DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYO7A and myo7aa

DIOPT Version :9

Sequence 1:	XP_011543348.2	Gene:	MYO7A / 4647	HGNCID:	7606	Length:	2258	Species:	Homo sapiens
Sequence 2:	XP_021323248.1	Gene:	myo7aa / 252846	ZFINID:	ZDB-GENE-020709-1	Length:	2185	Species:	Danio rerio

Alignment Length:	2119	Identity:	1759/2119 - (83%)
Similarity:	1928/2119 - (90%)	Gaps:	46/2119 - (2%)

- Green bases have known domain annotations that are detailed below.

Human    37 GDHVWMDLRLGQEFDVPIGAVVKLCDSGQVQVVDDEDNEHWISPQNATHIKPMHPTSVHGVEDMI 101
            ||:||:||:.|.||:||||||||||||||:||:|||.|||||||||||:||||||||:|||||||
Zfish     7 GDYVWLDLKTGHEFEVPIGAVVKLCDSGQIQVLDDEGNEHWISPQNATNIKPMHPTSIHGVEDMI 71

Human   102 RLGDLNEAGILRNLLIRYRDHLIY------TYTGSILVAVNPYQLLSIYSPEHIRQYTNKKIGEM 160
            |||||||||||||||||||:||||      ||||||||||||||||.||:.:.||.|||||||||
Zfish    72 RLGDLNEAGILRNLLIRYREHLIYTNCGGRTYTGSILVAVNPYQLLPIYTADQIRLYTNKKIGEM 136

Human   161 PPHIFAIADNCYFNMKRNSRDQCCIISGESGAGKTESTKLILQFLAAISGQHSWIEQQVLEATPI 225
            |||||||||||||||:||::||||||||||||||||||||||||||||||||||||||||||.||
Zfish   137 PPHIFAIADNCYFNMQRNNKDQCCIISGESGAGKTESTKLILQFLAAISGQHSWIEQQVLEANPI 201

Human   226 LEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQALDERNYHVFYCMLE 290
            |||||||||||||||||||||||||||||||||||||||||||||||||||.||||||:|||||:
Zfish   202 LEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQARDERNYHIFYCMLK 266

Human   291 GMSEDQKKKLGLGQASDYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDTENWEISKLLAAI 355
            ||:.||||:|||.:|:||.||.:|||..|:||.|.:||:|||||||||||||.||||||||||||
Zfish   267 GMTPDQKKQLGLSKATDYTYLTIGNCTVCDGRDDQKEYSNIRSAMKVLMFTDKENWEISKLLAAI 331

Human   356 LHLGNLQYEARTFENLDACEVLFSPSLATAASLLEVNPPDLMSCLTSRTLITRGETVSTPLSREQ 420
            ||:|||:|||||::|||||||:...:|.|||.||||:..|||:||||||:||||||||||||.||
Zfish   332 LHMGNLRYEARTYDNLDACEVVRCSALTTAAVLLEVDLKDLMNCLTSRTIITRGETVSTPLSIEQ 396

Human   421 ALDVRDAFVKGIYGRLFVWIVDKINAAIYKPPSQDVKNSRRSIGLLDIFGFENFAVNSFEQLCIN 485
            |||||||||||||||||||||:|||||||||||.::|..|||||||||||||||.||||||||||
Zfish   397 ALDVRDAFVKGIYGRLFVWIVEKINAAIYKPPSLELKAVRRSIGLLDIFGFENFMVNSFEQLCIN 461

Human   486 FANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQDALDMIANKPMNIISLIDEESKFPKGT 550
            ||||:|||||||||||||||||:||:|:|.|||||||||||||||.|||||||||||||||||||
Zfish   462 FANENLQQFFVRHVFKLEQEEYNLENINWQHIEFTDNQDALDMIAIKPMNIISLIDEESKFPKGT 526

Human   551 DTTMLHKLNSQHKLNANYIPPKNNHETQFGINHFAGIVYYETQGFLEKNRDTLHGDIIQLVHSSR 615
            |||||:|||||||||.|||||||.:||||||.||||:|||||:|||||||||||||||||||||:
Zfish   527 DTTMLNKLNSQHKLNTNYIPPKNTYETQFGIQHFAGVVYYETRGFLEKNRDTLHGDIIQLVHSSK 591

Human   616 NKFIKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNEFKKPMLFDRH 680
            ||||||||||||||||||||||||||||||||||||||||..|||||||||||||:||||||||.
Zfish   592 NKFIKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLSVCQPFFVRCIKPNEYKKPMLFDRE 656

Human   681 LCVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYRVLLPGVKPAYKQGDLRGTCQRMAEAVLGT 745
            ||||||||||||||||||||||||||:|||||:|||||:|||||||||.||||||||:||||||.
Zfish   657 LCVRQLRYSGMMETIRIRRAGYPIRYTFVEFVDRYRVLMPGVKPAYKQEDLRGTCQRIAEAVLGR 721

Human   746 HDDWQIGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRGFKDRSNFLKLKNAATLIQRHWRG 810
            .||||:||||||||||||||||:||||||||:|||:|||:|||||||||||:|.:|.|||:.|||
Zfish   722 DDDWQMGKTKIFLKDHHDMLLEIERDKAITDKVILIQKVVRGFKDRSNFLKMKKSAMLIQKTWRG 786

Human   811 HNCRKNYGLMRLGFLRLQALHRSRKLHQQYRLARQRIIQFQARCRAYLVRKAFRHRLWAVLTVQA 875
            :.||||||.||.||.|||||:|||||:|.|.:|||||:.||.|||.:|||:|||||||||:|:||
Zfish   787 YYCRKNYGAMRGGFSRLQALYRSRKLYQTYHVARQRIMLFQGRCRGFLVRRAFRHRLWAVITIQA 851

Human   876 YARGMIARRLHQRLRAEYLWRLEAEKMRLAEEEKLRKEMSAKKAKEEAERKHQERLAQLAREDAE 940
            |.||||||||::||:.||..||||||:|||||:|||.:|||:|||||||:.||||||||||||||
Zfish   852 YTRGMIARRLYKRLKGEYRRRLEAEKLRLAEEQKLRNQMSARKAKEEAEKMHQERLAQLAREDAE 916

Human   941 RELKEKEAARRKKELLEQMERARHEPVNHSDMVDKMFGFLGTSGGLPGQEGQAPSGFEDLERGRR 1005
            ||.||::.||||.|:|:|||:||.||||.|||||||||||||:...||||||||:|||||||..|
Zfish   917 REKKERQEARRKMEMLDQMEKARQEPVNDSDMVDKMFGFLGTTNSFPGQEGQAPAGFEDLERTHR 981

Human  1006 EMVEEDLDAALPLPDEDEEDLSEYKFAKFAATYFQGTTTHSYTRRPLKQPLLYHDDEGDQLAALA 1070
            |:..||||.:||||::|.|||||||||||:|||||||:||:|.|||||||||:|:||||||||||
Zfish   982 ELEVEDLDESLPLPEDDLEDLSEYKFAKFSATYFQGTSTHTYMRRPLKQPLLFHEDEGDQLAALA 1046

Human  1071 VWITILRFMGDLPEPKYHTAMSDGSEKIPVMTKIYETLGKKTYKRELQALQGEGEAQLPEGQKKS 1135
            ||||:|||||||||||||||:||||||||||||||||||||||||||||||||||....|..|||
Zfish  1047 VWITVLRFMGDLPEPKYHTAISDGSEKIPVMTKIYETLGKKTYKRELQALQGEGENTNIESHKKS 1111

Human  1136 SVRHKLVHLTLKKKSKLTEEVTKRLHDGESTVQGNSMLEDRPTSNLEKLHFIIGNGILRPALRDE 1200
            |||||||.||||||||:||||||||:|||.||.|||||||||||||||||||||||||||.||||
Zfish  1112 SVRHKLVSLTLKKKSKITEEVTKRLNDGEYTVHGNSMLEDRPTSNLEKLHFIIGNGILRPGLRDE 1176

Human  1201 IYCQISKQLTHNPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNFIHGGPPGYAPYCEERLRRTF 1265
            |||||.|||..||||||:||||||:|||||||||||||||||||||..|||||||||||||||||
Zfish  1177 IYCQICKQLNQNPSKSSHARGWILMSLCVGCFAPSEKFVKYLRNFISEGPPGYAPYCEERLRRTF 1241

Human  1266 VNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCNALADKISLKDRFGFS 1330
            ||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||:||||||
Zfish  1242 VNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCNALSDKISLQDRFGFS 1306

Human  1331 LYIALFDKVSSLGSGSDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEVFTPWHSPSEDNVATN 1395
            |||||||||||||||:||||||:||||||||||||||||||||||||||:|||||.|:||.||||
Zfish  1307 LYIALFDKVSSLGSGNDHVMDAVSQCEQYAKEQGAQERNAPWRLFFRKEIFTPWHDPAEDAVATN 1371

Human  1396 LIYQQVVRGVKFGEYRCEKEDDLAELASQQYFVDYGSEMILERLLNLVPTYIPDREITPLKTLEK 1460
            |||||:|||||||||||::| ||||||||||:||||||:::||||:|:|:|||||||:..||:|:
Zfish  1372 LIYQQIVRGVKFGEYRCDRE-DLAELASQQYYVDYGSEILVERLLSLIPSYIPDREISSAKTVER 1435

Human  1461 WAQLAIAAHKKGIYAQRRTDAQKVKEDVVSYARFKWPLLFSRFYEAYKFSGPSLPKNDVIVAVNW 1525
            |||..:||||||:|.|:|.|.|||||:||.:||:||||||||||||:||||||||||||||||||
Zfish  1436 WAQFIMAAHKKGVYTQKRVDPQKVKEEVVDFARYKWPLLFSRFYEAFKFSGPSLPKNDVIVAVNW 1500

Human  1526 TGVYFVDEQEQVLLELSFPEIMAVSSSRECRVWLSLGCSDLGCAAPHSGWAGLTPAGPCSPCWSC 1590
            |||||||||||||||||||||.|||||
Zfish  1501 TGVYFVDEQEQVLLELSFPEITAVSSS-------------------------------------- 1527

Human  1591 RGAKTTAPSFTLATIKGDEYTFTSSNAEDIRDLVVTFLEGLRKRSKYVVALQDNPNPAGEESGFL 1655
            :|.|..|.||||||||.||:||||:|||||||||||||||||||||:||||||||:||.::|.||
Zfish  1528 KGGKLQAQSFTLATIKADEFTFTSNNAEDIRDLVVTFLEGLRKRSKFVVALQDNPSPAADDSTFL 1592

Human  1656 SFAKGDLIILDHDTGEQVMNSGWANGINERTKQRGDFPTDSVYVMPTVTMPPREIVALVTMTPDQ 1720
            ||.|||||:||.|||||||.||||:|.|:|||||||||.|.|||:|||..||.::||.|||||||
Zfish  1593 SFLKGDLIVLDQDTGEQVMTSGWAHGTNDRTKQRGDFPADCVYVLPTVVRPPHDVVAFVTMTPDQ 1657

Human  1721 RQDVVRLLQL-RTAEPEVRAKPYTLEEFSYDYFRPPPKHTLSRVMVSKARGKDRLWSHTREPLKQ 1784
            ||:.:|:..: ...|.|.|.|||||||||||||||||||||||||::|.||||:||..||||:||
Zfish  1658 RQESLRISHVPALTETEERVKPYTLEEFSYDYFRPPPKHTLSRVMITKNRGKDKLWCCTREPIKQ 1722

Human  1785 ALLKKLLGSEELSQEACLAFIAVLKYMGDYPSKRTRSVNELTDQIFEGPLKAEPLKDEAYVQILK 1849
            |||||..|.||||||||:|||||:||||||||||||||||||||||||.|||||||||.|.||||
Zfish  1723 ALLKKCGGHEELSQEACMAFIAVMKYMGDYPSKRTRSVNELTDQIFEGALKAEPLKDEIYCQILK 1787

Human  1850 QLTDNHIRYSEERGWELLWLCTGLFPPSNILLPHVQRFLQSRKHCPLAIDCLQRLQKALRNGSRK 1914
            |||:|||:||||:||||||||.|||||||:|||||||||||:||.|||:||:|||||||||||||
Zfish  1788 QLTENHIKYSEEKGWELLWLCVGLFPPSNVLLPHVQRFLQSKKHHPLALDCMQRLQKALRNGSRK 1852

Human  1915 YPPHLVEVEAIQHKTTQIFHKVYFPDDTDEAFEVESSTKAKDFCQNIATRLLLKSSEGFSLFVKI 1979
            ||||||||||||||||||||||||||||||||||||||||||||.||::|||||:.|||||||||
Zfish  1853 YPPHLVEVEAIQHKTTQIFHKVYFPDDTDEAFEVESSTKAKDFCLNISSRLLLKTPEGFSLFVKI 1917

Human  1980 ADKVLSVPENDFFFDFVRHLTDWIKKARPIKDGIVPSLTYQVFFMKKLWTTTVPGKDPMADSIFH 2044
            :|||:||||.|||||||||||||||||||.|||||||||||||||||||||||||||..||||||
Zfish  1918 SDKVISVPEGDFFFDFVRHLTDWIKKARPAKDGIVPSLTYQVFFMKKLWTTTVPGKDSFADSIFH 1982

Human  2045 YYQELPKYLRGYHKCTREEVLQLGALIYRVKFEEDKSYFPSIPKLLRELVPQDLIRQVSPDDWKR 2109
            |||||||||||||||:||||.||||||||||||:|||:||||||:|:|::|||||||:|||||||
Zfish  1983 YYQELPKYLRGYHKCSREEVFQLGALIYRVKFEDDKSHFPSIPKMLKEMIPQDLIRQLSPDDWKR 2047

Human  2110 SIVAYFNKHAGKSKEEAKLAFLKLIFKWPTFGSAFFEVK 2148
            |||||||:|||||:|||||.|||:|||||||||||||||
Zfish  2048 SIVAYFNRHAGKSREEAKLMFLKIIFKWPTFGSAFFEVK 2086

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYO7A	XP_011543348.2	None
myo7aa	XP_021323248.1	MYSc_Myo7	79..735	CDD:276832	568/655 (87%)
		IQ	772..793	CDD:197470	12/20 (60%)
		MAP7	<863..941	CDD:310345	57/77 (74%)
		UFD1	893..>1160	CDD:332114	219/266 (82%)
		MyTH4	1023..1259	CDD:214535	211/235 (90%)
		B41	1265..1479	CDD:214604	178/214 (83%)
		FERM_C1_MyoVII	1473..1571	CDD:270019	87/135 (64%)
		SH3	1572..1636	CDD:327375	48/63 (76%)
		MyTH4	1716..1864	CDD:214535	129/147 (88%)
		B41	1871..2083	CDD:214604	187/211 (89%)
		FERM_C2_MyoVII	2079..2174	CDD:270020	8/8 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194331878
Domainoid	1	1.000	1187	1.000	Domainoid score	I251
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H219
Inparanoid	1	1.050	3781	1.000	Inparanoid score	I90
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG52371
OrthoDB	1	1.010	-	-		D10152at7742
OrthoFinder	1	1.000	-	-		FOG0001409
OrthoInspector	1	1.000	-	-		oto44601
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	O	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1286
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	15	15.410