Protein Alignment MYO7B and Myo28B1

DIOPT Version :10

• Sequence 1: XP_047300391.1
• Gene: MYO7B / 4648
• HGNCID: 7607
• Length: 2298
• Species: Homo sapiens
• Sequence 2: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Alignment Length: 2250
• Identity: 867/2250 - (38%)
• Similarity: 1269/2250 - (56%)
• Gaps: 279/2250 - (12%)

Human     5 RLGDHVWLEPP-STHKTGVAIGGIIKEAKPGKVLVEDDEGKEHWIRAEDFGVLSPMHPNSVQGVD 68
            |.|::||::|. :|.:..|..|..|...:..:.||.||..|:.|:.|.|  ||..||..|.:.|:
  Fly     8 RKGEYVWVKPQNTTSEFAVPFGARIVRTEKTQTLVCDDRNKQFWVPAGD--VLKAMHITSQEDVE 70

Human    69 DMIRLGDLNEAGMVHNLLIRYQQHKIYTYTGSILVAVNPFQVLPLYTLEQVQLYYSRHMGELPPH 133
            |||.||||.|..::.||..||.:..|||||||:|||:||:|:||:||..::|||.::.:.|||||
  Fly    71 DMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELPPH 135

Human   134 VFAIANNCYFSMKRNKRDQCCIISGESGAGKTETTKLILQFLATISGQHSWIEQQVLEANPILEA 198
            :|||::|.:..::|.|.:||.:|||||||||||:||||||:||.|||:|||||||::|||||:||
  Fly   136 IFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSWIEQQIIEANPIMEA 200

Human   199 FGNAKTIRNDNSSRFGKYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGVS 263
            ||||||:||||||||||||:|.|.|.|.|:||||:|:||||||:..|:.:|||||||||||.|:|
  Fly   201 FGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAGLS 265

Human   264 AEDKQLLSL--GTPSEYHYLTMGNCTSCEGLNDAKDYAHIRSAMKILQFSDSESWDVIKLLAAIL 326
            ..:::.|.|  .:||:||||..|.|.:..|..||||:|.||:|||:|.|...|.|.::.||||||
  Fly   266 TAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAIL 330

Human   327 HLGNVGFMASVFENLDASDVMETPAFPTVMKLLEVQHQELRDCLIKHTILIRGEFVTRSLNIAQA 391
            ||||:.|.|:...||..:::.:||....|.:||.:....|...|.:.||.:.||.||.||:...|
  Fly   331 HLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSKEAA 395

Human   392 ADRRDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFENNSFEQLCINF 456
            .:.||||||.:|..:|:.||::||..| ......|.|   :||:|||||||||:||||||||||:
  Fly   396 IEGRDAFVKSLYDGIFVRIVRRINETI-NKQVDQPMN---SIGVLDIFGFENFDNNSFEQLCINY 456

Human   457 ANEHLQQFFVQHVFTMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSIISLLDEESRFPQGTD 521
            |||:||||||.|:|.|||:||::|:|:|.:|.:.||:..|||:.:|||:::||:||||:||:|||
  Fly   457 ANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPKGTD 521

Human   522 LTMLQKLNSVHANNKAFLQPKNIHDARFGIAHFAGEVYYQAEGFLEKNRDVLSTDILTLVYSSKN 586
            .|:|:||:..|.|...:::.|....:.|||.|:||.|.|...||||||||..|.|:.|||..|.|
  Fly   522 QTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTN 586

Human   587 KFLREIFNLELAETKLGHGTIRQAKAGNHLFKSADSNKRPSTLGSQFKQSLDQLMKILTNCQPYF 651
            |:|.:||..|:                     ..|:.|:..||..:|:.|||.||:.|:...|||
  Fly   587 KYLVDIFPHEM---------------------PMDTAKKQPTLCVKFRNSLDMLMRTLSQAHPYF 630

Human   652 IRCIKPNEYKKPLLFDRELCLRQLRYSGMMETVHIRKSGFPIRYTFEEFSQRFGVLLPNAMRMQL 716
            ||||||||||:|..||:|||:|||||||||||..||::|:|||:.:..|.:|:.:|:|....::
  Fly   631 IRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLE- 694

Human   717 QGKLRQMTLGITDVWLRTDKDWKAGKTKIFLRDHQDTLLEVQRSQVLDRAALSIQKVLRGYRYRK 781
            |...|::...|.:|.|..|.|.:.||||:||||..|..||:||||::.::.::||:.:|...:|:
  Fly   695 QCDCRKLARQICEVALPADSDRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRR 759

Human   782 EFLRQRRAAVTLQAWWRGYCNRRNFKLILVGFERLQAIARSQPLARQYQAMRQRTVQLQALCRGY 846
            ...|.|.|.:|:|.:|||...||.::::..||.||.|...:|.|..::..:|.||::||||.|||
  Fly   760 YMKRYREAIITVQRYWRGRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTMVRCRTIKLQALSRGY 824

Human   847 LV-----------RQQVQAKRRAVVVI-------------------------------------- 862
            ||           |:|.|.|:..::.:
  Fly   825 LVRKDFQKKLLERRKQNQLKKEELLKLAKMKEAEELLRLQQLKEQKEREQREQQEKRLQEEQRLK 889

Human   863 -QAHARGMAARRNFQQR-----------KANGMQA---------PLVIPAEGQKSQGALPAKKRR 906
             :|.||...|....||:           ||..:||         .|::.|       .||.:...
  Fly   890 AEAAARNALAMAAVQQKRRTKPVKQEAPKAPTLQARNSLPPPPTTLIVAA-------PLPTRPAS 947

Human   907 SI------------YDTVTDTEMVEKVFGFLPAMIGGQEGQASPHFEDLESKTQKLLEVDL-DTV 958
            ::            .|..:..:||:.||.||.              ::.::..:||..:.. ||:
  Fly   948 AVTRINTIPESPGTIDVESSKQMVDDVFRFLN--------------DEPDAALRKLNNISSGDTI 998

Human   959 PMAEEPEEDVDGLAEYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDTDCLAALVIWNVILRF 1023
            .:.:....::| .:::::.|:|.|||...|:..|.|:||:..||.||...|.:|:..||..||||
  Fly   999 RLPKSVPNNID-TSDFSYLKYAATYFGGGATAQHERKPLKKSLLKHEHPIDEMASKAIWLTILRF 1062

Human  1024 MGDLPE----PVLYARSSQQGSSVMRQIHDTLGREHGAQVPQHSRSAQRSGCKDKGTKDISSMKL 1084
            |||||:    |.|:...::   ::|..:...|......:.....|.:||
  Fly  1063 MGDLPDVVSSPTLHVFDNE---NLMSDLASLLNTSDSYKPRLFVRQSQR---------------- 1108

Human  1085 KRSSRITGQVASQLNIGE-EALEPDGLGADRPMSNLEKVHFIVGYAILRPSLRDEIYCQICKQLS 1148
                ||...:||    || ||.|......:.|.|:|||:|||:|:.|::.||||||..||||||.
  Fly  1109 ----RIPKPLAS----GEKEAQEFYQHWLNVPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQLY 1165

Human  1149 ENFKTSSLARGWILLSLCLGCFPPSERFMKYLLNFIGQGPA-TYGPFCAERLRRTYANGVRAEPP 1212
            .|...||.:|||:||||||.|||||:.|..:|.:|:.||.| .......:||.||..||.|.:||
  Fly  1166 LNPSRSSYSRGWLLLSLCLSCFPPSKEFEPHLRSFMKQGTAQLQATPSLQRLERTLVNGPRCQPP 1230

Human  1213 TWLELQAVKSKKHIPIQVILATGESLTVPVDSASTSREMCMHIAHKQGLSDHLGFSLQVAVYDKF 1277
            :..||.|::.:..:.:.:.|..|:...:.||:|||:||....:....||:|..||.|.:::..|.
  Fly  1231 SLFELHAIRGRHPLRLDIHLMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKL 1295

Human  1278 WSLGSGRDHMMDAIARCEQMAQERGESQRQSPWRIYFRKEFFTPWHDSREDPVSTELIYRQVLRG 1342
            ..||:|::|::|||:.|||       .|..:||::|.|||.|..|:|...||.:|:|||:|:|.|
  Fly  1296 MPLGAGQEHVLDAISECEQ-------RQLDAPWKLYIRKEMFATWYDPSMDPKATQLIYKQILNG 1353

Human  1343 VWSGEYSFEKEEELVELLARHCYVQLGASAESKAVQELLPSCIPHKLYRTKPPD----RPHTLRS 1403
            :..|||....|:::..:.|..|:|:.|                |.::.|.||.:    .|..|.:
  Fly  1354 LKCGEYRCRSEKDIAMVCALACFVEYG----------------PGEILRLKPSEITAFVPSDLLA 1402

Human  1404 KSHHWPCE---SRWWTPPACSGRCSSPGSSKSSHSQVMASDRGQG-----AGMGWAPRGPMQPSH 1460
                 |.|   ..|....|.:...||....:.:...:.|..|.:.     |.:.|    ||:  |
  Fly  1403 -----PGERAIENWSRLIAATYEKSSYVKEEQNDLLLEAQKRAKEDICLFAHLSW----PMR--H 1456

Human  1461 CRL----SWPGPRLPKTQLILAVNWKGLCFLDQQEKMLLELSFPEVMGLATNREAQGGQRL-LLS 1520
            .||    ...||:|...:|:|.:|..||..:|:.|::|....|.||:.:    ..:...:| :::
  Fly  1457 SRLFEVVRKEGPKLQSDELMLGINSAGLFLIDETEQVLASCCFSEVLKV----HVESDDKLHVMT 1517

Human  1521 TMHEEYEFVSPSSVAIAELVALFLEGLKERSIFAMALQDRKATDDTTLLAFKKGDLLV----LTK 1581
            ..|..:.....|:....|::...|:.|::||.:.:||......|....|....|||:.    :|.
  Fly  1518 FQHVNFVLQCSSAQDANEVINYMLDNLRQRSSYGVALDPVVEGDLEDCLVLNPGDLIEFEAGVTG 1582

Human  1582 KQGLLASENWTLGQNDRTGKTGLVPMACLYTIPTVTKPSAQLLSLLAMSPEKRKLAAQEGQFTEP 1646
            .| |:|.......:....|:.|......:..:.|:||||.:|..:|           :||:|.||
  Fly  1583 AQ-LMAGNAQDCYRGCVNGQWGQFLAGNVRVLATLTKPSEKLQDIL-----------REGRFQEP 1635

Human  1647 RPEEPP-----KEKLHTLEEFSYEFFRAP-EKDMVSMAVLPLARARGHLWAYSCEPLRQPLLKRV 1705
             |:..|     :.:.|.:.:.:...||.| :.|..     ||::       :|.|||:.||||.|
  Fly  1636 -PKPTPRANYSRRRQHNISQLAESHFREPLDSDKA-----PLSK-------FSPEPLKAPLLKAV 1687

Human  1706 HANVDLWDIACQIFVAILRYMGDYPSRQAWPTLELTDQIFTLALQHPALQDEVYCQILKQLTHNS 1770
            .....|:..|..:...||:||||. :|...|.  .||.||..|||||.|.||:|||::|||:.|.
  Fly  1688 VKVPPLFQQALVMHHHILKYMGDI-ARSNLPV--NTDLIFQPALQHPLLCDELYCQLMKQLSDNP 1749

Human  1771 NRHSEERGWQLLWLCTGLFPPSKGLLPHAQKFIDTR-RGKLLAPDCSRRIQKVLRTGPRKQPPHQ 1834
            :..||:|||.||:|.|||..||  :|...:..|..| |...||..|.:|:::.|..|.||:.||.
  Fly  1750 SSESEKRGWDLLYLATGLVAPS--VLVMRELIILLRMRADALADACLKRLKRSLAQGQRKKAPHL 1812

Human  1835 VEVEAAEQNVSRICHKIYFPNDTSEMLEVVANTRVRDVCDSIATRLQLASWEGCSLFIKISDKVI 1899
            :|||..:|....|.||||||:||.|..|:.::||..::...||.||:|.|..|.|:|:|..|:|.
  Fly  1813 IEVEGIQQRCLHIYHKIYFPDDTVEAFEIESHTRGAELIADIAQRLELKSPVGYSIFLKTGDRVY 1877

Human  1900 SQKEGDFFFDSLREVSDWVKKNKPQK---EGAPVTLPYQVYFMRKLWLNISPGKDVNADTILHYH 1961
            :..|.:|.||.:.::..|:::.:..:   :|     .||::||||||||..||:|:|.|.|..|.
  Fly  1878 AMPEEEFVFDFITQLIYWLRQQRTIRSISDG-----QYQLHFMRKLWLNNHPGEDLNGDMIFSYP 1937

Human  1962 QELPKYLRGFHKCSREDAIHLAGLIYKAQFNNDRSQLASVPKILRELVPENLTRLMSSEEWKKSI 2026
            |||.|||:|::....|.|..||.|:|.|  ::|.| |..:|::|..|:||:|..|.:..||::.|
  Fly  1938 QELHKYLKGYYPIDCEQASRLAILVYSA--DHDVS-LQRLPEVLTRLIPEDLIPLQTVAEWRQQI 1999

Human  2027 LLAYDKHKDKTVEE-AKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDVILIAINRHGVLLIHPKT 2090
            |...  |:|...|: ||:.||:.:..:..|||.||.|||.::.:.|:.:|||||..|..::.|.|
  Fly  2000 LPKV--HRDHLTEDHAKILFLQELSHFACFGSTFFVVKQQNDDALPETLLIAINSTGFHMLDPTT 2062

Human  2091 KDLLTTYPFTKISSWSSGSTYFHMALGSLGRGSRLLCETS 2130
            |::|.:|.::::..||||..:||:..|::...|:|||.|:
  Fly  2063 KEILRSYEYSQLGIWSSGKNHFHIRFGNMIGASKLLCSTT 2102

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO7B	XP_047300391.1	MYSc_Myo7	79..748	CDD:276832	349/670 (52%)
		IQ	785..807	CDD:197470	10/21 (48%)
		MyTH4	992..1221	CDD:214535	94/234 (40%)
		FERM1_F1_Myosin-VII	1225..1323	CDD:340612	34/97 (35%)
		FERM_C1_MyoVII	1467..1550	CDD:270019	20/83 (24%)
		SH3	1551..1611	CDD:473055	14/63 (22%)
		MyTH4	1692..1839	CDD:214535	67/147 (46%)
		FERM2_F1_Myosin-VII	1846..1943	CDD:340613	37/99 (37%)
		B41	1848..2060	CDD:214604	85/215 (40%)
		FERM_C2_MyoVII	2056..>2131	CDD:270020	31/74 (42%)
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	349/670 (52%)
		IQ	765..785	CDD:197470	9/19 (47%)
		Atrophin-1	<820..>946	CDD:460830	24/132 (18%)
		MyTH4	1031..1239	CDD:470587	94/234 (40%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	34/97 (35%)
		B41	1248..1429	CDD:214604	65/208 (31%)
		PH-like	1454..1547	CDD:473070	24/98 (24%)
		MyTH4	1674..1819	CDD:214535	68/149 (46%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613	37/98 (38%)
		B41	1827..2032	CDD:214604	85/214 (40%)
		FERM_C2_MyoVII	2028..2121	CDD:270020	31/74 (42%)