DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYO5B and d

DIOPT Version :9

Sequence 1:	NP_001073936.1	Gene:	MYO5B / 4645	HGNCID:	7603	Length:	1848	Species:	Homo sapiens
Sequence 2:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	797	Identity:	238/797 - (29%)
Similarity:	375/797 - (47%)	Gaps:	119/797 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    73 DLTALS-YLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQL--PIYGQDVIYTYSGQNMGD 134
            ||..|| .|.|.||:..|:.||.|..: :|..|.:|::||||..:  |:       |.:......
  Fly   477 DLIHLSGPLTEHAVMRTLQARFNERRY-FTNVGPILLSINPYLDVGNPL-------TLTSTRAMP 533

Human   135 MDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASETNIEEKVLAS 199
            :.|.:..:.:||.:|.:.....|:||:||.||||||.:|...:|....:.|...||:..:.:.|:
  Fly   534 LAPQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLRQLFAIAGGGPETDAFKHLAAA 598

Human   200 SPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYHIIGANMRT----YLLEKSRVVFQADDERNYH 260
            ..::.::|:||||.|..|||.|::|::....     ||..||    |.|:::||:.....|:|||
  Fly   599 FTVLRSLGSAKTTTNSESSRIGQFIEVQVTD-----GALYRTKIHCYFLDQTRVIRPLPKEKNYH 658

Human   261 IFYQLCAAAGLPEFKELALTSAEDFFYTSQGGDTSIEGVDDAEDFEKTRQAFTLLGVKESHQMSI 325
            |||||.|.....|.::|.|............||......:||..|:..:....:||:.   .:.:
  Fly   659 IFYQLLAGLSREERQKLHLDGYSPANLRYLRGDIGQNEQEDAARFQAWKTCLGILGIP---FLDV 720

Human   326 FKIIASILHLGSVAIQAERDGDSCSISPQ-DVYLSNFCRLLGVEHSQMEHWLCHRKLVTTSETYV 389
            .:::|::|.||:|..   .||....:..: :..|::...||||..:.:...|      ||....|
  Fly   721 VRVLAAVLLLGNVQF---IDGGGLEVDVKGETELNSVASLLGVPPAALFRGL------TTRTHNV 776

Human   390 KTMSLQQVIN------ARNALAKHIYAQLFGWIVEHIN--KALHTSL------------------ 428
            :...::.|..      .|:.|||.:|.:....||...|  |.|.::|
  Fly   777 RGQLVKSVCGDGDANMTRDCLAKALYCRTVATIVRRANSLKRLGSTLGTLSSDSNESVHNQADVA 841

Human   429 KQHS---------------------------FIGVLDIYGFETFEVNS-FEQFCINYANEKLQQQ 465
            .||:                           |||:||::|||....:: .|..|||...|.:|..
  Fly   842 SQHASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDMFGFEEPSPHAHLEHLCINLCAETMQHF 906

Human   466 FNSHVFKLEQEEYMKEQIPW-TLIDFYDNQPCIDLIEA-KLGILDLLDEECKVPKGTDQNWAQKL 528
            :|:|:||...|....|.|.. |.:|:.||.||||||.: :.|:|.:||.||.| :||.:::..||
  Fly   907 YNTHIFKSSVESCRDEGIVCDTEVDYVDNVPCIDLISSLRTGLLSMLDAECSV-RGTAESYVTKL 970

Human   529 YDRHSSSQHFQ--------KPRMSNTAFIIVHFADKVEYLSDGFLEKNRDTVYEEQINIL--KAS 583
            ..:|.||...:        .|||    |:|.|||.:|||.:..||:.|||.|.::.:.:.  ...
  Fly   971 KVQHRSSTRLETKPTAEPHDPRM----FLIRHFAGRVEYDTTDFLDTNRDVVPDDLVGVFYKHTC 1031

Human   584 KFPLVADLFHDDKDPVPATTPG-KGSSSKISVRSARPPMKVSNKEHKKTVGHQFRTSLHLLMETL 647
            .|.....||..:...:.|.... :|.|.:||..|...  .::..|...|:...|.|.|..|:.||
  Fly  1032 NFGFATHLFGSELKALYAQQQAPRGLSFRISPTSHSD--LLNGDEPVSTLTQDFHTRLDNLLRTL 1094

Human   648 NATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWAYHDFFNRYRVLVK 712
            ....||:||||:.|..:....||....|:|:|:..||||:.:.|:|:|.|..:..|..|||:|..
  Fly  1095 VHARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQVLETVNLMASGFPHRMRFKQFNARYRMLAP 1159

Human   713 KRELANTDKKAI--CRSVLENLIKDPD--------KFQFGRTKIFFRAGQVAYLEKLRAD-KFRT 766
            .|.|..::.||:  |:.:|:..::.|.        .:..|:..:|...|...:||.||.: :.::
  Fly  1160 FRLLRRSEDKALEDCQLILKYAMEQPPVLDGSVTLAWAPGKRHVFLSEGIRQHLEHLRTEIRHKS 1224

Human   767 ATIMIQKTVRGWLQKVK 783
            ||:| |.|.|||..:.|
  Fly  1225 ATLM-QATWRGWWWRKK 1240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYO5B	NP_001073936.1	Requires for interaction with LIMA1. /evidence=ECO:0000269\|PubMed:29880681	21..40
		MYSc	64..760	CDD:214580	227/771 (29%)
		MYSc_Myo5	83..749	CDD:276831	218/749 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..630		7/34 (21%)
		Actin-binding. /evidence=ECO:0000255	640..662		10/21 (48%)
		IQ	860..881	CDD:197470
		CCDC144C	895..1172	CDD:291576
		RILP-like	<980..1080	CDD:304877
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1093..1123
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1166..1192
		Myo5b_CBD	1474..1845	CDD:271261
d	NP_001188730.1	MYSc	476..1217	CDD:214580	227/771 (29%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	218/749 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820