DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYO7B and Myo7b

DIOPT Version :9

Sequence 1:	XP_016859658.1	Gene:	MYO7B / 4648	HGNCID:	7607	Length:	2164	Species:	Homo sapiens
Sequence 2:	NP_001178870.1	Gene:	Myo7b / 498834	RGDID:	1561153	Length:	2152	Species:	Rattus norvegicus

Alignment Length:	2182	Identity:	1701/2182 - (77%)
Similarity:	1887/2182 - (86%)	Gaps:	86/2182 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSGFRLGDHVWLEPPSTHKTGVAIGGIIKEAKPGKVLVEDDEGKEHWIRAEDFGVLSPMHPNSVQ 65
            ||.|||||||||:|||::|||||||||:||.|.||.|:||||||||||.|||...|.||||||.|
  Rat     1 MSVFRLGDHVWLDPPSSNKTGVAIGGIVKETKLGKTLIEDDEGKEHWISAEDLSTLRPMHPNSAQ 65

Human    66 GVDDMIRLGDLNEAGMVHNLLIRYQQHKIYTYTGSILVAVNPFQVLPLYTLEQVQLYYSRHMGEL 130
            |||||||||||||||:||||||||||||||||||||||||||||:||||||||||:|||||||||
  Rat    66 GVDDMIRLGDLNEAGVVHNLLIRYQQHKIYTYTGSILVAVNPFQMLPLYTLEQVQIYYSRHMGEL 130

Human   131 PPHVFAIANNCYFSMKRNKRDQCCIISGESGAGKTETTKLILQFLATISGQHSWIEQQVLEANPI 195
            |||||||||:|||:||:||||||||||||||||||||||||||||||:|||||||||||||||||
  Rat   131 PPHVFAIANSCYFNMKKNKRDQCCIISGESGAGKTETTKLILQFLATVSGQHSWIEQQVLEANPI 195

Human   196 LEAFGNAKTIRNDNSSRFGKYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLM 260
            ||||||||||||||||||||||||:||.|||||||.||.||||||||||||.|||||||||||||
  Rat   196 LEAFGNAKTIRNDNSSRFGKYIDIHFNSSGVIEGASIEHFLLEKSRVCRQAAEERNYHIFYCMLM 260

Human   261 GVSAEDKQLLSLGTPSEYHYLTMGNCTSCEGLNDAKDYAHIRSAMKILQFSDSESWDVIKLLAAI 325
            |:|.|:|.:|.||.||||||||||||||.|||:|||||||:|||||||||||||:||:.||||||
  Rat   261 GMSLEEKNMLGLGMPSEYHYLTMGNCTSYEGLSDAKDYAHVRSAMKILQFSDSENWDISKLLAAI 325

Human   326 LHLGNVGFMASVFENLDASDVMETPAFPTVMKLLEVQHQELRDCLIKHTILIRGEFVTRSLNIAQ 390
            ||||||||||:||||||:||||||||||..|||||||||.||||||||||.|.||||:|.|||||
  Rat   326 LHLGNVGFMAAVFENLDSSDVMETPAFPFAMKLLEVQHQALRDCLIKHTIPILGEFVSRPLNIAQ 390

Human   391 AADRRDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFENNSFEQLCIN 455
            |||||||||||||||||||||||||||||||.||||:|||||||||||||||||:||||||||||
  Rat   391 AADRRDAFVKGIYGHLFLWIVKKINAAIFTPQAQDPQNVRRAIGLLDIFGFENFQNNSFEQLCIN 455

Human   456 FANEHLQQFFVQHVFTMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSIISLLDEESRFPQGT 520
            |||||||||||:||||||||||.||||:|:|||||||:|.||:||||||||||||||||||||||
  Rat   456 FANEHLQQFFVKHVFTMEQEEYLSENITWNYIHYTDNQPILDMLALKPMSIISLLDEESRFPQGT 520

Human   521 DLTMLQKLNSVHANNKAFLQPKNIHDARFGIAHFAGEVYYQAEGFLEKNRDVLSTDILTLVYSSK 585
            |:||||||||:|||||:||:||:|||.|||||||||:|||||||||||||||||||||.|::|||
  Rat   521 DVTMLQKLNSIHANNKSFLRPKSIHDTRFGIAHFAGDVYYQAEGFLEKNRDVLSTDILILIHSSK 585

Human   586 NKFLREIFNLELAETKLGHGTIRQ--AKAGNHLFKSADSNKRPSTLGSQFKQSLDQLMKILTNCQ 648
            ||||:|||||:|.:||||||||.|  .|.|..:||.:||.||..||.|||||||:||||||||||
  Rat   586 NKFLKEIFNLDLPQTKLGHGTICQVKTKTGGQIFKPSDSTKRSVTLSSQFKQSLEQLMKILTNCQ 650

Human   649 PYFIRCIKPNEYKKPLLFDRELCLRQLRYSGMMETVHIRKSGFPIRYTFEEFSQRFGVLLPNAMR 713
            |||:|||||||||||||||||||::||||||||||||||||||||||||:||||||.||||:..|
  Rat   651 PYFVRCIKPNEYKKPLLFDRELCIQQLRYSGMMETVHIRKSGFPIRYTFDEFSQRFRVLLPSPER 715

Human   714 MQLQGKLRQMTLGITDVWLRTDKDWKAGKTKIFLRDHQDTLLEVQRSQVLDRAALSIQKVLRGYR 778
            :|.|.|.||||..|.|:.|.|||:||.|||||||:|||||:||:||||.||.||:.||:||||::
  Rat   716 VQFQNKHRQMTSRIADLCLGTDKEWKMGKTKIFLKDHQDTMLEIQRSQALDGAAIRIQRVLRGHK 780

Human   779 YRKEFLRQRRAAVTLQAWWRGYCNRRNFKLILVGFERLQAIARSQPLARQYQAMRQRTVQLQALC 843
            ||||||||:||||||||.|||:..|:||||||:|||||||||||..|.||:|.|||:.|||||.|
  Rat   781 YRKEFLRQKRAAVTLQAVWRGHNQRKNFKLILMGFERLQAIARSHLLMRQFQTMRQKIVQLQARC 845

Human   844 RGYLVRQQVQAKRRAVVVIQAHARGMAARRNFQQRKANGMQAPLVIPAEGQKSQGALPAKKRRSI 908
            |||||||||||||||||:||||||||.||:::.|:|::|   |.||.|:..|.||....:||:||
  Rat   846 RGYLVRQQVQAKRRAVVIIQAHARGMVARKSYWQQKSSG---PPVILAKEPKGQGVALDRKRKSI 907

Human   909 YDTVTDTEMVEKVFGFLPAMIGGQEGQASPHFEDLESKTQKLLEVDLDTVPMAEEPEEDVDGLAE 973
            |||||||.||||||||||||||||||.|...|||||.|||||.|||||||||.|.|.||||||||
  Rat   908 YDTVTDTAMVEKVFGFLPAMIGGQEGPAPTRFEDLEVKTQKLHEVDLDTVPMTEMPGEDVDGLAE 972

Human   974 YTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDTDCLAALVIWNVILRFMGDLPEPVLYARSSQ 1038
            ||||||||||||||||||||::||||||||||:|||..|||.:|.:|||||||||||..|.|||.
  Rat   973 YTFPKFAVTYFQKSASHTHIQKPLRYPLLYHENDTDHSAALAVWIIILRFMGDLPEPQAYGRSSL 1037

Human  1039 QGSSVMRQIHDTLGREHGAQVPQHSRSAQRSGCKDKGTKDISSMKLKRSSRITGQVASQLNIGEE 1103
            .||||||||||.|.::...|.|||:||.                          |||||.|||||
  Rat  1038 TGSSVMRQIHDRLDKDSVTQGPQHNRST--------------------------QVASQQNIGEE 1076

Human  1104 ALEPDGLGADRPMSNLEKVHFIVGYAILRPSLRDEIYCQICKQLSENFKTSSLARGWILLSLCLG 1168
            ..:.||..:||||||||||||||||||:||.||||||||||||||||:||||.||||||||||||
  Rat  1077 VFKFDGPISDRPMSNLEKVHFIVGYAIMRPGLRDEIYCQICKQLSENYKTSSRARGWILLSLCLG 1141

Human  1169 CFPPSERFMKYLLNFIGQGPATYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKKHIPIQVILA 1233
            ||||||||||||||||.||||:|||||||||:||:||||||||||||||||||||||||||||||
  Rat  1142 CFPPSERFMKYLLNFISQGPASYGPFCAERLQRTFANGVRAEPPTWLELQAVKSKKHIPIQVILA 1206

Human  1234 TGESLTVPVDSASTSREMCMHIAHKQGLSDHLGFSLQVAVYDKFWSLGSGRDHMMDAIARCEQMA 1298
            ||.|||:.|||||||||:|..||.||||.|.|||||||||||||||||:..||:|||:|:|||:|
  Rat  1207 TGRSLTISVDSASTSREICQQIAQKQGLRDKLGFSLQVAVYDKFWSLGNSCDHVMDAVAQCEQLA 1271

Human  1299 QERGESQRQSPWRIYFRKEFFTPWHDSREDPVSTELIYRQVLRGVWSGEYSFEKEEELVELLARH 1363
            .||||||||:||||||||||||||||||||||||||||.|||||||||||:|||||:||||||||
  Rat  1272 WERGESQRQAPWRIYFRKEFFTPWHDSREDPVSTELIYHQVLRGVWSGEYNFEKEEDLVELLARH 1336

Human  1364 CYVQLGASAESKAVQELLPSCIPHKLYRTKPPDRPHTLRSKSHHWPCESRWWTPPACSGRCSSPG 1428
            |||||||:.:|.|||||||||:|.||||||.|::..:|...:|
  Rat  1337 CYVQLGATVKSNAVQELLPSCVPSKLYRTKSPEKWASLVIAAH---------------------- 1379

Human  1429 SSKSSHSQVMASDRGQGAGMGWAPRGPMQPSH-----CRLSWP-------------GPRLPKTQL 1475
             :|:.::|..|:              |::...     .||.||             |||||||||
  Rat  1380 -AKAPYTQSKAT--------------PLEVKEQTVEAARLLWPLLFSRLFEVTTLSGPRLPKTQL 1429

Human  1476 ILAVNWKGLCFLDQQEKMLLELSFPEVMGLATNREAQGGQRLLLSTMHEEYEFVSPSSVAIAELV 1540
            |||:||||:.||||:|:.||.|||.|||||..||:|.||:.|||||:||||||.|||||||||:|
  Rat  1430 ILAINWKGMYFLDQKERTLLGLSFAEVMGLIANRDAPGGKSLLLSTLHEEYEFASPSSVAIAEMV 1494

Human  1541 ALFLEGLKERSIFAMALQDRKATDDTTLLAFKKGDLLVLTKKQGLLASENWTLGQNDRTGKTGLV 1605
            ||||.||||||:|||||||||||||.|||.|||||||:|||||||||||||.|||||||||||||
  Rat  1495 ALFLAGLKERSVFAMALQDRKATDDVTLLPFKKGDLLILTKKQGLLASENWVLGQNDRTGKTGLV 1559

Human  1606 PMACLYTIPTVTKPSAQLLSLLAMSPEKRKLAAQEGQFTEPRPEEPPKEKLHTLEEFSYEFFRAP 1670
            |.|||||||:|||||||||:|||||||||||||||.|.:||..||...|..:|||||||::||||
  Rat  1560 PTACLYTIPSVTKPSAQLLNLLAMSPEKRKLAAQEVQASEPPLEEQLTELPYTLEEFSYQYFRAP 1624

Human  1671 EKDMVSMAVLPLARARGHLWAYSCEPLRQPLLKRVHANVDLWDIACQIFVAILRYMGDYPSRQAW 1735
            ||:.:|.|.:|:||:||||||||.|||||||||.||....|.|.|||||:|||:|.|||||||:|
  Rat  1625 EKETISRAAMPMARSRGHLWAYSPEPLRQPLLKSVHDKAKLRDSACQIFLAILKYTGDYPSRQSW 1689

Human  1736 PTLELTDQIFTLALQHPALQDEVYCQILKQLTHNSNRHSEERGWQLLWLCTGLFPPSKGLLPHAQ 1800
            .:||||||:|:|||:.||||||:||||||||||||.|.||||.|||||||||||||.|.||||||
  Rat  1690 HSLELTDQMFSLALKEPALQDELYCQILKQLTHNSIRFSEERAWQLLWLCTGLFPPGKALLPHAQ 1754

Human  1801 KFIDTRRGKLLAPDCSRRIQKVLRTGPRKQPPHQVEVEAAEQNVSRICHKIYFPNDTSEMLEVVA 1865
            ||||:|:.|.||.|||||:.::||.||||||||.|||:|||||||::.|::|.||||::.|||.:
  Rat  1755 KFIDSRKKKPLALDCSRRLHRILRVGPRKQPPHHVEVKAAEQNVSKLHHEVYLPNDTNKTLEVSS 1819

Human  1866 NTRVRDVCDSIATRLQLASWEGCSLFIKISDKVISQKEGDFFFDSLREVSDWVKKNKPQKEGAPV 1930
            ::||||:|:.||||||||||:||||||||:|||||.|||||||||||:||||||||:||||||..
  Rat  1820 SSRVRDLCEGIATRLQLASWDGCSLFIKITDKVISLKEGDFFFDSLRQVSDWVKKNRPQKEGAST 1884

Human  1931 TLPYQVYFMRKLWLNISPGKDVNADTILHYHQELPKYLRGFHKCSREDAIHLAGLIYKAQFNNDR 1995
            ||||||:||||||||::||||||||||||||||||||:||||||||||||:|||||||.||.:||
  Rat  1885 TLPYQVFFMRKLWLNVTPGKDVNADTILHYHQELPKYMRGFHKCSREDAIYLAGLIYKIQFGSDR 1949

Human  1996 SQLASVPKILRELVPENLTRLMSSEEWKKSILLAYDKHKDKTVEEAKVAFLKWICRWPTFGSAFF 2060
            ||:|||.|||:||||:||||||||||||||:||..||||:|:|.||||.|||.|.||||||||||
  Rat  1950 SQMASVSKILKELVPQNLTRLMSSEEWKKSLLLECDKHKNKSVAEAKVEFLKRIYRWPTFGSAFF 2014

Human  2061 EVKQTSEPSYPDVILIAINRHGVLLIHPKTKDLLTTYPFTKISSWSSGSTYFHMALGSLGRGSRL 2125
            ||||||||||||::||||||||:||||||||:||.|:|||||||||||:|||||||||||:||||
  Rat  2015 EVKQTSEPSYPDILLIAINRHGLLLIHPKTKELLDTFPFTKISSWSSGNTYFHMALGSLGQGSRL 2079

Human  2126 LCETSLGYKMDDLLTSYVQQLLSAMNKQRGSKAPALA 2162
            ||||||||||||||||||||:|||:||.||.:|||.|
  Rat  2080 LCETSLGYKMDDLLTSYVQQILSAVNKHRGFRAPAPA 2116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYO7B	XP_016859658.1	None
Myo7b	NP_001178870.1	MYSc	60..761	CDD:214580	603/700 (86%)
		MYSc_Myo7	79..750	CDD:276832	577/670 (86%)
		IQ	787..809	CDD:197470	15/21 (71%)
		MyTH4	991..1194	CDD:214535	162/228 (71%)
		B41	1201..1414	CDD:214604	150/249 (60%)
		FERM_B-lobe	1304..1405	CDD:271216	62/137 (45%)
		FERM_C1_MyoVII	1408..1504	CDD:270019	64/95 (67%)
		SH3	1505..1565	CDD:302595	53/59 (90%)
		MyTH4	1646..1793	CDD:214535	111/146 (76%)
		B41	1802..2014	CDD:214604	169/211 (80%)
		FERM_M	1912..2014	CDD:278785	83/101 (82%)
		FERM_C2_MyoVII	2010..2105	CDD:270020	85/94 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83691102
Domainoid	1	1.000	1207	1.000	Domainoid score	I989
eggNOG	1	0.900	-	-		E2759_KOG4229
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H81947
Inparanoid	1	1.050	3512	1.000	Inparanoid score	I336
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39495
OrthoDB	1	1.010	-	-		D10152at7742
OrthoFinder	1	1.000	-	-		FOG0001409
OrthoInspector	1	1.000	-	-		oto135238
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	LDO	PTHR13140
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1286
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270