Protein Alignment MYO5A and hum-2

DIOPT Version :9

• Sequence 1: NP_001369277.1
• Gene: MYO5A / 4644
• HGNCID: 7602
• Length: 1904
• Species: Homo sapiens
• Sequence 2: NP_001317742.1
• Gene: hum-2 / 179321
• WormBaseID: WBGene00002036
• Length: 1811
• Species: Caenorhabditis elegans
• Alignment Length: 1942
• Identity: 718/1942 - (36%)
• Similarity: 1054/1942 - (54%)
• Gaps: 221/1942 - (11%)

Human    33 KFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEEGKDLEYHLDPKTKELPHLRNPDILVGEND 97
            |..|:|...|..||..|.|.:|.....:.:.:.||:..::||.: ....:||.||||..|||::|
 Worm    20 KGVRIWHRHPTLVWIGATLEEDITFQTRNVRIRLEDDTEVEYAI-KSLDQLPFLRNPAFLVGKDD 83

Human    98 LTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLP-IYGEDIINAY--SGQNMGDM 159
            ||.|||||||||||||:|||:....|||||||||||||||.... ||||:||..|  :|::..:|
 Worm    84 LTLLSYLHEPAVLHNLQVRFVKGSSIYTYCGIVLVAINPYADCSHIYGEEIIQVYRGAGKSAREM 148

Human   160 DPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSASE----ANVEEKV 220
            |||||||||||:..|....::||||||||||||||||||:.|||.|:|:.|.:.    .::|.:|
 Worm   149 DPHIFAVAEEAHFDMGAFGKSQSIIVSGESGAGKTVSAKFVMRYLASVAASKTRNGGTTSIEARV 213

Human   221 LASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKR-YRIIGANMRTYLLEKSRVVFQAEEERNYH 284
            |||||||||||||||.||||||||||:|:|.|.:| .||:||.|:||||||||:||||..|||||
 Worm   214 LASNPIMESIGNAKTIRNDNSSRFGKFIQINFCERGRRIVGAEMKTYLLEKSRLVFQAPGERNYH 278

Human   285 IFYQLCASAKLPEFKMLRLGNADNFNYTKQGGSPVIEGVDDAKEMAHTRQACTLLGISESHQMGI 349
            |||||||:......|.|.||..::::|..|||...|.||||..:.....:|..|||..|.....:
 Worm   279 IFYQLCAARNHQVLKDLHLGPCESYSYLTQGGDSRIPGVDDKADFEALLKALQLLGFDEKQMSDV 343

Human   350 FRILAGILHLGNVGFTSRDADSCTIPPKHEPLCIFC-ELMGVDYEEMCHWLCHRKLATATETYIK 413
            ||:|||:|.||||.|.:.:..|.......:.:...| |...:...::..||..|::....|...|
 Worm   344 FRLLAGLLLLGNVHFENGEGSSAVSASSCQEISRLCREFWKISESDLRIWLTRREIRAVNEIVTK 408

Human   414 PISKLQATNARDALAKHIYAKLFNWIVDNVNQALHSAVK---------QHSFIGVLDIYGFETFE 469
            |::|.:|..:||||.|.:|:.||.|:||.:|:||:...|         ...|||||||||||||:
 Worm   409 PLTKNEAVRSRDALTKMLYSHLFGWLVDKINEALNEKDKLDGTNQKKRPDRFIGVLDIYGFETFD 473

Human   470 INSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESKLGILDLLD 534
            :||||||.|||||||||||||.||||||||||::|:|.|..:||:||||.|:|||..:|:::|||
 Worm   474 VNSFEQFSINYANEKLQQQFNQHVFKLEQEEYIREEIEWVRVDFHDNQPAIDLIEGPVGMINLLD 538

Human   535 EECKMPKGTDDTWAQKLYN-THLNKCALFEKPRLSNKAFIIQHFADKVEYQCEGFLEKNKDTVFE 598
            |:||...|:|..|..:|.| |.|.:......|::.:..||::|||..|.|..:||:|||:|.:.|
 Worm   539 EQCKRLNGSDADWLSQLQNSTELKRNPQLAFPKVRSNDFIVRHFAADVTYSTDGFVEKNRDAIGE 603

Human   599 EQIKVLKSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRTPAKPTKGRPGQMAKEHKKTVGHQF 663
            :.:.|:.:|||..:..:.    .:.:|||.:||..   :.||.|.|          .||||..||
 Worm   604 QLLDVVVASKFPFIRTVI----GSTAPTSVSSSSS---SSTPGKRT----------IKKTVASQF 651

Human   664 RNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQ 728
            |:||..||..|.:|.|||||||||||.|..|.|:.|||:|||||||||||:||||||||||:.|:
 Worm   652 RDSLKELMSVLCSTRPHYVRCIKPNDSKISFDFEPKRAIQQLRACGVLETVRISAAGFPSRYPYE 716

Human   729 EFFSRYRVL-MKQKDVLSDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRA 792
            ||..||||: .|:..:..|:.:....:..:..|::.||..||||||.|.||||.||::|.|.|.|
 Worm   717 EFARRYRVIYTKEAALWRDKPKQFAELACQQCLEEGKYAVGKTKIFLRTGQVAVLERVRLDTLAA 781

Human   793 ACIRIQKTIRGWLLRKKYLRMRKAAITMQRYVRGYQARCYAKFLRRTKAATIIQKYWRMYVVRRR 857
            |...|||..:|:|.|:||..||::.:.:|..::.:.|....|:|:..:|..::|...|.|:.||:
 Worm   782 AATVIQKMWKGFLARRKYETMRRSLLIVQASLKAFLAFRRIKYLQMHRAVIVMQSAVRGYLERRK 846

Human   858 YKIRRAATIVLQSYLRGFLARNRYRKILREHKAVIIQKRVRGWLARTHYKRSMHAIIYLQCCFRR 922
            |:..|.:.|.:|:..:....|....|:..|..|:.||...||:|||.....:...::.:||..|:
 Worm   847 YEQIRDSIIGIQAMFKANRVRRYVEKLRYEKSAITIQAAWRGYLARREQIANRKKVVMVQCAVRK 911

Human   923 MMAKRELKKLKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLVEKLTNLEGIYNSETEK 987
            .:|||.|::||||||||...:||:.|:||||::||.::|..|...|...||....    :...:|
 Worm   912 WLAKRRLRELKIEARSVGHLQKLNTGLENKIIELQMRLDIANARTKEEAEKFATA----SKNLQK 972

Human   988 LRSDL-----ERLQLSEEEAKVATGRVLSLQEEIAKLRKDLEQTRSEKKCIEEHADRYKQETE-- 1045
            .::||     |||.|.|     |..||..||||:.:|         |.:|..:.|.|...||:
 Worm   973 TKADLAMMEAERLTLLE-----ARNRVEVLQEEVERL---------ETECDLKEAQRGGMETKMV 1023

Human  1046 QLVSNLKEENTLLKQEKEALNHRIVQQAKEMTETMEKKLV------EETKQLELDLNDERLRYQN 1104
            :|.|.|.:    .:.:.|:     .|...|:||.:||...      ||.:::|..||.||.....
 Worm  1024 ELQSRLDQ----FQMQSES-----GQTIVELTEQLEKAKADRVLWDEERQRMEAALNTERSARNA 1079

Human  1105 LLNEFSRLEE---RYDDLKEEMTLMVHVPKPGHK--RTD---STHSSNESEYIFSSEIAEMEDIP 1161
            |..|.:.:.|   :..||.|..|..   .:|..|  |.|   |..:||.|:...|.....:..:.
 Worm  1080 LDAEMAAMREQLMKNVDLFESSTFQ---KRPSQKKNRDDDSCSRTTSNLSQLTGSFTAETINGVH 1141

Human  1162 SRTEEPSEKKVPLDMSLFLKLQKRVTELEQEKQVMQDELDRKEEQVLRSKAKE--EERPQIRGAE 1224
            |.:....|..:....|.|.:| :.:.:|.|..:..|.|.:|.:..:..|...|  :::..::.
 Worm  1142 STSRGSPEVLLDNMASTFEQL-RMINDLRQRNEHCQRETERMKAIIEASTLIETLDKKTSLKA-- 1203

Human  1225 LEYESLKRQELESENKKLKNELNELRKALSEKSAPEVTAPGAPAYRVLMEQLTSVSEELDVRKEE 1289
              :||::..|||....:|||::..|           |:......:.| .|::...:|.|   :||
 Worm  1204 --FESIRVGELEGAYNRLKNDMERL-----------VSGENGATHSV-FERIMEENERL---REE 1251

Human  1290 VLILRSQLVSQKEAIQPKDDKNTMTDSTILLEDVQKMKDKGEIAQAYIGLKETNRSSALDYHELN 1354
            .:.|||.|.|..|       |.::..|:......:  .|.|..:    |....:.||..|   |.
 Worm  1252 AVELRSMLSSHFE-------KQSVAGSSGYRRSPR--PDSGHCS----GADSEDGSSGAD---LE 1300

Human  1355 EDGELWLVYEGLKQANRLLESQLQSQKRSHENEAEALRGEIQSLKEENNRQQQLL---AQNLQLP 1416
            ||              ..:|.|.:..|...||..:.|..  |:|:.| ..||||.   :|.:..|
 Worm  1301 ED--------------LCIERQCRHLKNLAENLTKMLTN--QNLEIE-RLQQQLRFSESQTVFRP 1348

Human  1417 PEARIEASLQ--HEITRLTNENLYFEELYADDPKKYQSYRISLYKRMIDLMEQLEKQDKTVRKLK 1479
            .:..::.:::  |:.|:|                        |.::.:||.::|.:|.:.:.:.:
 Worm  1349 SDCSLDEAVRGAHKQTQL------------------------LAQQNMDLNDKLTRQSEELAEAR 1389

Human  1480 KQLKVFAKKIGELEVGQMENISPGQIIDEPIRPVNIPRKEK---DFQGMLEYKKEDEQKLVKNLI 1541
            .||:.::..:|      :||.|     ||.|  :.:...||   ...|.||.....|  ..:.::
 Worm  1390 AQLRGYSGPLG------LENAS-----DEEI--IRLEAFEKGSIKHSGFLEVYNVPE--FARIIV 1439

Human  1542 LELKPRGVAVNLIPGLPAYILFMCVRHADYLNDDQKVRSLLTSTINSIKKVLK---KRGDDFETV 1603
            .||||. :|..|...||||:|....|:    :|:::..:.||...:|:..|||   .|..|.:.:
 Worm  1440 CELKPT-LARLLTKNLPAYLLVAAFRN----HDEKRDETALTGLFSSVHLVLKDTISRSHDLDLL 1499

Human  1604 SFWLSNTCRFLHCLKQYSGEEG---FMKHNTSRQNEHCLTNFDLAEYRQVLSDLAIQIYQQLV-R 1664
            |.||.|..|..:.|:|||||:.   :...||..||.:....:|:|..|..|.....:.|..|: :
 Worm  1500 SLWLVNLWRLFNLLRQYSGEDSQPEWHVANTETQNSYRFKAYDVAPIRDQLKLRIEECYTSLMKK 1564

Human  1665 VLENILQPMIVSGMLEHETIQGVSGVKPTG--LRKRTSSIADEGTYTLDSILRQLNSFHSVMCQH 1727
            .:|::|.|.||.|:|:||:   .|.:...|  .|.|.|...:....:||.:|:.:...|:.:..:
 Worm  1565 AIEHVLSPKIVPGILQHES---SSDLMTAGQERRDRNSGSVESQRKSLDDLLQFMEIVHTKLTTY 1626

Human  1728 GMDPELIKQVVKQMFYIIGAITLNNLLLRKDMCSWSKGMQIRYNVSQLEEWLRDKNLMNSGAKET 1792
            |.|..::|||:.||...:.|:.||.::.|:::|::.|.:||::||:|::.||..|.|  |..::.
 Worm  1627 GGDDIVVKQVIGQMARWMCALALNYMMFRRELCNFEKAIQIKHNVTQIQNWLNAKGL--SDCRDH 1689

Human  1793 LEPLIQAAQLLQVKKKTDDDAEAIC-SMCNALTTAQIVKVLNLYTPVNEFEERVSVSFIRTIQMR 1856
            .|||:||..||| .:|...:.:.:| .|.:.|...|:|.:|..|.|.:|.|:.:|..|:..||.:
 Worm  1690 FEPLVQACHLLQ-SRKDPSNLDTLCGEMTSRLKPRQVVAILQHYDPSDEMEDGLSPEFLVQIQKK 1753

Human  1857 LRDR--------KDSPQLLMDAKHIFPV-TFPFNPSSLALETIQIPASLGLGFISRV 1904
            |.:|        :|..:|:|...::.|. |.||:.|...|||:.:|:.|.:..:.|:
 Worm  1754 LNERAIANNDPIEDKDKLIMLGTYLPPFDTQPFSYSDFPLETLSLPSCLHMQSVCRL 1810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO5A	NP_001369277.1	COG5022	35..1472	CDD:227355	579/1484 (39%)
		MYSc_Myo5	107..775	CDD:276831	351/687 (51%)
		Myo5a_CBD	1530..1904	CDD:271262	122/392 (31%)
hum-2	NP_001317742.1	MYSc_Myo5	93..764	CDD:276831	351/687 (51%)
		IQ	779..799	CDD:197470	9/19 (47%)
		IQ	826..847	CDD:197470	6/20 (30%)
		CCDC158	<864..1473	CDD:318193	191/735 (26%)
		Myo5_CBD	1429..1803	CDD:271254	121/386 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	661	1.000	Domainoid score	I76
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20100
Inparanoid	1	1.050	1036	1.000	Inparanoid score	I140
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52542
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm16538
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	O	PTHR13140
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4210
SonicParanoid	1	1.000	-	-		X244
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	14.010