DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYO5A and didum

DIOPT Version :9

Sequence 1:NP_001369277.1 Gene:MYO5A / 4644 HGNCID:7602 Length:1904 Species:Homo sapiens
Sequence 2:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster


Alignment Length:1933 Identity:764/1933 - (39%)
Similarity:1115/1933 - (57%) Gaps:207/1933 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    35 ARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEEGKDLEYHLDPKTKELPHLRNPDILVGENDLT 99
            |::|:|..:.||:||.|.:.|:.|...|.:..:.||..|..|.....:||.||||.||||:||||
  Fly    12 AKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLT 76

Human   100 ALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIF 164
            .|||||||.|||||||||.:.::|||||||:|||||||.::|:||..||.||.|..|||::||||
  Fly    77 TLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIF 141

Human   165 AVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSASEANVEEKVLASNPIMES 229
            |:|||||.::.|:..|.||||||||||||||||||||||||.|.||.||..||.|||||:||||:
  Fly   142 ALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLASSPIMEA 206

Human   230 IGNAKTTRNDNSSRFGKYIEIGFDKRYRII---GANMRTYLLEKSRVVFQAEEERNYHIFYQLCA 291
            .||||||||||||||||:.::.|..:..::   ||.|.||||||||||:||:.||||||||||||
  Fly   207 FGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCA 271

Human   292 S-AKLPEFKMLRLGNADNFNYTKQGGSPVIEGVDDAKEMAHTRQACTLLGISESHQMGIFRILAG 355
            : :|.||   |.|.:.|.|.:...||:|.||.|.||::...|.||.|:||.|......|.:||||
  Fly   272 ARSKYPE---LVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAG 333

Human   356 ILHLGNV--------GFTSRDADSCTIPPKHEPLCIFCELMGVDYEEMCHWLCHRKLATATETYI 412
            ||||||:        |....|:|||.|......|.|..:|:.|..:::..||..||:.:..|..:
  Fly   334 ILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYVL 398

Human   413 KPISKLQATNARDALAKHIYAKLFNWIVDNVNQALHSAVKQHSFIGVLDIYGFETFEINSFEQFC 477
            .|.|...|..||||||||||||||.:||..:|::|::..||.|||||||||||||||:|||||||
  Fly   399 IPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQFC 463

Human   478 INYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESKLGILDLLDEECKMPKG 542
            |||||||||||||.||||||||||:||.|.||:||||||||||:||||:||:||||||||:||||
  Fly   464 INYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRLGVLDLLDEECRMPKG 528

Human   543 TDDTWAQKLYNTHLNKCALFEKPRLSNKAFIIQHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSS 607
            :|::||.||.. ..||...|||||....:|.|:||:|.|||...||||||:|||.:|..:||..|
  Fly   529 SDESWAGKLIG-KCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSES 592

Human   608 KF---KMLPELFQDDEKAI-SPTSATSSGRTPLT---RTPAKPTKGR--PGQMAKEHKKTVGHQF 663
            ..   |.:..|.:.|...: |..|:|..||..::   :.....|:.|  |   :|:|:||||.||
  Fly   593 NMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVP---SKQHRKTVGSQF 654

Human   664 RNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQ 728
            :.||..|:.||:||||||||||||||.|..|.::..:.:|||||||||||:|||||||||||.|.
  Fly   655 QESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYP 719

Human   729 EFFSRYRVLM-KQKDVLSDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRA 792
            :|:.||::|: :.|...:|.|.:|:|::.|.|.|:|||:||.|:|||||||||:||::||:..:.
  Fly   720 DFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKK 784

Human   793 ACIRIQKTIRGWLLRKKYLRMRKAAITMQRYVRGYQARCYAKFLRRTKAATIIQKYWRMYVVRRR 857
            ....:|..:|.::.|:::||::|....:|::.|||.||...:.:|..:|..|:.||.|.::.|||
  Fly   785 YITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKYARGWLCRRR 849

Human   858 YKIRRAATIVLQSYLRGFLARNRYRKILREHKAVIIQKRVRGWLARTHYKRSMHAIIYLQCCFRR 922
            |...|.:...:|:|.||.||||::..:...::||.||:.|||.|||..|::....||..|...||
  Fly   850 YLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRR 914

Human   923 MMAKRELKKLKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLVEKLTNLEGIYNSETEK 987
            .:|:|:.|::|.||:::...:..::|:||||:.:|:::||.|:|...|..|        .||...
  Fly   915 FLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHK--------TSEISV 971

Human   988 LRSDLERLQLSEEEAKVATGRVLSLQEEIAKLRKDLEQTRSEK-KCIEE--HADR--------YK 1041
            |:..||..:..|.|.|..........:.|..|.|.||..|.|| :.:||  ||..        ::
  Fly   972 LKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWR 1036

Human  1042 QETEQLVSNLKEENTLLKQEKEALNHRIVQQAKEMTETMEKKLVEETKQLELDLNDERLRYQNLL 1106
            ||.|:|...:.|               |:..||  ...:.::..|:....|:|..:....||..:
  Fly  1037 QENEELRRQIDE---------------IIDMAK--NAEVNQRNQEDRMLAEIDNRELNEAYQRAI 1084

Human  1107 NEFSRLEERYDDLKEEMTLMVHVPKPGHKRTDSTHSS-NESEYIFSS-----EIAEMEDIPSRTE 1165
            .:...:|.....||||::.:.......|.|..|..|| ||.:..::|     :|....|:.|:..
  Fly  1085 KDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSKNY 1149

Human  1166 EPSEKKVPLDMSLFLKLQKRVTELEQEKQVMQDELDRKEEQVLRSKAKEEERPQIRGAELEYESL 1230
            ..::     ..||.:||:..:.|.:|:.:|:|::..:     |.|:.|..|           :|.
  Fly  1150 SYND-----STSLVVKLRSILEEEKQKHKVLQEQYIK-----LSSRHKPTE-----------DSF 1193

Human  1231 KRQELESENKKLKNELNELRKALSEKSAPEVTAPGAPAYRVLMEQLTSVSEELDVRKEEVLILRS 1295
            :..|||.||:||::|.::||.::  |...|:..        |..|..::.||:..|:||.:.|::
  Fly  1194 RVSELEVENEKLRSEYDQLRTSI--KHGVEINE--------LNAQHAALQEEVRRRREECIQLKA 1248

Human  1296 QLVSQKEAIQPKDDKNTMTDSTILLEDVQKMKDKGEIAQAYIGLKETNRSSALDYHELNEDGELW 1360
            .|:.|.::::..:.              :.::.:|                       |:..||.
  Fly  1249 VLLQQSQSMRSLEP--------------ESLQMRG-----------------------NDVNELM 1276

Human  1361 LVYEGLKQANRLLESQLQSQKRSHENEAEALRGEIQSLKEENNRQQQLLAQNLQLPPEARIEASL 1425
            ..:...|..||.|||:|::....|.::...:..||:.|..|.:..|:::.:::.           
  Fly  1277 EAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESID----------- 1330

Human  1426 QHEITRLTNENLYFEELYADDPKKYQSYRISLYKRMIDLMEQLEKQDKTVRKLKKQLKVFAKKIG 1490
                        .||:...|..::...|          |..:|:|.......::::||:...|:.
  Fly  1331 ------------EFEDSNVDTLRQNDRY----------LRRELQKAVAQFLLVQEELKLANAKLK 1373

Human  1491 --ELEVGQMENISPGQIIDEPIR----------PVNIPR-KEKDFQGMLEYKKEDEQKLVKNLIL 1542
              ..:.||:|:    :|.:|.||          ..|:.: |.::.||::::...|..|:::.|:.
  Fly  1374 AYRQDGGQLEH----KIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLS 1434

Human  1543 ELKPRGVAVNLIPGLPAYILFMCVRHADYLNDDQKVRSLLTSTINSIKKVLKKRGDDFETVSFWL 1607
            .|.||.| |.|:||.|||::|||:|:.|..|.|..||.||:..:..||| :.:.....|....||
  Fly  1435 ALTPRTV-VGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKK-MHRTPHPIENRVIWL 1497

Human  1608 SNTCRFLHCLKQYSGEEGFMKHNTSRQNEHCLTNFDLAEYRQVLSDLAIQIYQQLVRVLENILQP 1672
            .|:...|:.:|||...:.::|.||.:||:..|.||:|.|||:|:.||.:.:||.|:..::.:|.|
  Fly  1498 VNSITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDP 1562

Human  1673 MIVSGMLEHETIQGVSGVKPTGLRKRTSSIADE------GTYTLDSILRQLNSFHSVMCQHGMDP 1731
            .||..:|.::.||  .|.:..|:|.|.:||...      |......::.||..|:......|:|.
  Fly  1563 KIVPAILNNDEIQ--RGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDN 1625

Human  1732 ELIKQVVKQMFYIIGAITLNNLLLRKDMCSWSKGMQIRYNVSQLEEWLRDKNLMNSGAKETLEPL 1796
            ...:|:..|:.|.|.|:.||.|:||.|:|.|..||.||||:..:|:|:|.|.:.|. ....|.||
  Fly  1626 CYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSND-VLTALAPL 1689

Human  1797 IQAAQLLQVKKKTDDDAEAICSMCNALTTAQIVKVLNLYTPVNEFEERVSVSFIRTIQMRLRDRK 1861
            .|.:|||| .:|::.|.:.||.:|.:|:|||::||:..| .::::|..::..|:..:..:|..|:
  Fly  1690 NQVSQLLQ-SRKSEQDVQTICDLCTSLSTAQVLKVMKSY-KLDDYESEITNVFLEKLTEKLNARQ 1752

Human  1862 ----DSPQLLMDAKHIFPVTFPFNPSSLALETIQIPASLGLG-FISRV 1904
                :|.:..:|.|.|.|....|..|.:.||.|::|:.|.|. |::::
  Fly  1753 MQKSNSDEFTIDQKFIQPFKVVFRYSDIKLEDIELPSHLNLDEFLTKI 1800

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYO5ANP_001369277.1 COG5022 35..1472 CDD:227355 615/1475 (42%)
MYSc_Myo5 107..775 CDD:276831 396/689 (57%)
Myo5a_CBD 1530..1904 CDD:271262 135/384 (35%)
didumNP_724569.1 MYSc 65..778 CDD:214580 421/719 (59%)
MYSc_Myo5 84..767 CDD:276831 396/689 (57%)
IQ 900..922 CDD:197470 7/21 (33%)
GBP_C <971..1086 CDD:303769 31/131 (24%)
coiled coil 1049..1068 CDD:293879 4/20 (20%)
coiled coil 1077..1086 CDD:293879 2/8 (25%)
JAKMIP_CC3 <1190..1299 CDD:292653 35/166 (21%)
Myo5_CBD 1424..1792 CDD:271254 132/374 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 766 1.000 Domainoid score I83
eggNOG 1 0.900 - - E2759_KOG0160
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20100
Inparanoid 1 1.050 1254 1.000 Inparanoid score I175
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52542
OrthoDB 1 1.010 - - D311886at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 1 1.000 - - otm41050
orthoMCL 1 0.900 - - OOG6_100101
Panther 1 1.100 - - O PTHR13140
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4210
SonicParanoid 1 1.000 - - X244
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.870

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