DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CanB2 and CHP1

DIOPT Version :9

Sequence 1:	NP_001246192.1	Gene:	CanB2 / 46456	FlyBaseID:	FBgn0015614	Length:	170	Species:	Drosophila melanogaster
Sequence 2:	NP_009167.1	Gene:	CHP1 / 11261	HGNCID:	17433	Length:	195	Species:	Homo sapiens

Alignment Length:	171	Identity:	70/171 - (40%)
Similarity:	98/171 - (57%)	Gaps:	15/171 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SNFDADEIRRLGKRFRKLDLDNSGALSVDEFMSLPELQQNPLVQRVIDIFDADGNGEVDFKEFIQ 77
            :.|...:|.||..||..||...:|.||.::|..:|||..|||..|:|:.|..:|..:|:|:.|::
Human    21 TGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAINPLGDRIINAFFPEGEDQVNFRGFMR 85

  Fly    78 GVSQF----------SVKG-----DKLSKLRFAFRIYDMDNDGYISNGELFQVLKMMVGNNLKDT 127
            .::.|          .|.|     .:.:||.||||:||:|.|..||..||.|||:||||.|:.|.
Human    86 TLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFRLYDLDKDEKISRDELLQVLRMMVGVNISDE 150

  Fly   128 QLQQIVDKTIGFADKDEDGKISFDEFCSVVGNTDIHKKMVV 168
            ||..|.|:||..||:|.|..|||.||..|:...|:.:||.:
Human   151 QLGSIADRTIQEADQDGDSAISFTEFVKVLEKVDVEQKMSI 191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CanB2	NP_001246192.1	FRQ1	13..154	CDD:227455	65/155 (42%)
CHP1	NP_009167.1	FRQ1	1..182	CDD:227455	67/160 (42%)
		Necessary for association with microtubule and interaction with GAPDH. /evidence=ECO:0000250	2..6
		Nuclear export signal 1. /evidence=ECO:0000250	138..147		6/8 (75%)
		Necessary for nuclear export signal	143..185		20/41 (49%)
		Nuclear export signal 2. /evidence=ECO:0000250	176..185		2/8 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0034
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53747
OrthoDB	1	1.010	-	-		D1271942at2759
OrthoFinder	1	1.000	-	-		FOG0000640
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830