DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYO1E and ck

DIOPT Version :9

Sequence 1:	NP_004989.2	Gene:	MYO1E / 4643	HGNCID:	7599	Length:	1108	Species:	Homo sapiens
Sequence 2:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster

Alignment Length:	1079	Identity:	338/1079 - (31%)
Similarity:	537/1079 - (49%)	Gaps:	160/1079 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    14 HNVKHSGVDDMVLLSKITENSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQG 78
            |.....||:||:.|..:.|..|:.||..||.::.|:||.||:|::|||::.:|.:...:|::|:.
  Fly    58 HASSVQGVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKE 122

Human    79 AAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVSGGGTKVQHVK 143
            ....|.||||:|:.||.|.:|...|::||::||||||||||.:.|.|:.|::.:||   |...::
  Fly   123 RKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISG---KHSWIE 184

Human   144 DIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERS 208
            ..||::||:|||||||||:||:||||||||.:|.||..|..:|.||..:||||||:|.:|..||:
  Fly   185 QQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERN 249

Human   209 FHIFYQLIEGASAEQKHSLGITSMDYYYYLSLSGSYKVDDIDDRREFQETLHAMNVIGIFAEEQT 273
            :|:||.::.|.||::|..|.:.....|.||:...|...:..||..||.:...||.|: :|::::.
  Fly   250 YHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVL-LFSDQEI 313

Human   274 L-VLQIVAGILHLGNISFKE--VGNYAAVESEEFLAFP--AYLLGINQDRLKEKLTSRQMDSKWG 333
            . :::::|.:||.|||.:|.  |.|..|.|..|.:...  |.|||:....|.:.||.|.:.:
  Fly   314 WEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFA--- 375

Human   334 GKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEKDH--EEYNIGVLDIYGFEIFQ 396
             ..|::..||:.:|:...|||..|.::.|:|..:|..||.|:.|..  ....||||||:|||.|.
  Fly   376 -HGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFD 439

Human   397 KNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKVNPPGIMS 461
            :|.|||||||:.||.|||.|::...|.|||||..|.|.|..||:.:|:...|||  .:....||:
  Fly   440 QNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLI--AIKQLNIMA 502

Human   462 ILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHF----NSWNQGFIIHHYAGKVSYDMDGFCERN 522
            ::|:..    ...:|.|||:|.||....|||:::    :..|..|.::|:||.|.||..||.::|
  Fly   503 LIDEEA----RFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKN 563

Human   523 RDVLFMDLIELMQSSELPFIKSLFPENLQ--ADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIR 585
            ||....||:.|:..|...|::.:|.::::  |:.:.|..|..::.:|..:.|:.||..|.|.:||
  Fly   564 RDTFSPDLLHLVSQSTNKFLRQIFAQDIEMGAETRKRTPTLSTQFRKSLDALMKTLSSCQPFFIR 628

Human   586 CIKPNETKKPRDWEESRVKHQVEYLGLKENIRVRRAGYAYRRIFQKFLQRYAILTKATWPSWQGE 650
            ||||||.|||..::......|:.|.|:.|.||:|||||..|..|::|::||..|.....|:.: .
  Fly   629 CIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHR-T 692

Human   651 EKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEE----------MRERKYDGY------- 698
            :.|.....:.:|.:....:|||.:|||:|....|||.:|          :.:|...|:
  Fly   693 DCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFL 757

Human   699 -----ARVIQKSWRKFVARKKYVQMREEASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFV 758
                 |..:|:.|:.:..||:|..||.....|....:.|..:...|:..|..:|::.|  .:.::
  Fly   758 RLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAH--ARGYL 820

Human   759 GKRE---KIDFADTVTKYDRRFKGVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLK-RKIEIE 819
            .:||   |:.....:..:.||...::|         |...|.:.||      ..|||: ||:|.:
  Fly   821 VRREYGHKMWAVIKIQSHVRRMIAMRR---------YRKLRLEHKQ------FAEVLQLRKLEEQ 870

Human   820 RIL--------SVSLSTMQDDIFILHEQEYDSLLESVFKTE----FLSLLAKRYEEKTQKQLPLK 872
            .:|        .::....:|.:..|..:|....||:..:.|    .::..|::.||      |:.
  Fly   871 ELLHRGNKHAREIAEQHYRDRLHELERREIQEQLENRRRVEVNMNIINDAARKQEE------PVD 929

Human   873 FSNTLELKL----KKENWGPWSAGGSRQVQFHQGFGDLAVLKPSNKVLQVSIGPGLPKNSRPTRR 933
            ....:|...    ...:..|...||.....|                           |..|..:
  Fly   930 DGKLVEAMFDFLPDSSSDAPTPHGGRETSVF---------------------------NDLPHAQ 967

Human   934 NTTQN------------------------TGYSSGTQNANYPVRAAPPPPGYHQNGVIRNQYVPY 974
            |..|:                        ..|..|..|..|..:|            :::..:|.
  Fly   968 NVNQDDIIAPIHISEDEEDLSEFKFQKFAATYFQGNVNHQYAKKA------------LKHPLLPL 1020

Human   975 PHAPGSQRSNQKSLYTSMAR--PPLPRQQSTSSDRVSQT 1011
             |..|.|.:.| :|:.::.|  ..:|..:..:.||:..|
  Fly  1021 -HTQGDQLAAQ-ALWITILRFTGDMPEPKYHTMDRMDTT 1057

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYO1E	NP_004989.2	MYSc	14..692	CDD:214580	270/700 (39%)
		MYSc_Myo1	33..679	CDD:276829	258/658 (39%)
		Actin-binding. /evidence=ECO:0000255	581..591		7/9 (78%)
		Myosin_TH1	719..902	CDD:283635	39/202 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	919..966		9/70 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	993..1053		5/21 (24%)
		SH3_MyoIe_If_like	1056..1107	CDD:212761
ck	NP_001285949.1	MYSc	64..733	CDD:214580	269/683 (39%)
		MYSc_Myo7	77..721	CDD:276832	258/658 (39%)
		MyTH4	<1138..1245	CDD:214535
		B41	1251..1467	CDD:214604
		FERM_B-lobe	1355..1439	CDD:271216
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:302595
		MyTH4	1701..1849	CDD:214535
		B41	1856..2068	CDD:214604
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910