DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CanB2 and PPP3R1

DIOPT Version :9

Sequence 1:	NP_001246192.1	Gene:	CanB2 / 46456	FlyBaseID:	FBgn0015614	Length:	170	Species:	Drosophila melanogaster
Sequence 2:	NP_000936.1	Gene:	PPP3R1 / 5534	HGNCID:	9317	Length:	170	Species:	Homo sapiens

Alignment Length:	170	Identity:	149/170 - (87%)
Similarity:	159/170 - (93%)	Gaps:	0/170 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNETSLPMEMCSNFDADEIRRLGKRFRKLDLDNSGALSVDEFMSLPELQQNPLVQRVIDIFDAD 65
            ||||.|.|:||||:||||||:||||||:||||||||:|||:||||||||||||||||||||||.|
Human     1 MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTD 65

  Fly    66 GNGEVDFKEFIQGVSQFSVKGDKLSKLRFAFRIYDMDNDGYISNGELFQVLKMMVGNNLKDTQLQ 130
            |||||||||||:|||||||||||..||||||||||||.|||||||||||||||||||||||||||
Human    66 GNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQ 130

  Fly   131 QIVDKTIGFADKDEDGKISFDEFCSVVGNTDIHKKMVVDV 170
            |||||||..||||.||:|||:|||:|||..||||||||||
Human   131 QIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV 170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CanB2	NP_001246192.1	FRQ1	13..154	CDD:227455	125/140 (89%)
PPP3R1	NP_000936.1	FRQ1	13..157	CDD:227455	127/143 (89%)
PPP3R1	NP_000936.1	Calcineurin A binding. /evidence=ECO:0000269\|PubMed:12218175, ECO:0000269\|PubMed:12357034, ECO:0000269\|PubMed:17498738, ECO:0000269\|PubMed:22343722, ECO:0000269\|PubMed:23468591, ECO:0000269\|PubMed:26794871, ECO:0000269\|PubMed:27974827, ECO:0000269\|PubMed:8524402	131..136		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147790
Domainoid	1	1.000	122	1.000	Domainoid score	I5645
eggNOG	1	0.900	-	-		E2759_KOG0034
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68099
Inparanoid	1	1.050	302	1.000	Inparanoid score	I2681
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53747
OrthoDB	1	1.010	-	-		D1271942at2759
OrthoFinder	1	1.000	-	-		FOG0000640
OrthoInspector	1	1.000	-	-		otm40388
orthoMCL	1	0.900	-	-		OOG6_101614
Panther	1	1.100	-	-	LDO	PTHR45942
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R164
SonicParanoid	1	1.000	-	-		X1796
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800