Protein Alignment MYO7B and SPOM_SPAC25B8.08

DIOPT Version :10

• Sequence 1: XP_047300391.1
• Gene: MYO7B / 4648
• HGNCID: 7607
• Length: 2298
• Species: Homo sapiens
• Sequence 2: NP_594468.2
• Gene: SPOM_SPAC25B8.08 / 2542659
• PomBaseID: SPAC25B8.08
• Length: 573
• Species: Schizosaccharomyces pombe
• Alignment Length: 430
• Identity: 89/430 - (20%)
• Similarity: 162/430 - (37%)
• Gaps: 120/430 - (27%)

Human  1647 RPEEP-----PKEKLHTLEEFSYEFFRAPEKDMVSMAVLPLARARGHLWAYSCEPLRQPLLKRVH 1706
            |.::|     |.:..:....|:: |:...||::.::.          |.|:.|| :.|  :.:.|
pombe   143 RADKPALRLAPSKLFYLASRFAF-FYMPKEKELGTVL----------LNAFLCE-VNQ--VTQQH 193

Human  1707 ANVDLWDIACQIFVAILRYMGDYPSRQAWPTLELTDQIFTLALQHPALQDEVYCQILKQLTHNSN 1771
            .| |:  :.|..::|.:..:..|..:..    :|.|....:..:...|.:.:|..|.:......|
pombe   194 PN-DM--VLCVQWLANVSLLLFYLKKDN----KLDDLTVDIQNRCSELMNSLYITICQDAMRRMN 251

Human  1772 RHSEERGWQLLWLCTGLFPPSKGLLPHAQKFIDTRRGKLLAPDCSRRIQKVLRTGPRKQPPHQVE 1836
            .:.||.    :...||:    :||    :..:.:|...||    .||......|.||..|
pombe   252 ENLEEG----MVKYTGI----QGL----EDILRSRSWNLL----RRRPTNDASTSPRSTP----- 295

Human  1837 VEAAEQNVSRICHKIYFPNDTSEMLEV-VANTRVRDVCDSIATRLQLASWEGCSLF-IKISDKVI 1899
             .|:.:::::|.      ..|..:||| ..:..:|..|..     ||.||.|..|| |.||:|..
pombe   296 -SASPRSITKII------ASTLHLLEVFYIHPLIRAQCIE-----QLFSWLGARLFNIVISNKKY 348

Human  1900 SQK----EGDFFFDSLREVSDWVKKNKPQKEGAPVTLPYQVYFMRKLWLNISPGKDVNADTI--L 1958
            ..:    |..|...||.|   |.:.|.|:     :..|:..           |.:|:..|.|  |
pombe   349 LSRAAAMETRFNISSLEE---WSQTNSPK-----LQKPFDY-----------PDEDLKVDLISKL 394

Human  1959 HYHQELPKYLRGFHKCSRED------------------AIHLAGLIYKAQFNNDRSQLASVPKI- 2004
            ....:|.::|:..::.|.::                  .|:.|..:|:......:.....:.|:
pombe   395 LSLVQLLQWLQCLYRLSEDEDPRALQETLESLDALNPRQIYTAAKLYRPDITETKVSKTFLKKLD 459

Human  2005 ------LRELVPENLTRLMSSEEWKKSILLAYDKHKDKTV 2038
                  |||       ::.||:  |..:...::..||:||
pombe   460 AFHEEKLRE-------KINSSD--KGDVSYEFELLKDETV 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO7B	XP_047300391.1	MYSc_Myo7	79..748	CDD:276832
		IQ	785..807	CDD:197470
		MyTH4	992..1221	CDD:214535
		FERM1_F1_Myosin-VII	1225..1323	CDD:340612
		FERM_C1_MyoVII	1467..1550	CDD:270019
		SH3	1551..1611	CDD:473055
		MyTH4	1692..1839	CDD:214535	30/146 (21%)
		FERM2_F1_Myosin-VII	1846..1943	CDD:340613	27/102 (26%)
		B41	1848..2060	CDD:214604	48/224 (21%)
		FERM_C2_MyoVII	2056..>2131	CDD:270020
SPOM_SPAC25B8.08	NP_594468.2	Myo5p-like_CBD_DIL_ANK	123..507	CDD:271257	89/430 (21%)