DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYO7B and Myo7b

DIOPT Version :9

Sequence 1:	XP_016859658.1	Gene:	MYO7B / 4648	HGNCID:	7607	Length:	2164	Species:	Homo sapiens
Sequence 2:	NP_115770.2	Gene:	Myo7b / 17922	MGIID:	107709	Length:	2113	Species:	Mus musculus

Alignment Length:	2179	Identity:	1701/2179 - (78%)
Similarity:	1894/2179 - (86%)	Gaps:	83/2179 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSGFRLGDHVWLEPPSTHKTGVAIGGIIKEAKPGKVLVEDDEGKEHWIRAEDFGVLSPMHPNSVQ 65
            ||.|||||||||:|||:.|||||||||:||.|.||.|:|||||||||:.|||...|.||||||.|
Mouse     1 MSVFRLGDHVWLDPPSSSKTGVAIGGIVKETKLGKTLIEDDEGKEHWVHAEDLSTLRPMHPNSAQ 65

Human    66 GVDDMIRLGDLNEAGMVHNLLIRYQQHKIYTYTGSILVAVNPFQVLPLYTLEQVQLYYSRHMGEL 130
            |||||||||||||||:||||||||||||||||||||||||||||:||||||||||:|||||||||
Mouse    66 GVDDMIRLGDLNEAGVVHNLLIRYQQHKIYTYTGSILVAVNPFQMLPLYTLEQVQIYYSRHMGEL 130

Human   131 PPHVFAIANNCYFSMKRNKRDQCCIISGESGAGKTETTKLILQFLATISGQHSWIEQQVLEANPI 195
            |||:|||||:|||:||:||||||||||||||||||||||||||||||:|||||||||||||||||
Mouse   131 PPHIFAIANSCYFNMKKNKRDQCCIISGESGAGKTETTKLILQFLATVSGQHSWIEQQVLEANPI 195

Human   196 LEAFGNAKTIRNDNSSRFGKYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLM 260
            ||||||||||||||||||||||||:||.|||||||.||.||||||||||||||||||||||||||
Mouse   196 LEAFGNAKTIRNDNSSRFGKYIDIHFNSSGVIEGASIEHFLLEKSRVCRQAPEERNYHIFYCMLM 260

Human   261 GVSAEDKQLLSLGTPSEYHYLTMGNCTSCEGLNDAKDYAHIRSAMKILQFSDSESWDVIKLLAAI 325
            |:|.|:||:||||.||||||||||:|||.|||:|||||||:|||||||||||||:||:.||||||
Mouse   261 GMSPEEKQMLSLGMPSEYHYLTMGSCTSSEGLSDAKDYAHVRSAMKILQFSDSENWDISKLLAAI 325

Human   326 LHLGNVGFMASVFENLDASDVMETPAFPTVMKLLEVQHQELRDCLIKHTILIRGEFVTRSLNIAQ 390
            ||||||||||:||||||:||||||||||..|||||||||.||||||||||.:.||||:|.:||||
Mouse   326 LHLGNVGFMAAVFENLDSSDVMETPAFPLAMKLLEVQHQALRDCLIKHTIPVLGEFVSRPVNIAQ 390

Human   391 AADRRDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFENNSFEQLCIN 455
            |.||||||||||||.||.|||||||||||||.||||:|||||||||||||||||:||||||||||
Mouse   391 ATDRRDAFVKGIYGRLFQWIVKKINAAIFTPQAQDPQNVRRAIGLLDIFGFENFQNNSFEQLCIN 455

Human   456 FANEHLQQFFVQHVFTMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSIISLLDEESRFPQGT 520
            |||||||||||:||||||||||.||||:|:|||||||:|.||:||||||||||||||||||||||
Mouse   456 FANEHLQQFFVKHVFTMEQEEYLSENITWNYIHYTDNQPILDMLALKPMSIISLLDEESRFPQGT 520

Human   521 DLTMLQKLNSVHANNKAFLQPKNIHDARFGIAHFAGEVYYQAEGFLEKNRDVLSTDILTLVYSSK 585
            |:||||||||:|||||:||.|::|||.|||||||||:|||||||||||||||||||||.|::|||
Mouse   521 DVTMLQKLNSIHANNKSFLSPRSIHDTRFGIAHFAGDVYYQAEGFLEKNRDVLSTDILILIHSSK 585

Human   586 NKFLREIFNLELAETKLGHGTIRQAKAGNHLFKSADSNKRPSTLGSQFKQSLDQLMKILTNCQPY 650
            ||||:||||::.::||||||||.|.|||:.||||:||.|||.||.|||||||||||:||||||||
Mouse   586 NKFLKEIFNVDSSQTKLGHGTICQVKAGSQLFKSSDSIKRPVTLASQFKQSLDQLMRILTNCQPY 650

Human   651 FIRCIKPNEYKKPLLFDRELCLRQLRYSGMMETVHIRKSGFPIRYTFEEFSQRFGVLLPNAMRMQ 715
            |:|||||||||||||||||||::||||||||||||||||||||||||:||||||.||||:..|||
Mouse   651 FVRCIKPNEYKKPLLFDRELCIQQLRYSGMMETVHIRKSGFPIRYTFDEFSQRFRVLLPSPERMQ 715

Human   716 LQGKLRQMTLGITDVWLRTDKDWKAGKTKIFLRDHQDTLLEVQRSQVLDRAALSIQKVLRGYRYR 780
            .|.|.|||||.|.|:.|.||||||.|||||||:|||||:||::|||.||.||:.||:||||::||
Mouse   716 FQNKPRQMTLHIADLCLGTDKDWKVGKTKIFLKDHQDTVLEIRRSQALDGAAIRIQRVLRGHKYR 780

Human   781 KEFLRQRRAAVTLQAWWRGYCNRRNFKLILVGFERLQAIARSQPLARQYQAMRQRTVQLQALCRG 845
            |||||||||||||||.||||..|:||||||||||||||||||..|.||:||||||.|||||.|||
Mouse   781 KEFLRQRRAAVTLQAGWRGYSQRKNFKLILVGFERLQAIARSHLLMRQFQAMRQRIVQLQARCRG 845

Human   846 YLVRQQVQAKRRAVVVIQAHARGMAARRNFQQRKANGMQAPLVIPAEGQKSQGALPAKKRRSIYD 910
            |||||||||||||||:||||||||..|:::.|:|:.|   |.||.|:..|:|.|:..:||:||||
Mouse   846 YLVRQQVQAKRRAVVIIQAHARGMVVRKSYWQQKSTG---PQVILAKEPKAQVAVHERKRKSIYD 907

Human   911 TVTDTEMVEKVFGFLPAMIGGQEGQASPHFEDLESKTQKLLEVDLDTVPMAEEPEEDVDGLAEYT 975
            |||||.||||||||||||||||||.|...|||||.|||||.|||||||||...|||:||.|||||
Mouse   908 TVTDTAMVEKVFGFLPAMIGGQEGPAPTRFEDLEVKTQKLHEVDLDTVPMMAMPEEEVDSLAEYT 972

Human   976 FPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDTDCLAALVIWNVILRFMGDLPEPVLYARSSQQG 1040
            ||||||||||||||||||::||||||||||:|||..|||.:|.:||||||||||||:|.|:|..|
Mouse   973 FPKFAVTYFQKSASHTHIQKPLRYPLLYHENDTDHSAALDVWIIILRFMGDLPEPVVYGRNSLTG 1037

Human  1041 SSVMRQIHDTLGREHGAQVPQHSRSAQRSGCKDKGTKDISSMKLKRSSRITGQVASQLNIGEEAL 1105
            |||||||||.||::   .|.||:||:                          |||||||.||||.
Mouse  1038 SSVMRQIHDKLGKD---SVTQHNRSS--------------------------QVASQLNFGEEAF 1073

Human  1106 EPDGLGADRPMSNLEKVHFIVGYAILRPSLRDEIYCQICKQLSENFKTSSLARGWILLSLCLGCF 1170
            :.||..:||||||||||||||||||:||.||||||||||||||||:||||.||||||||||||||
Mouse  1074 KFDGPISDRPMSNLEKVHFIVGYAIMRPGLRDEIYCQICKQLSENYKTSSRARGWILLSLCLGCF 1138

Human  1171 PPSERFMKYLLNFIGQGPATYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKKHIPIQVILATG 1235
            ||||||||||||||.|||.:|||||||||:||:||||||||||||||||||||||||||||||||
Mouse  1139 PPSERFMKYLLNFISQGPPSYGPFCAERLQRTFANGVRAEPPTWLELQAVKSKKHIPIQVILATG 1203

Human  1236 ESLTVPVDSASTSREMCMHIAHKQGLSDHLGFSLQVAVYDKFWSLGSGRDHMMDAIARCEQMAQE 1300
            .|||:.|||||||||:|.|:|.||||.|:|||||||||||||||||||.||:|||:|:|||:|:|
Mouse  1204 RSLTISVDSASTSREICQHVAQKQGLRDNLGFSLQVAVYDKFWSLGSGCDHLMDAVAQCEQLARE 1268

Human  1301 RGESQRQSPWRIYFRKEFFTPWHDSREDPVSTELIYRQVLRGVWSGEYSFEKEEELVELLARHCY 1365
            |||||||:|||||||||||||||||:||||||||||.|||||||||||:||||||||||||||||
Mouse  1269 RGESQRQAPWRIYFRKEFFTPWHDSQEDPVSTELIYHQVLRGVWSGEYNFEKEEELVELLARHCY 1333

Human  1366 VQLGASAESKAVQELLPSCIPHKLYRTKPPDRPHTLRSKSHHWPCESRWWTPPACSGRCSSPGSS 1430
            |||||:.:|.|||||||||:|.||||||.|::..:|.:.:|                       :
Mouse  1334 VQLGATVKSNAVQELLPSCVPSKLYRTKSPEKWASLVTAAH-----------------------A 1375

Human  1431 KSSHSQVMASD---RGQGAGMGWAPRGPMQPSHCRLSWP-------------GPRLPKTQLILAV 1479
            |:.::|..|:.   |.|..            ...||.||             |||||||||:||:
Mouse  1376 KAQYTQSKATPLAVREQTV------------EAARLLWPLLFSRLFEVTTLSGPRLPKTQLVLAI 1428

Human  1480 NWKGLCFLDQQEKMLLELSFPEVMGLATNREAQGGQRLLLSTMHEEYEFVSPSSVAIAELVALFL 1544
            ||||:.||||:|:.||.|||.|||||..||:|.||::|||:|:.|||||||||||||||:|||||
Mouse  1429 NWKGMYFLDQKERTLLGLSFAEVMGLVANRDAPGGKKLLLATLQEEYEFVSPSSVAIAEMVALFL 1493

Human  1545 EGLKERSIFAMALQDRKATDDTTLLAFKKGDLLVLTKKQGLLASENWTLGQNDRTGKTGLVPMAC 1609
            .||||||:||||||||:||||.|||.|||||||:|||||||||||||.||||||||||||||.||
Mouse  1494 GGLKERSVFAMALQDRRATDDITLLPFKKGDLLILTKKQGLLASENWALGQNDRTGKTGLVPTAC 1558

Human  1610 LYTIPTVTKPSAQLLSLLAMSPEKRKLAAQEGQFTEPRPEEPPKEKLHTLEEFSYEFFRAPEKDM 1674
            |||||:|||||.|||||||||||||||||||.:..||..|:...|..:|||||||:|||||||:.
Mouse  1559 LYTIPSVTKPSTQLLSLLAMSPEKRKLAAQEVRALEPPLEDQLTESPYTLEEFSYQFFRAPEKET 1623

Human  1675 VSMAVLPLARARGHLWAYSCEPLRQPLLKRVHANVDLWDIACQIFVAILRYMGDYPSRQAWPTLE 1739
            :|.|.:|:||:||||||||.|||||||||.||....|.|.|||||:|||:|.|||||||:|.:||
Mouse  1624 ISRAAMPMARSRGHLWAYSPEPLRQPLLKSVHDKAKLRDAACQIFLAILKYTGDYPSRQSWHSLE 1688

Human  1740 LTDQIFTLALQHPALQDEVYCQILKQLTHNSNRHSEERGWQLLWLCTGLFPPSKGLLPHAQKFID 1804
            ||||:|:||||.||||||:||||||||||||.|.||||.|||||||||||||.|.||||||||||
Mouse  1689 LTDQMFSLALQDPALQDELYCQILKQLTHNSIRFSEERAWQLLWLCTGLFPPGKTLLPHAQKFID 1753

Human  1805 TRRGKLLAPDCSRRIQKVLRTGPRKQPPHQVEVEAAEQNVSRICHKIYFPNDTSEMLEVVANTRV 1869
            :|:.|.||.|||||:.:|||.||||||||.|||:|||||||::.|::|.|||||:.:||.:::||
Mouse  1754 SRKKKPLALDCSRRLHRVLRVGPRKQPPHDVEVKAAEQNVSKLHHEVYLPNDTSKSMEVGSSSRV 1818

Human  1870 RDVCDSIATRLQLASWEGCSLFIKISDKVISQKEGDFFFDSLREVSDWVKKNKPQKEGAPVTLPY 1934
            ||:|:.|.||||||||:||||||||:|||||.|||||||||||:||||||||:||||||.|||||
Mouse  1819 RDLCEGIGTRLQLASWDGCSLFIKITDKVISLKEGDFFFDSLRQVSDWVKKNRPQKEGASVTLPY 1883

Human  1935 QVYFMRKLWLNISPGKDVNADTILHYHQELPKYLRGFHKCSREDAIHLAGLIYKAQFNNDRSQLA 1999
            ||:||||||||::|||||||||||||||||||||||||||||||||||.|||.|.||.:|.||||
Mouse  1884 QVFFMRKLWLNVTPGKDVNADTILHYHQELPKYLRGFHKCSREDAIHLGGLICKIQFGSDSSQLA 1948

Human  2000 SVPKILRELVPENLTRLMSSEEWKKSILLAYDKHKDKTVEEAKVAFLKWICRWPTFGSAFFEVKQ 2064
            ||.|:|:||||:||||||||||||||:||..||:|.|||.||||.|||::.||||||||||||||
Mouse  1949 SVSKVLKELVPQNLTRLMSSEEWKKSLLLECDKNKRKTVAEAKVEFLKYMYRWPTFGSAFFEVKQ 2013

Human  2065 TSEPSYPDVILIAINRHGVLLIHPKTKDLLTTYPFTKISSWSSGSTYFHMALGSLGRGSRLLCET 2129
            ||||||||::||||||||:||||||||:||.|||||||||||||:|||||||||||:||||||||
Mouse  2014 TSEPSYPDILLIAINRHGLLLIHPKTKELLNTYPFTKISSWSSGNTYFHMALGSLGQGSRLLCET 2078

Human  2130 SLGYKMDDLLTSYVQQLLSAMNKQRGSKAPALAS 2163
            ||||||||||||||||||:.:|||||.:|||.|:
Mouse  2079 SLGYKMDDLLTSYVQQLLNTVNKQRGFRAPAPAN 2112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYO7B	XP_016859658.1	None
Myo7b	NP_115770.2	MYSc	60..759	CDD:214580	603/698 (86%)
		MYSc_Myo7	79..748	CDD:276832	577/668 (86%)
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	637..659		19/21 (90%)
		IQ	785..807	CDD:197470	17/21 (81%)
		Mediates interaction with ANKS4B. /evidence=ECO:0000269\|PubMed:26812017	962..1578		480/679 (71%)
		MyTH4	989..1189	CDD:214535	162/228 (71%)
		B41	1196..1409	CDD:214604	153/247 (62%)
		FERM_B-lobe	1299..1400	CDD:271216	64/135 (47%)
		FERM_C1_MyoVII	1403..1499	CDD:270019	62/95 (65%)
		Mediates interaction with CDHR2, CDHR5 and USH1C. /evidence=ECO:0000250\|UniProtKB:Q6PIF6	1497..2113		491/616 (80%)
		SH3	1500..1560	CDD:302595	52/59 (88%)
		MyTH4	1641..1788	CDD:214535	113/146 (77%)
		B41	1797..2009	CDD:214604	167/211 (79%)
		FERM_M	1907..2009	CDD:278785	81/101 (80%)
		FERM_C2_MyoVII	2005..2100	CDD:270020	85/94 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83967724
Domainoid	1	1.000	1217	1.000	Domainoid score	I1071
eggNOG	1	0.900	-	-		E2759_KOG4229
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H81947
Inparanoid	1	1.050	3532	1.000	Inparanoid score	I398
Isobase	1	0.950	-	0	Normalized mean entropy	S1958
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39495
OrthoDB	1	1.010	-	-		D10152at7742
OrthoFinder	1	1.000	-	-		FOG0001409
OrthoInspector	1	1.000	-	-		oto118929
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	LDO	PTHR13140
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11496
SonicParanoid	1	1.000	-	-		X1286
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	20	20.250