Protein Alignment MYO1E and ck

DIOPT Version :10

• Sequence 1: NP_004989.2
• Gene: MYO1E / 4643
• HGNCID: 7599
• Length: 1108
• Species: Homo sapiens
• Sequence 2: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Alignment Length: 1079
• Identity: 338/1079 - (31%)
• Similarity: 537/1079 - (49%)
• Gaps: 160/1079 - (14%)

Human    14 HNVKHSGVDDMVLLSKITENSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQG 78
            |.....||:||:.|..:.|..|:.||..||.::.|:||.||:|::|||::.:|.:...:|::|:.
  Fly    58 HASSVQGVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKE 122

Human    79 AAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVSGGGTKVQHVK 143
            ....|.||||:|:.||.|.:|...|::||::||||||||||.:.|.|:.|::.:||   |...::
  Fly   123 RKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISG---KHSWIE 184

Human   144 DIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERS 208
            ..||::||:|||||||||:||:||||||||.:|.||..|..:|.||..:||||||:|.:|..||:
  Fly   185 QQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERN 249

Human   209 FHIFYQLIEGASAEQKHSLGITSMDYYYYLSLSGSYKVDDIDDRREFQETLHAMNVIGIFAEEQT 273
            :|:||.::.|.||::|..|.:.....|.||:...|...:..||..||.:...||.|: :|::::.
  Fly   250 YHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVL-LFSDQEI 313

Human   274 L-VLQIVAGILHLGNISFKE--VGNYAAVESEEFLAFP--AYLLGINQDRLKEKLTSRQMDSKWG 333
            . :::::|.:||.|||.:|.  |.|..|.|..|.:...  |.|||:....|.:.||.|.:.:
  Fly   314 WEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFA--- 375

Human   334 GKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEKDH--EEYNIGVLDIYGFEIFQ 396
             ..|::..||:.:|:...|||..|.::.|:|..:|..||.|:.|..  ....||||||:|||.|.
  Fly   376 -HGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFD 439

Human   397 KNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKVNPPGIMS 461
            :|.|||||||:.||.|||.|::...|.|||||..|.|.|..||:.:|:...|||  .:....||:
  Fly   440 QNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLI--AIKQLNIMA 502

Human   462 ILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHF----NSWNQGFIIHHYAGKVSYDMDGFCERN 522
            ::|:..    ...:|.|||:|.||....|||:::    :..|..|.::|:||.|.||..||.::|
  Fly   503 LIDEEA----RFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKN 563

Human   523 RDVLFMDLIELMQSSELPFIKSLFPENLQ--ADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIR 585
            ||....||:.|:..|...|::.:|.::::  |:.:.|..|..::.:|..:.|:.||..|.|.:||
  Fly   564 RDTFSPDLLHLVSQSTNKFLRQIFAQDIEMGAETRKRTPTLSTQFRKSLDALMKTLSSCQPFFIR 628

Human   586 CIKPNETKKPRDWEESRVKHQVEYLGLKENIRVRRAGYAYRRIFQKFLQRYAILTKATWPSWQGE 650
            ||||||.|||..::......|:.|.|:.|.||:|||||..|..|::|::||..|.....|:.: .
  Fly   629 CIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHR-T 692

Human   651 EKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEE----------MRERKYDGY------- 698
            :.|.....:.:|.:....:|||.:|||:|....|||.:|          :.:|...|:
  Fly   693 DCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFL 757

Human   699 -----ARVIQKSWRKFVARKKYVQMREEASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFV 758
                 |..:|:.|:.:..||:|..||.....|....:.|..:...|:..|..:|::.|  .:.::
  Fly   758 RLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAH--ARGYL 820

Human   759 GKRE---KIDFADTVTKYDRRFKGVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLK-RKIEIE 819
            .:||   |:.....:..:.||...::|         |...|.:.||      ..|||: ||:|.:
  Fly   821 VRREYGHKMWAVIKIQSHVRRMIAMRR---------YRKLRLEHKQ------FAEVLQLRKLEEQ 870

Human   820 RIL--------SVSLSTMQDDIFILHEQEYDSLLESVFKTE----FLSLLAKRYEEKTQKQLPLK 872
            .:|        .::....:|.:..|..:|....||:..:.|    .::..|::.||      |:.
  Fly   871 ELLHRGNKHAREIAEQHYRDRLHELERREIQEQLENRRRVEVNMNIINDAARKQEE------PVD 929

Human   873 FSNTLELKL----KKENWGPWSAGGSRQVQFHQGFGDLAVLKPSNKVLQVSIGPGLPKNSRPTRR 933
            ....:|...    ...:..|...||.....|                           |..|..:
  Fly   930 DGKLVEAMFDFLPDSSSDAPTPHGGRETSVF---------------------------NDLPHAQ 967

Human   934 NTTQN------------------------TGYSSGTQNANYPVRAAPPPPGYHQNGVIRNQYVPY 974
            |..|:                        ..|..|..|..|..:|            :::..:|.
  Fly   968 NVNQDDIIAPIHISEDEEDLSEFKFQKFAATYFQGNVNHQYAKKA------------LKHPLLPL 1020

Human   975 PHAPGSQRSNQKSLYTSMAR--PPLPRQQSTSSDRVSQT 1011
             |..|.|.:.| :|:.::.|  ..:|..:..:.||:..|
  Fly  1021 -HTQGDQLAAQ-ALWITILRFTGDMPEPKYHTMDRMDTT 1057

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1E	NP_004989.2	MYSc_Myo1	33..679	CDD:276829	258/658 (39%)
		Actin-binding. /evidence=ECO:0000255	581..591		7/9 (78%)
		Myosin_TH1	719..920	CDD:461801	39/220 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	919..966		9/70 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	993..1053		5/21 (24%)
		SH3_MyoIe_If_like	1056..1107	CDD:212761
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	258/658 (39%)
		MyTH4	<1138..1245	CDD:214535
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612
		B41	1251..1467	CDD:214604
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:473055
		MyTH4	1701..1849	CDD:214535
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613
		B41	1856..2068	CDD:214604
		FERM_C2_MyoVII	2064..2159	CDD:270020