DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYO9A and ck

DIOPT Version :9

Sequence 1:XP_011519915.1 Gene:MYO9A / 4649 HGNCID:7608 Length:2638 Species:Homo sapiens
Sequence 2:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster


Alignment Length:2552 Identity:605/2552 - (23%)
Similarity:999/2552 - (39%) Gaps:720/2552 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    98 LSGEDYRFLLREKNLDGSIHYGSLQSWLRVTEERRRMMERGFLPQPQQKDFDDLCSLPDLNEKTL 162
            :|.|..|..:|:.:.|        :.|| ..|.|.:.|....:     :..:|:.||.||:|..:
  Fly    29 VSAEGRRIQVRDDDGD--------EVWL-APERRIKAMHASSV-----QGVEDMISLGDLHEAGI 79

Human   163 LENLRNRFKHEKIYTYVGSILIVINPFKFLPIYNPKYVKMYDNHQLGKLEPHIYAVADVAYHAML 227
            |.||..|:|...||||.||||:.:||::.||||....:|:|...::|:|.|||:|:.|.||..|.
  Fly    80 LRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHMK 144

Human   228 QRKKNQCIVISGESGSGKTQSTNFLIHHLTALSQKGFASGVEQIILGAGPVLEAFGNAKTAHNNN 292
            :.:::||||||||||:|||:||..::.:|.|:|  |..|.:||.||.|.|:|||||||||..|:|
  Fly   145 RYRQDQCIVISGESGAGKTESTKLILQYLAAIS--GKHSWIEQQILEANPILEAFGNAKTIRNDN 207

Human   293 SSRFGKFIQVNYQETGTVLGAYVEKYLLEKSRLVYQEHNERNYHVFYYLLAGASEDERSAFHLKQ 357
            ||||||:|.:::...|.:.||.:|:|||||||:|.|.|:||||||||.:|||.|.||:|...|..
  Fly   208 SSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGM 272

Human   358 PEEYHYL---NQITKKPLRQSWDDYCYDSEPDCFTVEGEDLRHDFERLQLAMEMVGFLPKTRRQI 419
            ..:|.||   |.||                  |   ||.|...:|..::.||:::.|..:...:|
  Fly   273 AADYKYLTGGNSIT------------------C---EGRDDAAEFSDIRSAMKVLLFSDQEIWEI 316

Human   420 FSLLSAILHLGNICYKKKTYRDDSIDICN-PEVLPI--VSELLEVKEEMLFEALVTRKTVTVGEK 481
            ..||:|:||.|||.||....  |::|... ||.:.:  |:.||.:..:.|.:||..|.....||.
  Fly   317 IKLLAALLHCGNIKYKATVV--DNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGET 379

Human   482 LILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLNSKDLEHNTKTLSIGVLDIFGFEDYEN 546
            ::......::|.||::..|.:|..:|..||.:||.|:...:....|    :||||||||||:::.
  Fly   380 VVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRN----AIGVLDIFGFENFDQ 440

Human   547 NSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDYIDNTCCINLISKKPTGLLHLLD 611
            |||||||||:|||.||.:|.|||||||||||..|.|:|.:|:::||...::||:.|...::.|:|
  Fly   441 NSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALID 505

Human   612 EESNFPQATNQTLLDKFKHQH-EDNSYIEFPAVMEPAFIIKHYAGKVKYGVKDFREKNTDHMRPD 675
            ||:.||:.|:||:|.|....| ...:|::..:.:..:|.:.|:||.|.|..:.|.:||.|...||
  Fly   506 EEARFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPD 570

Human   676 IVALLRSSKNAFISGMIGIDPVAVFRWAILRAFFRAMVAFREAGKRNIHRKTGHDDTAPCAILKS 740
            ::.|:..|.|.|                 ||..|..                             
  Fly   571 LLHLVSQSTNKF-----------------LRQIFAQ----------------------------- 589

Human   741 MDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSDLQGMNALNEKNQHDTFDIAWNGRTG 805
                                                                    ||.....| 
  Fly   590 --------------------------------------------------------DIEMGAET- 597

Human   806 IRQSRLSSGTSLLDKDGIFANSTSSKLLERAHGILTRNKNFKSKPALPKHLLEVNSLKHLTRLTL 870
                                                                             
  Fly   598 ----------------------------------------------------------------- 597

Human   871 QDRITKSLLHLHKKKKPPSISAQFQASLSKLMETLGQAEPYFVKCIRSNAEKLPLRFSDVLVLRQ 935
                         :|:.|::|.||:.||..||:||...:|:|::||:.|..|.|:.|...|..||
  Fly   598 -------------RKRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQ 649

Human   936 LRYTGMLETVRIRQSGYSSKYSFQDFVSHFHVLLPRNIIPS-KFNIQDFFRKI---NLNPDNYQV 996
            |||:||:||:|||::||..::.|::||..:..|:| .:.|: :.:.|....:|   .|...:||:
  Fly   650 LRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP-GVPPAHRTDCQAATSRICAVVLGKSDYQL 713

Human   997 GKTMVFLKEQERQHLQDLLHQEVLRRIILLQRWFRVLLCRQHFLHLRQASVIIQRFWRNYLNQKQ 1061
            |.|.||||:.....|:....:.:.|:|::|||..|..:.|:.||.||.|::.:||||:.|..:|:
  Fly   714 GHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKR 778

Human  1062 VRDAAVQKDAFVMASAAALLQASWRAHLERQRYLELRAAAIVIQQKWRDYYRRRHMAAICIQARW 1126
            .|:         |......|||..|:.:...|:..||...:.:|...|.|..||           
  Fly   779 YRN---------MRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRR----------- 823

Human  1127 KAYRESKRYQEQRKKIILLQSTCRGFRARQRFKALKEQ--------RLRETKPEVGLVNIKGYGS 1183
                   .|..:...:|.:||..|...|.:|::.|:.:        :||:.: |..|::.....:
  Fly   824 -------EYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLE-EQELLHRGNKHA 880

Human  1184 LEIQGSDPSGWEDCSFDNRIKAIE--ECKSVIESNRISRESSVDCLKESPNKQQERAQSQSGVDL 1246
            .||        .:..:.:|:..:|  |.:..:| ||...|.:::.:.::..||:|.......|:.
  Fly   881 REI--------AEQHYRDRLHELERREIQEQLE-NRRRVEVNMNIINDAARKQEEPVDDGKLVEA 936

Human  1247 QEDVLVRERPRSLEDLHQKKVGRAKRESRRMRELEQAIFSLELLKVRSLGG---ISP---SEDRR 1305
            ..|.|    |.|..|......||           |.::|: :|...:::..   |:|   |||..
  Fly   937 MFDFL----PDSSSDAPTPHGGR-----------ETSVFN-DLPHAQNVNQDDIIAPIHISEDEE 985

Human  1306 WSTELVPEGLQSP--RGTPDSESSQGSLE--LLSYEESQKSKLE------SVISDEGDLQFPSPK 1360
            ..:|...:...:.  :|..:.:.::.:|:  ||.. .:|..:|.      :::...||:  |.||
  Fly   986 DLSEFKFQKFAATYFQGNVNHQYAKKALKHPLLPL-HTQGDQLAAQALWITILRFTGDM--PEPK 1047

Human  1361 ISSSPKFDSRDNALSASNETSSAEHLKDGTMKEMVVCSSESITCKPQLKDSFISNSLPTFFYIPQ 1425
            ..:..:.|: .:.:|....|.....::....:|..:...:        .|:|:.....:..:...
  Fly  1048 YHTMDRMDT-TSVMSKVTATLGRNFIRSKEFQEAQLMGLD--------PDAFLKQKPRSIRHKLV 1103

Human  1426 QDPLKTNSQLDTSIQRNKLLENEDTAGEALTLDINRET---RRYH---------CSGKDQIVPSL 1478
            ...||..::|...::| :|.::|.||....:...:|.|   .:.|         ...:|:|...:
  Fly  1104 SLTLKRKNKLGEDVRR-RLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQI 1167

Human  1479 NTESSNPVLKKLEKLN-------------TEK--------------------EERQKQLQQQNEK 1510
            ..:.:|..||......             :||                    |||.|:......:
  Fly  1168 CKQLTNNPLKSSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTR 1232

Human  1511 EMMEQIRQQTDILEKERKAFKTIEKPRIGECLVAPSSYQSKQRVERPSSLLSLNTSNKGEL-NVL 1574
                  .|....||.:....|   ||     ::.|.::..    ....:||:.:.:...|| |.|
  Fly  1233 ------NQPPSWLELQATKSK---KP-----IMLPITFMD----GNTKTLLADSATTARELCNQL 1279

Human  1575 G-SLSLKD-------AALAQKDSS----SAHL----------------PPKDRPVTVFFERK-GS 1610
            . .:||||       .||..|.||    ..|:                ..::.|..:||.:: .:
  Fly  1280 SDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFA 1344

Human  1611 PCQSSTVKELSKTDRMGTQLNVACKLSNNRISKREH---FRPTQSYSHNSDDLSRE------GNA 1666
            |....|..::: |:.:..|:....|....|..|.|.   ....|.:...|.|:|.|      .|.
  Fly  1345 PWHEPTHDQVA-TNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNF 1408

Human  1667 RPIF-----------------------FTPKDNMSIPLVSK-------------------EALNS 1689
            .|.|                       :..||.:: ||..|                   ||..:
  Fly  1409 IPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKIA-PLKIKEDIVSYAKYKWPLLFSRFYEAYRN 1472

Human  1690 KNPQLHKED---EPAWKPVKLAGPGQREQV----------ARPAHKKKARMARTRSDFLTRGTFA 1741
            ..|.|.|.|   ...|..|.:.  ..:|||          |..:.|......:|.|....||...
  Fly  1473 SGPNLPKNDVIIAVNWTGVYVV--DDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEF 1535

Human  1742 DGEGDTEEDDYDDIIEPLLSLDQASHCELG----PAPSLGQASHSDSEMTSQRFSS--------V 1794
            ..:....||..|.::..|..|.:.|...:.    .|||.|.:           |.|        :
  Fly  1536 TFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQDYRAPSDGTS-----------FLSFFKGDLIIL 1589

Human  1795 DEQAKLHKTMSQGEITKLAVRQKASDSDIRPQRAKMRFWAKGK------QGE--KKTTRVKPTTQ 1851
            ::::.....::.|                         |..|:      :|:  .:|..|.||..
  Fly  1590 EDESCGESVLNNG-------------------------WCIGRCDRSQERGDFPAETVYVLPTLS 1629

Human  1852 SEVSPLFAGTDVIPAH-----QFPDELAAYHPTPPLSPELPGSCRKEFKENKEPSPKAKRKRSVK 1911
            .....:.|..::..||     .......|..|.     :.|.:..:...::....||....:::.
  Fly  1630 KPPQDILALFNIEEAHHGRRLSMASNGGAVEPR-----DRPHTLMEYALDHFRLPPKRTMSKTLT 1689

Human  1912 ISNVALDSMHWQNDSVQIIAS-VSDLKSMDEF----------LLKKVNDLDNEDSKK-DTLVDVV 1964
            :|:...:.: |:.....|.|. :..|:|.:||          :||.:.||.::..:. :.:.|.:
  Fly  1690 LSSKRSEEL-WRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITDHI 1753

Human  1965 FKKALKEFRQNIFSFYSSALAMDDGKSIRYKDLYA-LFEQILEKTMRLEQRDSLGESPVRVWVNT 2028
            |...||.                   .|...::|. |.:|:.:...|:.:.    .....:|:.|
  Fly  1754 FDGPLKH-------------------EILRDEIYCQLMKQLTDNRNRMSEE----RGWELMWLAT 1795

Human  2029 -----FKVFLDEYMNEFKT-----SDCTATKVPKTERKKRRKKETDLVEEHNGHIFKATQYSIPT 2083
                 .:..|.|.:...:|     |..:..::.||.|..:||.....||      .:|.|:    
  Fly  1796 GLFACSQGLLKELLLFLRTRRHPISQDSMHRLQKTIRHGQRKYPPHQVE------VEAIQH---- 1850

Human  2084 YCEYCSSLIWIMDRASVCKLCKYACHKKCCLKTTAKCSKKYDPELSSRQFGVE------------ 2136
                                           |||....|.|.|:.:...|.|:            
  Fly  1851 -------------------------------KTTQIFHKVYFPDDTDEAFEVDSSTRAKDFCNNI 1884

Human  2137 ---LSRLTSEDRTVPL-VVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESVNLDDY 2197
               ||..|||..::.: :.:|:|:..| ...:.:.:...:....|.:.:|.|.            
  Fly  1885 SQRLSLRTSEGFSLFVKIADKVISVPE-GDFFFDFVRHLTDWIKKARPIRDGA------------ 1936

Human  2198 NIHVIASVF---KQWLRDLP----NPLMTFELYEEFLRAMGLQERKETIRGVYSVIDQLSRTHLN 2255
            |......||   |.|...:|    |..:.|..:         ||..:.:||.:    :.||....
  Fly  1937 NPQFTYQVFFMKKLWTNTVPGKDRNADLIFHYH---------QELPKLLRGYH----KCSREEAA 1988

Human  2256 TLERLIFHLVRIALQEDTNRMSA--NALAIVFAPCILRCPDTTDPLQSV-----QDISKTTTCVE 2313
            .|..|:|   |:...|:...:.|  ..|..:....|::...|::..:|:     ||...|:...:
  Fly  1989 KLAALVF---RVRFGENKQELQAIPQMLRELIPSDIMKIQSTSEWKRSIVASYNQDGGMTSEDAK 2050

Human  2314 LIVVEQMNKYKA------RLKDISSLEFAENKA----KTRLSLIRRSMKPVLIAVRFMNITRNSV 2368
            :..::.:.::..      .:|..:...:.|...    |..:|||....|.:|:...|..|: |..
  Fly  2051 VAFLKIVYRWPTFGSAFFEVKQTTEPNYPEMLLIAINKHGVSLIHPVTKDILVTHPFTRIS-NWS 2114

Human  2369 SGK-------GRIRRGN 2378
            ||.       |.:.||:
  Fly  2115 SGNTYFHMTIGNLVRGS 2131

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYO9AXP_011519915.1 UBQ 6..110 CDD:294102 4/11 (36%)
MYSc 143..1014 CDD:214580 293/881 (33%)
MYSc_Myo9 160..1004 CDD:276836 284/854 (33%)
C1 2072..2120 CDD:237996 5/47 (11%)
RhoGAP_myosin_IX 2133..2318 CDD:239842 40/214 (19%)
ckNP_001285949.1 MYSc 64..733 CDD:214580 293/879 (33%)
MYSc_Myo7 77..721 CDD:276832 284/854 (33%)
MyTH4 <1138..1245 CDD:214535 17/112 (15%)
B41 1251..1467 CDD:214604 41/221 (19%)
FERM_B-lobe 1355..1439 CDD:271216 14/84 (17%)
FERM_C1_MyoVII 1461..1559 CDD:270019 22/99 (22%)
SH3 1560..1624 CDD:302595 12/99 (12%)
MyTH4 1701..1849 CDD:214535 33/176 (19%)
B41 1856..2068 CDD:214604 43/240 (18%)
FERM_M 1966..2068 CDD:278785 20/117 (17%)
FERM_C2_MyoVII 2064..2159 CDD:270020 16/69 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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