DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYO9B and ck

DIOPT Version :9

Sequence 1:NP_004136.2 Gene:MYO9B / 4650 HGNCID:7609 Length:2157 Species:Homo sapiens
Sequence 2:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster


Alignment Length:2148 Identity:541/2148 - (25%)
Similarity:837/2148 - (38%) Gaps:685/2148 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   109 LQERNADG---------TIKYVHMQLVAQATATRRLVERGLLPRQQADFDDLCNLPELTEGNLLK 164
            :|.|:.||         .||.:|...|           :|:        :|:.:|.:|.|..:|:
  Fly    36 IQVRDDDGDEVWLAPERRIKAMHASSV-----------QGV--------EDMISLGDLHEAGILR 81

Human   165 NLKHRFLQQKIYTYAGSILVAINPFKFLPIYNPKYVKMYENQQLGKLEPHVFALADVAYYTMLRK 229
            ||..|:.:..||||.||||||:||::.||||....:|:|:.:::|:|.||:||:.|.||..|.|.
  Fly    82 NLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHMKRY 146

Human   230 RVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGYASGVERTILGAGPVLEAFGNAKTAHNNNSS 294
            |.:||||||||||:|||:||..::..|.|:|  |..|.:|:.||.|.|:|||||||||..|:|||
  Fly   147 RQDQCIVISGESGAGKTESTKLILQYLAAIS--GKHSWIEQQILEANPILEAFGNAKTIRNDNSS 209

Human   295 RFGKFIQVSYLESGIVRGAVVEKYLLEKSRLVSQEKDERNYHVFYYLLLGVSEEERQEFQLKQPE 359
            ||||:|.:.:..:|::.||.:|:|||||||:|||...||||||||.:|.|:|.:|:....|....
  Fly   210 RFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGMAA 274

Human   360 DYFYLNQHNLKIEDGEDLKHDFERLKQAMEMVGFLPATKKQIFAVLSAILYLGNVTYKKRATGRE 424
            ||.||...|....:|.|...:|..::.||:::.|......:|..:|:|:|:.||:.||.......
  Fly   275 DYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYKATVVDNL 339

Human   425 EGLEVGPPEVLDTLSQLLKVKREILVEVLTKRKTVTVNDKLILPYSLSEAITARDSMAKSLYSAL 489
            :..|:.....::.::.||.:..:.|::.||:|......:.::...|..:::..||:..|.:|..:
  Fly   340 DATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRM 404

Human   490 FDWIVLRINHALLNKKDVEEAVSCLSIGVLDIFGFEDFERNSFEQFCINYANEQLQYYFNQHIFK 554
            |..||.:||.|:...:    ..|..:||||||||||:|::|||||||||||||.||.:|.|||||
  Fly   405 FVHIVRKINTAIFKPR----GTSRNAIGVLDIFGFENFDQNSFEQFCINYANENLQQFFVQHIFK 465

Human   555 LEQEEYQGEGITWHNIGYTDNVGCIHLISKKPTGLFYLLDEESNFPHATSQTLLAKFKQQHEDNK 619
            ||||||..|.|.|.:|.:.||...:.||:.|...:..|:|||:.||..|.||:|||..:.|..:|
  Fly   466 LEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTMLAKLHKTHGSHK 530

Human   620 YFLGTPV-MEPAFIIQHFAGKVKYQIKDFREKNMDYMRPDIVALLRGSDSSYVRELIGMDPVAVF 683
            .:|.... :..:|.:.||||.|.|..:.|.:||.|...||::.|:..|.:.::|::...|     
  Fly   531 NYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQD----- 590

Human   684 RWAVLRAAIRAMAVLREAGRLRAERAEKAAGMSSPGAQSHPEELPRGASTPSEKLYRDLHNQMIK 748
                                                       :..||.|               
  Fly   591 -------------------------------------------IEMGAET--------------- 597

Human   749 SIKGLPWQGEDPRSLLQSLSRLQKPRAFILKSKGIKQKQIIPKNLLDSKSLKLIISMTLHDRTTK 813
                                                                             
  Fly   598 ----------------------------------------------------------------- 597

Human   814 SLLHLHKKKKPPSISAQFQTSLNKLLEALGKAEPFFIRCIRSNAEKKELCFDDELVLQQLRYTGM 878
                   :|:.|::|.||:.||:.|::.|...:|||||||:.|..||.:.||..|..:||||:||
  Fly   598 -------RKRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGM 655

Human   879 LETVRIRRSGYSAKYTFQDFTEQFQVLLP-------KDAQPCREVISTLLEKMKIDKRNYQIGKT 936
            :||:||||:||..::.|::|.|:::.|:|       .|.|.....|..::    :.|.:||:|.|
  Fly   656 METIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHRTDCQAATSRICAVV----LGKSDYQLGHT 716

Human   937 KVFLKETERQALQETLHREVVRKILLLQSWFRMVLERRHFLQMKRAAVTIQACWRSYRVRR---- 997
            |||||:.....|::...|.:.||||:||...|..:.||.||:::.||:|:|..|:.|..|:    
  Fly   717 KVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRN 781

Human   998 ---------ALERTQA-----------AVYLQASWRGYWQRKLYRHQKQSIIRLQSLCRGHLQRK 1042
                     ||.|::.           .|.|||..|||..|:.|.|:..::|::||..|..:..:
  Fly   782 MRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMR 846

Human  1043 SFSQM-ISEKQKAEEKEREALEAARAGAEEGGQGQAAGGQQVAEQGPEPAEDGGHLASEPEVQPS 1106
            .:.:: :..||.||..:...||.                |::..:|                   
  Fly   847 RYRKLRLEHKQFAEVLQLRKLEE----------------QELLHRG------------------- 876

Human  1107 DRSPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKVPSSREKRESRRQRGLEHVKFQNKHIQSCKE 1171
                                                                    |||.:...|
  Fly   877 --------------------------------------------------------NKHAREIAE 885

Human  1172 E---SALREPSRRVTQEQGVSLLEDKKESREDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEE 1233
            :   ..|.|..||..|||    ||:::  |.:..:.::...|.  .|::|.:.      ||:.|.
  Fly   886 QHYRDRLHELERREIQEQ----LENRR--RVEVNMNIINDAAR--KQEEPVDD------GKLVEA 936

Human  1234 TEKTLPSGS-----PRPGQLERPTSLALD----SRVSPP---APGSAPETPEDKSKPCGSPRVQE 1286
            ....||..|     |..|   |.||:..|    ..|:..   ||....|..||.|         |
  Fly   937 MFDFLPDSSSDAPTPHGG---RETSVFNDLPHAQNVNQDDIIAPIHISEDEEDLS---------E 989

Human  1287 KPDSPGGSTQIQRYLDAERLASAVE------LWRGKKLVAAASPSAMLSQSLDLSDRHRATGAAL 1345
            .......:|..|..::.:....|::      ..:|.:|.|.|....:|          |.||...
  Fly   990 FKFQKFAATYFQGNVNHQYAKKALKHPLLPLHTQGDQLAAQALWITIL----------RFTGDMP 1044

Human  1346 TP---TEERRTSFSTSDVSKLLPSLAKAQPAAETTDGERSAKKPAVQKKKPGDASSLPDAGLSPG 1407
            .|   |.:|..  :||.:||:..:|.                :..::.|:..:|..:   ||.|.
  Fly  1045 EPKYHTMDRMD--TTSVMSKVTATLG----------------RNFIRSKEFQEAQLM---GLDPD 1088

Human  1408 SQVDSKSTFKRLFLHKTKDKKYSLEGAEELENAVSGHVVLEATTMKKGLEAPSGQQHRHAAGEKR 1472
            :.:..|   .|...||                       |.:.|:|                   
  Fly  1089 AFLKQK---PRSIRHK-----------------------LVSLTLK------------------- 1108

Human  1473 TKEPGGKGKKNRNVKIGKITVSEKWRESVFRQITNANELKYLDEFLLNKIND-LRSQKTPIESLF 1536
                    :||   |:|         |.|.|::.:       ||:..:.... |:|:.|      
  Fly  1109 --------RKN---KLG---------EDVRRRLQD-------DEYTADSYQSWLQSRPT------ 1140

Human  1537 IEATEKFRSNI-KTMYSVPNGKIHVGYKDLMENYQIVVSNLATERGQKDTN----LVLNL----- 1591
                    ||: |..:.:.:|.:....:|  |.|..:...| |....|.::    ::|:|     
  Fly  1141 --------SNLEKLHFIIGHGILRAELRD--EIYCQICKQL-TNNPLKSSHARGWILLSLCVGCF 1194

Human  1592 -----FQSLLDEFTR----GY---------------TKNDFEPVKQSKAQKKKRKQERAVQEHNG 1632
                 |.:.|..|.|    ||               |:|......:.:|.|.|:.....:...:|
  Fly  1195 APSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDG 1259

Human  1633 H---VFASYQVSIPQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVE 1694
            :   :.|....:..:.|.|....|.|.|:                                    
  Fly  1260 NTKTLLADSATTARELCNQLSDKISLKDQ------------------------------------ 1288

Human  1695 PGHFGVCVDSLTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKL 1759
               ||..:.....||.|   .|....:||.......|...::.||..|....|...:.:      
  Fly  1289 ---FGFSLYIALFDKVS---SLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKE------ 1341

Human  1760 ENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPE----KQEQLAAIYAVLEHLPEANHN 1820
                      :...|.....:.:.|...|...:|.|:..|    |:|.||.|.|....:..:...
  Fly  1342 ----------IFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDM 1396

Human  1821 SLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQM 1885
            |:|||.      .||.:            |.|..  |....|.        .|.....::::...
  Fly  1397 SMERLF------TLLPN------------FIPDF--CLSGVDK--------AIERWAALVLQAYK 1433

Human  1886 RKYKVKMEEISQLEAAESIAFRRLSLLRQNAPWPLKLGFSSPYEGVLNKSPKTRD---------- 1940
            :.|.|| ::|:.|:..|.|    :|..:..  |||.  ||..||...|..|....          
  Fly  1434 KSYYVK-DKIAPLKIKEDI----VSYAKYK--WPLL--FSRFYEAYRNSGPNLPKNDVIIAVNWT 1489

Human  1941 ---IQEEELEVLLE---EEAAGGDEDREKEILIE--RIQSIKEEK--------EDI----TYRLP 1985
               :.:::.:||||   .|.......:..::..:  .:.:::.|:        |||    .|.|.
  Fly  1490 GVYVVDDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLD 1554

Human  1986 ELDPRG------------SDEENLDS---------ETSASTESLLEE-----RAGRGASEGPPAP 2024
            .|..|.            ||..:..|         |..:..||:|..     |..|....|.   
  Fly  1555 GLKKRSKYVIALQDYRAPSDGTSFLSFFKGDLIILEDESCGESVLNNGWCIGRCDRSQERGD--- 1616

Human  2025 ALPCPGAPTPSPLPTVAAPPR--------------RRPSSFVTVRVKTPRRTP--IMPTA--NIK 2071
             .|   |.|...|||::.||:              ||.|.........||..|  :|..|  :.:
  Fly  1617 -FP---AETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEYALDHFR 1677

Human  2072 LPP 2074
            |||
  Fly  1678 LPP 1680

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYO9BNP_004136.2 Myosin_IXb_RA 7..112 CDD:176374 1/2 (50%)
MYSc 141..950 CDD:214580 283/816 (35%)
MYSc_Myo9 160..941 CDD:276836 276/788 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 709..734 2/24 (8%)
Actin-binding. /evidence=ECO:0000305 844..855 7/10 (70%)
Neck or regulatory domain. /evidence=ECO:0000305 940..1044 39/127 (31%)
IQ 978..999 CDD:197470 7/33 (21%)
IQ 1000..1022 CDD:197470 9/32 (28%)
Tail. /evidence=ECO:0000305 1045..2157 213/1171 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1046..1298 46/267 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1320..1410 19/92 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1455..1484 1/28 (4%)
C1 1633..1681 CDD:237996 6/50 (12%)
RhoGAP_myosin_IXB 1698..1883 CDD:239872 36/188 (19%)
Interaction with RHOA. /evidence=ECO:0000269|PubMed:26529257 1739..1744 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1980..2157 34/143 (24%)
ckNP_001285949.1 MYSc 64..733 CDD:214580 284/821 (35%)
MYSc_Myo7 77..721 CDD:276832 276/788 (35%)
MyTH4 <1138..1245 CDD:214535 22/123 (18%)
B41 1251..1467 CDD:214604 56/310 (18%)
FERM_B-lobe 1355..1439 CDD:271216 23/111 (21%)
FERM_C1_MyoVII 1461..1559 CDD:270019 19/99 (19%)
SH3 1560..1624 CDD:302595 13/70 (19%)
MyTH4 1701..1849 CDD:214535
B41 1856..2068 CDD:214604
FERM_M 1966..2068 CDD:278785
FERM_C2_MyoVII 2064..2159 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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