DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYO1E and didum

DIOPT Version :9

Sequence 1:NP_004989.2 Gene:MYO1E / 4643 HGNCID:7599 Length:1108 Species:Homo sapiens
Sequence 2:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster


Alignment Length:1276 Identity:344/1276 - (26%)
Similarity:594/1276 - (46%) Gaps:282/1276 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    20 GVDDMVLLSKITENSIVENLKKRYMD-DYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQGAAQYE 83
            |.:|:..||.:.|..::.||:.|:.: ..|:||.|.:|:::||:.:||.:|...|..|:|.|..:
  Fly    71 GQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGD 135

Human    84 NPPHIYALADNMYRNMIIDRENQC---VIISGESGAGKTVAAKYIMSYISRVSGGGTKVQHVKDI 145
            ..|||:|||:..|..  ::||| |   :|:||||||||||:|||.|.|.:.|.|..::.| |:..
  Fly   136 LEPHIFALAEEAYTK--LEREN-CNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQ-VERK 196

Human   146 ILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQF-SPGGEP--DGGKISNFLLEKSRVVMRNPGER 207
            :|.|:|::||||||||.||:|||||||:.::.| :..|..  .|..:..:||||||||.:..|||
  Fly   197 VLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGER 261

Human   208 SFHIFYQLIEGASAEQKH-SLGITSMDYYYYLSLSGSYKVDDIDDRREFQETLHAMNVIGIFAEE 271
            ::||||||   .:|..|: .|.:...|.:.:|::.|:.:::.:.|..:|.||:.||.|:|...::
  Fly   262 NYHIFYQL---CAARSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQ 323

Human   272 QTLVLQIVAGILHLGNISFKEVGNYAAVESEE----------FLAFPAYLLGINQDRLKEKLTSR 326
            ...:::|:|||||||||...:..|..:.|.:.          .|...|.||.::.|.|:..|..|
  Fly   324 IADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMR 388

Human   327 QMDSKWGGKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEKDHEEYN-IGVLDIY 390
            :::|    .:|.:.:..::|.|...||||||.::|::|.::|..:||::....::.: |||||||
  Fly   389 KIES----VNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIY 449

Human   391 GFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKVN 455
            |||.|:.|.|||||||:.||||||.|.:...|.|||||::|||.||.|::::|:...||||::: 
  Fly   450 GFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRL- 513

Human   456 PPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHFNSWNQG---FIIHHYAGKVSYDMDG 517
              |::.:||:.|    .:.:|:|::...||..:.....||.....|   |.|.|::..|.||::|
  Fly   514 --GVLDLLDEEC----RMPKGSDESWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNG 572

Human   518 FCERNRDVLFMDLIELMQSSELPFIKSLFP----ENLQADKKGRPTTAGSKI------KKQAND- 571
            |.|:|||.:..:|.:::..|.:...|.:..    :.|..| ..:.:|.|.::      |:|.|| 
  Fly   573 FLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVD-SAKSSTLGGRVVISAGRKQQGNDT 636

Human   572 ------------------------LVSTLMKCTPHYIRCIKPNETKKPRDWEESRVKHQVEYLGL 612
                                    |:|||...||||:||||||:.|....||.:::..|:...|:
  Fly   637 RRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGV 701

Human   613 KENIRVRRAGYAYRRIFQKFLQRYAILTKATWPSWQGEEKQGVLHLLQSVNMDSDQFQLGRSKVF 677
            .|.:|:..||:..|.::..|..||.:|...:... :.:.|....:::.....|.|:::.|.:::|
  Fly   702 LETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLD-KNDMKLSCRNIVMKWIQDEDKYRFGNTQIF 765

Human   678 IKAPESLFLLEEMRERKYDGYARVIQKSWRKFVARKKYV-----------------------QMR 719
            .:|.:..| ||::|......|..::|...|:||.|::::                       :||
  Fly   766 FRAGQVAF-LEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMR 829

Human   720 EEASDLLLNKKE----------RRRNSIN-----------RNFIGDYIGMEEH---PELQQFVG- 759
            |..:.|:|:|..          |.|:||:           ||   .:..|.:|   .::|:||. 
  Fly   830 EARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARN---KFHAMRDHYRAVQIQRFVRG 891

Human   760 ------------------------------KREKIDFADTVTKYDRRFKGVKRDLLLTPKCLYLI 794
                                          ||.|.: |.|::..:.::.|::..::...:.:..:
  Fly   892 ALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAE-AKTISHMENKYMGLENKIISMQQRIDEL 955

Human   795 GREKVKQGPDKGLVK------EVLKRKIEIERILSVSLSTMQDDIFILHEQEYDSLLESVFKTEF 853
            .|       |...:|      .|||.|:|:::.|......::...     |:.|.|:|:      
  Fly   956 NR-------DNSNLKHKTSEISVLKMKLELKKTLEAEFKNVKAAC-----QDKDKLIEA------ 1002

Human   854 LSLLAKRYEEKTQKQLPLKFSN---TLELKLKKENWGPWSAGGSRQVQ----------------- 898
               |.|:.|.:..:::.|...|   ..|...:|:.|...:....||:.                 
  Fly  1003 ---LNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQE 1064

Human   899 ---------------FHQGFGDLAVLKPSNKVLQVSI----GPGLPKNSRPTRRNTTQN---TGY 941
                           :.:...|..|::..|.:|:..:    ......::|.....::||   .||
  Fly  1065 DRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGY 1129

Human   942 SS--GTQNANYPVRAAPPPPGYH------------------QNGVIRNQYVPYP--HAPGSQRSN 984
            :|  .|.:.|.|.........|:                  ::.|::.||:...  |.|     .
  Fly  1130 ASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKP-----T 1189

Human   985 QKSLYTSMARPPLPRQQSTSSDRVSQTPESLDFLKVPDQGAA---GVRRQTTSRPPPAGGRPKPQ 1046
            :.|...|.......:.:|......:.....::..::..|.||   .|||:               
  Fly  1190 EDSFRVSELEVENEKLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRRR--------------- 1239

Human  1047 PKPKPQVPQCKALYAYDAQ-----DTDELSFNANDIIDIIK 1082
               :.:..|.||:....:|     :.:.|....||:.::::
  Fly  1240 ---REECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELME 1277

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYO1ENP_004989.2 MYSc 14..692 CDD:214580 256/728 (35%)
MYSc_Myo1 33..679 CDD:276829 247/702 (35%)
Actin-binding. /evidence=ECO:0000255 581..591 8/9 (89%)
Myosin_TH1 719..902 CDD:283635 45/278 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 919..966 10/73 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 993..1053 7/62 (11%)
SH3_MyoIe_If_like 1056..1107 CDD:212761 6/32 (19%)
didumNP_724569.1 MYSc 65..778 CDD:214580 256/727 (35%)
MYSc_Myo5 84..767 CDD:276831 247/702 (35%)
IQ 900..922 CDD:197470 0/21 (0%)
GBP_C <971..1086 CDD:303769 20/128 (16%)
coiled coil 1049..1068 CDD:293879 0/18 (0%)
coiled coil 1077..1086 CDD:293879 0/8 (0%)
JAKMIP_CC3 <1190..1299 CDD:292653 16/106 (15%)
Myo5_CBD 1424..1792 CDD:271254
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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