Protein Alignment MYO7B and MYO2

DIOPT Version :10

• Sequence 1: XP_047300391.1
• Gene: MYO7B / 4648
• HGNCID: 7607
• Length: 2298
• Species: Homo sapiens
• Sequence 2: NP_014971.1
• Gene: MYO2 / 854504
• SGDID: S000005853
• Length: 1574
• Species: Saccharomyces cerevisiae
• Alignment Length: 1338
• Identity: 421/1338 - (31%)
• Similarity: 627/1338 - (46%)
• Gaps: 217/1338 - (16%)

Human     4 FRLGDHVWLEPPSTHKTGVAIGG-IIKEAKPGKVLVEDDEGKEHW-IRAEDFGVLS--------- 57
            |.:|...|.    .||....||. :||.        |.::||.|. ::.||..::|
Yeast     3 FEVGTRCWY----PHKELGWIGAEVIKN--------EFNDGKYHLELQLEDDEIVSVDTKDLNND 55

Human    58 -----PM--HPNSVQGVDDMIRLGDLNEAGMVHNLLIRYQQHKIYTYTGSILVAVNPF-QVLPLY 114
                 |:  :|..::..:|:..|..|||..::|.:..||.|..||||:|.:|:|.||| :|..||
Yeast    56 KDQSLPLLRNPPILEATEDLTSLSYLNEPAVLHAIKQRYSQLNIYTYSGIVLIATNPFDRVDQLY 120

Human   115 TLEQVQLYYSRHMGELPPHVFAIANNCYFSMKRNKRDQCCIISGESGAGKTETTKLILQFLATI- 178
            |.:.:|.|..:..|||.||:||||...|..||.:|::|..::|||||||||.:.|.|:::.|::
Yeast   121 TQDMIQAYAGKRRGELEPHLFAIAEEAYRLMKNDKQNQTIVVSGESGAGKTVSAKYIMRYFASVE 185

Human   179 -----SGQH----SWIEQQVLEANPILEAFGNAKTIRNDNSSRFGKYIDIYFNPSGVIEGARIEQ 234
                 :.||    |..||::|..|||:||||||||.|||||||||||::|.|:....|.||||..
Yeast   186 EENSATVQHQVEMSETEQKILATNPIMEAFGNAKTTRNDNSSRFGKYLEILFDKDTSIIGARIRT 250

Human   235 FLLEKSRVCRQAPEERNYHIFYCMLMGVSAEDKQLLSLGTPSEYHYLTMGNCTSCEGLNDAKDYA 299
            :|||:||:..|.|.||||||||.::.|:.|:.|:.|.|...|:|.|:..|..|...|::|||:|.
Yeast   251 YLLERSRLVYQPPIERNYHIFYQLMAGLPAQTKEELHLTDASDYFYMNQGGDTKINGIDDAKEYK 315

Human   300 HIRSAMKILQFSDSESWDVIKLLAAILHLGNVGFMASVFENLDASDVMETPAFPTVMKLLEVQHQ 364
            ....|:.::..:......:.|:|||:||:||:....:   ..|||...:.|......:||.:...
Yeast   316 ITVDALTLVGITKETQHQIFKILAALLHIGNIEIKKT---RNDASLSADEPNLKLACELLGIDAY 377

Human   365 ELRDCLIKHTILIRGEFVTRSLNIAQAADRRDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNV 429
            .....:.|..|:.|.|.:..:||.:||...:|:..|.||..||.|:|:.||..:..|...|  .:
Yeast   378 NFAKWVTKKQIITRSEKIVSNLNYSQALVAKDSVAKFIYSALFDWLVENINTVLCNPAVND--QI 440

Human   430 RRAIGLLDIFGFENFENNSFEQLCINFANEHLQQFFVQHVFTMEQEEYRSENISWDYIHYTDNRP 494
            ...||:|||:|||:||.|||||.|||:|||.|||.|.||||.:|||||..|.|.|.:|.:.||:|
Yeast   441 SSFIGVLDIYGFEHFEKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYVKEEIEWSFIEFNDNQP 505

Human   495 TLDLLALKPMSIISLLDEESRFPQGTDLTMLQKLNSV---HANNKAFLQPKNIHDARFGIAHFAG 556
            .:||:..| :.|:||||||||.|.|:|.:..|||...   ...||.|.:|: ....:|.::|:|.
Yeast   506 CIDLIENK-LGILSLLDEESRLPAGSDESWTQKLYQTLDKSPTNKVFSKPR-FGQTKFIVSHYAL 568

Human   557 EVYYQAEGFLEKNRDVLSTDILTLVYSSKNKFLREIF-NLELAETKLGHG-TIRQAKAGNHLFKS 619
            :|.|..|||:|||||.:|...|.::.:|.|:.|..|. .||.|..||... .:...:||:.....
Yeast   569 DVAYDVEGFIEKNRDTVSDGHLEVLKASTNETLINILEGLEKAAKKLEEAKKLELEQAGSKKPGP 633

Human   620 ADSNKRPSTLGSQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELCLRQLRYSGMMETV 684
            ..:..|..||||.|||||.:||..:.:...::|||||||..|:...||..:.|.|||..|::||:
Yeast   634 IRTVNRKPTLGSMFKQSLIELMNTINSTNVHYIRCIKPNADKEAWQFDNLMVLSQLRACGVLETI 698

Human   685 HIRKSGFPIRYTFEEFSQRFGVLLPNAMRMQLQGKLRQMT--------LGITDVWLRTDKDWKAG 741
            .|..:|||.|:|||||..|:.:|:|:. :..|..|.::.|        ..|.|..::....::.|
Yeast   699 RISCAGFPSRWTFEEFVLRYYILIPHE-QWDLIFKKKETTEEDIISVVKMILDATVKDKSKYQIG 762

Human   742 KTKIFLRDHQDTLLEVQRSQVLDRAALSIQKVLRGYRYRKEFL------------------RQR- 787
            .||||.:......||..||..:..:.:.|||.:|...|||::|                  |||
Yeast   763 NTKIFFKAGMLAYLEKLRSNKMHNSIVMIQKKIRAKYYRKQYLQISQAIKYLQNNIKGFIIRQRV 827

Human   788 ------RAAVTLQAWWRGYCNRRNFKLILVGFERLQAIARSQPLARQYQAMRQ--RTVQLQALCR 844
                  ..|..|||.:||:..|.|...:|.....||...|.:...||.:...:  ..|.:|:..|
Yeast   828 NDEMKVNCATLLQAAYRGHSIRANVFSVLRTITNLQKKIRKELKQRQLKQEHEYNAAVTIQSKVR 892

Human   845 GYLVRQQVQAKRRAVVVIQAHARGMAARRNFQQRKANG--------------------------- 882
            .:..|.:....::..||:|:..|..||:|..:|.||:.
Yeast   893 TFEPRSRFLRTKKDTVVVQSLIRRRAAQRKLKQLKADAKSVNHLKEVSYKLENKVIELTQNLASK 957

Human   883 ----------MQAPLVIPAEGQKSQGALPAKKRRSIYDTVTDTEMVEKVFGFLPAMIGGQEGQAS 937
                      ::...|...|..|.|..|...|:..:.|.                     :.|.|
Yeast   958 VKENKEMTERIKELQVQVEESAKLQETLENMKKEHLIDI---------------------DNQKS 1001

Human   938 PHFE-------DLESKTQKLLEVDLDTVPMA-------EEPEEDVDGLAEYTFPKFAVTYFQKSA 988
            ...|       :|:|..|.|.:..|:...|.       ||.::.::.| |.| .|..|.|...:.
Yeast  1002 KDMELQKTIENNLQSTEQTLKDAQLELEDMVKQHDELKEESKKQLEEL-EQT-KKTLVEYQTLNG 1064

Human   989 SHTHIRRPLRYPLLYHEDDTDCLAALVIWNVILRFMGDLPEPVLYARSSQQGSSVMRQIHDTLGR 1053
            ...:..:.|:      |:......|:.:..|....:...|...:....:...:::|.:..|....
Yeast  1065 DLQNEVKSLK------EEIARLQTAMSLGTVTTSVLPQTPLKDVMGGGASNFNNMMLENSDLSPN 1123

Human  1054 EHGAQVPQHSRSAQRSGCKDKGTKDISSMKLKRSSRITGQVASQLNIGEEALEPDGLGADRPMSN 1118
            :...:    |||...|     |...|.|:.:.|.:   |..|:|:|  ||...   |..|..:.|
Yeast  1124 DLNLK----SRSTPSS-----GNNHIDSLSVDREN---GVNATQIN--EELYR---LLEDTEILN 1171

Human  1119 LEKVH-FIVGYAI------LRPSLRDEIYCQ--ICKQLSENFKTSSLARGWILLSLCLGCFPPSE 1174
            .|... .:.|:.:      ::.|.||.:|..  :...|||.::              .|....||
Yeast  1172 QEITEGLLKGFEVPDAGVAIQLSKRDVVYPARILIIVLSEMWR--------------FGLTKQSE 1222

Human  1175 RFMKYLLNFI--------GQGPATYGPFCAERLRRTYA 1204
            .|:..:|..|        |......|.|....:|..|:
Yeast  1223 SFLAQVLTTIQKVVTQLKGNDLIPSGVFWLANVRELYS 1260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO7B	XP_047300391.1	MYSc_Myo7	79..748	CDD:276832	287/692 (41%)
		IQ	785..807	CDD:197470	11/28 (39%)
		MyTH4	992..1221	CDD:214535	44/230 (19%)
		FERM1_F1_Myosin-VII	1225..1323	CDD:340612
		FERM_C1_MyoVII	1467..1550	CDD:270019
		SH3	1551..1611	CDD:473055
		MyTH4	1692..1839	CDD:214535
		FERM2_F1_Myosin-VII	1846..1943	CDD:340613
		B41	1848..2060	CDD:214604
		FERM_C2_MyoVII	2056..>2131	CDD:270020
MYO2	NP_014971.1	COG5022	2..1567	CDD:227355	421/1338 (31%)