Protein Alignment MYO7B and hum-6

DIOPT Version :10

• Sequence 1: XP_047300391.1
• Gene: MYO7B / 4648
• HGNCID: 7607
• Length: 2298
• Species: Homo sapiens
• Sequence 2: NP_508420.1
• Gene: hum-6 / 180539
• WormBaseID: WBGene00002039
• Length: 2098
• Species: Caenorhabditis elegans
• Alignment Length: 2228
• Identity: 958/2228 - (42%)
• Similarity: 1358/2228 - (60%)
• Gaps: 238/2228 - (10%)

Human     7 GDHVWLEPPSTHKTGVAIGGIIKEAKPGKVLVEDDEGKEHWIRAEDFGVLSPMHPNSVQGVDDMI 71
            ||.:|:||..| :..:.||..:.:...|::.|.||.|.|.|:.|:....|  |||.|||||:||.
 Worm     7 GDFIWIEPGKT-EGSIPIGARVIDQDHGRLKVIDDLGNEQWLSADRRVRL--MHPTSVQGVEDMC 68

Human    72 RLGDLNEAGMVHNLLIRYQQHKIYTYTGSILVAVNPFQVLPLYTLEQVQLYYSRHMGELPPHVFA 136
            :|||.:|:.::.||.|||::..||.||||||:||||:..:.:||.:::::|..:.:||||||:||
 Worm    69 QLGDFHESAILRNLFIRYREKLIYAYTGSILIAVNPYMDIAIYTADEIRMYKRKRIGELPPHIFA 133

Human   137 IANNCYFSMKRNKRDQCCIISGESGAGKTETTKLILQFLATISGQHSWIEQQVLEANPILEAFGN 201
            ||:|.|.:|:|.|::|..||||||||||||:|||:|||||||||||||||||||||||:||||||
 Worm   134 IADNAYTNMRREKKNQSVIISGESGAGKTESTKLVLQFLATISGQHSWIEQQVLEANPVLEAFGN 198

Human   202 AKTIRNDNSSRFGKYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGVSAED 266
            |||||||||||||||||::||.||.||||:|||:||||||:..|:..|||||||||:|.|:|.|:
 Worm   199 AKTIRNDNSSRFGKYIDVHFNESGSIEGAKIEQYLLEKSRIVTQSENERNYHIFYCLLAGLSREE 263

Human   267 KQLLSLGTPSEYHYLTMGNCTSCEGLNDAKDYAHIRSAMKILQFSDSESWDVIKLLAAILHLGNV 331
            |..|.|||.::|:||..|...:.||.:||.|.|.|||||::|..::.|...:.||||::||:||:
 Worm   264 KSELELGTAADYYYLIQGKTLTAEGRDDAADLAEIRSAMRVLMINEQEIGSIFKLLASLLHIGNI 328

Human   332 GFMASVFENLDASDVMETPAFPTVMKLLEVQHQELRDCLIKHTILIRGEFVTRSLNIAQAADRRD 396
            .|..:..:|:::.||.:......:.|||::..|.|.|.:...:::.|.|.|...||..||.|.||
 Worm   329 RFRQNTNDNMESVDVADPSTLVRIAKLLQLHEQNLLDAITTKSLVTREERVISRLNGQQAVDARD 393

Human   397 AFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFENNSFEQLCINFANEHL 461
            |..|.|||.||:.||:::|.||:.|    .::.|.:||:||||||||||:|||||||||||||.|
 Worm   394 ALAKAIYGKLFIHIVRRVNDAIYKP----SQSRRTSIGILDIFGFENFESNSFEQLCINFANETL 454

Human   462 QQFFVQHVFTMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSIISLLDEESRFPQGTDLTMLQ 526
            |||||.|||.|||:||..|:|:|.:|.:.||:.|:||:|.:|::|:||:||||.||:|||.|||.
 Worm   455 QQFFVHHVFKMEQKEYDEEHINWRHIKFVDNQATVDLIAQRPLNILSLIDEESIFPKGTDKTMLL 519

Human   527 KLNSVHANNKAFLQPKNIHDARFGIAHFAGEVYYQAEGFLEKNRDVLSTDILTLVYSSKNKFLRE 591
            ||:|.|..|:.:||||:.....||:.||||.|:|...||||||||..|.|:..|:.|||..||..
 Worm   520 KLHSTHGRNELYLQPKSELQRAFGVTHFAGNVFYNTRGFLEKNRDSFSADLSVLISSSKMPFLAR 584

Human   592 IFNLELAETKLGHGTIRQAKAGNHLFKSADSNKRPSTLGSQFKQSLDQLMKILTNCQPYFIRCIK 656
            :|:      .:.:.|               |:::..|:|:||::||:|||..||...|:||||||
 Worm   585 LFD------DIEYDT---------------SSRKKVTVGNQFRRSLEQLMSQLTQTHPFFIRCIK 628

Human   657 PNEYKKPLLFDRELCLRQLRYSGMMETVHIRKSGFPIRYTFEEFSQRFGVLLPNAMRMQLQGKLR 721
            |||.|:.|:.||:|.||||||||||||:.||:||:|||:.:..|..|:.||:.:     :||.:.
 Worm   629 PNEMKRALVMDRDLVLRQLRYSGMMETIKIRRSGYPIRHDYYPFVFRYRVLVSS-----IQGPVN 688

Human   722 QMTL-----GITDVWLRTDKDWKAGKTKIFLRDHQDTLLEVQRSQVLDRAALSIQKVLRGYRYRK 781
            ::.|     .|..:.|.|:.|::.||||:||:|..|.:||.:..::|...|:.|||.:|.:..||
 Worm   689 RIDLHDAAKKICHMILGTNADYQLGKTKVFLKDKHDLVLEQEYYRILKDKAIVIQKNVRRWLVRK 753

Human   782 EFLRQRRAAVTLQAWWRGYCNRRNFKLILVGFERLQAIARSQPLARQYQAMRQRTVQLQALCRGY 846
            :|.:||:||||:|..|||:..|:.::.|:.||.||||:.||:.|...||.:|:..:|.||:|||.
 Worm   754 DFEKQRQAAVTIQTAWRGFDQRKRYRQIISGFSRLQAVLRSRQLVSHYQTLRKTIIQFQAVCRGS 818

Human   847 LVRQQVQAKRRAVVVIQAHARGMAARRNFQQRKANGMQAPLVIPAEGQKSQGALPAKKRRSIYDT 911
            |||:||..||:                       .|.:|||.               :..|....
 Worm   819 LVRRQVGEKRK-----------------------RGEKAPLT---------------EVSSTASV 845

Human   912 VTDT--EMVEKVFGFLPAMIGGQEGQASPHFEDLESKTQKLLEVDLDT---VPMAEEPEED--VD 969
            ::|:  |:|..:|.|||:     :|:.|.:..|....:::.....|.|   :|.|..|..|  ||
 Worm   846 ISDSHEELVGHLFDFLPS-----DGKDSGNENDSADSSRRGSYSRLHTSPVMPPANIPRVDSYVD 905

Human   970 -GLAEYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDTDCLAALVIWNVILRFMGDLPEPVLY 1033
             .|::|.|.|:|.|:||..|:.||:::||:..||.|.:.:..||||..|..||||||||.:   .
 Worm   906 EDLSKYQFGKYAATFFQAQATATHVKKPLKTALLTHTEPSAQLAALTAWTTILRFMGDLAD---V 967

Human  1034 ARSSQQGSS------VMRQIHDTLGREHGA-QVPQHSRSAQRSGCK--DKGT-KDISSMKLKRSS 1088
            ...|..||.      ||.:::.|||::..| .:.:...|::..|.|  .||. :.:.||.|||..
 Worm   968 KPGSTNGSEVYDKTPVMIKLYATLGKKFSAHDLEEAMLSSEYGGAKTLKKGMGRKLISMTLKRKG 1032

Human  1089 RITGQVASQLNIGEEALEPDGLGADRPMSNLEKVHFIVGYAILRPSLRDEIYCQICKQLSENFKT 1153
            :|.|...|.::........:.:..::||::|:|:|:|:|..|||..||||||||:|||||.|...
 Worm  1033 KINGSDTSSISSDSVYSSFNAMLENKPMTSLDKLHYIIGLGILREDLRDEIYCQLCKQLSNNPSK 1097

Human  1154 SSLARGWILLSLCLGCFPPSERFMKYLLNFIGQ-GPA--TYGPFCAERLRRTYANGVRAEPPTWL 1215
            .|.||||||||||:|||.|||||:|||..||.: |||  .|..:..:|||||..||.|.:||:::
 Worm  1098 LSAARGWILLSLCVGCFAPSERFIKYLFCFIRERGPAGTGYSKYIEDRLRRTQVNGTRHQPPSYV 1162

Human  1216 ELQAVKSKKHIPIQVILATGESLTVPVDSASTSREMCMHIAHKQGLSDHLGFSLQVAVYDKFWSL 1280
            ||||.||:|.:.:.|....|...|:..|||:|:.|:|..:|.|.||::..||||.:|::||..||
 Worm  1163 ELQANKSQKPVVLAVTFMDGSVKTLCADSATTAAELCKQLAEKVGLTNSFGFSLYIALFDKVSSL 1227

Human  1281 GSGRDHMMDAIARCEQMAQERGESQRQSPWRIYFRKEFFTPWHDSREDPVSTELIYRQVLRGVWS 1345
            |||.||:||||::|||.|:|:|..:|.:|||::||||.|:||||.|:|||||.|||:||:||:..
 Worm  1228 GSGTDHVMDAISQCEQYAKEQGRQERNAPWRLFFRKEIFSPWHDPRDDPVSTNLIYQQVIRGIKY 1292

Human  1346 GEYSFEKEEELVELLARHCYVQLGASAESKAVQELLPSCIP-------------------HKLYR 1391
            |||..:|:|||..:.|:..|:..|....:| ::..|||.:|                   |: ||
 Worm  1293 GEYRCDKDEELAAICAQQYYIDEGTMDVNK-LENNLPSYLPDFEMSGKEMALEKWTQTIMHQ-YR 1355

Human  1392 TKPPDR-PHTLRSKSH-------HWP-CESRWWTPPACSGRCSSPGSSKSSHSQVMASDRGQGAG 1447
            .|...| |..:..|.:       .|| ..||::.
 Worm  1356 KKFTGRLPSQIEVKENVVSVAKTKWPLLFSRFYE------------------------------- 1389

Human  1448 MGWAPRGPMQPSHCRLSWPGPRLPKTQLILAVNWKGLCFLDQQEKMLLELSFPEVMGLATNREAQ 1512
                          .|.:.||.|||.::|:||||.|:..:|.:|.::||.||||:......:
 Worm  1390 --------------ALKFAGPPLPKNEVIIAVNWTGVYVVDDREHVMLEFSFPEISTAYYGK--- 1437

Human  1513 GGQRLLLST------MHEEYEFVSPSSVAIAELVALFLEGLKERSIFAMALQDRKATDDTTLLAF 1571
             |:|....|      :.:||.|.||::..|..|:.:||||||:||.:.:|::.:|..:....|.|
 Worm  1438 -GKRSTTDTCTVRTVVGDEYTFQSPNADDITNLIVMFLEGLKKRSRYLVAIKSQKGDEKNNFLEF 1501

Human  1572 KKGDLLVLTKK--QGLLASENWTLGQNDRTGKTGLVPMACLYTIPTVTKPSAQLLSLLAMSPEKR 1634
            :|||||:|..:  ...|.:|:...|:|.||...||:....:|.:||:.|||...|.:.   |:..
 Worm  1502 EKGDLLILVNEFTGNTLLTESVVKGENSRTCLFGLIRAENVYVLPTLVKPSKNTLQIF---PKDM 1563

Human  1635 KLAA----QEGQFT------EPRPEEPPKEKLHTLEEFSYEFFRAPEK---DMVSMAVLPLARAR 1686
            .|:.    ...|.|      ||          :|||.|:.:.|.:..|   ..:|:..|....::
 Worm  1564 DLSLDLFNNNKQVTVVDYNAEP----------YTLENFAEDNFNSQVKRVGSQISLMTLRKKESQ 1618

Human  1687 GHLWAYSCEPLRQPLLKRVHANVDLWDIACQIFVAILRYMGDYPSRQAWPTLELTDQIFTLALQH 1751
            ...|.:|.|.:.|||||:::...|....|.:||.||::||||.||:::.....|||.||.|.:..
 Worm  1619 IECWRFSREHIDQPLLKKLNGREDACRGAIEIFAAIMKYMGDEPSKRSRLGTHLTDHIFKLPISM 1683

Human  1752 PALQDEVYCQILKQLTHNSNRHSEERGWQLLWLCTGLFPPSKGLLPHAQKFIDTRRGKLLAPDCS 1816
            .||:||:|||::||||.|.:..||||||:|||:.||||.||..|......|:.:|... :|.||.
 Worm  1684 EALRDELYCQLVKQLTLNPSIMSEERGWELLWMATGLFAPSAALAKEISHFLKSRPHP-IALDCQ 1747

Human  1817 RRIQKVLRTGPRKQPPHQVEVEAAEQNVSRICHKIYFPNDTSEMLEVVANTRVRDVCDSIATRLQ 1881
            .|:||:.:.|.||.|||.|||||.:...::|.||::||::|.|.:||.:.||.||.|..|..||.
 Worm  1748 NRMQKLAKGGSRKYPPHLVEVEAIQHKTTQIFHKVFFPDNTDEAIEVDSATRARDFCHKIGYRLG 1812

Human  1882 LASWEGCSLFIKISDKVISQKEGDFFFDSLREVSDWVKKN-KPQKEGAPVTLPYQVYFMRKLWLN 1945
            |.|.:|.|||:||.|||::..|.:||||.:|.:||||..| ..||:...:.:.||||||||||.|
 Worm  1813 LKSSDGFSLFVKIKDKVLAVPESEFFFDYVRSLSDWVHTNHATQKDATMIPINYQVYFMRKLWYN 1877

Human  1946 ISPGKDVNADTILHYHQELPKYLRGFHKCSREDAIHLAGLIYKAQFNNDR-SQLASVPKILRELV 2009
            ...|.|..||.|.|||||..|||.|:||.::.|.|.||.||.::...:.: :.||.:|::|.|::
 Worm  1878 FVAGADPQADIIFHYHQESQKYLLGYHKTTKNDVIELAALILRSMTKDGKNAPLAQIPQLLDEII 1942

Human  2010 PENLTRLMSSEEWKKSILLAYDKHKDKTVEEAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDVI 2074
            |::..::.|:.||:|:|..||.:.:....::||:.||.:||||||||||||.|.|.|:.:.||.:
 Worm  1943 PKDSLKMYSASEWRKTISNAYARIEHLKSDQAKIEFLNYICRWPTFGSAFFPVSQYSDLNLPDRL 2007

Human  2075 LIAINRHGVLLIHPKTKDLLTTYPFTKISSWSSGSTYFHMALGSL---GRGSRLLCET------- 2129
            |:|||:.||.:.|..||:||..|||..|.:|:||:|||:|.:|::   ..|.:||.:|
 Worm  2008 LLAINQTGVNIYHLDTKNLLVQYPFNVICNWTSGNTYFNMTVGNMLKGNEGKKLLLDTTVGYKMD 2072

Human  2130 -------SLVSSGSFSHP 2140
                   ||:.|...:||
 Worm  2073 DLLTSYISLLISNQNNHP 2090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO7B	XP_047300391.1	MYSc_Myo7	79..748	CDD:276832	354/673 (53%)
		IQ	785..807	CDD:197470	11/21 (52%)
		MyTH4	992..1221	CDD:214535	107/241 (44%)
		FERM1_F1_Myosin-VII	1225..1323	CDD:340612	47/97 (48%)
		FERM_C1_MyoVII	1467..1550	CDD:270019	35/88 (40%)
		SH3	1551..1611	CDD:473055	19/61 (31%)
		MyTH4	1692..1839	CDD:214535	70/146 (48%)
		FERM2_F1_Myosin-VII	1846..1943	CDD:340613	49/97 (51%)
		B41	1848..2060	CDD:214604	100/213 (47%)
		FERM_C2_MyoVII	2056..>2131	CDD:270020	37/91 (41%)
hum-6	NP_508420.1	MYSc_Myo7	76..720	CDD:276832	354/673 (53%)
		CBD_MYO6-like	738..>808	CDD:409646	32/69 (46%)
		IQ	757..779	CDD:197470	11/21 (52%)
		MyTH4	929..1168	CDD:214535	107/241 (44%)
		FERM1_F1_Myosin-VII	1172..1270	CDD:340612	47/97 (48%)
		B41	1174..1388	CDD:214604	89/215 (41%)
		FERM_C1_MyoVII	1382..1480	CDD:270019	38/146 (26%)
		SH3	1481..1544	CDD:473055	19/62 (31%)
		MyTH4	1624..1772	CDD:214535	72/148 (49%)
		FERM2_F1_Myosin-VII	1777..1875	CDD:340613	49/97 (51%)
		B41	1779..1993	CDD:214604	100/213 (47%)
		FERM_C2_MyoVII	1989..2087	CDD:270020	40/97 (41%)