Protein Alignment MYO1D and Myo28B1

DIOPT Version :10

• Sequence 1: NP_056009.1
• Gene: MYO1D / 4642
• HGNCID: 7598
• Length: 1006
• Species: Homo sapiens
• Sequence 2: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Alignment Length: 872
• Identity: 301/872 - (34%)
• Similarity: 475/872 - (54%)
• Gaps: 122/872 - (13%)

Human     1 MAEQESLEFGKADFVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQ 65
            :..||.:|    |.:.:..:.....:.||:.|:.|..|||:.|.::|::|||::|.||....|:.
  Fly    63 ITSQEDVE----DMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQL 123

Human    66 YKGRELYERPPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAE 130
            |:.:.|.|.|||:|||:|.|::.::|..::.|:||||||||||||::|.|:||:|||:     .:
  Fly   124 YRNKSLAELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAIS-----GK 183

Human   131 VERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQ 195
            ...::..::::|.::||||||||.|||||||||||::|.|..:|...|..|..|||||||::.|.
  Fly   184 HSWIEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQS 248

Human   196 PGERSFHSFYQLLQGGSEQMLRSLHLQ-KSLSSYNYIHVGAQLK-SSINDAAEFRVVADAMKVIG 258
            ..||::|.||.:|.|.|......|.|| :|.|.|:|:..|.... ....||.:|..:..||||:.
  Fly   249 RDERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLS 313

Human   259 FKPEEIQTVYKILAAILHLGNLKFV-----------VDGDTPLIENGKVVSIIAELLSTKTDMVE 312
            |||||:.::..:||||||||||:|.           :| |||.::.      :|:||......:.
  Fly   314 FKPEEVWSILSLLAAILHLGNLRFTATEVANLATAEID-DTPNLQR------VAQLLGIPISALN 371

Human   313 KALLYRTVATGRDIIDKQHTEQEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTIHGKNT 377
            .||..||:....:.:....:::.|..|||||.|::|:.:|..||.|||:.|. |..|..::.
  Fly   372 AALTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETIN-KQVDQPMNS--- 432

Human   378 VIGVLDIYGFEIFDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIV 442
             ||||||:|||.||||||||.||||.||.|||.|:..:.|.||:|||.|.|.|:||::.:||.|:
  Fly   433 -IGVLDIFGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQIL 496

Human   443 DLVEQQHKGIIAILDDACMNVGKVTDEMFLEALNSKLGKHAHFSSRKLCASDKILEFDRDFRIRH 507
            ||:..:...:::::|:. ....|.||:..||.|      |....:|.:....|..:... |.|||
  Fly   497 DLIGMKPMNLMSLIDEE-SKFPKGTDQTLLEKL------HVQHGNRSIYVKGKTTQTSL-FGIRH 553

Human   508 YAGDVVYSVIGFIDKNKDTLFQDFKRLMYNSSNPVLKNMWPEGKLSITEVTKRPLTAATLFKNSM 572
            |||.|:|:.:||::||:|:...|.:.|:..|:|..|.:::|. ::.:....|:| |....|:||:
  Fly   554 YAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTNKYLVDIFPH-EMPMDTAKKQP-TLCVKFRNSL 616

Human   573 IALVDNLASKEPYYVRCIKPNDKKSPQIFDDERCRHQVEYLGLLENVRVRRAGFAFRQTYEKFLH 637
            ..|:..|:...||::||||||:.|.|:.||.|.|..|:.|.|::|..|:||||:..|..|..|:.
  Fly   617 DMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVE 681

Human   638 RYKMISEFTWPNHDLPSDKEAVKKLIERCGFQ--------------DDVAYGKTKIFIRTPRTLF 688
            ||:::.....|              :|:|..:              .|..|||||:|:|.....
  Fly   682 RYRLLVPPVGP--------------LEQCDCRKLARQICEVALPADSDRQYGKTKLFLRDEDDA- 731

Human   689 TLEELRAQMLIRIVLFLQKVWRGTLARMRYKRTKAALTIIRYYRRYKVKSYIHEVARR-FH---- 748
            :||..|:|::::.::.:|:..|..|.|...||.:.|:..::.|.|.:::...::|.|: ||
  Fly   732 SLELQRSQLMLKSIVTIQRGIRRVLFRRYMKRYREAIITVQRYWRGRLQRRKYQVMRQGFHRLGA 796

Human   749 --------------------------GVKTMRDYGKHVKWPSPPKVLRRFEEALQTIFNRWRASQ 787
                                      |....:|:.|        |:|.|.::      |:.:..:
  Fly   797 CIAAQQLTTKFTMVRCRTIKLQALSRGYLVRKDFQK--------KLLERRKQ------NQLKKEE 847

Human   788 LIKSIPASDLPQVRAKVAAVEMLKGQR 814
            |:|.....:..:    :..::.||.|:
  Fly   848 LLKLAKMKEAEE----LLRLQQLKEQK 870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1D	NP_056009.1	MYSc_Myo1	24..682	CDD:276829	267/684 (39%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	572..594		9/21 (43%)
		Myosin_TH1	803..996	CDD:461801	3/12 (25%)
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	267/685 (39%)
		IQ	765..785	CDD:197470	3/19 (16%)
		Atrophin-1	<820..>946	CDD:460830	12/69 (17%)
		MyTH4	1031..1239	CDD:470587
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612
		B41	1248..1429	CDD:214604
		PH-like	1454..1547	CDD:473070
		MyTH4	1674..1819	CDD:214535
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613
		B41	1827..2032	CDD:214604
		FERM_C2_MyoVII	2028..2121	CDD:270020