DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CanB2 and RCVRN

DIOPT Version :9

Sequence 1:	NP_001246192.1	Gene:	CanB2 / 46456	FlyBaseID:	FBgn0015614	Length:	170	Species:	Drosophila melanogaster
Sequence 2:	NP_002894.1	Gene:	RCVRN / 5957	HGNCID:	9937	Length:	200	Species:	Homo sapiens

Alignment Length:	185	Identity:	45/185 - (24%)
Similarity:	88/185 - (47%)	Gaps:	26/185 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNETS--------LPMEMCSNFDADEIRRLGKRFRKLDLDNSGALSVDEFMSL-----PELQQN 52
            |||..|        ..:::.:.|..:|:....:.|.| |.. :|.::..:|.|:     |:....
Human     1 MGNSKSGALSKEILEELQLNTKFSEEELCSWYQSFLK-DCP-TGRITQQQFQSIYAKFFPDTDPK 63

  Fly    53 PLVQRVIDIFDADGNGEVDFKEFIQGVSQFSVKGDKLSKLRFAFRIYDMDNDGYISNGELFQVL- 116
            ...|.|...||::.:|.:||||::..: ..:..|....||.:||.:||:|.:|.||..|:.:::
Human    64 AYAQHVFRSFDSNLDGTLDFKEYVIAL-HMTTAGKTNQKLEWAFSLYDVDGNGTISKNEVLEIVM 127

  Fly   117 ---KMMVGNNLK-----DTQLQQIVDKTIGFADKDEDGKISFDEFC-SVVGNTDI 162
               ||:...::|     :...::..:|...:..|::|.|::..||. ..:.|.:|
Human   128 AIFKMITPEDVKLLPDDENTPEKRAEKIWKYFGKNDDDKLTEKEFIEGTLANKEI 182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CanB2	NP_001246192.1	FRQ1	13..154	CDD:227455	38/154 (25%)
RCVRN	NP_002894.1	FRQ1	14..182	CDD:227455	40/170 (24%)
RCVRN	NP_002894.1	Interaction with GRK1. /evidence=ECO:0000250\|UniProtKB:P21457	189..192
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53747
OrthoDB	1	1.010	-	-		D1271942at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.930