066 SSSGESTYC--------MPQN------------------AGDLPSPDGDYDYDQDDYEDGAITSG 1104
            ..:....|.        :|.:                  .||:|.|  .| :..|..:..::.|.
  Fly  1001 QGNVNHQYAKKALKHPLLPLHTQGDQLAAQALWITILRFTGDMPEP--KY-HTMDRMDTTSVMSK 1062

Human  1105 SSVTFSNSY--GSQW--------SPD--------------YRCSVGTYNSSGAYRFSSEGAQSSF 1145
            .:.|...::  ..::        .||              ...::...|..|      |..:...
  Fly  1063 VTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLG------EDVRRRL 1121

Human  1146 EDSEEDFD-------SRFDTD-DELSY----------RRDSVYS--CVTLPYFHSFLYMKGGLMN 1190
            :|.|...|       ||..:: ::|.:          .||.:|.  |..|        ....|.:
  Fly  1122 QDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQL--------TNNPLKS 1178

Human  1191 SWKRRW--------CVLKDETFL-WFRS------------KQEALKQGWLHKKGGGSSTLSRRNW 1234
            |..|.|        |....|.|: :.|:            .:|.||:.:    ..|:     ||.
  Fly  1179 SHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTF----NNGT-----RNQ 1234

Human  1235 KKRWFVLRQSK--------LMYFENDSEEKLKGTVEVRTAKEIIDNTT------KENGIDIIMAD 1285
            ...|..|:.:|        :.:.:.:::..|..:  ..||:|:.:..:      .:.|..:.:| 
  Fly  1235 PPSWLELQATKSKKPIMLPITFMDGNTKTLLADS--ATTARELCNQLSDKISLKDQFGFSLYIA- 1296

Human  1286 RTFHLIAESPEDASQWFSVLSQVHA-STDQEIQE--------------------MHDEQANP--- 1326
             .|..::............:||... :.:|..||                    .||:.|..   
  Fly  1297 -LFDKVSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIY 1360

Human  1327 QNAVGTLDVGLIDSVCASDSPDRPNSFVIITANRVLHCNADTPEEMHHWITLLQRSKGDTRVEGQ 1391
            |..|..:..|  :..|     |:.....:|.|.:.. ....|...|....|||.....|..:.|.
  Fly  1361 QQVVRGVKFG--EYRC-----DKEEDLAMIAAQQYF-IEYSTDMSMERLFTLLPNFIPDFCLSGV 1417

Human  1392 EFIVRGW-------LHKEVKNSPKMSSLKLKK--------RWFVLTHNSLDYYKSSEKNALKLGT 1441
            :..:..|       ..|......|::.||:|:        :|.:|.....:.|::|..|..|...
  Fly  1418 DKAIERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDV 1482

Human  1442 LVLNSLCS--VVPPDEKIFKETGYWNVTVYGRKHCYRLYTKL----------------------- 1481
            ::..:...  ||...|::..|..:..:|....:...:::|:.                       
  Fly  1483 IIAVNWTGVYVVDDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRD 1547

Human  1482 --------LNEATRWSSAIQNVTDTKAPIDTPT--------QQLIQDIKENCLNSDV-------- 1522
                    |.:.:::..|:|   |.:||.|..:        ..:::|  |:|..|.:        
  Fly  1548 LVVYFLDGLKKRSKYVIALQ---DYRAPSDGTSFLSFFKGDLIILED--ESCGESVLNNGWCIGR 1607

Human  1523 VEQIYKRNPILRYTHHPLHSPLLPLPYGDI-------------NLNLLKDKGYT-------TLQD 1567
            .::..:|......|.:.|  |.|..|..||             .|::..:.|..       ||.:
  Fly  1608 CDRSQERGDFPAETVYVL--PTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLME 1670

Human  1568 EAIKIFNSLQQLESMS------------------DPI--PIIQ-----------------GILQT 1595
            .|:..|. |....:||                  |||  |:::                 .||:.
  Fly  1671 YALDHFR-LPPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILKY 1734

Human  1596 GHDL---RP-------------------LRDELYCQLIKQTNKVPHPGSVGNLYSWQILTCLSCT 1638
            ..||   ||                   ||||:||||:||.  ..:...:.....|:::...:..
  Fly  1735 MGDLPSKRPRMGNEITDHIFDGPLKHEILRDEIYCQLMKQL--TDNRNRMSEERGWELMWLATGL 1797

Human  1639 FLPSRGILKYLKFHLKRIREQFPGSEMEKYALFTYESLKKT---KCREFVPSRDEIEALIHR-QE 1699
            |..|:|:||.|...|:..|.......|.:        |:||   ..|::.|.:.|:||:.|: .:
  Fly  1798 FACSQGLLKELLLFLRTRRHPISQDSMHR--------LQKTIRHGQRKYPPHQVEVEAIQHKTTQ 1854

Human  1700 MTSTVYCHGGGSCKITINSHTTAGEVVEKLIRGLAMEDSRNMFAL-----------------FEY 1747
            :...||..........::|.|.|.:....:.:.|::..|.. |:|                 |::
  Fly  1855 IFHKVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLRTSEG-FSLFVKIADKVISVPEGDFFFDF 1918

Human  1748 NGHVDKAIESRTVVADVLAKFEKLAATSEVGDLPWKFYFKLYCF--LDTDNVP-KD-SVEFAFMF 1808
            ..|:...|:....:.|              |..| :|.::::..  |.|:.|| || :.:..|.:
  Fly  1919 VRHLTDWIKKARPIRD--------------GANP-QFTYQVFFMKKLWTNTVPGKDRNADLIFHY 1968

Human  1809 EQAHEAVIHGHHPAPEENLQVLAALRLQYLQGDYTLHAAIPPLEEVYSLQRLKARISQSTKTFTP 1873
            .|....::.|:|....|....||||..:...|:              :.|.|:| |.|..:...|
  Fly  1969 HQELPKLLRGYHKCSREEAAKLAALVFRVRFGE--------------NKQELQA-IPQMLRELIP 2018

Human  1874 CERLEKRRTSFLEGTLRRSFRTGSVVRQKVEEEQMLDMWIKEEVSSARASIIDKWRKFQGMNQEQ 1938
            .:.::.:.||                           .|        :.||:..:.:..||..|.
  Fly  2019 SDIMKIQSTS---------------------------EW--------KRSIVASYNQDGGMTSED 2048

Human  1939 AMAKYMALIKEWPGYGSTLFDV-ECKEGGFPQELWLGVSADAVSVYKRGEGRPLEVFQYEHILSF 2002
            |...::.::..||.:||..|:| :..|..:|:.|.:.::...||:........|....:..|.::
  Fly  2049 AKVAFLKIVYRWPTFGSAFFEVKQTTEPNYPEMLLIAINKHGVSLIHPVTKDILVTHPFTRISNW 2113

Human  2003 GAPLANTY-----KIVVDERELLFETSEVVDVAKLMKAYISMIV 2041
            .:  .|||     ..:|...:||.|||....:..|:.:|||:::
  Fly  2114 SS--GNTYFHMTIGNLVRGSKLLCETSLGYKMDDLLTSYISLML 2155

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYO10NP_036466.2 MYSc 58..739 CDD:214580 320/699 (46%)
MYSc_Myo10 77..727 CDD:276840 308/668 (46%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 619..641 15/21 (71%)
SAH. /evidence=ECO:0000250|UniProtKB:F8VQB6, ECO:0000250|UniProtKB:P79114 815..908 19/106 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 819..840 1/20 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 847..866 4/31 (13%)
Mediates antiparallel dimerization. /evidence=ECO:0000269|PubMed:23012428 883..933 13/49 (27%)
MYO10_CC 883..933 CDD:293340 13/49 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1090 27/157 (17%)
PH-like 1181..>1223 CDD:302622 11/62 (18%)
PH2_MyoX 1215..1316 CDD:270108 17/115 (15%)
PH 1215..1308 CDD:278594 15/106 (14%)
PH3_MyoX-like 1381..1506 CDD:270109 27/172 (16%)
PH 1396..1495 CDD:278594 21/146 (14%)
MyTH4 1549..1695 CDD:214535 49/227 (22%)
B41 1704..1958 CDD:214604 51/274 (19%)
UBQ 1705..>1753 CDD:294102 10/64 (16%)
FERM_M 1796..1958 CDD:278785 33/163 (20%)
FERM_C_MyoX 1954..2042 CDD:270023 24/94 (26%)
ckNP_001285949.1 MYSc 64..733 CDD:214580 319/693 (46%)
MYSc_Myo7 77..721 CDD:276832 308/668 (46%)
MyTH4 <1138..1245 CDD:214535 23/123 (19%)
B41 1251..1467 CDD:214604 37/227 (16%)
FERM_B-lobe 1355..1439 CDD:271216 17/91 (19%)
FERM_C1_MyoVII 1461..1559 CDD:270019 12/97 (12%)
SH3 1560..1624 CDD:302595 12/68 (18%)
MyTH4 1701..1849 CDD:214535 38/157 (24%)
B41 1856..2068 CDD:214604 51/277 (18%)
FERM_M 1966..2068 CDD:278785 29/151 (19%)
FERM_C2_MyoVII 2064..2159 CDD:270020 24/94 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.710

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