DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYO5B and didum

DIOPT Version :9

Sequence 1:NP_001073936.1 Gene:MYO5B / 4645 HGNCID:7603 Length:1848 Species:Homo sapiens
Sequence 2:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster


Alignment Length:1915 Identity:745/1915 - (38%)
Similarity:1110/1915 - (57%) Gaps:193/1915 - (10%)


- Green bases have known domain annotations that are detailed below.


Human     6 LYSQCTRVWIPDPDEVWRSAELTKDYKEGDKSLQLRLEDETILEYPIDVQRNQLPFLRNPDILVG 70
            ||:|..::|:|..|.||.||.|.:.|::|...|::..:...:.|..:....:.||.||||.||||
  Fly     7 LYAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVG 71

Human    71 ENDLTALSYLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYTYSGQNMGDM 135
            :||||.|||||||.|||||:|||.|...|||||||:|||||||.::|:||..:|..|.|..|||:
  Fly    72 QNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDL 136

Human   136 DPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASETNIEEKVLASS 200
            :|||||:|||||.::.|:..|.||||||||||||||||||||||||.||||.|||.:|.||||||
  Fly   137 EPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLASS 201

Human   201 PIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYHII---GANMRTYLLEKSRVVFQADDERNYHIF 262
            |||||.||||||||||||||||:.::.|..:..::   ||.|.||||||||||:||..|||||||
  Fly   202 PIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIF 266

Human   263 YQLCAAAGLPEFKELALTSAEDFFYTSQGGDTSIEGVDDAEDFEKTRQAFTLLGVKESHQMSIFK 327
            ||||||..  ::.||.|...:.|.:.:.||...||.|.|||.|.:|.||.|:||........|.|
  Fly   267 YQLCAARS--KYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVK 329

Human   328 IIASILHLGSVAI-------QAERDGDSCSISPQDVYLSNFCRLLGVEHSQMEHWLCHRKLVTTS 385
            |:|.|||||::.:       ..|.|.|||.|...|::|.....||.|....:..||..||:.:.:
  Fly   330 ILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVN 394

Human   386 ETYVKTMSLQQVINARNALAKHIYAQLFGWIVEHINKALHTSLKQHSFIGVLDIYGFETFEVNSF 450
            |..:...|::....||:||||||||:||.:||..:||:|:...||.|||||||||||||||||||
  Fly   395 EYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSF 459

Human   451 EQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGILDLLDEECK 515
            |||||||||||||||||.||||||||||:||.|.||:||||||||||||||::||:||||||||:
  Fly   460 EQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRLGVLDLLDEECR 524

Human   516 VPKGTDQNWAQKLYDRHSSSQHFQKPRMSNTAFIIVHFADKVEYLSDGFLEKNRDTVYEEQINIL 580
            :|||:|::||.||..:.:...||:|||...|:|.|.||:|.|||..:||||||||||.:|...:|
  Fly   525 MPKGSDESWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVL 589

Human   581 KASKFPLVADLFHDDKDPVPATTPGKGSS--SKISVRSARPPM-------KVSNKEHKKTVGHQF 636
            ..|...|...:...::.........|.|:  .::.:.:.|...       .|.:|:|:||||.||
  Fly   590 SESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQF 654

Human   637 RTSLHLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWAYH 701
            :.||..|:.||:||||||||||||||:|:.|.::..:.:|||||||||||:||||||:||||.|.
  Fly   655 QESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYP 719

Human   702 DFFNRYRVLVKKRELANTDKKAICRSVLENLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRT 766
            ||:.||::||.:.:|...|.|..||:::...|:|.||::||.|:|||||||||:||::||:..:.
  Fly   720 DFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKK 784

Human   767 ATIMIQKTVRGWLQKVKYHRLKGATLTLQRYCRGHLARRLAEHLRRIRAAVVLQKHYRMQRARQA 831
            ...::|..||.::.:.::.|::.....:|::.||:|||...:.:|..||.::|.|:.|....|:.
  Fly   785 YITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKYARGWLCRRR 849

Human   832 YQRVRRAAVVIQAFTRAMFVRRTYRQVLMEHKATTIQKHVRGWMARRHFQRLRDAAIVIQCAFRM 896
            |.|:|.:...||.:.|.|..|..:..:...::|..||:.|||.:|||.:|:.|...|:.|.|.|.
  Fly   850 YLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRR 914

Human   897 LKARRELKALRIEARSAEHLKRLNVGMENKVVQLQRKIDEQNKEFKTLSEQLSVTTSTYTMEVER 961
            ..|||:.|.::.||::..|::...:|:|||::.:|::|||.|::...|..:      |..:.|.:
  Fly   915 FLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHK------TSEISVLK 973

Human   962 LKKELVHYQQSPGEDTSLRLQEE---VESLRTELQRAHSERKIL--EDAHSREKDELRKRVADLE 1021
            :|.||....::..::.....|::   :|:|..:|:....|:..|  |:.|::|:...:|:.  ..
  Fly   974 MKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQT--WR 1036

Human  1022 QENALLKDEKEQLNNQILCQSKDEFAQNSVKENLMKKELE--EERSRYQNLVKEYSQLEQRYDNL 1084
            |||    :|..:..::|:..:|:.......:|:.|..|::  |....||..:|:...:|.....|
  Fly  1037 QEN----EELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFML 1097

Human  1085 RDEMTIIKQTPG----HRRNPSNQSSL-ESDSNYPSI-STSEIGDTEDALQQVEEIGLEKAAMDM 1143
            ::|::  :.|.|    |.|..||.||. |.|..|.|. :|.:|....|.|.:      ..:..|.
  Fly  1098 KEELS--RLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSK------NYSYNDS 1154

Human  1144 T-VFLKLQKRVRELEQERKKLQVQLEKREQQDSKKVQAEPPQTDIDLDPNADLAYNSLKRQELES 1207
            | :.:||:..:.|.:|:.|.||.|..|...:..               |..|    |.:..|||.
  Fly  1155 TSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHK---------------PTED----SFRVSELEV 1200

Human  1208 ENKKLKNDLNELRKAVADQATQNNSSHGSPDSYSLLLNQLKLAH----EELEVRKEEVLILRTQI 1268
            ||:||:::.::||.::         .||      :.:|:|...|    ||:..|:||.:.|:..:
  Fly  1201 ENEKLRSEYDQLRTSI---------KHG------VEINELNAQHAALQEEVRRRREECIQLKAVL 1250

Human  1269 VSADQRRLAGRNAEP-NINARSSWPNSEKHVDQEDAIEAYHGVCQTNSKTEDWGYLNEDGELGLA 1332
            :...|   :.|:.|| ::..|.:        |..:.:||:|                        
  Fly  1251 LQQSQ---SMRSLEPESLQMRGN--------DVNELMEAFH------------------------ 1280

Human  1333 YQGLKQVARLLEAQLQAQSLEHEEEVEHLKAQLEALKEEMDKQQQTFCQTLLLSPEAQVEFGVQQ 1397
              ..|.:.|.||::|:|.:.||..::..:..::|.|..|.|:.|:...::               
  Fly  1281 --SQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFES--------------- 1328

Human  1398 EISRLTNENLDLKELVEKLEKNERKLKKQLK----IYMKKAQDLEAAQALAQSERK-----RHEL 1453
             |....:.|:|      .|.:|:|.|:::|:    .::...::|:.|.|..::.|:     .|::
  Fly  1329 -IDEFEDSNVD------TLRQNDRYLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKI 1386

Human  1454 NRQV---------------TVQRKEKDFQGMLEYHKEDEALLIRNLVTDLKPQMLSGTVPCLPAY 1503
            ..::               ..::|.::.||::::|..|...:::.|::.|.|:.:.|.:|..|||
  Fly  1387 EEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAY 1451

Human  1504 ILYMCIRHADYTNDDLKVHSLLTSTINGIKKVLKKHNDDFEMTSFWLSNTCRLLHCLKQYSGDEG 1568
            :::||||:.|.||.|..|..||:..:..||| :.:.....|....||.|:..||:.:|||...:.
  Fly  1452 LIFMCIRYTDLTNADDDVRELLSKFVIQIKK-MHRTPHPIENRVIWLVNSITLLNLMKQYGDVDE 1515

Human  1569 FMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGVLQPMIVSAMLENESIQGLSGV 1633
            ::..||.|||:..||||:|.|||:|:.||.:.:||.||...:|:|.|.||.|:|.|:.||  .|.
  Fly  1516 YVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQ--RGR 1578

Human  1634 KPTGYRKR-----SSSMADGDNSYCLEAIIRQMNAFHTVMCDQGLDPEIILQVFKQLFYMINAVT 1693
            :..|.|.|     :||..:.......:.:|.|:..|:......|||.....|:|.||.|.|.||.
  Fly  1579 QAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVA 1643

Human  1694 LNNLLLRKDVCSWSTGMQLRYNISQLEEWLRGRNLHQSGAVQTMEPLIQAAQLLQLKKKTQEDAE 1758
            ||.|:||.|:|.|.|||.:||||..:|:|:|.:.: .:..:..:.||.|.:|||| .:|:::|.:
  Fly  1644 LNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKM-SNDVLTALAPLNQVSQLLQ-SRKSEQDVQ 1706

Human  1759 AICSLCTSLSTQQIVKILNLYTPLNEFEERVTVAFI----RTIQAQLQERNDPQQLLLDAKHMFP 1819
            .||.|||||||.|::|::..| .|:::|..:|..|:    ..:.|:..::::..:..:|.|.:.|
  Fly  1707 TICDLCTSLSTAQVLKVMKSY-KLDDYESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQP 1770

Human  1820 VLFPFNPSSLTMDSIHIPACLNL-EFLNEV 1848
            ....|..|.:.::.|.:|:.||| |||.::
  Fly  1771 FKVVFRYSDIKLEDIELPSHLNLDEFLTKI 1800

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYO5BNP_001073936.1 Requires for interaction with LIMA1. /evidence=ECO:0000269|PubMed:29880681 21..40 8/18 (44%)
MYSc 64..760 CDD:214580 408/714 (57%)
MYSc_Myo5 83..749 CDD:276831 383/684 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 596..630 6/42 (14%)
Actin-binding. /evidence=ECO:0000255 640..662 16/21 (76%)
IQ 860..881 CDD:197470 9/20 (45%)
CCDC144C 895..1172 CDD:291576 76/290 (26%)
RILP-like <980..1080 CDD:304877 24/106 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1093..1123 14/35 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1166..1192 2/25 (8%)
Myo5b_CBD 1474..1845 CDD:271261 137/380 (36%)
didumNP_724569.1 MYSc 65..778 CDD:214580 408/714 (57%)
MYSc_Myo5 84..767 CDD:276831 383/684 (56%)
IQ 900..922 CDD:197470 8/21 (38%)
GBP_C <971..1086 CDD:303769 26/120 (22%)
coiled coil 1049..1068 CDD:293879 3/18 (17%)
coiled coil 1077..1086 CDD:293879 2/8 (25%)
JAKMIP_CC3 <1190..1299 CDD:292653 37/164 (23%)
Myo5_CBD 1424..1792 CDD:271254 133/373 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 766 1.000 Domainoid score I83
eggNOG 1 0.900 - - E2759_KOG0160
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1254 1.000 Inparanoid score I175
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52542
OrthoDB 1 1.010 - - D311886at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 1 1.100 - - LDO PTHR13140
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4210
SonicParanoid 1 1.000 - - X244
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.870

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