DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYO5A and myo5aa

DIOPT Version :9

Sequence 1:	NP_001369277.1	Gene:	MYO5A / 4644	HGNCID:	7602	Length:	1904	Species:	Homo sapiens
Sequence 2:	XP_017207607.1	Gene:	myo5aa / 562188	ZFINID:	ZDB-GENE-041027-2	Length:	1854	Species:	Danio rerio

Alignment Length:	1881	Identity:	1473/1881 - (78%)
Similarity:	1643/1881 - (87%)	Gaps:	34/1881 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    27 LDETALKFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEEGKDLEYHLDPKTKELPHLRNPDI 91
            ||...:|:|||||||.||||:||||.|||:.||.||.|.||:|||||:.|||||..|||||||||
Zfish     5 LDFMFIKYARVWIPDDEEVWRSAELTKDYRQGDGVLQLQLEDGKDLEFKLDPKTNNLPHLRNPDI 69

Human    92 LVGENDLTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNM 156
            ||||||||||||||||||||||:||||||||||||||||||||||||.|||||.|||||||||||
Zfish    70 LVGENDLTALSYLHEPAVLHNLKVRFIDSKLIYTYCGIVLVAINPYETLPIYGADIINAYSGQNM 134

Human   157 GDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSASEANVEEKVL 221
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   135 GDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSASEANVEEKVL 199

Human   222 ASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIF 286
            |||||||||||||||||||||||||||||||||:|.||||||||||||||||||||:||||||||
Zfish   200 ASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKKYHIIGANMRTYLLEKSRVVFQADEERNYHIF 264

Human   287 YQLCASAKLPEFKMLRLGNADNFNYTKQGGSPVIEGVDDAKEMAHTRQACTLLGISESHQMGIFR 351
            |||||||.|||||.|:||.|::|:|||||.:|||:||||||||:.||.|..||||:||:|||:|:
Zfish   265 YQLCASAHLPEFKALKLGKANDFHYTKQGRNPVIDGVDDAKEMSTTRNAFILLGINESYQMGLFQ 329

Human   352 ILAGILHLGNVGFTSRDADSCTIPPKHEPLCIFCELMGVDYEEMCHWLCHRKLATATETYIKPIS 416
            |||.|||||||....||:||..|||.:..|.:|||||||.|::|.|||||:||.||||||||||.
Zfish   330 ILASILHLGNVDVKDRDSDSSIIPPNNGHLSVFCELMGVTYQDMSHWLCHKKLKTATETYIKPIP 394

Human   417 KLQATNARDALAKHIYAKLFNWIVDNVNQALHSAVKQHSFIGVLDIYGFETFEINSFEQFCINYA 481
            ||||.||||||||||||||||||||:||:||||.|||||||||||||||||||||||||||||||
Zfish   395 KLQAINARDALAKHIYAKLFNWIVDHVNKALHSTVKQHSFIGVLDIYGFETFEINSFEQFCINYA 459

Human   482 NEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESKLGILDLLDEECKMPKGTDDT 546
            |||||||||||||||||||||||||||||||||||||||||||:|:|||||||||||||||:||:
Zfish   460 NEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIEAKMGILDLLDEECKMPKGSDDS 524

Human   547 WAQKLYNTHLNKCALFEKPRLSNKAFIIQHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKM 611
            ||||||||||..||||||||:||||||||||||||||||:||||||||||.||||.|||:|||.:
Zfish   525 WAQKLYNTHLKTCALFEKPRMSNKAFIIQHFADKVEYQCDGFLEKNKDTVNEEQINVLKASKFDL 589

Human   612 LPELFQDDEKAISPTSAT--SSGRTPLTRTPAKPTKGRPGQMAKEHKKTVGHQFRNSLHLLMETL 674
            |.|||.|:|||.|||.|.  ..||   ||...||.||:..|.:||||||||.||||||.||||||
Zfish   590 LVELFHDEEKATSPTGAAPGPGGR---TRLSVKPDKGKSSQASKEHKKTVGLQFRNSLQLLMETL 651

Human   675 NATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMK 739
            |||||||||||||||:|..||||.|||||||||||||||||||||||||||||||||||||||||
Zfish   652 NATTPHYVRCIKPNDYKHAFTFDPKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMK 716

Human   740 QKDVLSDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGW 804
            |||||:|:|.|||||||||:.|.||||||||||||||||||||||||||||||||||||||||.|
Zfish   717 QKDVLTDKKMTCKNVLEKLVQDPDKYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRCW 781

Human   805 LLRKKYLRMRKAAITMQRYVRGYQARCYAKFLRRTKAATIIQKYWRMYVVRRRYKIRRAATIVLQ 869
            |.|||||||:.||.|:||:||||||||.|||||||:||.|||||.|||:.:..||.::||.:.:|
Zfish   782 LARKKYLRMKHAATTIQRFVRGYQARCLAKFLRRTRAAIIIQKYQRMYIQKTCYKRKQAAALAMQ 846

Human   870 SYLRGFLARNRYRKILREHKAVIIQKRVRGWLARTHYKRSMHAIIYLQCCFRRMMAKRELKKLKI 934
            ..||.::||..|:.:|||||||||||.|||||||..:|||:.||:|||||.|||.||||||||||
Zfish   847 CILRAYMARQLYKALLREHKAVIIQKMVRGWLARQWFKRSLKAIVYLQCCIRRMRAKRELKKLKI 911

Human   935 EARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLVEKLTNLEGIYNSETEKLRSDLERLQLSE 999
            ||||||.:|||:||||||||||||::|:|||:.:.:.|:|..||..:..|:|::|:::.||:.:|
Zfish   912 EARSVEHFKKLNIGMENKIMQLQRRIDDQNKENRSMSERLNTLETSHAVESERMRAEVTRLRGAE 976

Human  1000 EEAKVATGRVLSLQEEIAKLRKDLEQTRSEKKCIEEHADRYKQETEQLVSNLKEENTLLKQEKEA 1064
            |:||....:|.||.||:.:|||||:.|:.|||.||:.|..|:.|.|:::|.|||:|.|||.||..
Zfish   977 EDAKNNANKVTSLLEELERLRKDLQNTQKEKKAIEDWAQTYQDEMEKMISELKEQNQLLKTEKNN 1041

Human  1065 LNHRIVQQAKEMTETMEKKLVEETKQLELDLNDERLRYQNLLNEFSRLEERYDDLKEEMTLMVHV 1129
            ||..|.:|:::.|:.|::.|.|||:|||.|||:||.||||||.|..||||:|||||||:||.|:|
Zfish  1042 LNQLIQEQSQQWTDKMQRALKEETQQLENDLNEERSRYQNLLTEHLRLEEKYDDLKEEITLAVNV 1106

Human  1130 PKPGHKRTDSTHSSNESEYIFSSEIAEMEDIPSRTEEPSEKKVPLDMSLFLKLQKRVTELEQEKQ 1194
            |||||:||||||||||||..::||.||.|: .||..|...|.: |||||||||||||:|||||||
Zfish  1107 PKPGHRRTDSTHSSNESECTYNSEFAESEE-GSRVGEDVSKSI-LDMSLFLKLQKRVSELEQEKQ 1169

Human  1195 VMQDELDRKEEQVLRSKAK-EEERPQIRGAELEYESLKRQELESENKKLKNELNELRKALSEKSA 1258
            .:|:||||:|||..|::|: :||..:.|||||||||||||||||||||||::||::|::|.....
Zfish  1170 SLQNELDRREEQFQRARARDDEEHKKARGAELEYESLKRQELESENKKLKHDLNQMRQSLRGSVE 1234

Human  1259 PEVTAPGAPAYRVLMEQLTSVSEELDVRKEEVLILRSQLVSQKEAIQPKDDKNTMTDSTILLEDV 1323
            ....|||:|||.||::||.:.:|||:|||||||||||||||||||:|.||:|.|||:....:|||
Zfish  1235 AGSGAPGSPAYTVLLDQLNASNEELEVRKEEVLILRSQLVSQKEAMQHKDEKTTMTEPLPYIEDV 1299

Human  1324 QKMKDKGEIAQAYIGLKETNRSSALDYHELNEDGELWLVYEGLKQANRLLESQLQSQKRSHENEA 1388
            ||:.|..||:|||:|||:||||...|||:|||||||||||||||:.|||||||||:|:|||:||.
Zfish  1300 QKLTDAKEISQAYMGLKDTNRSPFPDYHKLNEDGELWLVYEGLKETNRLLESQLQAQRRSHDNEV 1364

Human  1389 EALRGEIQSLKEENNRQQQLLAQNLQLPPEARIEASLQHEITRLTNENLYFEELYADDPKKYQSY 1453
            |.||||:.|||||||||||||||||||||||||||||||||||||||||
Zfish  1365 EVLRGELHSLKEENNRQQQLLAQNLQLPPEARIEASLQHEITRLTNENL---------------- 1413

Human  1454 RISLYKRMIDLMEQLEKQDKTVRKLKKQLKVFAKKIGELEVGQMENISPGQIIDEPIRPVNIPRK 1518
                     |||||||||||||||||||||||||||.:||.|||: :||||..|||:.||||||:
Zfish  1414 ---------DLMEQLEKQDKTVRKLKKQLKVFAKKINDLEGGQMD-VSPGQTADEPVHPVNIPRR 1468

Human  1519 EKDFQGMLEYKKEDEQKLVKNLILELKPRGVAVNLIPGLPAYILFMCVRHADYLNDDQKVRSLLT 1583
            |||||||||||||||.|||||:|||||||||||||||||||||||||:|||||:|||||||||||
Zfish  1469 EKDFQGMLEYKKEDELKLVKNIILELKPRGVAVNLIPGLPAYILFMCLRHADYINDDQKVRSLLT 1533

Human  1584 STINSIKKVLKKRGDDFETVSFWLSNTCRFLHCLKQYSGEEGFMKHNTSRQNEHCLTNFDLAEYR 1648
            |.||||||:|||||||||||||||:||||||||||||||:|.|||||:.:||||||:||||||||
Zfish  1534 SVINSIKKILKKRGDDFETVSFWLANTCRFLHCLKQYSGDEQFMKHNSPKQNEHCLSNFDLAEYR 1598

Human  1649 QVLSDLAIQIYQQLVRVLENILQPMIVSGMLEHETIQGVSGVKPTGLRKRTSSIADEGTYTLDSI 1713
            ||||||||||||||::.:|||||||||||||||||||||||||||||||||||||||||||||||
Zfish  1599 QVLSDLAIQIYQQLIKCMENILQPMIVSGMLEHETIQGVSGVKPTGLRKRTSSIADEGTYTLDSI 1663

Human  1714 LRQLNSFHSVMCQHGMDPELIKQVVKQMFYIIGAITLNNLLLRKDMCSWSKGMQIRYNVSQLEEW 1778
            :||||:|||:||.||.|||||||||||.||||||:||||||||||||||||||||||||||||||
Zfish  1664 IRQLNTFHSIMCHHGTDPELIKQVVKQQFYIIGAVTLNNLLLRKDMCSWSKGMQIRYNVSQLEEW 1728

Human  1779 LRDKNLMNSGAKETLEPLIQAAQLLQVKKKTDDDAEAICSMCNALTTAQIVKVLNLYTPVNEFEE 1843
            |||||||..|||||||||||||||||||||||:||||||||||||:|||||||||||||||.|||
Zfish  1729 LRDKNLMTCGAKETLEPLIQAAQLLQVKKKTDEDAEAICSMCNALSTAQIVKVLNLYTPVNAFEE 1793

Human  1844 RVSVSFIRTIQMRLRDRKDSPQLLMDAKHIFPVTFPFNPSSLALETIQIPASLGLGFISRV 1904
            ||||.||||||.||||||:|||||||.|.|:|||||||||||||||||||:||.|.|::||
Zfish  1794 RVSVLFIRTIQTRLRDRKESPQLLMDTKLIYPVTFPFNPSSLALETIQIPSSLNLAFLTRV 1854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYO5A	NP_001369277.1	COG5022	35..1472	CDD:227355	1087/1439 (76%)
		MYSc_Myo5	107..775	CDD:276831	572/669 (86%)
		Myo5a_CBD	1530..1904	CDD:271262	333/373 (89%)
myo5aa	XP_017207607.1	MYSc_Myo5	85..752	CDD:276831	572/669 (86%)
		IQ	766..787	CDD:197470	18/20 (90%)
		IQ	789..811	CDD:197470	15/21 (71%)
		SMC_N	<920..1279	CDD:330553	217/360 (60%)
		SMC_N	<1156..>1445	CDD:330553	216/313 (69%)
		Myo5a_CBD	1480..1854	CDD:271262	333/373 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194329303
Domainoid	1	1.000	1181	1.000	Domainoid score	I255
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20100
Inparanoid	1	1.050	2905	1.000	Inparanoid score	I173
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG52542
OrthoDB	1	1.010	-	-		D19269at7742
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		oto43028
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	LDO	PTHR13140
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4210
SonicParanoid	1	1.000	-	-		X244
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	17	17.440