Protein Alignment MYO7A and myo51

DIOPT Version :10

• Sequence 1: XP_011543348.2
• Gene: MYO7A / 4647
• HGNCID: 7606
• Length: 2258
• Species: Homo sapiens
• Sequence 2: NP_596233.1
• Gene: myo51 / 2540560
• PomBaseID: SPBC2D10.14C
• Length: 1471
• Species: Schizosaccharomyces pombe
• Alignment Length: 1337
• Identity: 412/1337 - (30%)
• Similarity: 629/1337 - (47%)
• Gaps: 246/1337 - (18%)

Human    99 DMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQ-LLSIYSPEHIRQYTNKKIGEMPP 162
            |:..|..|||..:|..|..||.:..||||:|.:||::|||| |...|:...|:.:.........|
pombe    69 DLTNLPYLNEPSVLHALHNRYNNKQIYTYSGIVLVSINPYQNLPEFYNDNLIKHFHKDPEAAKVP 133

Human   163 HIFAIADNCYFNMKRNSRDQCCIISGESGAGKTESTKLILQFLAAISG-QHSW-----IEQQVLE 221
            |:::||.:||..:..:|::|..|:|||||||||.:.|.|:::|.::.| .|:.     :|.|||.
pombe   134 HLYSIASSCYHALTTDSKNQTIIVSGESGAGKTVAAKYIMRYLTSVQGVDHNGVVKRSVENQVLA 198

Human   222 ATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQALDERNYHVFY 286
            ..||:||||||||||||||||||||:.|.|::...|.||.:..||||:|||......|||||:||
pombe   199 TNPIMEAFGNAKTIRNDNSSRFGKYVTISFDENLLITGANVNTYLLERSRVVSLLKGERNYHIFY 263

Human   287 CMLEGMSEDQKKKLGLGQASDYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDTENWEISKL 351
            .::.|.:|:|:.|..|..||.:|||:.|||....|..||.::.....|:..:..:::...::..|
pombe   264 QLITGCTEEQRDKWFLESASSFNYLSQGNCDEISGVDDSNDFTITCRALSTIGISESRQEDVFCL 328

Human   352 LAAILHLGNLQYEARTFENLDAC----EVLFSPS---LATAASLLEVNPPDLMSCLTSRTLITRG 409
            |||:||||          |::.|    |....|.   |..||.||.|:...|...:..|.|.||.
pombe   329 LAALLHLG----------NIEVCATRNEAQIQPGDGYLQKAALLLGVDSSTLAKWIVKRQLKTRS 383

Human   410 ETVSTPLSREQALDVRDAFVKGIYGRLFVWIVDKINAAIYKPPSQDVKNSR-RSIGLLDIFGFEN 473
            ||:.|..:.|.|:.:||:..|.:|..||:|||..|||::   ....||.:. :.||::||:|||:
pombe   384 ETIITSSTLEHAISIRDSVAKYLYSALFLWIVHMINASL---DHNKVKRAAYKYIGVVDIYGFEH 445

Human   474 FAVNSFEQLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQDALDMIANKPMNIIS 538
            |..||.||.|||:|||.|||.|.:||||||||||..|.:||..||::|||..:.:|.:| :.|:|
pombe   446 FEKNSMEQFCINYANEKLQQEFNKHVFKLEQEEYVKEGLDWRLIEYSDNQGCISLIEDK-LGILS 509

Human   539 LIDEESKFPKGTDTTMLHKLNSQHKLNANYIPPKNN--------HETQFGINHFAGIVYYETQGF 595
            |:|||.:.|.|...:.|.|||:|       :|.|::        ::..|.:.|:|..|.|:...|
pombe   510 LLDEECRLPSGNHQSFLQKLNNQ-------LPTKHSQFYKKSRFNDGSFMVKHYALDVSYQVHDF 567

Human   596 LEKNRDTLHGDIIQLVHSSRNKFIKQIFQADVAMGAETRK--------RSPTLSSQFKRSLELLM 652
            |.||.|.:..:.|.|:.:|:|:||..:....:.:.:...|        |.|||||.||.||..||
pombe   568 LAKNSDAIPDEFISLLQNSKNEFITYLLDFYMQLVSSQNKNPRKTAISRKPTLSSMFKSSLSQLM 632

Human   653 RTLGACQPFFVRCIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYRV 717
            .|:.:....::|||||||.|.|..|...:.:.|||..|:.|||||...|:|.|:|:.||..|:|:
pombe   633 TTVSSTNVHYIRCIKPNEEKLPWTFSPPMVLSQLRACGVFETIRISSLGFPARFSYEEFAHRFRI 697

Human   718 LLPGVKPAYKQGDLRGTCQRMAEAVLGTHD--DWQIGKTKIFLKDHHDMLLEVERDKAITDRVIL 780
            ||...:   .:.|.:.....:..:|: .||  ::|:|::|||.:.:.....|.......:...:|
pombe   698 LLSSKE---WEEDNKKLTLNIVNSVI-PHDNLNFQVGRSKIFFRSNVIGNFEEAHRATCSKSTVL 758

Human   781 LQKVIRGFKDRSNFL-------------------------KLKNAATLIQRHWRGHNCRKNY-GL 819
            ||..||||..|..:.                         |::.||.|||.|||.:..||.| .|
pombe   759 LQSAIRGFFTRKEYQRTVKFIIKLQSVIMGWLTRQRFEREKIERAAILIQAHWRSYIQRKRYLSL 823

Human   820 MRLGFLRLQALHRSRKLHQQY--RLARQRIIQFQARCRAYLVRKAFRHRLWAVLTVQAYARGMIA 882
            ::...: :|::.|....:.:|  .|............|||..||.||....:|:.:|..:|.::.
pombe   824 IKCAIV-IQSIVRKNIAYSRYINELRESSATLLAKFWRAYNARKTFRGLKKSVIALQCVSRSVLT 887

Human   883 RRLHQRL-----RAEYLW----RLEAEKMRLAEEEK--------LRKEMS------------AKK 918
            ||..:||     |...|:    .|:|....::::.|        ||.:::            .||
pombe   888 RRYLRRLQDSAGRTSILYEKQKNLQASITEVSKQLKSNSKKVTVLRNKLNILNNSLSKWKCLIKK 952

Human   919 AKEEAE------RKHQERLAQLAREDAERELKEKE----AARRKKEL-LEQMERARHEPVNHSD- 971
            ..:.:|      ..:.|:|.||.:  ||.:|::..    .|.:|.|| ..|.:.||....|:..
pombe   953 PSDFSEPVSMDFTSNDEQLVQLLQ--AESKLRQASQQLYMAAKKSELGFVQSQTARENLSNYYQA 1015

Human   972 ---MVDKMFGFLGTSGGLPGQEGQAPS--------GFEDLERGRREMVE-EDLDAALPLPDE--- 1021
               .|.:.|.:         ...|.||        .:..:.:..::::| ..::.|..||:|
pombe  1016 LQMTVSEKFEY---------DTEQLPSRVLFYAMDRYFSIHKKLKQLLELVGVENASLLPNEVVN 1071

Human  1022 -DEEDLSEYKFAKFAATYFQGTTTHSYTRRPLKQPLLYHDD-----EGDQLAAL-AVWITILRFM 1079
             ..:||...|...|.....|..|..|     |...:.|.|.     |.||.:.| |..:..|.|.
pombe  1072 KQTKDLLYEKRVVFLKQIKQALTVSS-----LFNAVGYKDGVMRLLETDQNSLLFAGVVNFLIFA 1131

Human  1080 G---DLPEP---------KYHTAMSDGS-----------EKIPVMTKIY--ETLGK-KTYKRELQ 1118
            |   ||...         .|.|.:.||:           || |:...:|  .||.| :::...|.
pombe  1132 GISLDLKTQISEFLSQLCSYFTKIVDGTVIENDKTLDFYEK-PLQAVLYWFATLHKIRSFLVHLL 1195

Human  1119 ALQGEGEAQLPE----------GQKKSSVRHKLVHLTLKKKSKLTEEVTKRL------------H 1161
            ::...|:..:.|          .:..|::.:....|..|..|..||.....|            .
pombe  1196 SINSHGKQSVVEDLWNPLILKFSKHFSNLENSFHSLVQKLLSCCTEGSINALLNSKCLPEFIDAA 1260

Human  1162 DGESTVQGNSMLEDRPTSNLEKLHFIIGNGILRPALRDEIYCQISKQLTH--------------- 1211
            |..:|..|.::.|.....||  :|.::.:..|:|.|   :...||..|.|
pombe  1261 DENTTPTGMNIYELIDRMNL--IHKLLISSALQPNL---LELTISHMLQHIGQRAFQTLIHGRSP 1320

Human  1212 ----NPSKSSYARGWILVSLCVGCFAPSEKFVKYLRN 1244
                :.|:.|| ...:|::.|      .:|.:.|:.:
pombe  1321 YTWKSASQVSY-NASLLINWC------HQKGISYVNS 1350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO7A	XP_011543348.2	MYSc_Myo7	109..759	CDD:276832	270/682 (40%)
		CBD_MYO6-like	<796..>839	CDD:409646	15/43 (35%)
		tolA	<826..>996	CDD:236545	48/223 (22%)
		MAP7	<887..963	CDD:461709	24/115 (21%)
		MyTH4	1047..1283	CDD:214535	55/271 (20%)
		FERM1_F1_Myosin-VII	1287..1385	CDD:340612
		B41	1289..1504	CDD:214604
		FERM_C1_MyoVII	1498..1634	CDD:270019
		SH3	1635..1699	CDD:473055
		MyTH4	1793..1926	CDD:214535
		FERM2_F1_Myosin-VII	1931..2028	CDD:340613
		B41	1933..2145	CDD:214604
myo51	NP_596233.1	COG5022	1..1471	CDD:227355	412/1337 (31%)