Protein Alignment MYO1D and Myo61F

DIOPT Version :10

• Sequence 1: NP_056009.1
• Gene: MYO1D / 4642
• HGNCID: 7598
• Length: 1006
• Species: Homo sapiens
• Sequence 2: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Alignment Length: 1060
• Identity: 424/1060 - (40%)
• Similarity: 614/1060 - (57%)
• Gaps: 117/1060 - (11%)

Human    10 GKADFVLMDTVSMPE-FMANLRLRFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQYKGRELYE 73
            |..||||::.....| |:.||:.||::..|||:||:|::||||||.|.||..|.::.|:.:..||
  Fly    38 GVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYE 102

Human    74 RPPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNML 138
            .|||:||:.|.|::::...::..|::||||||:|||||||.::|:|||.:  ..:..||.||:.|
  Fly   103 MPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACS--GNQTTVEGVKDKL 165

Human   139 LKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGERSFHS 203
            ||||.|||||||||||||||||||||||||.|||||.||||:|.|||||||||:.|..|||:||.
  Fly   166 LKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHI 230

Human   204 FYQLLQGGSEQMLRSLHLQKSLSSYNYIHVGAQ-LKSSINDAAEFRVVADAMKVIGFKPEEIQTV 267
            |||||.|..|.:|:.|.|:::|.:|:|:..|.. ..:.||||..|:.|..|:.||.|..||.:.:
  Fly   231 FYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQREI 295

Human   268 YKILAAILHLGNLKFV-VDGDTPLIENGKVVSIIAELLSTKTDMVEKALLYRTVATGRDIIDKQH 331
            :.|:|:||||||:.|. |:|:..:.....||: .|.||......:|.||.:||:....|::....
  Fly   296 FGIVASILHLGNVGFTEVEGNAKVNSRDLVVT-AARLLGVNASELEAALTHRTIDARGDVVTSPL 359

Human   332 TEQEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTIHGKNTVIGVLDIYGFEIFDNNSFE 396
            .::.|.|.|||.|||:|:|||.|:|.|:|..::.|.   |...:|.|:|:|||||||||..||||
  Fly   360 NQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKE---TRASRNNVMGILDIYGFEIFQKNSFE 421

Human   397 QFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIIAILDDACM 461
            |||||:||||||||||:|.||.||:||:||||.|..::||:|::|.:|:|::|||||:|||:.|:
  Fly   422 QFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDEECL 486

Human   462 NVGKVTDEMFLEALNSKLGKHAHF-SSRKLCASDKILEFDRDFRIRHYAGDVVYSVIGFIDKNKD 525
            ..|:.||:.|||.|..||.:|.|: ...|..|..|.:....:||:.||||:|.|||.||:|||.|
  Fly   487 RPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGFLDKNND 551

Human   526 TLFQDFKRLMYNSSNPVLKNMWPEGKLSITEVTKRPLTAATLFKNSMIALVDNLASKEPYYVRCI 590
            .||:|.|..:..:.|.:::|.:||.:|   ...|||.||.|.|:.|:..|:|.|..|||.|:|||
  Fly   552 LLFRDLKETLSKAGNGIVRNCFPEKEL---RSLKRPETAITQFRASLNNLMDILMCKEPSYIRCI 613

Human   591 KPNDKKSPQIFDDERCRHQVEYLGLLENVRVRRAGFAFRQTYEKFLHRYKMISEFTWPNHDLP-S 654
            ||||.::..:|:||...|||:||||:||:||||||||:|:|||.||.|||.:|:.||||:..| .
  Fly   614 KPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYKGPGG 678

Human   655 DKEAVKKLIERCGFQDDVAY--GKTKIFIRTPRTLFTLEELRAQMLIRIVLFLQKVWRGTLARMR 717
            .|..|::|::..|: |:..|  |:||:|||.|||||..|:...:....|...:|..|:|.:.|.:
  Fly   679 PKAGVQQLVKDLGW-DEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGLMQRRK 742

Human   718 YKRTKAALTIIRYYRRYK-------------------VKSYIHE-------------VARRFHGV 750
            |.:.:|.:.|::.|.|.|                   :|.:|..             .|:|...:
  Fly   743 YLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEFIANAKRMWLL 807

Human   751 KTMRDYGKHV---KWPSPPKVLRRFEEALQTIFNRWRASQLIKSIPASDLPQVR----AKVAAVE 808
            :..::....|   .||..|   ...||| ..|.:|.....|.:.......||.:    .||.|.:
  Fly   808 RLAKELPTKVLDKSWPHAP---GHCEEA-SGILHRLHRLHLARIYRLKLTPQQKRQFELKVLAEK 868

Human   809 MLKGQRADLGLQRAWEGNYLASKPDTPQTSGTF----VPVANELKRKDKYMNVLFSCHVRKVNRF 869
            :.||::          .||.:|      .|..|    :| ...::|.:.::...|.....|...|
  Fly   869 VFKGKK----------NNYASS------VSTWFQEDRIP-KEHIQRVNDFVASTFGSEQLKYQSF 916

Human   870 S--------KVEDRAIFVTDRHLYKMDPTKQYKVMKTIPLYNLTGLSVSNGKDQLVVFH-----T 921
            .        |..||.|.::::.:|.:| .|.||....:||..: ..:::|..|.|:|..     .
  Fly   917 CTKFDRHGYKSRDRFILLSNKAIYVLD-GKTYKQKHRLPLDKI-DFTLTNHNDDLMVIRIPLDLK 979

Human   922 KDNKDLIVCL-----FSKQPTHESRIGELVGVLVNHFKSEKRHLQVNVTNPVQCSLHGKKCTVSV 981
            ||..|||:.:     ||...........:|.::      ::..|:.||       :.||...:.:
  Fly   980 KDKGDLILIIPRIIEFSTYIIDTVGTASIVSIV------DRNSLEHNV-------VKGKGGVIDI 1031

Human   982 ETRLNQPQPDFTKNRSGFIL 1001
            :|   ..:|...:::...::
  Fly  1032 QT---GAEPGVVRDKGHLVI 1048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1D	NP_056009.1	MYSc_Myo1	24..682	CDD:276829	339/664 (51%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	572..594		12/21 (57%)
		Myosin_TH1	803..996	CDD:461801	45/214 (21%)
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	339/664 (51%)
		Myosin_TH1	863..1049	CDD:461801	45/221 (20%)