Protein Alignment MYO1D and jar

DIOPT Version :10

• Sequence 1: NP_056009.1
• Gene: MYO1D / 4642
• HGNCID: 7598
• Length: 1006
• Species: Homo sapiens
• Sequence 2: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Alignment Length: 1227
• Identity: 331/1227 - (26%)
• Similarity: 517/1227 - (42%)
• Gaps: 316/1227 - (25%)

Human    25 FMANLRLRFEKGRIYTFIGEVVVSVNPYK-LLNIYGRDTIEQYKGRELYERPPHLFAIADAAYKA 88
            |:.||:.|:.|.:|||::..::::||||: :..:|..|||::|.||.|.|.|||:|||||.|.:.
  Fly    73 FLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFAIADKAIRD 137

Human    89 MKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNMLLKSNCVLEAFGNAKT 153
            |:.......|::||||||||||::||:::|:....:.:...|.:     :|.:|.||||||||||
  Fly   138 MRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIETK-----ILDANPVLEAFGNAKT 197

Human   154 NRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGERSFHSFYQLLQGGSEQMLRS 218
            .||:|||||||::::::|.|...:||:|::|||||||:..|...||::|.||.||.|..:|:...
  Fly   198 TRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLLAGAPQQLRDK 262

Human   219 LHLQK-------------------------SLSSYNYIHVGAQLKSSINDAAEFRVVADAMKVIG 258
            |.|.|                         |..|.|:...|......|:|...|..:..|:..:|
  Fly   263 LSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQHFHNLDKALGRLG 327

Human   259 FKPEEIQTVYKILAAILHLGNLKFV-----VDGDTPLIE-NGKVVSIIAELLSTKTDMVEKALLY 317
            ....|...:|.::||:|||||:.|.     |.|...:.| :.:.::|.:.||......:..||:.
  Fly   328 LSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGLLGVDQTELRTALVS 392

Human   318 RTVAT-----GRDIIDKQHTEQEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTIHGKNT 377
            |.:.:     ...:|.......|||..|||.|||||.|||..||..||..|       .....|.
  Fly   393 RVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSI-------PFQASNF 450

Human   378 VIGVLDIYGFEIFDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIV 442
            .||||||.|||.|..||||||||||||||||:.|...:||.|||.|:|||:....|.:.:||.|:
  Fly   451 YIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFTDNQDII 515

Human   443 DLVEQQHKGIIAILDDACMNVGKVTDEMFLEALNSKLGK--HAHF------------------SS 487
            :|:|.:..||..:||:                 .|||.|  ::||                  ||
  Fly   516 ELIEAKSNGIFTLLDE-----------------ESKLPKPSYSHFTAEVHKSWANHYRLGLPRSS 563

Human   488 RKLCASDKILEFDRDFRIRHYAGDVVYSVIGFIDKNKDTLFQDFKRLMYNSSNPVLKNMWPEGKL 552
            |  ..:.:.|..:..|.:||:||.|.|:...||:||.|.|....:.|:....||:|:.::|.|..
  Fly   564 R--LKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGSS 626

Human   553 SITEVTKRPLTAATLFKNSMIALVDNLASKEPYYVRCIKPNDKKSPQIFDDERCRHQVEYLGLLE 617
            :........::..:.||..:..|::.|......::||||||.|...:.|:......|::..|.:.
  Fly   627 TSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTIS 691

Human   618 NVRVRRAGFAFRQTYEKFLHRYKMISEFTWPNHDLPSDKEAV-KKLIERCGFQD------DVAYG 675
            .:.:...|:..|..:......||.:         ||.:..:: .:......||.      |..:|
  Fly   692 VLELMEHGYPSRVLFADLYSMYKSV---------LPPELVSLPARTFCEAMFQSLNLSAKDFKFG 747

Human   676 KTKIFIR-------------TPRTLFTLE-----------------------ELRAQMLIR--IV 702
            .||:|.|             .|..:..:.                       :||.:::.|  .|
  Fly   748 ITKVFFRPGKFVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRNRIIYRNKCV 812

Human   703 LFLQKVWRGTLARMRYK------------RTKAALTI-----IRYYRRYKVKSYIHEVARRF-HG 749
            |..|::.||.|||.:::            ||....||     ::..|. ::.|.::::.|:. ..
  Fly   813 LIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASGLKMGRE-EIISGVNDIYRQIDDA 876

Human   750 VK--------TMRDYG---------------------KHVKWPSPPKVLRRFEEALQT------- 778
            :|        |.|:..                     |..:.....:.||:.:|||:.
  Fly   877 IKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTKLKEQQQAEEQERLRKIQEALEAERAAKEA 941

Human   779 --------IFNRWRASQL---IKSIPASDLPQV----RAKVAAVEMLKGQRAD------------ 816
                    |.|:...:::   .|:..|..|.|.    ||.:|..|.|:.:..|
  Fly   942 EEQRQREEIENKRLKAEMETRRKAAEAQRLRQEEEDRRAALALQEQLEKEAKDDAKYRQQLEQER 1006

Human   817 ----LGLQRAWEGNYLASKPDTPQTSGTFVPVANELKRKDKYMNVLFSCHVRKVNRFSKVEDRAI 877
                |.|:.|.|.|  ....|:|......|..|:.:.     .|.|.|        ||:|...
  Fly  1007 RDHELALRLANESN--GQVEDSPPVIRNGVNDASPMG-----PNKLIS--------FSQVVSN-- 1054

Human   878 FVTDRHLYKMDPTKQYKVMKTIPLYNLTGLSVSNGKD--------------------QLVVFH-- 920
             :..|:|.|.:..:..:.......|:|:....|..:|                    :|.|:|
  Fly  1055 -IASRYLNKSENVRAQQQALGKQKYDLSKWKYSELRDAINTSCDIELLEACRQEFHRRLKVYHAW 1118

Human   921 --------TKDN-----KDLIVCLFSKQPTHESRIGELV----------------------GVLV 950
                    |.|.     :.::...| |||.....|.|:|                      |:..
  Fly  1119 KAKNRKRTTMDENERAPRSVMEAAF-KQPPLVQPIQEIVTAQHRYFRIPFMRANAPDNTKRGLWY 1182

Human   951 NHFKSE--KRHLQVNVTNPVQCSLHG----KKCTVSVETRLNQPQPDFTKNRSGFIL 1001
            .||..:  .|.::::...|....:.|    :.|.:|:|      :...|:.|...||
  Fly  1183 AHFDGQWIARQMELHADKPPILLVAGTDDMQMCELSLE------ETGLTRKRGAEIL 1233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1D	NP_056009.1	MYSc_Myo1	24..682	CDD:276829	243/720 (34%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	572..594		7/21 (33%)
		Myosin_TH1	803..996	CDD:461801	48/271 (18%)
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670
		MYSc_Myo6	71..754	CDD:276833	243/720 (34%)
		CBD_MYO6-like	765..913	CDD:409646	22/148 (15%)
		ERM_helical	<954..1020	CDD:466641	14/65 (22%)
		MYO6_MIU_linker	1002..1093	CDD:480843	22/108 (20%)
		MyUb_Myo6	1076..1116	CDD:439319	6/39 (15%)
		Myosin-VI_CBD	1160..1246	CDD:465157	13/80 (16%)