DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYO7B and myo52

DIOPT Version :9

Sequence 1:	XP_016859658.1	Gene:	MYO7B / 4648	HGNCID:	7607	Length:	2164	Species:	Homo sapiens
Sequence 2:	NP_588492.1	Gene:	myo52 / 2538846	PomBaseID:	SPCC1919.10c	Length:	1516	Species:	Schizosaccharomyces pombe

Alignment Length:	902	Identity:	326/902 - (36%)
Similarity:	497/902 - (55%)	Gaps:	84/902 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    24 IGGIIK----EAKPGKVLVEDDEGKEH--WIRAEDFGVLS----PMHPNSVQGVDDMIRLGDLNE 78
            |.|.||    |.:...:.|:|:...|.  .::.:|.....    |...:.....||:..|..|||
pombe    22 IPGSIKDCRVEGEKAFLTVQDENENETVITVKPDDLNYEGRNGLPFLRSINSDADDLTDLSYLNE 86

Human    79 AGMVHNLLIRYQQHKIYTYTGSILVAVNPFQVLP-LYTLEQVQLYYSRHMGELPPHVFAIANNCY 142
            ..::..|..||.|.:||||:|.:|:||||||.|| |||.|.|:.|..:...||.||::|||.:.|
pombe    87 PSVLDALSTRYNQLQIYTYSGIVLIAVNPFQRLPNLYTHEIVRAYSEKSRDELDPHLYAIAEDSY 151

Human   143 FSMKRNKRDQCCIISGESGAGKTETTKLILQFLATISG-------------QHSWIEQQVLEANP 194
            ..|.:..::|..|||||||||||.:.:.|:::.|::..             |.:.:|.::|..||
pombe   152 KCMNQEHKNQTIIISGESGAGKTVSARYIMRYFASVQALIQSTDSNFHEAPQLTAVENEILATNP 216

Human   195 ILEAFGNAKTIRNDNSSRFGKYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCML 259
            |:|||||:||.||||||||||||.|.|:.:..|.||:|:.:|||:||:..|..:||||||||.:|
pombe   217 IMEAFGNSKTSRNDNSSRFGKYIQILFDGNATIIGAKIQTYLLERSRLVFQPNQERNYHIFYQIL 281

Human   260 MGVSAEDKQLLSLGTPS-EYHYLTMGNCTSCEGLNDAKDYAHIRSAMKILQFSDSESWDVIKLLA 323
            .|.|:|..:...|...| |::||..|||::.||:||.:::.....|:|.:...:.....:..|||
pombe   282 AGSSSEQLEKWKLVENSQEFNYLKQGNCSTIEGVNDKEEFKATVDALKTVGIDNDTCECIFSLLA 346

Human   324 AILHLGNV--------GFMASVFENLDASDVMETPAFPTVMKLLEVQHQELRDCLIKHTILIRGE 380
            |:||:||:        .::.|..|||           .....||.|....|...|.|..|.:..|
pombe   347 ALLHIGNIEVKHSRNDAYIDSKNENL-----------INATSLLGVDPSSLVKWLTKRKIKMASE 400

Human   381 FVTRSLNIAQAADRRDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFE 445
            .:.:.||..||...||:..|.:|..||.|:|..||.|:.....:..:..:..||:|||:|||:|:
pombe   401 GILKPLNEFQAVVARDSVAKFLYASLFDWLVATINKALMYSADKSNQTAKSFIGVLDIYGFEHFK 465

Human   446 NNSFEQLCINFANEHLQQFFVQHVFTMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSIISLL 510
            .|||||.|||:|||.|||.|.:|||.:|||||.:|.::|.||.|.||:..:.::..: :.|:|||
pombe   466 KNSFEQFCINYANEKLQQEFYRHVFKLEQEEYAAEGLNWSYIDYQDNQQCISMIESR-LGILSLL 529

Human   511 DEESRFPQGTDLTMLQKLNSVHANNKAFLQP--KNIHD-ARFG-----IAHFAGEVYYQAEGFLE 567
            |||.|.|..:|...:.|||.      ||.:|  ||.:. :|||     |.|:|.:|.|.||||::
pombe   530 DEECRMPTNSDENWVSKLND------AFSKPEFKNSYQKSRFGNKEFTIKHYALDVVYCAEGFID 588

Human   568 KNRDVLSTDILTLVYSSKNKFLREIFNLELAETKLGHGTIRQAKAGNHLFKSADSNKRPSTLGSQ 632
            ||||.:|.::|.|..:|...|::::....|.:|.....|           |...:..:.:||||.
pombe   589 KNRDTISDELLELFTNSDVPFVKDLVLFRLEQTAPPADT-----------KKIKTKPKSNTLGSM 642

Human   633 FKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELCLRQLRYSGMMETVHIRKSGFPIRYTF 697
            ||.||..||..:.....::||||||||.|:...||.::.:.|||..|::||:.|..:|||.|:||
pombe   643 FKSSLVSLMSTINETNAHYIRCIKPNEEKEAWKFDNQMVVSQLRACGVLETIKISCAGFPSRWTF 707

Human   698 EEFSQRFGVLLPNAMRMQLQGKLRQMTLGITDVWLRTDKD---WKAGKTKIFLRDHQDTLLEVQR 759
            :||..|:.:|:|:|:|       ...:|..:...|....|   ::.||||||.|.....|||..|
pombe   708 DEFVSRYYMLVPSAVR-------TTESLTFSKAILEKHADPTKYQIGKTKIFFRSGVTPLLESAR 765

Human   760 SQVLDRAALSIQKVLRGYRYRKEFLRQRRAAVTLQAWWRGYCNRRN--FKLILVGFERLQAIARS 822
            .:.|..||..:.:......||..||..|:...:.||...|:.:||:  ::|:.....:||::.|:
pombe   766 DKALKHAAHLLYEAFAVNYYRTRFLLSRKRVRSFQAVAHGFLSRRHTEYELLSSNIIKLQSLWRT 830

Human   823 QPLARQYQAMRQRTVQLQALCRGYLVRQQVQAKRR--AVVVIQAHARGMAARRNFQQ 877
            ....:::...:...:::|::.||:|:||.::.|.:  |.::||:......|.:::::
pombe   831 ALKRKEFIQTKNSILKVQSIIRGFLLRQTLEEKTKHDATLIIQSLWLTFKAHKHYKE 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYO7B	XP_016859658.1	None
myo52	NP_588492.1	COG5022	1..1501	CDD:227355	326/902 (36%)
		MYSc_Myo5	87..754	CDD:276831	277/702 (39%)
		Myo5p-like_CBD_fungal	1105..1434	CDD:271258
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810