Protein Alignment MYO7A and myo7a

DIOPT Version :10

• Sequence 1: XP_011543348.2
• Gene: MYO7A / 4647
• HGNCID: 7606
• Length: 2258
• Species: Homo sapiens
• Sequence 2: XP_004912319.1
• Gene: myo7a / 100491335
• XenbaseID: XB-GENE-494060
• Length: 2212
• Species: Xenopus tropicalis
• Alignment Length: 2180
• Identity: 1818/2180 - (83%)
• Similarity: 1988/2180 - (91%)
• Gaps: 59/2180 - (2%)

Human    17 GKWALVRSLNQAFKTYAVLPGDHVWMDLRLGQEFDVPIGAVVKLCDSGQVQVVDDEDNEHWISPQ 81
            |||||:|::|||.|...:||||:||:||:.|:|||||:|||||||||||:||:|||.||||||||
 Frog    16 GKWALLRNVNQALKPSTLLPGDYVWLDLKTGREFDVPVGAVVKLCDSGQIQVLDDEGNEHWISPQ 80

Human    82 NATHIKPMHPTSVHGVEDMIRLGDLNEAGILRNLLIRYRDHLIY------TYTGSILVAVNPYQL 140
            ||:|||||||||:||||||||||||||||||||||||||:||||      |||||||||||||||
 Frog    81 NASHIKPMHPTSIHGVEDMIRLGDLNEAGILRNLLIRYREHLIYTNCGGRTYTGSILVAVNPYQL 145

Human   141 LSIYSPEHIRQYTNKKIGEMPPHIFAIADNCYFNMKRNSRDQCCIISGESGAGKTESTKLILQFL 205
            |.||:|:.||.|||:||||||||||||||||||||:||::|||||||||||||||||||||||||
 Frog   146 LPIYTPDQIRLYTNRKIGEMPPHIFAIADNCYFNMQRNNKDQCCIISGESGAGKTESTKLILQFL 210

Human   206 AAISGQHSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKS 270
            |||||||||||||||||.||||||||||||||||||||||||||||||:||||||||||||||||
 Frog   211 AAISGQHSWIEQQVLEANPILEAFGNAKTIRNDNSSRFGKYIDIHFNKKGAIEGAKIEQYLLEKS 275

Human   271 RVCRQALDERNYHVFYCMLEGMSEDQKKKLGLGQASDYNYLAMGNCITCEGRVDSQEYANIRSAM 335
            ||||||.||||||:|||||:|||.:|||||.||||||||||.||.|.||:||.||:|||||||||
 Frog   276 RVCRQAQDERNYHIFYCMLKGMSPEQKKKLSLGQASDYNYLCMGKCTTCDGRDDSKEYANIRSAM 340

Human   336 KVLMFTDTENWEISKLLAAILHLGNLQYEARTFENLDACEVLFSPSLATAASLLEVNPPDLMSCL 400
            ||||||||||||||:|||||||:|||:||||.::|||||||::|.||.|||:||||.|.:||:||
 Frog   341 KVLMFTDTENWEISRLLAAILHMGNLRYEARMYDNLDACEVVYSTSLTTAATLLEVGPQELMNCL 405

Human   401 TSRTLITRGETVSTPLSREQALDVRDAFVKGIYGRLFVWIVDKINAAIYKPPSQDVKNSRRSIGL 465
            ||||:||||||||||||.|||||||||||||||||||||||||||||||:|.|.:.|.:||||||
 Frog   406 TSRTIITRGETVSTPLSMEQALDVRDAFVKGIYGRLFVWIVDKINAAIYRPLSNEPKAARRSIGL 470

Human   466 LDIFGFENFAVNSFEQLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQDALDMIA 530
            |||||||||.||||||||||||||:|||||||||||||||||:||:|:|.|||||||||||||||
 Frog   471 LDIFGFENFTVNSFEQLCINFANENLQQFFVRHVFKLEQEEYNLENINWQHIEFTDNQDALDMIA 535

Human   531 NKPMNIISLIDEESKFPKGTDTTMLHKLNSQHKLNANYIPPKNNHETQFGINHFAGIVYYETQGF 595
            .||||||||||||||||||||||||:|||.|||||..|||||||:|||||||||||||||||:||
 Frog   536 IKPMNIISLIDEESKFPKGTDTTMLNKLNVQHKLNTFYIPPKNNYETQFGINHFAGIVYYETKGF 600

Human   596 LEKNRDTLHGDIIQLVHSSRNKFIKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLGACQP 660
            ||||||||||||||||||::||||||||||||||||||||||||||||||||||||||||..|||
 Frog   601 LEKNRDTLHGDIIQLVHSAKNKFIKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLSVCQP 665

Human   661 FFVRCIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYRVLLPGVKPA 725
            ||||||||||:||||||||.||||||||||||||||||||||||||:|||||:|||||:||||||
 Frog   666 FFVRCIKPNEYKKPMLFDRELCVRQLRYSGMMETIRIRRAGYPIRYTFVEFVDRYRVLMPGVKPA 730

Human   726 YKQGDLRGTCQRMAEAVLGTHDDWQIGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRGFKD 790
            ||||||||||:|:||:|||..|||||||||||||||||||||:||||||||:|||:|||:|||||
 Frog   731 YKQGDLRGTCERIAESVLGKDDDWQIGKTKIFLKDHHDMLLEIERDKAITDKVILIQKVVRGFKD 795

Human   791 RSNFLKLKNAATLIQRHWRGHNCRKNYGLMRLGFLRLQALHRSRKLHQQYRLARQRIIQFQARCR 855
            ||||||::.||.||||.|||||||:||..||:||||||||:||||||.||.:||.||..||||||
 Frog   796 RSNFLKIRKAALLIQRCWRGHNCRRNYTAMRIGFLRLQALYRSRKLHTQYHVARMRISYFQARCR 860

Human   856 AYLVRKAFRHRLWAVLTVQAYARGMIARRLHQRLRAEYLWRLEAEKMRLAEEEKLRKEMSAKKAK 920
            .||||||||||||||.|:||:|||||||||::||:.||..||||||:||||||:.:|||||||||
 Frog   861 GYLVRKAFRHRLWAVYTIQAHARGMIARRLYKRLKGEYHRRLEAEKLRLAEEERFKKEMSAKKAK 925

Human   921 EEAERKHQERLAQLAREDAERELKEKEAARRKKELLEQMERARHEPVNHSDMVDKMFGFLGTSGG 985
            :|||:|||||||||||||||||::|||.|||||||||:||:||:||||.|||||||||||||:..
 Frog   926 QEAEKKHQERLAQLAREDAEREVREKEEARRKKELLEKMEKARNEPVNDSDMVDKMFGFLGTTSS 990

Human   986 LPGQEGQAPSGFEDLERGRREMVEEDLDAALPLPDEDEEDLSEYKFAKFAATYFQGTTTHSYTRR 1050
            |||||||||:|||||||.:.||.|||||.|||||:|:||||||||||||||||||||||::|.||
 Frog   991 LPGQEGQAPTGFEDLERPQGEMEEEDLDGALPLPEEEEEDLSEYKFAKFAATYFQGTTTNTYIRR 1055

Human  1051 PLKQPLLYHDDEGDQLAALAVWITILRFMGDLPEPKYHTAMSDGSEKIPVMTKIYETLGKKTYKR 1115
            |||||||||:||||||||||||||||||||||||||||||||:||||||||||||||||||||||
 Frog  1056 PLKQPLLYHEDEGDQLAALAVWITILRFMGDLPEPKYHTAMSNGSEKIPVMTKIYETLGKKTYKR 1120

Human  1116 ELQALQGEGEAQLPEGQKKSSVRHKLVHLTLKKKSKLTEEVTKRLHDGESTVQGNSMLEDRPTSN 1180
            ||||||||||:...:|.||:|||||||.||||||||:||||||||||||||:|||||||||||||
 Frog  1121 ELQALQGEGESTQIDGYKKNSVRHKLVSLTLKKKSKITEEVTKRLHDGESTLQGNSMLEDRPTSN 1185

Human  1181 LEKLHFIIGNGILRPALRDEIYCQISKQLTHNPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNF 1245
            ||||||||||||||||||||||||||||||.||||||:||||||:||||||||||||||||||||
 Frog  1186 LEKLHFIIGNGILRPALRDEIYCQISKQLTQNPSKSSHARGWILMSLCVGCFAPSEKFVKYLRNF 1250

Human  1246 IHGGPPGYAPYCEERLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTA 1310
            |.||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||
 Frog  1251 ISGGPPGYAPYCEERLRRTFANGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTA 1315

Human  1311 KELCNALADKISLKDRFGFSLYIALFDKVSSLGSGSDHVMDAISQCEQYAKEQGAQERNAPWRLF 1375
            |||||:||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||
 Frog  1316 KELCNSLADKISLKDRFGFSLYIALFDKVSSLGSGSDHVMDAVSQCEQYAKEQGAQERNAPWRLF 1380

Human  1376 FRKEVFTPWHSPSEDNVATNLIYQQVVRGVKFGEYRCEKEDDLAELASQQYFVDYGSEMILERLL 1440
            ||||:|||||.|:||||||||||||:|||||||||||:||:||||||||||:||||||:|:||||
 Frog  1381 FRKEIFTPWHDPTEDNVATNLIYQQIVRGVKFGEYRCDKEEDLAELASQQYYVDYGSELIMERLL 1445

Human  1441 NLVPTYIPDREITPLKTLEKWAQLAIAAHKKGIYAQRRTDAQKVKEDVVSYARFKWPLLFSRFYE 1505
            ||:|:|||||||||.|.:|||||..|||||||||||:|:|:|||||:||.:||||||||||||||
 Frog  1446 NLIPSYIPDREITPSKNVEKWAQFIIAAHKKGIYAQKRSDSQKVKENVVDFARFKWPLLFSRFYE 1510

Human  1506 AYKFSGPSLPKNDVIVAVNWTGVYFVDEQEQVLLELSFPEIMAVSSSRECRVWLSLGCSDLGCAA 1570
            |:|||||||||||||||||||||||||||||||||||||||.|||||
 Frog  1511 AFKFSGPSLPKNDVIVAVNWTGVYFVDEQEQVLLELSFPEITAVSSS------------------ 1557

Human  1571 PHSGWAGLTPAGPCSPCWSCRGAKTTAPSFTLATIKGDEYTFTSSNAEDIRDLVVTFLEGLRKRS 1635
                                ||.|....|||:||||||||||||:||||||||||||||||||||
 Frog  1558 --------------------RGGKMQGQSFTMATIKGDEYTFTSNNAEDIRDLVVTFLEGLRKRS 1602

Human  1636 KYVVALQDNPNPAGEESGFLSFAKGDLIILDHDTGEQVMNSGWANGINERTKQRGDFPTDSVYVM 1700
            ||||||||||||.||:||||||.|||||:|||||||.:||||||:|.|||||.:|||||:.||||
 Frog  1603 KYVVALQDNPNPVGEDSGFLSFQKGDLILLDHDTGETIMNSGWAHGYNERTKHKGDFPTEIVYVM 1667

Human  1701 PTVTMPPREIVALVTMTPDQRQDVVRLLQLRTAEPEVRAKPYTLEEFSYDYFRPPPKHTLSRVMV 1765
            ||||.|..|:||||||||||:|||||.:||..:|.|.:.|||||||||||||||||||||||||:
 Frog  1668 PTVTKPSGEVVALVTMTPDQKQDVVRAVQLNPSEQEEKMKPYTLEEFSYDYFRPPPKHTLSRVMI 1732

Human  1766 SKARGKDRLWSHTREPLKQALLKKLLGSEELSQEACLAFIAVLKYMGDYPSKRTRSVNELTDQIF 1830
            :|.||||:|||:||||:|||||||:|.|:|:|||||:||||:|||||||||||.|||||||||||
 Frog  1733 TKNRGKDKLWSYTREPIKQALLKKVLMSDEMSQEACMAFIAILKYMGDYPSKRMRSVNELTDQIF 1797

Human  1831 EGPLKAEPLKDEAYVQILKQLTDNHIRYSEERGWELLWLCTGLFPPSNILLPHVQRFLQSRKHCP 1895
            ||.||.||||||.|.|:|||||||||:||||:|||||||.||||||||:||||:|||:||||...
 Frog  1798 EGALKGEPLKDEIYCQVLKQLTDNHIKYSEEKGWELLWLITGLFPPSNVLLPHIQRFIQSRKQHA 1862

Human  1896 LAIDCLQRLQKALRNGSRKYPPHLVEVEAIQHKTTQIFHKVYFPDDTDEAFEVESSTKAKDFCQN 1960
            ||.||:.|||:|||||||||||||||||||||||||||||||||||||||||||||||||||||:
 Frog  1863 LATDCMHRLQRALRNGSRKYPPHLVEVEAIQHKTTQIFHKVYFPDDTDEAFEVESSTKAKDFCQD 1927

Human  1961 IATRLLLKSSEGFSLFVKIADKVLSVPENDFFFDFVRHLTDWIKKARPIKDGIVPSLTYQVFFMK 2025
            ||.||||||:|||||||||:|||:||||.|||||||||||||||||||.||||||||||||||||
 Frog  1928 IANRLLLKSAEGFSLFVKISDKVISVPEGDFFFDFVRHLTDWIKKARPSKDGIVPSLTYQVFFMK 1992

Human  2026 KLWTTTVPGKDPMADSIFHYYQELPKYLRGYHKCTREEVLQLGALIYRVKFEEDKSYFPSIPKLL 2090
            |||||||||||.|||||||||||||||||||||||||:||||.|||||||||:||||||:|||:|
 Frog  1993 KLWTTTVPGKDSMADSIFHYYQELPKYLRGYHKCTREDVLQLAALIYRVKFEDDKSYFPNIPKML 2057

Human  2091 RELVPQDLIRQVSPDDWKRSIVAYFNKHAGKSKEEAKLAFLKLIFKWPTFGSAFFEVKV------ 2149
            :||||||||||::||:|||||:|||||||||::||:|:||||||:|||||||||||||.
 Frog  2058 KELVPQDLIRQLNPDEWKRSIIAYFNKHAGKTREESKVAFLKLIYKWPTFGSAFFEVKQTTEPHF 2122

Human  2150 ---------HHGLLRAEEEGNRALIKHRDSSLGLW 2175
                     .||:...:.:....|..|..:.:..|
 Frog  2123 PEILLIAINKHGVSLIDPKTKDILATHPFTKISNW 2157

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO7A	XP_011543348.2	MYSc_Myo7	109..759	CDD:276832	574/655 (88%)
		CBD_MYO6-like	<796..>839	CDD:409646	32/42 (76%)
		tolA	<826..>996	CDD:236545	136/169 (80%)
		MAP7	<887..963	CDD:461709	59/75 (79%)
		MyTH4	1047..1283	CDD:214535	217/235 (92%)
		FERM1_F1_Myosin-VII	1287..1385	CDD:340612	94/97 (97%)
		B41	1289..1504	CDD:214604	190/214 (89%)
		FERM_C1_MyoVII	1498..1634	CDD:270019	88/135 (65%)
		SH3	1635..1699	CDD:473055	51/63 (81%)
		MyTH4	1793..1926	CDD:214535	109/132 (83%)
		FERM2_F1_Myosin-VII	1931..2028	CDD:340613	89/96 (93%)
		B41	1933..2145	CDD:214604	188/211 (89%)
myo7a	XP_004912319.1	MYSc_Myo7	108..764	CDD:276832	574/655 (88%)
		IQ	801..822	CDD:197470	14/20 (70%)
		PTZ00121	<883..>995	CDD:173412	89/111 (80%)
		MyTH4	1052..1288	CDD:214535	217/235 (92%)
		FERM1_F1_Myosin-VII	1292..1390	CDD:340612	94/97 (97%)
		B41	1294..1509	CDD:214604	190/214 (89%)
		FERM_C1_MyoVII	1503..1601	CDD:270019	88/135 (65%)
		SH3	1602..1666	CDD:473055	51/63 (81%)
		MyTH4	1744..1893	CDD:214535	121/148 (82%)
		FERM2_F1_Myosin-VII	1898..1995	CDD:340613	89/96 (93%)
		B41	1900..2112	CDD:214604	188/211 (89%)
		FERM_C2_MyoVII	2108..2203	CDD:270020	13/50 (26%)