Protein Alignment MYO1D and zip

DIOPT Version :10

• Sequence 1: NP_056009.1
• Gene: MYO1D / 4642
• HGNCID: 7598
• Length: 1006
• Species: Homo sapiens
• Sequence 2: NP_523860.2
• Gene: zip / 38001
• FlyBaseID: FBgn0287873
• Length: 2056
• Species: Drosophila melanogaster
• Alignment Length: 917
• Identity: 301/917 - (32%)
• Similarity: 469/917 - (51%)
• Gaps: 136/917 - (14%)

Human     3 EQESLEFGKADFVLMDTV---SMPEF-----------------MANLRLRFEKGRIYTFIGEVVV 47
            |.|..|.||...:|.|.:   :.|:|                 :.|::.|:..|.|||:.|...|
  Fly   105 EVELAETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCV 169

Human    48 SVNPYKLLNIYGRDTIEQYKGRELYERPPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEAS 112
            .|||||.|.||....:|:|||.:.:|.|||:|||.|:||:.|....:|..|:.:|||||||||.:
  Fly   170 VVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENT 234

Human   113 KYIMQYIA-----------AITNPS---------------------------------------- 126
            |.::|::|           |:.:|:
  Fly   235 KKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSN 299

Human   127 -QRAEVERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSR 190
             |..|:|:   .||::|.:|||||||||.:|||||||||::.||||..|...|.:|..|||||||
  Fly   300 CQEGELEQ---QLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSR 361

Human   191 VIVQQPGERSFHSFYQLLQGGSEQMLRSLHLQKSLSSYNYIHVGAQLKSSINDAAEFRVVADAMK 255
            .|.|...||:||.|||||.|.:.:. |...:...:.||.::..|:.....::|.|||:....:|.
  Fly   362 AIRQAKDERTFHIFYQLLAGATPEQ-REKFILDDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMN 425

Human   256 VIGFKPEEIQTVYKILAAILHLGNLKFVVD--GDTPLIENGKVVSIIAELLSTKTDMVEKALLYR 318
            ::|...|:..::::|::|:|..|::||..:  .|...:.:..|...||.||......:.:|.|..
  Fly   426 IMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTP 490

Human   319 TVATGRDIIDKQHTEQEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTIHGKNTVIGVLD 383
            .:..|||.:.|..|:::..:..:|.|||.|||:|.|:|.|||     ::.|.|.....:.||:||
  Fly   491 RIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRIN-----RSLDRTKRQGASFIGILD 550

Human   384 IYGFEIFDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDY-FNNQIIVDLVEQ 447
            :.|||||:.|||||.||||.||||||||...:...||||||||||.||.||: .:.|..:||:::
  Fly   551 MAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDK 615

Human   448 QHKGIIAILDDACMNVGKVTDEMFLEALNSKLGKHAHFSSRKLCASDKILEFDRDFRIRHYAGDV 512
            . .||:|:||:.|. ..|.||:.|::.|.|     ||....|...:|  .....||.|.||||.|
  Fly   616 P-GGIMALLDEECW-FPKATDKTFVDKLVS-----AHSMHPKFMKTD--FRGVADFAIVHYAGRV 671

Human   513 VYSVIGFIDKNKDTLFQDFKRLMYNSSNPVLKNMWPEGKL------SITEV-----TKRPL--TA 564
            .||...::.||.|.|.::...|:..|.:|.:.|:|.:.::      ::|:.     |::.:  |.
  Fly   672 DYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALTDTQFGARTRKGMFRTV 736

Human   565 ATLFKNSMIALVDNLASKEPYYVRCIKPNDKK------SPQIFDDERCRHQVEYLGLLENVRVRR 623
            :.|:|..:..|:|.|.:..|.:||||.||.:|      :|.:.|..||.      |:||.:|:.|
  Fly   737 SHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCN------GVLEGIRICR 795

Human   624 AGFAFRQTYEKFLHRYKMISEFTWPNHDLPSDKEAVKKLIERCGFQDDV-AYGKTKIFIRTPRTL 687
            .||..|..:::|..||::::....|. .....|:|.:|:|:......:: ..|::|||.|. ..|
  Fly   796 QGFPNRIPFQEFRQRYELLTPNVIPK-GFMDGKKACEKMIQALELDSNLYRVGQSKIFFRA-GVL 858

Human   688 FTLEELRAQMLIRIVLFLQKVWRGTLARMRYKRTKAALTIIRYYRR-----YKVKSYIHEVARRF 747
            ..|||.|...:..:::..|...||.|||..|::....|..||..:|     .|::::  :..|.:
  Fly   859 AHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNW--QWWRLY 921

Human   748 HGVKTMRDYGKHVKWPSPPKVLRRFEEALQTIFNRWRASQLIKSIPASDLPQVRAKVAAVEMLKG 812
            ..||.:.:..|..:     |::::.:|..|.   |.:...|.|:....:....:|.|....:.:.
  Fly   922 TKVKPLLEVTKQEE-----KLVQKEDELKQV---REKLDTLAKNTQEYERKYQQALVEKTTLAEQ 978

Human   813 QRADLGL 819
            .:|::.|
  Fly   979 LQAEIEL 985

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1D	NP_056009.1	MYSc_Myo1	24..682	CDD:276829	261/749 (35%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	572..594		9/21 (43%)
		Myosin_TH1	803..996	CDD:461801	3/17 (18%)
zip	NP_523860.2	Myosin_N	79..122	CDD:460670	7/16 (44%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	260/733 (35%)
		Myosin_tail_1	931..2011	CDD:460256	11/63 (17%)