Protein Alignment MYO7B and LOC108190403

DIOPT Version :9

• Sequence 1: XP_016859658.1
• Gene: MYO7B / 4648
• HGNCID: 7607
• Length: 2164
• Species: Homo sapiens
• Sequence 2: XP_021327440.1
• Gene: LOC108190403 / 108190403
• -ID: -
• Length: 2219
• Species: Danio rerio
• Alignment Length: 2261
• Identity: 1164/2261 - (51%)
• Similarity: 1549/2261 - (68%)
• Gaps: 160/2261 - (7%)

Human     5 RLGDHVWLEPPSTHKTGVAIGGIIKEAKPGKVLVEDDEGKEHWIRAEDFGVLSPMHPNSVQGVDD 69
            |.||:||::    ...||.||..::.:..|::.:.|||||||.|:.|  ..|.||||.||.||||
Zfish     5 RKGDYVWVD----CSDGVQIGAEVRLSDTGQLQLIDDEGKEHKIKKE--STLKPMHPTSVNGVDD 63

Human    70 MIRLGDLNEAGMVHNLLIRYQQHKIYTYTGSILVAVNPFQVLPLYTLEQVQLYYSRHMGELPPHV 134
            |||||||||||::.|||:||::..||||||||||||||:|:||:||.|||:.|..|.:|:|||||
Zfish    64 MIRLGDLNEAGLLRNLLVRYKEGAIYTYTGSILVAVNPYQLLPIYTPEQVEQYTDRRLGDLPPHV 128

Human   135 FAIANNCYFSMKRNKRDQCCIISGESGAGKTETTKLILQFLATISGQHSWIEQQVLEANPILEAF 199
            ||||::|:|:|:||::||||||||||||||||:|||:|||||.:|||.|||||||||||||||||
Zfish   129 FAIADSCFFNMRRNRKDQCCIISGESGAGKTESTKLMLQFLAAVSGQRSWIEQQVLEANPILEAF 193

Human   200 GNAKTIRNDNSSRFGKYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGVSA 264
            ||||||||||||||||||||:||.||.||||||||:|||||||||||.:|||||||||||||:.|
Zfish   194 GNAKTIRNDNSSRFGKYIDIHFNKSGAIEGARIEQYLLEKSRVCRQASQERNYHIFYCMLMGMPA 258

Human   265 EDKQLLSLGTPSEYHYLTMGNCTSCEGLNDAKDYAHIRSAMKILQFSDSESWDVIKLLAAILHLG 329
            :.|::||||..:||:|||||.||||||.:|.|:||..|||||||.|:::::|::.||||:|||||
Zfish   259 DQKKILSLGNAAEYNYLTMGKCTSCEGRDDIKEYASFRSAMKILTFTENDTWEINKLLASILHLG 323

Human   330 NVGFMASVFENLDASDVMETPAFPTVMKLLEVQHQELRDCLIKHTILIRGEFVTRSLNIAQAADR 394
            ||.|..::..||:..|::.:..|....:||||....|...|.:.:::...|.||:.|..|||.|.
Zfish   324 NVDFEETIMNNLEGCDILSSTHFKMATQLLEVAPNALDASLTQRSLMTNRESVTKPLTSAQALDG 388

Human   395 RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFENNSFEQLCINFANE 459
            ||||||.|||.||:|||.|||:||:.||:.|||:||.:||||||||||||:||||||||||||||
Zfish   389 RDAFVKAIYGRLFVWIVTKINSAIYKPPSDDPKHVRHSIGLLDIFGFENFKNNSFEQLCINFANE 453

Human   460 HLQQFFVQHVFTMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSIISLLDEESRFPQGTDLTM 524
            .||||||:|||.:||:||..|:|.|..|.:.||:.|||:||:|.::|:||:|||||||:|||.||
Zfish   454 QLQQFFVKHVFKLEQQEYAREDIVWKNIEFNDNQSTLDVLAIKSLNILSLIDEESRFPKGTDATM 518

Human   525 LQKLNSVHANNKAFLQPKNIHDARFGIAHFAGEVYYQAEGFLEKNRDVLSTDILTLVYSSKNKFL 589
            |.|:|..|.....::.|||.|:.:|||.||||.|:|.::||||||||.||:||:.|:::|.||.|
Zfish   519 LNKMNQHHGKGDIYMPPKNNHETQFGIRHFAGVVHYDSKGFLEKNRDALSSDIIQLIHTSSNKLL 583

Human   590 REIFNLELA----ETKLGHGTIRQAKAGNHLFKSADSNKRPSTLGSQFKQSLDQLMKILTNCQPY 650
            ::||:.|::    :|.:.| ||...|:.  |.::||:.|:..||..||:||||.|||.||.|||:
Zfish   584 KQIFHSEISTIEGKTSINH-TIVTPKSS--LRQTADTKKQVPTLTGQFRQSLDSLMKTLTACQPF 645

Human   651 FIRCIKPNEYKKPLLFDRELCLRQLRYSGMMETVHIRKSGFPIRYTFEEFSQRFGVLLPNAMRMQ 715
            ||||||||::|||:|||||||:|||||||||||:.|||:|:|||:||:||.:|:.|||.:.:...
Zfish   646 FIRCIKPNDFKKPMLFDRELCIRQLRYSGMMETIRIRKAGYPIRHTFDEFLERYRVLLKSTVCDP 710

Human   716 LQGKLRQMTLGITDVWLRTDKDWKAGKTKIFLRDHQDTLLEVQRSQVLDRAALSIQKVLRGYRYR 780
            ....:::....|..:.| |:.|||.||||:||:|..||:||:.|.:.|:..||.||||||||::|
Zfish   711 QTETVKKCCESICKIIL-TEDDWKIGKTKVFLKDFHDTVLELARDKALNEKALLIQKVLRGYKHR 774

Human   781 KEFLRQRRAAVTLQAWWRGYCNRRNFKLILVGFERLQAIARSQPLARQYQAMRQRTVQLQALCRG 845
            |.|||:|.||||:|..|||:..|:.::::.:|:.||||..||:.:|.:|:..|:.|:.||:..||
Zfish   775 KAFLRKRGAAVTIQKTWRGHKGRKLYRVVQLGYARLQAQVRSRKMAWEYKQKRKATLLLQSQTRG 839

Human   846 YLVRQQVQAKRRAVVVIQAHARGMAARR-----------NFQQRKANGMQAPLVIPAEGQKS-QG 898
            .|.|::.:.||.||:::||:.||..||:           :.|:|:|..:.|     .|.|:. :.
Zfish   840 CLARKEWKRKRDAVILLQAYTRGTLARKAVNKMKRDAFLSLQERRAEELAA-----LERQRRLEE 899

Human   899 ALPAKKRRSI---YDTVTDTEMVEKVFGFLPAMIGGQEGQASPHFEDLESKTQKLLEVDLDTVPM 960
            .|..|:.|..   .:::||.|||:.:|||||:|:|||||||...|||||.|...|.|||||..||
Zfish   900 VLRQKREREAAQQLESITDQEMVDDIFGFLPSMVGGQEGQAPVGFEDLEGKRTVLEEVDLDDAPM 964

Human   961 AEEPEEDVDGLAEYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDTDCLAALVIWNVILRFMG 1025
            ...||||.|.|.||:|.|||..|||.:|:.||||:.||.|||||||:.|.||:|.:|.:||||||
Zfish   965 MPIPEEDYDDLDEYSFSKFASMYFQGAATPTHIRQRLRQPLLYHEDENDVLASLTVWWMILRFMG 1029

Human  1026 DLPEP---------VLYARSSQQGSSVMRQ----------------------------------- 1046
            |||||         ..:|..|.|.....||
Zfish  1030 DLPEPKAQVVSRSGTAFADRSVQKDVASRQDRRLSHMVGVDQRIRNSRIVQNKAVPTVPEEASRN 1094

Human  1047 -----IHDTLGREHGA----QVPQHSRSA-QRSGCKDKGTK---DISSMKL-----------KRS 1087
                 ..|.|.|...:    .||....|| ...|.:::.|.   ||.|...           |||
Zfish  1095 RKSSTFTDLLSRSRKSVQDDGVPNRKLSALPEQGPRNRKTSTFTDIMSRNRKTSTAEGPPSNKRS 1159

Human  1088 SRITGQVASQLNIG--------------EEALEPDGLGADRPMSNLEKVHFIVGYAILRPSLRDE 1138
            :|....:|.:...|              |:.:..|||..||||::|||:|.||||||:|..||||
Zfish  1160 ARKPSVIAEEAEDGSEVPRQSTVQTISEEDEMNTDGLTLDRPMTSLEKLHIIVGYAIVRRDLRDE 1224

Human  1139 IYCQICKQLSENFKTSSLARGWILLSLCLGCFPPSERFMKYLLNFIGQGPATYGPFCAERLRRTY 1203
            |||||||||.||....|..|||||||:|||.|||:|||:|||.:|:..||..|.|:||||||||.
Zfish  1225 IYCQICKQLQENSNRGSFFRGWILLSICLGIFPPTERFIKYLQSFLRFGPVGYAPYCAERLRRTV 1289

Human  1204 ANGVRAEPPTWLELQAVKSKKHIPIQVILATGESLTVPVDSASTSREMCMHIAHKQGLSDHLGFS 1268
            |||||.|||:||||||.||||.|.|.|.|..|.::::||||||||:|:|..::.|..|.|..|||
Zfish  1290 ANGVRGEPPSWLELQATKSKKPIAISVTLMDGRTISMPVDSASTSKEVCQMLSQKVKLQDTFGFS 1354

Human  1269 LQVAVYDKFWSLGSGRDHMMDAIARCEQMAQERGESQRQSPWRIYFRKEFFTPWHDSREDPVSTE 1333
            :.||:|||.|||||||:|:||||::|||..:.:|..::.:|||:|||||.|.||||..:|.|||:
Zfish  1355 IYVALYDKVWSLGSGREHVMDAISQCEQEVKRKGGQEQHAPWRLYFRKEVFAPWHDCAQDNVSTD 1419

Human  1334 LIYRQVLRGVWSGEYSFEKEEELVELLARHCYVQLGASAESKAVQELLPSCIPHKLYRTKPPDRP 1398
            ||||||:||:..|||..||||:.|.|.|:|.|||.|:....:..:.::..||..||...|..|:
Zfish  1420 LIYRQVIRGLKYGEYQCEKEEDYVGLAAKHFYVQHGSDISMENTKTVVRECINSKLLEAKSEDK- 1483

Human  1399 HTLRSKSHHWPCESRWWTPPACSGRCSSPGSSKSSHSQVMASDRGQGAGMGWAPRGPMQPSH--- 1460
                            |.....:.....|..:..:.|..:.::....|...|    ||..|.
Zfish  1484 ----------------WAQMVNTAHAQGPFITSRTKSDKVKAEVVDFARQKW----PMFFSKFFE 1528

Human  1461 -CRLSWPGPRLPKTQLILAVNWKGLCFLDQQEKMLLELSFPEVMGLATNREAQGGQRLLLSTMHE 1524
             .:||  ||.|||::.|||:|..|:.|||::||.||.||:||:.|:.|.||.   :.:.|.|:..
Zfish  1529 VAKLS--GPPLPKSKFILAINSTGITFLDEREKNLLILSYPELTGVNTIRER---KCVCLLTLKG 1588

Human  1525 EYEFVSPSSVAIAELVALFLEGLKERSIFAMALQDRKATDDTTLLAFKKGDLLVLTKKQGLLASE 1589
            ::...:..:|.|::|||:||.||.:||.:|:|||:....||.|:|:|||.:|:.|.|.:...|:.
Zfish  1589 DFTLNAIMAVEISDLVAMFLAGLIQRSQYAVALQEVNRQDDRTILSFKKAELIYLIKDEEFSAAR 1653

Human  1590 NWTLGQNDRTGKTGLVPMACLYTIPTVTKPSAQLLSLLAMSPEKRKLA---AQEGQFTEPRPEEP 1651
            .|..|:|:|||:.|.:|...:..:||:|||:.::|||:::||::||..   ..:|..||
Zfish  1654 GWLKGKNERTGEIGAIPADAVLILPTLTKPTNEVLSLISLSPDQRKTIIDNTSKGTLTE------ 1712

Human  1652 PKEKLHTLEEFSYEFFRAPEKDMVSMAVLPLARARGHLWAYSCEPLRQPLLKRVHANVDLWDIAC 1716
             :....||:|||.|:||.|.|| |:..|:........|||.|.||:|||||||:..|.||...||
Zfish  1713 -RVAPSTLKEFSVEYFRPPIKD-VNRQVISKNATPERLWANSREPIRQPLLKRLVGNPDLSPQAC 1775

Human  1717 QIFVAILRYMGDYPSRQAWPTLELTDQIFTLALQHPALQDEVYCQILKQLTHNSNRHSEERGWQL 1781
            |:|.|||:||||||:||....||||||||....|:..|:||:||||:||:|.|:||:|.|:||||
Zfish  1776 QVFTAILKYMGDYPTRQVQSPLELTDQIFGPPTQNEELRDEIYCQIMKQMTSNNNRYSIEQGWQL 1840

Human  1782 LWLCTGLFPPSKGLLPHAQKFIDTRRGKLLAPDCSRRIQKVLRTGPRKQPPHQVEVEAAEQNVSR 1846
            ||||.||||||..|:.|||:||:||:.:.||.||.:|:|...|..|||.|||||||:|.:||.::
Zfish  1841 LWLCCGLFPPSNSLMKHAQRFIETRKREPLATDCLQRLQGARRMDPRKLPPHQVEVDAIQQNSTQ 1905

Human  1847 ICHKIYFPNDTSEMLEVVANTRVRDVCDSIATRLQLASWEGCSLFIKISDKVISQKEGDFFFDSL 1911
            |.||||||||:.|:.||..||::||:..:||.:|.|::.||.|||:|..|||:|..|.|:|||||
Zfish  1906 IFHKIYFPNDSQEIFEVATNTKIRDLVRTIANKLMLSTAEGFSLFMKTPDKVLSLNETDYFFDSL 1970

Human  1912 REVSDWVKKNKPQKEGAPVTLPYQVYFMRKLWLNISPGKDVNADTILHYHQELPKYLRGFHKCSR 1976
            |:::||.|:.|...:||||.:.|.|:||||||.||.||:||.||.|.||.|||||||||:|:|::
Zfish  1971 RQITDWSKRAKRVNQGAPVNVSYTVFFMRKLWFNIIPGRDVEADLIFHYPQELPKYLRGYHRCTK 2035

Human  1977 EDAIHLAGLIYKAQFNNDRSQLASVPKILRELVPENLTRLMSSEEWKKSILLAYDKHKDKTVEEA 2041
            |:.:.|..|:::.:.|||::|...:||:|::|||.:..:.:|::||||||...|:|....|||||
Zfish  2036 EEMVMLGALLFRVKVNNDKTQFPMIPKMLKDLVPNDQLKALSADEWKKSIFAEYNKQTGMTVEEA 2100

Human  2042 KVAFLKWICRWPTFGSAFFEVKQTSEPSYPDVILIAINRHGVLLIHPKTKDLLTTYPFTKISSWS 2106
            .:.|||.:.:|||||.|||:|||||||::||::.:||::.|:.:|:|||||.|..:|:.||::|.
Zfish  2101 MIGFLKIVYKWPTFGCAFFDVKQTSEPNFPDIVRMAISKQGITIINPKTKDALAIHPYNKIANWC 2165

Human  2107 SGSTYFHMALGSLGRGSRLLCETSLGYKMDDLLTSYVQQLLSAMNKQRGSK 2157
            ||||||||.:|:|.:|:::||||||||||||||||||...|   |::||.:
Zfish  2166 SGSTYFHMTVGNLVKGNKILCETSLGYKMDDLLTSYVNMYL---NERRGQR 2213

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO7B	XP_016859658.1	None
LOC108190403	XP_021327440.1	MYSc_Myo7	73..742	CDD:276832	417/672 (62%)
		IQ	779..801	CDD:197470	11/21 (52%)
		MyTH4	<1198..1307	CDD:214535	77/108 (71%)
		B41	1314..1527	CDD:214604	95/233 (41%)
		FERM_C1_MyoVII	1521..1614	CDD:270019	40/97 (41%)
		SH3	1615..1676	CDD:327375	24/60 (40%)
		MyTH4	1752..1900	CDD:214535	92/147 (63%)
		B41	1907..2119	CDD:214604	111/211 (53%)
		FERM_C2_MyoVII	2115..2210	CDD:270020	58/97 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194338676
Domainoid	1	1.000	192	1.000	Domainoid score	I13456
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG39495
OrthoDB	1	1.010	-	-		D10152at7742
OrthoFinder	1	1.000	-	-		FOG0001409
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	O	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1286
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.720