Protein Alignment MYO1D and Mhc

DIOPT Version :10

• Sequence 1: NP_056009.1
• Gene: MYO1D / 4642
• HGNCID: 7598
• Length: 1006
• Species: Homo sapiens
• Sequence 2: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Alignment Length: 1031
• Identity: 317/1031 - (30%)
• Similarity: 500/1031 - (48%)
• Gaps: 135/1031 - (13%)

Human    16 LMDTVSMPEF-----------------MANLRLRFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTI 63
            |:..|:.|::                 :.|||.|:....|||:.|...|::||||...:|.....
  Fly    76 LLQQVNPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCA 140

Human    64 EQYKGRELYERPPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQR 128
            :.|:|:...|.|||:|||:|.||..|.....:..::|:|||||||||.:|.::.|.|.:....:.
  Fly   141 KMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKT 205

Human   129 AEVERVKNML----LKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKS 189
            .|..:.|..|    :::|.||||||||||.||||||||||::.|:|...|...|..|..|||||:
  Fly   206 DEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKA 270

Human   190 RVIVQQPGERSFHSFYQLLQGGSEQMLRSLHLQKSLSSYNYIHVGAQLKSSINDAAEFRVVADAM 254
            |||.||..|||:|.|||::.|....:.....|..::..|:.:..|....:||:||.||.:...|.
  Fly   271 RVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAF 335

Human   255 KVIGFKPEEIQTVYKILAAILHLGNLKF---------VVDGDTPLIENGKVVSIIAELLSTKTDM 310
            .::||..:|.:.||:|.||::|:|.:||         ..||:.   |.|:|    ::|....|..
  Fly   336 DILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEE---EGGRV----SKLFGCDTAE 393

Human   311 VEKALLYRTVATGRDIIDKQHTEQEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTIHGK 375
            :.|.||...:..|.:.:.:....|:.:....|..|.:::|||.|:|.:.|:.::      |...:
  Fly   394 LYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLD------TQQKR 452

Human   376 NTVIGVLDIYGFEIFDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDY-FNNQ 439
            ...||||||.|||||:.|.|||.|||:.||||||.|...:...||||||||||.|..||: .:.|
  Fly   453 QHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQ 517

Human   440 IIVDLVEQQHKGIIAILDDACMNVGKVTDEMFLEAL-NSKLGKHAHFSSRKLCASDKILEFDRDF 503
            :.:||:|:. .||::||::..| ..|.||:.|.|.| |:.|||.|.|...|   ..|..:....|
  Fly   518 LCIDLIEKP-MGILSILEEESM-FPKATDQTFSEKLTNTHLGKSAPFQKPK---PPKPGQQAAHF 577

Human   504 RIRHYAGDVVYSVIGFIDKNK----DTLFQDFKRLMYNSSNPVLKNMWPE--GKLSITEVTKRP- 561
            .|.||||.|.|::.|:::|||    ||:...||:    |.|.:|..::.:  |:....|..|..
  Fly   578 AIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKK----SQNKLLIEIFADHAGQSGGGEQAKGGR 638

Human   562 -------LTAATLFKNSMIALVDNLASKEPYYVRCIKPNDKKSPQIFDDERCRHQVEYLGLLENV 619
                   .|.::.:|..:.:|:..|.|.:|::||||.||:.|.|.:.|.....||:...|:||.:
  Fly   639 GKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGI 703

Human   620 RVRRAGFAFRQTYEKFLHRYKMISEFTWPN--HDLPSDKEAVKKLIERCGF-QDDVAYGKTKIFI 681
            |:.|.||..|..|..|..|||::.    |.  ..:..||:|.:.:|:.... :|....|.||:|.
  Fly   704 RICRKGFPNRMMYPDFKMRYKIMC----PKLLQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFF 764

Human   682 RTPRTLFTLEELRAQMLIRIVLFLQKVWRGTLARMRYKR---TKAALTIIRYYRRYKVKSYIHEV 743
            |. ..|..:||.|.:.|.:|:.::|...||.|:|..:|:   .:.||.:::
  Fly   765 RA-GVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQ-------------- 814

Human   744 ARRFHGVKTMRDYGKHVKWP--------SPPKVLRRFEEALQTIFNRWRASQLI--------KSI 792
                   :.:|.|.:...||        .|...:.|.|:.:..:..:.:.::.:        |.:
  Fly   815 -------RNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKEL 872

Human   793 PASDLPQVRAKVAAVEMLKGQRADLGLQRAWEGNYLASKPDTPQTSGTFVPVANELKRKDKYMNV 857
            .|.:...:..|.|.::.|.|::..|...:.......|.|.|   .......:...|.:::...|.
  Fly   873 EALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKND---LENQLRDIQERLTQEEDARNQ 934

Human   858 LFSCHVRKVNRFSKVEDRAIFVTDRHLYKMDPTKQYKVMKTIPLYNLTGLSVSNGKDQLVVFHTK 922
            ||.   :|.....::......:.|..| .:...:|.|..|...:.||.. .::: :|:|:   .|
  Fly   935 LFQ---QKKKADQEISGLKKDIEDLEL-NVQKAEQDKATKDHQIRNLND-EIAH-QDELI---NK 990

Human   923 DNKDLIVCLFSKQPTHESRIGELVGV--LVNHFKSEKRHLQVNVTNPVQCSLHGKK 976
            .||:..:...:.|.|.|    ||...  .:||....|..|: ...:.::.||..:|
  Fly   991 LNKEKKMQGETNQKTGE----ELQAAEDKINHLNKVKAKLE-QTLDELEDSLEREK 1041

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1D	NP_056009.1	MYSc_Myo1	24..682	CDD:276829	253/706 (36%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	572..594		9/21 (43%)
		Myosin_TH1	803..996	CDD:461801	37/176 (21%)
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	253/690 (37%)
		Myosin_tail_1	842..1922	CDD:460256	41/217 (19%)